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Advances in Veterinary Vaccine Technologies: From RNA Platforms to Nanovaccines | ||
| Archives of Razi Institute | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 12 مهر 1404 اصل مقاله (400.5 K) | ||
| نوع مقاله: Review Article | ||
| شناسه دیجیتال (DOI): 10.22092/ari.2025.369881.3710 | ||
| نویسندگان | ||
| Abdol Ghaffar Ebadi1؛ Shahid Abbas2؛ Umar Murad Khan3، 4؛ Zeliha Selamoglu* 5، 6، 7 | ||
| 1Department of Agriculture, Jo.C, Islamic Azad University, Jouybar, Iran. | ||
| 2Allergy and Asthma Center, Blue Area, Islamabad, Pakistan. | ||
| 3Department of Clinical and Tropical Diseases Research, National Institute of Health, Islamabad. Former HOD Allergy & Immunology, NIH, Islamabad, Pakistan. | ||
| 4Department Of Food Hygiene and Technology, Faculty of Veterinary Medicine, Selcuk University, Konya, Turkey. | ||
| 5Department of Medical Biology, Medicine Faculty, Nigde Omer Halisdemir University, Nigde, Türkiye. | ||
| 6Western Caspian University, Baku, Azerbaijan. | ||
| 7Department of Biology, Faculty of Sciences, Khoja Akhmet Yassawi International Kazakh-Turkish University, Turkestan, Kazakhstan. | ||
| چکیده | ||
| The swift development of veterinary vaccine technologies represents a revolutionary change in global animal health management, uniting conventional immunization strategies with advanced molecular platforms. Traditional veterinary vaccines—primarily live attenuated, killed (inactivated), or protein subunit vaccines—have been central to disease outbreak prevention. This review delves into the path from traditional live and inactivated vaccines to future solutions like RNA-based vaccines, viral vectors, protein subunits, and nanovaccine systems. While there has been a growing clamour of epizootic and zoonotic diseases in companion animals and livestock, traditional vaccine constraints—i.e., suboptimal immunogenicity, cold-chain dependency, and limited pathogen coverage—have driven the growth of new platforms. We place the drivers of vaccine innovation in regulatory, ethical, and economic contexts and illustrate the imperative for urgency in scalable and species-specific interventions. In the manuscript, evidence from six technological areas is integrated through a systematic sequence of data gathering-including peer-reviewed articles, patent libraries, and analyses of stakeholders-between RNA vaccines, viral vectors, recombinant subunits, nanotechnology-based platforms, mucosal delivery systems, and AI-augmented design-in each section conceptual and data tables which improve comparative transparency and translation significance. The results highlight accelerated approval pathways, promising immunological outcomes, and integration of omics and artificial intelligence technologies in epitope prediction and delivery optimization. Importantly, the article highlights collaboration on a global scale to combat logistics, regulatory, and ethical hurdles—particularly in resource-constrained settings. By taking account of science and infrastructure of modern veterinary vaccinology, this review aims to guide future research, policy-making, and industry practice towards a more durable, One Health-responsive future for animal and human populations. | ||
| کلیدواژه‌ها | ||
| RNA platforms؛ Nanovaccines؛ One Health؛ Veterinary vaccines؛ Viral vectors | ||
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آمار تعداد مشاهده مقاله: 367 تعداد دریافت فایل اصل مقاله: 722 |
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