اخبار و اعلانات

 آمار

تعداد نشریات282
تعداد نشریات سازمان80
تعداد شماره‌ها3,251
تعداد مقالات35,918
تعداد مشاهده مقاله54,585,109
تعداد دریافت فایل اصل مقاله93,700,312
Rabizadeh, Fatemeh, Mirian, Maryam Sadat, Arab Khabouri, Atena, Abbasi, Negin, Nasiry, Zahra, Jahangir, Saba, Salemian, Kiana. (1405). Traditional Persian Medicinal Plants for Neurological Disorders: A Phytochemical and Ethnobotanical Review. سامانه مدیریت نشریات علمی, 15(4), 512-523. doi: 10.22034/jmpb.2025.369183.1947
Fatemeh Rabizadeh; Maryam Sadat Mirian; Atena Arab Khabouri; Negin Abbasi; Zahra Nasiry; Saba Jahangir; Kiana Salemian. "Traditional Persian Medicinal Plants for Neurological Disorders: A Phytochemical and Ethnobotanical Review". سامانه مدیریت نشریات علمی, 15, 4, 1405, 512-523. doi: 10.22034/jmpb.2025.369183.1947
Rabizadeh, Fatemeh, Mirian, Maryam Sadat, Arab Khabouri, Atena, Abbasi, Negin, Nasiry, Zahra, Jahangir, Saba, Salemian, Kiana. (1405). 'Traditional Persian Medicinal Plants for Neurological Disorders: A Phytochemical and Ethnobotanical Review', سامانه مدیریت نشریات علمی, 15(4), pp. 512-523. doi: 10.22034/jmpb.2025.369183.1947
Rabizadeh, Fatemeh, Mirian, Maryam Sadat, Arab Khabouri, Atena, Abbasi, Negin, Nasiry, Zahra, Jahangir, Saba, Salemian, Kiana. Traditional Persian Medicinal Plants for Neurological Disorders: A Phytochemical and Ethnobotanical Review. سامانه مدیریت نشریات علمی, 1405; 15(4): 512-523. doi: 10.22034/jmpb.2025.369183.1947

Traditional Persian Medicinal Plants for Neurological Disorders: A Phytochemical and Ethnobotanical Review

Journal of Medicinal plants and By-products
مقاله 12، دوره 15، شماره 4، مهر و آبان 2026، صفحه 512-523    اصل مقاله (1.65 M)
نوع مقاله: Research Article
شناسه دیجیتال (DOI): 10.22034/jmpb.2025.369183.1947
نویسندگان
Fatemeh Rabizadeh* 1؛ Maryam Sadat Mirian2؛ Atena Arab Khabouri1؛ Negin Abbasi1؛ Zahra Nasiry1؛ Saba Jahangir1؛ Kiana Salemian1
1Farzanegan Campus, Semnan University, Semnan, Iran
2Department of Plant and Animal Biology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, Iran
چکیده
Neurological disorders—including Alzheimer’s disease, Parkinson’s disease, anxiety, depression, and insomnia—are among the most challenging global health issues. Due to the limitations and side effects of conventional treatments, there is increasing interest in natural, plant-based alternatives. This review aims to evaluate medicinal plants used in Traditional Iranian Medicine (TIM) for neurological disorders and to assess their phytochemical and pharmacological relevance based on both classical texts and modern scientific literature. A total of 52 plant species belonging to 26 botanical families were identified, with Lamiaceae, Apiaceae, Euphorbiaceae, Pinaceae, Asteraceae, and Fabaceae being the most frequently represented. Phytochemical analyses revealed that compounds such as terpenoids (68%), phenolic compounds (52%), and flavonoids (20%)—alongside glycosides, alkaloids, steroids, amines, and saponins—are key contributors to neuropharmacological activity. These metabolites may exert neuroprotective, antioxidant, anti-inflammatory, anxiolytic, and cognition-enhancing effects through various mechanisms, including neurotransmitter modulation (e.g., serotonin, dopamine, GABA), suppression of neuroinflammation, and oxidative stress reduction. Notable species such as Curcuma longa, Cannabis sativa, Mentha spp., Narcissus jonquilla, and Peucedanum officinale contain well-documented bioactive compounds like curcumin, cannabidiol, linalool, galanthamine, and α-pinene. The phytochemical richness of Apiaceae and Lamiaceae suggests their prominence in traditional neurological care. In conclusion, this review highlights the therapeutic potential of traditional Iranian medicinal plants for neurological disorders and advocates for future bioassay-guided studies, synergistic compound analysis, and formulation standardization to support their integration into evidence-based modern medicine.
کلیدواژه‌ها
Botanical therapeutics؛ Ethnomedicine؛ Herbal neuroprotective؛ Natural compounds؛ Neuropharmacology
مراجع
  1. World Health Organization. Neurological disorders: public health challenges. Geneva: WHO; 2006.
  2. Cummings J.L. Biomarkers in Alzheimer's disease drug development. Alzheimer's & Dementia: The Journal of the Alzheimer's Association. 2011;7(3): e13-e44. DOI: 10.1016/j.jalz.2010.06.004.
  3. Debas H.T., Laxminarayan R., Straus S.E. Complementary and alternative medicine. Washington (DC): The World Bank; 2011.
  4. Moeini R., Memariani Z., Enayati A., Gorji N., Kolangi F. Nephrotonic and nephroprotective medicinal herbs in traditional Persian medicine: review and assessment of scientific evidence. Current Traditional Medicine. 2022;8(3):11-25. DOI: 10.2174/2215083807666211118145406.
  5. Wink M. Modes of action of herbal medicines and plant secondary metabolites. Medicines. 2015;2(3):251-286. DOI: 10.3390/medicines2030251.
  6. Dewick P.M. Medicinal natural products: a biosynthetic approach. 2nd ed. Chichester: John Wiley & Sons; 2002.
  7. Ahmed T., Gilani A.H. Therapeutic potential of turmeric in Alzheimer's disease: curcumin or curcuminoids? Phytotherapy Research. 2014;28(4):517-525. DOI: 10.1002/ptr.5030.
  8. Panickar K.S. Anti-inflammatory properties of botanical extracts contribute to their protective effects in brain edema in cerebral ischemia. In: Watson R.R., Preedy V.R., editors. Bioactive nutraceuticals and dietary supplements in neurological and brain disease. San Diego (CA): Academic Press; 2015. p. 3-15.
  9. Fernández-Ruiz J., Sagredo O., Pazos M.R., García C., Pertwee R., Mechoulam R., Martínez‐Orgado, J. Cannabidiol for neurodegenerative disorders: important new clinical applications for this phytocannabinoid? British Journal of Clinical Pharmacology. 2013;75(2):323-333. DOI: 10.1111/j.1365-2125.2012.04341. x.
  10. Hewlings S.J., Kalman D.S. Curcumin: a review of its effects on human health. Foods. 2017;6(10):92. DOI: 10.3390/foods6100092.
  11. Zafar S., Saeed R., Fatima S., Jahan S. Neuroprotective potential of Artemisia species: a review on ethnopharmacology, phytochemistry, and pharmacological activities. Phytotherapy Research. 2021;35(1):13-35. doi:10.1002/ptr.6802.
  12. Khazdair M.R., Kianmehr M., Anaeigoudari A. Effects of medicinal plants and flavonoids on Parkinson’s disease: a review on basic and clinical evidences. Advanced Pharmaceutical Bulletin. 2020;11(2):224-231. DOI: 10.34172/apb.2021.026.
  13. Cragg G.M., Newman D.J. Natural products: a continuing source of novel drug leads. Biochimica et Biophysica Acta (BBA) - General Subjects. 2013;1830(6):3670-3695. DOI: 10.1016/j.bbagen.2013.02.008.
  14. Etkin N.L., Ticktin T. Integrating ethnographic and ecological perspectives for ethnopharmacology field research. In: Etkin N.L., editor. Eating on the wild side: the pharmacologic, ecologic, and social implications of using noncultigens. Tucson (AZ): University of Arizona Press; 2005. p. 187-206.
  15. Fabricant D.S., Farnsworth N.R. The value of plants used in traditional medicine for drug discovery. Environmental Health Perspectives. 2001;109(Suppl 1):69-75. DOI: 10.1289/ehp.01109s169.
  16. Barnes J., Anderson L.A., Phillipson J.D., Heinrich M. Fundamentals of pharmacognosy and phytotherapy. London: Churchill Livingstone; 2004.
  17. Alamgir A.N.M. Origin, definition, scope and area, subject matter, importance, and history of development of pharmacognosy. In: Alamgir A.N.M., editor. Therapeutic Use of Medicinal Plants and Their Extracts. Volume 1: Pharmacognosy. Cham: Springer; 2017. p. 19-60.
  18. Balick M.J., Cox P.A. Plants, people, and culture: the science of ethnobotany. 2nd ed. Boca Raton (FL): CRC Press; 2020.
  19. Gurib-Fakim A. Medicinal plants: traditions of yesterday and drugs of tomorrow. Molecular Aspects of Medicine. 2006;27(1):1-93. DOI: 10.1016/j.mam.2005.07.008.
  20. Hongratanaworakit T. Simultaneous aromatherapy massage with rosemary oil on humans. Scientia Pharmaceutica. 2009;77(2):375-388. DOI: 10.3797/scipharm.090312.
  21. Kadı A., Öner S., Yuca H., Arslan M.E., Atila A., İncekara Ü., Karakaya S. Integrative study of Plantago lanceolata L.: Phytochemical properties and therapeutic effects on cancer, diabetes, and Alzheimer’s disease. Natural Product Research. 2025;1-11. DOI:10.1080/14786419.2025.2469311.
  22. Wink M. Annual Plant Reviews, Functions and Biotechnology of Plant Secondary Metabolites. Chichester: John Wiley & Sons; 2010.
  23. Khosravi M.S., Heidari R., Jamei R., Kouhi S.M.M., Moudi M. Comparative growth and physiological responses of tetraploid and hexaploid species of wheat to flooding stress. Acta Agriculturae Slovenica. 2018;111(2):285-292.
  24. Harborne J.B. Introduction to Ecological Biochemistry. 4th ed. London: Academic Press/Elsevier; 2014.
  25. Gershenzon J., Dudareva N. The function of terpene natural products in the natural world. Nature Chemical Biology. 2007;3(7):408-414. DOI: 10.1038/nchembio0707-408.
  26. Isman M.B. Plant essential oils for pest and disease management. Crop Protection. 2000;19(8-10):603-608.
  27. Raut J.S., Karuppayil S.M. A status review on the medicinal properties of essential oils. Industrial Crops and Products. 2014; 62:250-264. DOI: 10.1016/j.indcrop.2014.09.091.
  28. Zhang X., Wei X., Shi L., Jiang H., Ma F., Li Y., Li C., Ma Y. The latest research progress: active components of Traditional Chinese medicine as promising candidates for ovarian cancer therapy. Journal of Ethnopharmacology. 2024;118811. DOI: 10.1016/j.jep.2023.118811.
  29. Fauci A.S., Morens D.M. The perpetual challenge of infectious diseases. The New England Journal of Medicine. 2012;366(5):454-461. DOI: 10.1056/NEJMra1108296.
  30. Cullen P. Mental illness in the oldest-old. In: Advanced Age Geriatric Care: A Comprehensive Guide. Cham: Springer International Publishing; 2018. p. 145-157.
  31. Patwardhan B., Vaidya A.D., Chorghade M. Ayurveda and natural products drug discovery. Current Science. 2004; 78:789–799.
  32. Prince M., Ali G.C., Guerchet M., Yu-Tzu W., Prina M. The global prevalence of dementia. World Alzheimer Report. 2009; 25:45.
  33. Sarris J., Panossian A., Schweitzer I., Stough C., Scholey A. Herbal medicine for depression, anxiety and insomnia: a review of psychopharmacology and clinical evidence. European Neuropsychopharmacology. 2011;21(12):841–860. DOI: 10.1016/j.euroneuro.2011.07.004.
  34. Pandey S. Phytochemicals: Recent trends pertaining to beneficial effects on neurological disorders. Neuro Phytomedicine. 2024; 1:1–20.
  35. Butterfield D.A., Castegna A., Pocernich C.B., Drake J., Scapagnini G., Calabrese V. Nutritional approaches to combat oxidative stress in Alzheimer’s disease. Journal of Nutritional Biochemistry. 2002;13(8):444–461. DOI: 10.1016/S0955-2863(02)00111-X.

 

  1. Singh S., Chib S., Akhtar M.J., Kumar B., Chawla P.A., Bhatia R. Paradigms and success stories of natural products in drug discovery against neurodegenerative disorders (NDDs). Current Neuropharmacology. 2024;22(6):992–1015. DOI: 10.2174/1570159X22666240617124417.
  2. Alzobaidi N., Quasimi H., Emad N.A., Alhalmi A., Naqvi M. Bioactive compounds and traditional herbal medicine: promising approaches for the treatment of dementia. Degenerative Neurological and Neuromuscular Disease. 2021; 11:1–14. DOI: 10.2147/DNND.S287723.
  3. Howes M.J.R., Perry N.S., Houghton P.J. Plants with traditional uses and activities, relevant to the management of Alzheimer’s disease and other cognitive disorders. Phytotherapy Research. 2003;17(1):1–18. DOI: 10.1002/ptr.1114.
  4. Nimrouzi M., Zarshenas M.M. Anorexia: highlights in Traditional Persian medicine and conventional medicine. Avicenna Journal of Phytomedicine. 2018;8(1):1–9. DOI: 10.22038/AJP.2017.26625.1884.
  5. Moradi S.Z., Momtaz S., Bayrami Z., Farzaei M.H., Abdollahi M. Nanoformulations of herbal extracts in treatment of neurodegenerative disorders. Frontiers in Bioengineering and Biotechnology. 2020; 8:238. DOI: 10.3389/fbioe.2020.00238.
  6. Sadeghi H.S., Rezaei Tavirani M., Mokaberinejad R., Poormohammadi M. Medicinal plants used to relieve toothache in Iranian traditional medicine. Research Journal of Pharmacognosy. 2025;12(1):63–78.
  7. Gamel R.M.E., Haroun S.A., Alkhateeb O.A., Soliman E.A., Tanash A.B., Sherief A.D.A., Abdel-Mogib M., Abdou A.H., Ali H.S.A.M., Al-Harbi N.A., Abdelaal, K. Role of biotransformation of Acacia nilotica metabolites by Aspergillus subolivaceus in boosting Lupinus termis yield: a promising approach to sustainable agriculture. Sustainability. 2023; 15:9509. DOI: 10.3390/su15129509.
  8. Batubara R., Hanum T.I., Affandi O. GC-MS analysis of young and mature wild agarwood leaves (Aquilaria malaccensis Lamk) and its antioxidant potential. IOP Conference Series: Earth and Environmental Science. 2021; 912:012003.
  9. Aati H.Y., Attia H.A., Alanazi A.S., Al Tamran L.K., Wanner J.K. Phytochemical characterization utilizing HS-SPME/GC-MS: exploration of the antioxidant and enzyme inhibition properties of essential oil from Saudi Artemisia absinthium L. Pharmaceuticals. 2024; 17:1460. DOI: 10.3390/ph17101460.
  10. Shah A.J., Gilani A.H., Abbas K., Rasheed M., Ahmed A., Ahmad V.U. Studies on the chemical composition and possible mechanisms underlying the antispasmodic and bronchodilatory activities of the essential oil of Artemisia maritima L. Archives of Pharmacal Research. 2011;34(8):1227–1238. DOI: 10.1007/s12272-011-0806-9.
  11. Zhigzhitzhapova S.V., Popov D.V., Pintaeva E.T., Radnaeva L.D., Chimittsyrenova L.I., Randalova T. Essential oil from Artemisia sieversiana Willd. and development of related oil-in-water emulsions. Pharmaceutical Chemistry Journal. 2017; 51:388–390. DOI: 10.1007/s11094-017-1634-0.
  12. Antsyshkina A.M., Ars Yu.V., Bokov D.O., Pozdnyakova N.A., Prostodusheva T.V., Zaichikova S.G. The genus Asarum L.: a phytochemical and ethnopharmacological review. Systematic Reviews in Pharmacy. 2020;11(5):472–502.
  13. Watekar R., Patil S., Pawar S., Jadhav V., Kadam V. Phytochemical screening of oil extracted from two categories of fruit of Semecarpus anacardium Linn. using traditional Indian method. International Journal of Botany Studies. 2020;5(4):236–248.
  14. Mustafa H.H., Al-Khafaji Z.S., Al-Khafaji A.A., Al-Khafaji A.H., Al-Khafaji H.A. Extraction and identification of effective compounds from natural plants. Journal of Composites Science. 2022;6(5):149. DOI: 10.3390/jcs6050149.
  15. Fernández N., Lanosa D.A., Janezic N.S., Quiroga P.N. Development and validation of a GC-MS method for quantification of terpenes in Cannabis sativa L. oil: application to commercially available preparations in Argentina. Journal of Applied Research on Medicinal and Aromatic Plants. 2023; 35:100466. DOI: 10.1016/j.jarmap.2023.100466.
  16. Kianasab M.R., Asghari G., Mahdavi M.A. GC/MS analysis of the hydrodistilled essential oils and volatiles from the aerial parts of Cannabis sativa L. Natural Product Research. 2023; 37:1–5. doi:10.1080/14786419.2023.2241845.
  17. Umezu T., Sano T., Hayashi J., Yoshikawa Y., Shibata Y. Identification of isobutyl angelate, isoamyl angelate, and 2-methylbutyl isobutyrate as active constituents in Roman chamomile essential oil that promotes mouse ambulation. Flavour and Fragrance Journal. 2017; 32:1–7. doi:10.1002/ffj.3356.
  18. Wang M., Avula B., Wang Y.H., Zhao J., Avonto C., Parcher J.F., Khan I.A., Willmann J.T. An integrated approach utilising chemometrics and GC/MS for classification of chamomile flowers, essential oils, and commercial products. Food Chemistry. 2014; 152:391–398. doi: 10.1016/j.foodchem.2013.11.114.
  19. Cui Q., Zhang X., Liu T., Li F., Zhang L. Metabolomic profiles of Citrus aurantium pericarp during development. Food Chemistry: X. 2024; 23:101631. doi: 10.1016/j.fochx.2024.101631.
  20. Fahmy N.M., Fayez S., Uba A.I., Shariati M.A., Aljohani A.S.M., El-Ashmawy I.M., Batiha G.E.S., Eldahshan O.A., Singab A.N.B., Zengin G. Comparative GC-MS analysis of fresh and dried Curcuma essential oils with insights into their antioxidant and enzyme inhibitory activities. Plants. 2023; 12:1785. doi:10.3390/plants12101785.
  21. Memariani T., Shaterian B., Esfandiar M. Evaluation of the cytotoxic effects of Cyperus longus extract, fractions, and its essential oil on the PC3 and MCF7 cancer cell lines. Oncology Letters. 2016;11(2):1353–1360. doi:10.3892/ol.2016.4097.
  22. Abo-Altemen R.A., Al-Shammari A.M., Shawkat M.S., Al-Marzouqi A.S. GC-MS analysis and chemical composition identification of Cyperus rotundus L. from Iraq. Energy Procedia. 2019; 157:1462–1474. doi: 10.1016/j.egypro.2018.11.325.
  23. Dormousoglou M., Tzima E., Papadopoulou V., Antonopoulou E., Tsatsakis K. Investigation of the genotoxic, antigenotoxic, and antioxidant profile of different extracts from Equisetum arvense L. Antioxidants. 2022; 11:1393. doi:10.3390/antiox11071393.
  24. Zhu Q., Li H., Xu F., Wei S., Zhang C. Chemical composition and antimicrobial activity of essential oil from Euphorbia helioscopia L. Natural Product Communications. 2020;15(9):1934578X20953249. doi:10.1177/1934578X20953249.
  25. Karki S., Raut P., Rai M., Shrestha B., Joshi R. Phytochemical screening and GC-MS analysis of Euphorbia hirta. Journal of Pharmacognosy and Phytochemistry. 2020;9(1):1883–1889.
  26. Sosa A.A., Bagi S.H., Hameed I.H. Analysis of bioactive chemical compounds of Euphorbia lathyrus using gas chromatography-mass spectrometry and Fourier-transform infrared spectroscopy. Journal of Pharmacognosy and Phytotherapy. 2016;8(5):109–126.
  27. Rautela I., Singh S., Singh A., Singh R., Singh S. Comparative GC-MS analysis of Euphorbia hirta and Euphorbia milii for therapeutic potential utilities. Plant Archives. 2020;20(2):3515–3522.
  28. Adil M., Filimban F.Z., Ambrin, Quddoos A., Sher A.A., Naseer M. Phytochemical screening, HPLC analysis, antimicrobial and antioxidant effect of Euphorbia parviflora L. (Euphorbiaceae Juss.). Scientific Reports. 2024;14(1):5627. doi:10.1038/s41598-024-55905-w.
  29. El-Amier Y.A., Al-Hadithy O.N., Fahmy A.A., El-Eraky T.E., El-Sayed A.I., El-Banna O.M., El-Shahat Z.A. Euphorbia retusa (Forssk.): A promising source for bioactive compounds in biomedical and agriculture applications. Plant Archives. 2021;21(1):23–31.
  30. Darweesh K.F., Ahmed K.M. Anatomical and phytochemical study of Glossostemon bruguieri (Desf.) Sterculiaceae in Kurdistan Region of Iraq. Diyala Journal for Pure Science. 2017;13(1):23–41. doi:10.24237/djps.1301.115B.
  31. Asadi M. Chemical structure of Glycyrrhiza glabra L. and Salvia officinalis L. essential oils collected from Kermanshah Province in west of Iran. Journal of Medicinal Herbs. 2021;12(4):33–42. doi:10.22092/medherb.2021.687756.
  32. Semiz N., Deveci M.Z.Y. Effects of common centaury (Centaurium erythraea) oil and laurel (Laurus nobilis) seed oil on full-thickness excisional skin wound healing in rats. Ankara Üniversitesi Veteriner Fakültesi Dergisi. 2024;71(4):487–496. doi:10.33988/auvfd.1085562.
  33. Kıvrak Ş., Göktürk T., Kıvrak İ. Assessment of volatile oil composition, phenolics and antioxidant activity of bay (Laurus nobilis) leaf and usage in cosmetic applications. International Journal of Secondary Metabolite. 2017;4(2):148–161. doi:10.21448/ijsm.323800.
  34. Saeedi M., Khanavi M., Shahsavari K., Manayi A. Matricaria chamomilla: An updated review on biological activities of the plant and constituents. Research Journal of Pharmacognosy. 2024;11(1):109–136.
  35. El Omari N., Benaissa A., El Ghouizi A., Aazza S., Aouinty B., Gseyra N., Tamsouri N., Naceiri Mrabti H., Cherrah Y., Alaoui K., El Mzibri M. GC-MS-MS analysis and biological properties determination of Mentha piperita L. essential oils. Biochemical Systematics and Ecology. 2024; 116:104875. doi: 10.1016/j.bse.2024.104875.
  36. Karami H., Rasekh M., Darvishi Y., Khaledi R. Effect of drying temperature and air velocity on the essential oil content of Mentha aquatica L. Journal of Essential Oil-Bearing Plants. 2017;20(4):1131–1136.
  37. Al-Taie S., Al-Kenane N. Study biochemistry of Mentha longifolia (L.) Huds. A review. Herbs and Spices. 2020; 27:1–8.
  38. El Maimouni M.A., Bencheikh N., Zair T., Hassikou R., El Azhary K., Lahrichi A., Ouahhoud S., Bendaoud H. Chemical composition, antioxidant activity, and multivariate analysis of four Moroccan essential oils: Mentha piperita, Mentha pulegium, Thymus serpyllum, and Thymus zygis. The Scientific World Journal. 2024; 2024:5552496. DOI: 2024/5552496.
  39. Choudhury P.P.N., Choudhury S. GC-MS profiling and bioactivity prediction of compounds from Momordica charantia L. extract. Bioinformation. 2022;18(10):1009. DOI: 973206300181009.
  40. Ferreira Almeida N., dos Santos Niculau E., Cordeiro Toledo Lima P., Ferreira da Silva W. Determination of the volatile chemical profile of Momordica charantia (bitter melon) leaf and fruit by GC-MS. Natural Product Research. 2024;1–8. DOI: 14786419.2024.2325595.
  41. Gotti R., Bertucci C., Cavrini V., Andrisano V. Analysis of Amaryllidaceae alkaloids from Narcissus by GC–MS and capillary electrophoresis. Journal of Pharmaceutical and Biomedical Analysis. 2006;42(1):17–24. DOI: j. jpba.2006.01.003.
  42. Tallini L.R., Manfredini G., Rodríguez-Escobar M.L., Ríos S., Martínez-Francés V., Feresin G.E., Borges W.S., Bastida J., Viladomat F., Torras-Claveria L. The anti-cholinesterase potential of fifteen different species of Narcissus L. (Amaryllidaceae) collected in Spain. Life. 2024;14(4):536. DOI: life14040536.
  43. Mgbeje B.I.A., Abu C. Chemical fingerprinting of Nauclea latifolia, an antidiabetic plant, using GC-MS. Journal of Complementary and Alternative Medical Research. 2020;9(4):25–34. DOI: jocamr/2020/v9i430148.
  44. Zaid R., Smaili A., Abouraicha E., Ghaout S., Elbouzidi A., El Bouhali B., Taourirte M., Haddioui A. Phytochemical analyses and toxicity of Nerium oleander (Apocynaceae) leaf extracts against Chaitophorus leucomelas Koch, 1854 (Homoptera: Aphididae). Journal of the Saudi Society of Agricultural Sciences. 2022;21(5):310–317.
  45. Ababutain I.M. Antimicrobial activity and gas chromatography-mass spectrometry (GC-MS) analysis of Saudi Arabian Ocimum basilicum leaves extracts. Journal of Pure and Applied Microbiology. 2019;13(2):823–833. DOI: JPAM.13.2.17.
  46. Önder A., Nahar L., Nath S., Sarker S.D. Phytochemistry, traditional uses and pharmacological properties of the genus Opopanax W.D.J. Koch: A mini-review. Pharmaceutical Sciences. 2020;26(2):99–106.
  47. Kenari H.M., Kordafshari G., Moghimi M., Eghbalian F., TaherKhani D. Review of pharmacological properties and chemical constituents of Pastinaca sativa. Journal of Pharmacopuncture. 2021;24(1):14. DOI: jopc.2021.24.1.14.
  48. Ušjak L., Niketić M., Petrović S. Composition of essential oils from fruits of Peucedanum longifolium and Rhizomatophora aegopodioides (Apiaceae) with regard to other related taxa—A chemometric approach. Separations. 2024;11(1):14. DOI: separations11010014.
  49. Wajs-Bonikowska A., Stachurska M., Kula J., Kuźma Ł., Zawirska-Wojtasiak R., Krajewska U. Composition and biological activity of Picea pungens and Picea orientalis seed and cone essential oils. Chemistry & Biodiversity. 2017;14(3): e1600264. DOI: chem.201600264.
  50. Alperth F., Schneebauer A., Kunert O., Bucar F. Phytochemical analysis of Pinus cembra heartwood—UHPLC-DAD-ESI-MSn with focus on flavonoids, stilbenes, bibenzyls and improved HPLC separation. Plants. 2023;12(19):3388. DOI: plants12193388.
  51. Ghaffari T., Kafil H.S., Asnaashari S., Farajnia S., Delazar A., Baek S.C., Kim K.H. Chemical composition and antimicrobial activity of essential oils from the aerial parts of Pinus eldarica grown in Northwestern Iran. Molecules. 2019;24(17):3203. DOI: molecules24173203.
  52. Amri I., Hanana M., Jamoussi B., Hamrouni L. Essential oils of Pinus nigra J.F. Arnold subsp. laricio Maire: Chemical composition and study of their herbicidal potential. Arabian Journal of Chemistry. 2017;10: S3877–S3882. DOI: j. arabjc.2017.05.019.
  53. Salem M.Z.M., Zeidler A., Böhm M., Mohamed M.E.A., Ali H.M. GC/MS analysis of oil extractives from wood and bark of Pinus sylvestris, Abies alba, Picea abies, and Larix decidua. BioResources. 2015;10(4):7725–7737. doi:10.15376/biores.10.4.7725-7737.
  54. Jordan I.N., Halub B., Shakya A.K., Elagbar Z.A., Naik R.R. GC-MS analysis and biological activity of essential oil of fruits, needles and bark of Pinus pinea grown wildly in Jordan. Acta Poloniae Pharmaceutica – Drug Research. 2019;76(6):1137–1146. DOI: 10.32383/appdr/110548.
  55. Arsana I.N., Suprapta D.N., Putra D.P., Mardika I.W., Ardiansyah H., Lestari D.R. GC-MS analysis of the active compound in ethanol extracts of white pepper (Piper nigrum L.) and pharmacological effects. Cellular and Molecular Biomedical Reports. 2022;2(3):151–161. DOI: cmbmr.2022.151161.
  56. El-Feky A.M., El-Deek S.E.M., Abou-Elkhair R., Taha R.A., El-Baz F.K., Abdelaziz A.Z. A therapeutic insight of carbohydrate and fixed oil from Plantago ovata L. seeds against ketoprofen-induced hepatorenal toxicity in rats. Bulletin of the national research Centre. 2018; 42:1–16. DOI: s42269-018-0036-1.
  57. Sadeghi H., Ahmadian-Attari M.M., Nezhad Z.K., Hosseini A., Sadat-Hoseini A.S., Amanlou M. Protective effects of hydroalcoholic extract of Rosa canina fruit on vancomycin-induced nephrotoxicity in rats. Journal of Toxicology. 2021; 2021:5525714. DOI: 2021/5525714.
  58. Öz M., Deniz I., Okan O.T., Baltaci C., Karatas S.M. Determination of the chemical composition, antioxidant and antimicrobial activities of different parts of Rosa canina L. and Rosa pimpinellifolia L. essential oils. Journal of Essential Oil-Bearing Plants. 2021;24(3):519–537. DOI: 0972060X.2021.1923250.
  59. Kumar M., Upadhyay S.N., Mishra P.K. Pyrolysis of sugarcane (Saccharum officinarum L.) leaves and characterization of products. ACS Omega. 2022;7(32):28052–28064. DOI: acsomega.2c03524.
  60. Sánchez-Hernández E., González-García V., Correa-Guimarães A., Casanova-Gascón J., Martín-Gil J., Martín-Ramos P. Phytochemical profile and activity against Fusarium species of Tamarix gallica bark aqueous ammonia extract. Agronomy. 2023;13(2):496. DOI: agronomy13020496.
  61. Fayed M.A.A., Abou El-Kassem L.T., Soliman W.E., Fayed Y.H., Rabeh M.A., Abdelhafez O.H. Chemical profiling and cytotoxic potential of the n-butanol fraction of Tamarix nilotica flowers. BMC Complementary Medicine and Therapies. 2023; 23:169. DOI: s12906-023-04082-0.
  62. Uraku A.J., Uraku O.H., Nwalo F.N., Obasi O., Okorie I.I., Nzubechukwu E., Nwamaka E.N. Phytochemical and GC-MS evaluation of bioactive principle of Vitis vinifera peels. Asian Journal of Applied Sciences. 2018; 11:192–198. DOI: 10.3923/ajaps.2018.192.198.
  63. Roy C.L., Das S., Das N., Maity P., Datta K., Dey D. GCMS and FTIR analysis on the methanolic extract of red Vitis vinifera peel. World Journal of Pharmaceutical Sciences. 2018;7(8):1110–1123.
  64. Mahmoud A.E.D., Mahmoud A.E., Elsharkawy M.M., Ghareeb M.A., Elshamy A.M., Refaat M.M., Elnaggar M.H. Biogenic synthesis of reduced graphene oxide from Ziziphus spina-christi (Christ’s thorn jujube) extracts for catalytic, antimicrobial, and antioxidant potentialities. Environmental Science and Pollution Research International. 2022; 29:89772–89787. DOI: s11356-022-21763-5. https://doi.org/10.1007/s11356-022-21871-x.
  65. Ads E.N., Soliman A.M., Zalat E.M., Tammam A.M., Ghazal A.A., Khalil K.F. Phytochemical screening of different organic crude extracts from the stem bark of Ziziphus spina-christi (L.). Biomedical Research. 2018;29(8):1645–1652. DOI:10.4066/biomedicalresearch.29-17-1668.
  66. Cadi H.E., Bouzidi H.E., Selama G., Cadi A.E., Ramdan B., Oulad El Majdoub Y., Alibrando F., Dugo P., Mondello L., Fakih Lanjri A., Brigui J., Cacciola F. Physico-chemical and phytochemical characterization of Moroccan wild jujube “Zizyphus lotus (L.)” fruit crude extract and fractions. Molecules. 2020;25(22):5237. DOI: molecules25225237.
  67. Fiore C., Eisenhut M., Krausse R., Ragazzi E., Pellati D., Armanini D., Bielenberg J. Antiviral effects of Glycyrrhiza species. Phytotherapy Research. 2008;22(2):141–148. DOI: 10.1002/ptr.2295
  68. Koulivand P.H., Khaleghi Ghadiri M., Gorji A. Lavender and the nervous system. Evidence-Based Complementary and Alternative Medicine. 2013; 2013:681304. DOI:10.1155/2013/681304
  69. Yang H., Woo J., Pae A.N., Um M.Y., Cho N.C., Park K.D., Yoon M., Kim J., Lee C.J., Cho S. α-Pinene, a major constituent of pine tree oils, enhances non-rapid eye movement sleep in mice through GABAA-benzodiazepine receptors. Molecular Pharmacology. 2016;90(5):530–539. DOI: 10.1124/mol.116.105080.
  70. Cheng Y., Feng Z., Zhang Q.Z., Zhang J.T. Beneficial effects of melatonin in experimental models of Alzheimer disease. Acta Pharmacologica Sinica. 2006;27(2):129–139. DOI: aps06212.
  71. Dubey A., Singh Y. Medicinal properties of Cinchona alkaloids—a brief review. Journal of Medicinal Plants Studies. 2021; 9(3):1–6.
  72. Zierau O., Geis R.B., Tischer S., Schwab P., Metz P., Vollmer G. Uterine effects of the phytoestrogen 6-(1,1-dimethylallyl) naringenin in rats. Planta Medica. 2004;70(7):590–593. DOI: s-2004-815515.
  73. Boubakri A., Leri M., Bucciantini M., Najjaa H., Ben Arfa A., Stefani M., Neffati M. Allium roseum L. extract inhibits amyloid beta aggregation and toxicity involved in Alzheimer’s disease. PLoS One. 2020;15(9): e0223815. DOI: journal. pone. 0223815.
  74. Mandel S., Amit T., Reznichenko L., Weinreb O., Youdim M.B. Green tea catechins as brain-permeable, natural iron chelators-antioxidants for the treatment of neurodegenerative disorders. Molecular Nutrition & Food Research. 2006;50(2):229–234. DOI: mnfr.200500167.
  75. Saeedi M., Vahedi-Mazdabadi Y., Rastegari A., Soleimani M., Eftekhari M., Akbarzadeh T. Evaluation of Asarum europaeum L. rhizome for the biological activities related to Alzheimer’s disease. Research Journal of Pharmacognosy. 2020;7(3):25–33.
  76. Le J., Ji H., Zhou X., Wei X., Chen Y., Fu Y., Ma Y., Han Q., Sun Y., Gao Y., Wu H. Pharmacology, toxicology, and metabolism of sennoside A, a medicinal plant-derived natural compound. Frontiers in Pharmacology. 2021; 12:714586. DOI: fphar.2021.714586.
  77. Zhang R., Zeng M., Zhang X., Zheng Y., Lv N., Wang L., Gan J., Li Y., Jiang X., Yang L. Therapeutic candidates for Alzheimer’s disease: saponins. International Journal of Molecular Sciences. 2023;24(13):10505. DOI: ijms241310505.
  78. Kennedy D., Okello E., Chazot P., Howes M.J., Ohiomokhare S., Jackson P., Haskell-Ramsay C., Khan J., Forster J., Wightman E. Volatile terpenes and brain function: investigation of the cognitive and mood effects of Mentha × piperita L. essential oil with in vitro properties relevant to central nervous system function. Nutrients. 2018;10(8):1029. DOI: nu10081029.
  79. Sarkhail P. Traditional uses, phytochemistry and pharmacological properties of the genus Peucedanum: A review. Journal of Ethnopharmacology. 2014; 156:235–270. DOI: j.jep.2014.08.041.
  80. Viola H., Wasowski C., De Stein M.L., Wolfman C., Silveira R., Dajas F., Medina J.H., Paladini A.C. Apigenin, a component of Matricaria recutita flowers, is a central benzodiazepine receptors-ligand with anxiolytic effects. Planta Medica. 1995;61(3):213–216. DOI: s-2006-958027.
  81. Hadi A., Hossein N., Shirin P., Najmeh N., Abolfazl M. Anti-inflammatory and analgesic activities of Artemisia absinthium and chemical composition of its essential oil. International Journal of Pharmaceutical Sciences and Review Research. 2014; 38:237–244.
  82. Zulfugarova P., Zivari-Ghader T., Maharramova S., Ahmadian E., Eftekhari A., Khalilov R., Turksoy V.A., Rosić G., Selakovic D. A mechanistic review of pharmacological activities of homeopathic medicine licorice against neural diseases. Frontiers in Neuroscience. 2023; 17:1148258. DOI: fnins.2023.1148258.
  83. Kemboi D., Peter X., Langat M., Tembu J. A review of the ethnomedicinal uses, biological activities, and triterpenoids of Euphorbia species. Molecules. 2020;25(17):4019. DOI: molecules25174019.
  84. Shoaib S., Ansari M.A., Fatease A.A., Safhi A.Y., Hani U., Jahan R., Alomary M.N., Ansari M.N., Ahmed N., Wahab S., Ahmad W. Plant-derived bioactive compounds in the management of neurodegenerative disorders: challenges, future directions and molecular mechanisms involved in neuroprotection. Pharmaceutics. 2023;15(3):749. DOI: pharmaceutics15030749.
  85. Rabizadeh F., Mirian M.S., Doosti R., Kiani-Anbouhi R., Eftekhari E. Phytochemical classification of medicinal plants used in the treatment of kidney disease based on traditional Persian medicine. Evidence-Based Complementary and Alternative Medicine. 2022; 2022:8022599. DOI: 2022/8022599.
  86. Rabizadeh F., Mirian M.S. The classification of medicinal plants used in traditional Persian medicine for the treatment of liver disease based on phytochemical properties. Journal of Medicinal Plants By-products. 2024;13(2):257–284. 10.22034/jmpb.2023.363981.1623.
آمار
تعداد مشاهده مقاله: 669
تعداد دریافت فایل اصل مقاله: 602


counter
سامانه مدیریت نشریات علمی. طراحی و پیاده سازی از سیناوب