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Madani, Rasool, Golchinfar, Fariba, Hezarosi, Mahsa. (1404). Monoclonal Antibodies in Modern Medicine and laboratory: A comprehensive review. سامانه مدیریت نشریات علمی, 80(Special Issue), 11-19. doi: 10.32592/ARI.2025.80.SpecialIssue.11
Rasool Madani; Fariba Golchinfar; Mahsa Hezarosi. "Monoclonal Antibodies in Modern Medicine and laboratory: A comprehensive review". سامانه مدیریت نشریات علمی, 80, Special Issue, 1404, 11-19. doi: 10.32592/ARI.2025.80.SpecialIssue.11
Madani, Rasool, Golchinfar, Fariba, Hezarosi, Mahsa. (1404). 'Monoclonal Antibodies in Modern Medicine and laboratory: A comprehensive review', سامانه مدیریت نشریات علمی, 80(Special Issue), pp. 11-19. doi: 10.32592/ARI.2025.80.SpecialIssue.11
Madani, Rasool, Golchinfar, Fariba, Hezarosi, Mahsa. Monoclonal Antibodies in Modern Medicine and laboratory: A comprehensive review. سامانه مدیریت نشریات علمی, 1404; 80(Special Issue): 11-19. doi: 10.32592/ARI.2025.80.SpecialIssue.11

Monoclonal Antibodies in Modern Medicine and laboratory: A comprehensive review

Archives of Razi Institute
مقاله 2، دوره 80، Special Issue - شماره پیاپی 1، 2025، صفحه 11-19    اصل مقاله (256.18 K)
نوع مقاله: Review Article
شناسه دیجیتال (DOI): 10.32592/ARI.2025.80.SpecialIssue.11
نویسندگان
Rasool Madani* ؛ Fariba Golchinfar؛ Mahsa Hezarosi
Department of Proteomics and Biochemistry, Razi vaccine and serum research institute, Agricultural research education and extension organization (AREEO), Karaj, Iran
چکیده
Monoclonal antibodies (mAbs) are a revolutionary advancement in therapeutic interventions, offering specificity in the treatment of various diseases, including cancers, autoimmune disorders, and infectious diseases. These agents have also changed diagnosis tests, particularly immunoassays which are based on antibodies like ELISA, Immunohistochemistry and Flowcytometry. This review article critically evaluates the development, mechanisms of action, clinical applications of monoclonal antibodies, and their usage in diagnosis. We also explain the process of mAb production, such as hybridoma technology, as well as the emergence of novel formats such as bispecific antibodies and antibody-drug conjugates. Additionally, we analyze the current landscape of mAb therapies in clinical practice and highlight recent FDA approvals and ongoing clinical trials. Challenges such as immunogenicity, production costs, and access to therapy are also discussed. This comprehensive review aims to provide a deep understanding of monoclonal antibodies’ impact on modern medicine and their potential to shape future therapeutic plans. Additionally, this review highlights monoclonal antibody projects in Iran, particularly at the Razi Vaccine and Serum Research Institute. In this institute, monoclonal antibodies have not only been produced but also developed and applied for the first time in Iran in diagnostic tests for human and animal infectious diseases. Therefore, the Razi Vaccine and Serum Research Institute can be considered one of the pioneers in this field, and its advancements may also benefit neighboring developing countries by providing monoclonal antibodies for both therapeutic and diagnostic purposes.
کلیدواژه‌ها
Monoclonal antibodies؛ mechanisms؛ clinical applications؛ future therapeutic paradigms
عنوان مقاله [English]
آنتی بادی های مونوکلونال در پزشکی و آزمایشگاه مدرن: بررسی جامع
چکیده [English]
مونوکلونال آنتی‌بادی‌ها (mAbs) یک پیشرفت انقلابی در مداخلات درمانی به شمار می‌روند و به دلیل ویژگی اختصاصی خود در درمان بیماری‌های مختلف از جمله سرطان‌ها، اختلالات خودایمنی و بیماری‌های عفونی کاربرد دارند. این عوامل همچنین آزمون‌های تشخیصی را متحول کرده‌اند، به‌ویژه ایمنواسی‌هایی که بر پایه آنتی‌بادی‌ها هستند، مانند ELISA، ایمونوهیستوشیمی و فلوسایتومتری. این مقاله مروری به بررسی توسعه، مکانیسم‌های عمل، کاربردهای بالینی مونوکلونال آنتی‌بادی‌ها و استفاده آن‌ها در تشخیص می‌پردازد. همچنین فرآیند تولید mAbها مانند فناوری هیبریدوما و ظهور قالب‌های جدیدی همچون آنتی‌بادی‌های bispecific و کونژوگه‌های آنتی‌بادی-دارو (ADC) توضیح داده می‌شود. علاوه بر این، چشم‌انداز کنونی درمان‌های مبتنی بر mAb در عمل بالینی بررسی شده و به تأییدیه‌های اخیر FDA و کارآزمایی‌های بالینی در حال انجام اشاره شده است. چالش‌هایی همچون ایمنوژنیسیته، هزینه‌های تولید و دسترسی به درمان نیز مورد بحث قرار گرفته‌اند. این مقاله مروری با هدف ارائه درکی عمیق از تأثیر مونوکلونال آنتی‌بادی‌ها بر پزشکی مدرن و پتانسیل آن‌ها در شکل‌دهی برنامه‌های درمانی آینده نگاشته شده است. همچنین، این مقاله به پروژه‌های تولید مونوکلونال آنتی‌بادی در ایران، به‌ویژه در مؤسسه تحقیقات واکسن و سرم‌سازی رازی، می‌پردازد. در این مؤسسه، مونوکلونال آنتی‌بادی‌ها نه تنها تولید شده‌اند، بلکه برای نخستین بار در ایران در آزمون‌های تشخیصی بیماری‌های عفونی انسانی و دامی نیز توسعه یافته و به کار گرفته شده‌اند. بنابراین، مؤسسه تحقیقات واکسن و سرم‌سازی رازی را می‌توان یکی از پیشگامان این حوزه دانست و پیشرفت‌های آن حتی می‌تواند به کشورهای همسایه در حال توسعه نیز سود برساند؛ چرا که این آنتی‌بادی‌ها در زمینه درمان و آزمون‌های تشخیصی بیماری‌های عفونی انسان و دام قابل استفاده‌اند.
کلیدواژه‌ها [English]
آنتی بادی های مونوکلونال, مکانیسم ها, کاربردهای بالینی, مدل های درمانی آینده
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آمار
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