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Ansari, Fereshteh, Pourjafar, Hadi, Alian Samakkhah, Shohreh, Kazemikhoo, Nooshafarin, Lotfi, Razieh, Armand, Nezam, Atarod, Atefeh, Neshat Gharamaleki, Mehrdad. (1404). Burn Wound Healing Effect of Traditionally Used Persian Medicine Ointment Containing Herbal Extracts and Yogurt Butter. سامانه مدیریت نشریات علمی, 14(6), 632-638. doi: 10.22034/jmpb.2025.368757.1912
Fereshteh Ansari; Hadi Pourjafar; Shohreh Alian Samakkhah; Nooshafarin Kazemikhoo; Razieh Lotfi; Nezam Armand; Atefeh Atarod; Mehrdad Neshat Gharamaleki. "Burn Wound Healing Effect of Traditionally Used Persian Medicine Ointment Containing Herbal Extracts and Yogurt Butter". سامانه مدیریت نشریات علمی, 14, 6, 1404, 632-638. doi: 10.22034/jmpb.2025.368757.1912
Ansari, Fereshteh, Pourjafar, Hadi, Alian Samakkhah, Shohreh, Kazemikhoo, Nooshafarin, Lotfi, Razieh, Armand, Nezam, Atarod, Atefeh, Neshat Gharamaleki, Mehrdad. (1404). 'Burn Wound Healing Effect of Traditionally Used Persian Medicine Ointment Containing Herbal Extracts and Yogurt Butter', سامانه مدیریت نشریات علمی, 14(6), pp. 632-638. doi: 10.22034/jmpb.2025.368757.1912
Ansari, Fereshteh, Pourjafar, Hadi, Alian Samakkhah, Shohreh, Kazemikhoo, Nooshafarin, Lotfi, Razieh, Armand, Nezam, Atarod, Atefeh, Neshat Gharamaleki, Mehrdad. Burn Wound Healing Effect of Traditionally Used Persian Medicine Ointment Containing Herbal Extracts and Yogurt Butter. سامانه مدیریت نشریات علمی, 1404; 14(6): 632-638. doi: 10.22034/jmpb.2025.368757.1912

Burn Wound Healing Effect of Traditionally Used Persian Medicine Ointment Containing Herbal Extracts and Yogurt Butter

Journal of Medicinal plants and By-products
مقاله 16، دوره 14، شماره 6، بهمن و اسفند 2025، صفحه 632-638    اصل مقاله (1.05 M)
نوع مقاله: Research Article
شناسه دیجیتال (DOI): 10.22034/jmpb.2025.368757.1912
نویسندگان
Fereshteh Ansari1، 2، 3؛ Hadi Pourjafar* 4؛ Shohreh Alian Samakkhah5؛ Nooshafarin Kazemikhoo6؛ Razieh Lotfi7؛ Nezam Armand8؛ Atefeh Atarod9؛ Mehrdad Neshat Gharamaleki10
1Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Tehran, Iran
2Research Center for Evidence-Based Medicine, Health Management and Safety Promotion Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran
3Iranian EBM Centre: A Joanna Briggs Institute Affiliated Group, Tabriz, Iran
4Dietary Supplements and Probiotic Research Center, Alborz University of Medical Sciences, Karaj, Iran
5Department of Food Hygiene, Faculty of Veterinary Medicine, Amol University of Special Modern Technologies (AUSMT), Amol, Iran
6St George and Sutherland Clinical School, UNSW, Sydney, Australia
7School of Nursing and Midwifery, Alborz University of Medical Sciences, Karaj, Iran
8Evidence-based Phytotherapy and Complementary Medicine Research Center, Alborz University of Medical Sciences, Karaj, Iran
9Qom University of Medical Sciences and Health Services, Qom, Iran
10Department of Clinical Sciences, Faculty of Veterinary Medicine, Tabriz Medical Sciences, Islamic Azad University, Tabriz, Iran
چکیده
This study aimed to assess the burn healing efficacy of this traditionally used formulation (herbal ointment) in deep second-degree burns in a Florida white rabbit model. On the dorsal surface of the two rabbits, six burn wounds of the same size were inflicted. Herbal ointment was applied to the wounds on the right side, and silver sulfadiazine was applied to the wounds on the left side. On the 5th and 18th day of the treatment, the burn wound site was excised in a square shape with a narrow surrounding healthy skin for histopathological examination. At the end of day 18 of the treatment period, all the ulcers in the traditional herbal ointment group were covered entirely with epithelial tissue, while in the silver sulfadiazine group, the mean and SD of the ulcer diameter were (1.4 ± 0.1). The duration of pain, blister, and open wound in the silver sulfadiazine group was 6, 8, and 18 days; however, in the traditional herbal ointment group, on the second day, none of these complications were observed. Regarding the pathological findings, epithelial tissue renewal on day 18th was 6.63 ± 0.74 in the traditional herbal ointment group compared to 4.93 ± 0.48 in the silver sulfadiazine (P< 0.05). The findings indicate that the traditional herbal ointment can reduce the duration of the wound healing process as well as the complications, including pain and blister formation. The pathological findings also suggest better epithelial tissue renewal in the traditional herbal ointment group.
کلیدواژه‌ها
Burn wound, Persian medicine؛ Herbal ointment, Yogurt butter, Silver sulfadiazine
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