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Antibiotic Resistance and ESβLs-producing in Enterococcus spp. isolated from patients admitted to Al Women's and Children's Educational Hospital in Al-Qadisiyah, Iraq. | ||
| Archives of Razi Institute | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 08 شهریور 1404 اصل مقاله (918.62 K) | ||
| نوع مقاله: Original Articles | ||
| شناسه دیجیتال (DOI): 10.22092/ari.2025.369308.3640 | ||
| نویسندگان | ||
| Raid R Ojaimi* 1؛ Azhar Noory Hussein2 | ||
| 1Department of Medical Biotechnology, College of Biotechnology, Al-Qasim Green University, Babylon 51013, Iraq. | ||
| 2Department of Biology, College of Education, AL-Qadisiyah University, Al- Diwaniya, Iraq. | ||
| چکیده | ||
| Enterococcus spp., which produce extended-spectrum β-lactamases (ESβLs), are resistant to nearly all β-lactam antibiotics. Due to the limited quantity of therapeutic options available, enterococci infections are often difficult to treat, resulting in higher antibiotic and healthcare costs and a threat to patients' lives. This research, therefore, aimed to determine the antibiotic resistance pattern of Enterococcus spp. and evaluate their potential to produce phenotypically and genotypically ESβLs in Iraq. The epidemiological data available on β-lactam-resistant enterococci in Iraq are inadequate. This laboratory-based study was conducted from December 2020 to May 2021. 500 clinical specimens were obtained from patients with clinical cases and identified using standard microbiological procedures. The antibacterial resistance profiles of all Enterococcus spp. isolates were evaluated using the disk diffusion method. Enterococcal strains were examined for ESβL production utilizing the approximation method and PCR, respectively. All Enterococcus spp. isolates were completely resistant to ceftriaxone and cefotaxime. 85.45% Isolates were resistant to gentamicin, 43.63% to chloramphenicol, 10.9% to ampicillin, and 7.2% to nitrofurantoin. The prevalence rates of Multidrug resistance (MDR) and Extensive drug resistance (XDR) isolates were 41.81% and 3.63%, respectively. Phenotypically, all 55 isolates were ESβLs-positive. Genotypically, the spread rates of the bla-TEM, bla-SHV, and bla-CTX-M2 genes were 27.27%, 23.63%, and 7.27%, respectively. Our conclusion demonstrated a wide prevalence of ESβL among Enterococcus spp. isolated from patients in Hospital Al-Women's and Children's Educational Hospital in Al-Qadisiyah province, Iraq. Also observed was the essential rate of resistance to β-lactam. This highlights the need for a rational policy on the less use of antibiotics. | ||
| کلیدواژه‌ها | ||
| Antibacterial-resistance؛ ß-lactamase؛ Enterococci؛ ESβLs-genes؛ MDR | ||
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آمار تعداد مشاهده مقاله: 5 تعداد دریافت فایل اصل مقاله: 6 |
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