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Nanoemulsion of clove essential oil in the experimental cystic hydatid disease in mice, evidence on the high importance of in vivo models in nano drug delivery systems studies | ||
| Archives of Razi Institute | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 08 شهریور 1404 اصل مقاله (618.76 K) | ||
| نوع مقاله: Original Articles | ||
| شناسه دیجیتال (DOI): 10.22092/ari.2025.364380.2976 | ||
| نویسندگان | ||
| Ali Nasser1؛ Saloomeh Shirali* 2؛ mohammad reza youssefi3؛ Bahar Shemshadi4؛ Mohaddeseh Abouhosseini Tabari5 | ||
| 1Department of Pathobiology, Science and Research Branch, Islamic Azad University, Tehran, Iran. | ||
| 2Department of Biotechnology, Ahvaz Branch, Islamic Azad University, Ahvaz, Iran. Department of Pathobiology, Science and Research Branch, Islamic Azad University, Tehran, Iran. | ||
| 3Department of Veterinary Parasitology, Babol Branch, Islamic Azad University, Babol, Iran | ||
| 4Pathobiology department,faculty of veterinary medicine,Islamic Azad university ,sciences and research branch,Tehran,Iran | ||
| 5Faculty of Veterinary Medicine, Amol University of Special Modern Technologies (AUSMT), Amol, Iran. | ||
| چکیده | ||
| Cystic hydatid disease (CHD) is a global zoonotic infection caused by Echinococcus granulosus. Several in vitro researches have demonstrated high efficacy of nanoformulations against protoscoleces of E. granulosus, but only a limited number of them evaluated their safety on CHD animal models. Based on our previous report on the in vitro effectiveness of clove essential oil (CEO) and the developed nanoemulsion (N-CEO) against E. granulosus, herein we evaluated the therapeutic and side effects of CEO and N-CEO on CHD-mice. Number of 48 mice were infected to CHD by intraperitoneal injection of 103 protoscoleces, and 8-week post injection received the treatments, CEO-20 and -50 and N-CEO-20 and -50 (20 and 50 mg/kg), and albendazole (ALB) as the standard treatment (50 mg/kg), by oral gavage for a 6-week period. D-CON served as the control and were infected to CHD but received only saline. All the tested treatments resulted in a significant reduction in the average number and size of cysts. Treatment with ALB, CEO-20 and CEO-50 had no increasing effect on serum activity of liver enzymes. However, the highest alkaline phosphatase and alanine transferase activities have been observed in N-CEO-50. The level of antioxidant enzymes, and the gluthathione content were lower in N-CEO-50 compared to the D-CON mice. The most significant histopathological damages were noted in N-CEO-50 including infiltration of edematous cells, inflammation, hyperemia and degeneration. Further studies to find the mechanism of liver injury despite the slight in vitro cytotoxicity can be a step forward in reevaluating the safety of nanoformulations. | ||
| کلیدواژهها | ||
| zoonoses؛ herbal preparation؛ nanomedicine؛ toxicity؛ safety | ||
| عنوان مقاله [English] | ||
| نانوامولسیون اسانس میخک در بیماری کیست هیداتید تجربی در موش، شواهدی بر اهمیت بالای مدل های in vivo در مطالعات سیستم های داروسازی نانو | ||
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