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Impact of Aqueous Hibiscus sabdariffa Extract on Lipid Profile in Women with Subclinical Hypothyroidism: A Study in Al-Nasiriyah City | ||
| Journal of Medicinal plants and By-products | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 25 مرداد 1404 اصل مقاله (623.34 K) | ||
| نوع مقاله: Research Paper | ||
| شناسه دیجیتال (DOI): 10.22034/jmpb.2025.369351.1958 | ||
| نویسندگان | ||
| Wafa Saleh Abdulredha* 1؛ Riyadh Khion Abdullah1؛ Amal Hussein Anatheil2 | ||
| 1Department of Pharmacognosy and Medicinal Plants, College of Pharmacy, University of Thi-qar, Thi-qar 64001, Iraq | ||
| 2Department of Pharmaceutical Chemistry, University of Thi-qar, Thi-qar 64001, Iraq | ||
| چکیده | ||
| Subclinical thyroid disorders, particularly subclinical hypothyroidism (SHT), are prevalent conditions characterized by abnormal serum thyrotropin (TSH) levels and normal triiodothyronine (T3) and thyroxine (T4) concentrations. SHT is associated with dyslipidemia, which is characterized by elevated total cholesterol (TC) and low-density lipoprotein cholesterol (LDL), increasing cardiovascular disease risk. Hibiscus sabdariffa L. (sour tea) is known for its bioactive compounds, including anthocyanins and polyphenols, which exhibit lipid-lowering and cardioprotective properties. This study aimed to investigate the effects of H. sabdariffa extract (20 g/100 ml) on lipid metabolism in women with SHT. A total of 50 participants were recruited, including 10 healthy women (G1) and 40 women with SHT, who were further divided into a control group (G2, n=25) and treatment group (G3, n=15) that consumed two daily cups of H. sabdariffa extract for six weeks. Biochemical analyses, including analyses of thyroid hormone levels and lipid profiles, were performed before and after the intervention. Results showed a significant reduction in TC, triglyceride (TG), and LDL levels, along with an increase in high-density lipoprotein cholesterol (HDL) in the intervention group compared with those in the control group. Additionally, slight improvements in serum TSH and thyroid hormone levels were observed. The lipid-lowering effects of H. sabdariffa may be attributed to its ability to inhibit lipid synthesis enzymes, increase cholesterol metabolism, and increase antioxidant activity. In conclusion, H. sabdariffa extract shows promise as a natural intervention for managing dyslipidemia in SHT patients. Further studies with larger sample sizes and longer follow-up periods are recommended to confirm its therapeutic potential in thyroid-related metabolic disorders. | ||
| کلیدواژه‌ها | ||
| Cardioprotective properties؛ Dyslipidemia؛ Hibiscus sabdariffa؛ Lipid metabolism؛ Subclinical hypothyroidism (SHT) | ||
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