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Immunomodulatory and Therapeutic Potentials of Honeybee Products: A Comprehensive Review of Their Role in Health and Disease Management | ||
| Archives of Razi Institute | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 15 مرداد 1404 اصل مقاله (507.84 K) | ||
| نوع مقاله: Review Article | ||
| شناسه دیجیتال (DOI): 10.22092/ari.2025.368827.3570 | ||
| نویسندگان | ||
| Muhammad Yasir Naeem1؛ Hamdia Yousif Issa2؛ Shahid Abbas3؛ Zeliha Selamoglu* 4 | ||
| 1Department of Agronomy, Animals, Food, Natural Resources and the Environment (DAFNAE), University of Padua, Italy | ||
| 2Department of Biology, College of Science, University of Zakho, Duhok, Iraq | ||
| 33Allergy and Asthma Center, Blue Area, Islamabad, Pakistan. Former Chief, Clinical and Tropical Diseases Research Division, National Institute of Health, Islamabad. Former HOD Allergy & Immunology, NIH, Islamabad, Pakistan | ||
| 4Nigde Omer Halisdemir University | ||
| چکیده | ||
| In this review study, we explore the therapeutic potential of bee products, including royal jelly, propolis, and honey in modulating the immune system and addressing many different health conditions. This review aims to provide a comprehensive understanding of the bioactive components of bee products and their role in enhancing human health. Products by honeybees (bee), such as propolis, royal jelly, and their bioactive ingredients, have drawn interest for their potential as treatments for a range of skin conditions because of their strong antibacterial, anti-inflammatory, regenerative, and immunomodulatory qualities. Studies have demonstrated the ability of royal jelly and its constituent 10-hydroxy-2-decenoic acid (10-HDA) to regulate melanogenesis, offering promising avenues for treating pigmentation disorders such as melasma and skin aging by modulating key enzymes involved in melanin production. Additionally, these bee products have been shown to enhance wound healing by promoting tissue regeneration, reducing inflammation, and accelerating the closure of wounds. Royal jelly's water-soluble proteins, such as MRJP2, MRJP3, and MRJP7, stimulate epidermal cell proliferation and migration, while propolis exhibits strong antibacterial and anti-inflammatory activities, further supporting its use in treating wounds and skin infections. The combination of propolis with polymer-based wound dressings has demonstrated enhanced wound closure and accelerated healing, particularly in diabetic and burn models. These findings suggest that bee products offer a natural and effective alternative for dermatological treatments, with the potential for incorporation into tissue engineering approaches for improved wound healing. However, further clinical studies are required to validate the safety, efficacy, and mechanisms of action of these bee-derived products in human dermatology, which could ultimately lead to their integration into mainstream therapeutic strategies for skin diseases. | ||
| کلیدواژه‌ها | ||
| Honeybee products؛ Royal jelly؛ Wound healing؛ Melanogenesis؛ Propolis | ||
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