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Khoshvaghti, Ameneh, Panahi, Zahra, Rahmani Kahnamoei, Jafar. (1404). Echium amoenum Hydroalcoholic Extract Effect on Oxidative Stress Due to Heat Stress in Rats. سامانه مدیریت نشریات علمی, 15(1), 14-19. doi: 10.22034/jmpb.2025.368747.1910
Ameneh Khoshvaghti; Zahra Panahi; Jafar Rahmani Kahnamoei. "Echium amoenum Hydroalcoholic Extract Effect on Oxidative Stress Due to Heat Stress in Rats". سامانه مدیریت نشریات علمی, 15, 1, 1404, 14-19. doi: 10.22034/jmpb.2025.368747.1910
Khoshvaghti, Ameneh, Panahi, Zahra, Rahmani Kahnamoei, Jafar. (1404). 'Echium amoenum Hydroalcoholic Extract Effect on Oxidative Stress Due to Heat Stress in Rats', سامانه مدیریت نشریات علمی, 15(1), pp. 14-19. doi: 10.22034/jmpb.2025.368747.1910
Khoshvaghti, Ameneh, Panahi, Zahra, Rahmani Kahnamoei, Jafar. Echium amoenum Hydroalcoholic Extract Effect on Oxidative Stress Due to Heat Stress in Rats. سامانه مدیریت نشریات علمی, 1404; 15(1): 14-19. doi: 10.22034/jmpb.2025.368747.1910

Echium amoenum Hydroalcoholic Extract Effect on Oxidative Stress Due to Heat Stress in Rats

Journal of Medicinal plants and By-products
مقاله 2، دوره 15، شماره 1، فروردین و اردیبهشت 2026، صفحه 14-19    اصل مقاله (816.39 K)
نوع مقاله: Research Article
شناسه دیجیتال (DOI): 10.22034/jmpb.2025.368747.1910
نویسندگان
Ameneh Khoshvaghti* 1؛ Zahra Panahi2؛ Jafar Rahmani Kahnamoei2
1Department of Clinical Sciences, Kaz.C., Islamic Azad University, Kazerun, Iran
2Department of Biochemistry, Agriculture and New Technologies, Shiraz Branch, Islamic Azad University, Shiraz, Iran
چکیده
Among the biggest problems facing the world today are climate change and heat stress in the environment. It is crucial to look into these effects on various organisms. One of the most critical consequences of global warming is heat stress, which significantly disrupts the oxidative balance in living organisms by increasing reactive oxygen species (ROS) and reducing antioxidant capacity. This imbalance leads to cellular and tissue damage. Therefore, identifying effective strategies to reduce oxidative damage caused by heat stress is essential. One of the top priorities is to eradicate heat stress in living things. Plant extracts can significantly reduce heat stress by enhancing the immune system, improving effectiveness, and having few side effects. Residual medicinal plant extracts, such as Echium amoenum Fisch. & C.A.Mey., are known for their antioxidant properties. In this study, the protective effect of E. amoenum hydroalcoholic extract on oxidative stress induced by acute and chronic heat exposure in rats was investigated. Six groups of sixty rats were prepared. These groups include healthy control, sham, acute and chronic heat stress control stress groups (groups T1 and T2), group T3: chronic heat stress conditions with daily injection of 400 mg/kg body weight of the extract for 21 days, and group T4: acute heat stress conditions with daily injection of 400 mg/kg body weight of the extract for 21 days. Blood was taken from the rats under sterile conditions at the end of the study. The investigated parameters were measured using conventional techniques in the resultant sera. The findings demonstrated that prolonged exposure to heat significantly lowers serum catalase. All of the indicators that were examined catalase, vitamin D, superoxide dismutase, glutathione peroxidase, malondialdehyde, and total antioxidant capacity showed a noteworthy variation in response to acute heat stress in comparison to the control group. However, following the extract injection, a comparison of two heat stress groups and the control group demonstrated the extract's beneficial effects on stress reduction. In conclusion, the findings of this study showed that treatment with E. amoenum notably improves oxidative markers, especially under acute heat stress. This extract can alleviate oxidative damage caused by heat stress in rats.
کلیدواژه‌ها
Echium amoenum flower؛ Heat stress؛ Hydroalcoholic extract؛ Rat
مراجع
  1. Bhardwaj S., Verma R., Gupta J. Challenges and future prospects of herbal medicine. International Journal of Medical Research and Health Sciences. 2018; 1(1): 12-15.
  2. Naderi Haji B., Candi M., Rezaee M.J. IJOM., Research A.P. Primory phytochemical investigation of Echium amoenium. Iranian Journal of Medicinal and Aromatic Plants Research. 2004; 20(3): 377-383.
  3. Nouri M., Farajdokht F., Torbati M., Ranjbar F., Hamedyazdan S., Araj-Khodaei M., Sadigh-Eteghad S.A. Close look at Echium amoenum processing, neuroactive components, and effects on neuropsychiatric disorders. Galen Medical Journal. 2019; 8: e1559.
  4. Farahani M., Azad I., Branch Q. Antiviral effect assay of aqueous extract of Echium amoenum-L against HSV-1. Zahedan Journal of Research in Medical Sciences. 2013; 15(8): (In Persian)
  5. Sabaeifard P. Antibacterial activity of Echium amoenum aqueous and ethanolic extracts. Third Int. Stud. Biotech. Cong. 2015.
  6. Mahmoudi M., Shahidi S., Golmohammadi H., Mohammadi S. The effect of Echium amoenum hydroalcoholic extract on blood glucose level, lipid profile and lipoproteins in streptozotocin-induced diabetic male rats. Journal of Advances in Medical and Biomedical Research. 2015; 23(97): 72-81.
  7. Patocka J., Navratilova Z.J.P. Bioactivity of Echium amoenum: A mini review. Biomed. Biomedical Journal of Scientific & Technical research. 2019; 20(2):14915-14917. DOI:10.26717/BJSTR.2019.20.003429.
  8. Sayyah M., Boostani H., Pakseresht S., Malaieri A.J.P.I.N.P., Psychiatry B. Efficacy of aqueous extract of Echium amoenum in treatment of obsessive–compulsive disorder. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 2009; 33(8):1513-1516. doi: 10.1016/j.pnpbp.2009.08.021.
  9. 9.Sadighara P., Barin A., JAHED G., Farjadmand F. Assessment of antioxidant capacity and anti-inflammatory of alcoholic extraction of chamomile, morus, marshmallow, borage and rosemary. Knowledge and Healthy. 2013; 8(1):31-34.
  10. Erdemoglu N., Kusmenoglu S., Vural M. γLinolenic acid content and fatty acid composition of Boraginaceae seed oils. European Journal of Lipid Science and Technology. 2004; 106(3):160-164.
  11. Hajghanbari L., Alizadeh A., Honarvar M. Essential oil constituents and fatty acids in Echium amoenum grown wild in Iran. International Journal of Biosciences. 2015; 6(1): 156-161.
  12. Chandran R. and Abrahamse H. Identifying plant-based natural medicine against oxidative stress and neurodegenerative disorders. Oxidative Medicine and Cellular Longevity. 2020;8648742. 10.115/2020/8648742.
  13. Jomova K., Raptova R., Alomar S., Awasel S.Y., Nepovimova E., Kuca K., Valko M. Reactive oxygen species, toxicity, oxidative stress, and antioxidants: chronic diseases and aging. Archives of Toxicology. 2023; 97(10):2499–2574. doi: 10.1007/s00204-023-03562-9
  14. Andrade-Cuvi M.J., Moreno C., Zaro M.J., Vicente A.R., Concellón A. Improvement of the antioxidant properties and postharvest life of three exotic Andean fruits by UV-C treatment. Food Quality. 2017. https://doi.org/10.1155/2017/4278795 .
  15. Schumacker P.T. Reactive oxygen species in cancer: a dance with the devil. Cancer cell. 2015; 27(2):156-157.
  16. Abbasi Larki R., Zayerzadeh E., Harzandi N., Anissian A. Protective effects of Echium amoenum on oxidative stress and gene expression induced by permethrin in Wistar rats. Hepatitis Monthly. 2020;20(6): 2103774. Doi: 10.5812/hepatmon.103774.
  17. Ranjbar M and Motiee N. Comparative and combined effects of Echium amoenum and Cichorium intybus extracts on live of Wistar rats. Medicinal Plants By- products. 2023;4:495-503. https://doi.org/10.22092/jmpb.2022.356065.1403.
  18. World Health Organization. COP24 special report: health and climate change.2018.
  19. Ncongwane K.P., Botai J.O., Sivakumar V., Botai C.M.J.S.A literature review of the impacts of heat stress on human health across Africa .Iran J .Med .Arom. Plants Res. 2021; 13(9), 5312.
  20. Shamuni A., Razmi N. Effects of heat stress on malondialdehyde levels and catalase, glutathione peroxidase and superoxide dismutase activity in Rattus. J. Anim. Environ. 2021; 13(2), 107-112.
  21. Wasti S., Sah N., Mishra B. Impact of heat stress on poultry health and performances, and potential Mitigation strategies Animals (Basel). 2020; 24; 10(8):1266. doi: 10.3390/ani10081266
  22. Raptova R., Alomar S.Y., Alwasel S.H., Nepovimova E., Kuca K., Valko M. Reactive oxygen species, toxicity, oxidative stress, and antioxidants: chronic diseases and aging Klaudia Jomova1. Archives of Toxicology. 2023; 97:2499–2574 https://doi.org/10.1007/s00204-023-03562-9 .
  23. Rabiei Z., Setorki M. Effect of hydroalcoholic Echium amoenum extract on scopolamine induced learning and memory impairment in rats. Pharmaceutical Biology. 2018; 12: 56(1):672-677.
  24. Nofouzi K., Mahmoudi R., Tahapour K., Amini E. Verbascum speciosum methanolic extract: phytochemical components and antibacterial properties. Journal of Essential Oil Bearing Plants. 2014; 19(2):499-505.
  25. Chaichi M.J., Mehrzad J., Sedaghat R. GC-MS analysis of chemical compounds from aceton extract of Echium amoenum Fisch. Journal of Research in Pharmacy. (RJP) 4(Supplement). 2017: 9.
  26. Hamidi E., Khaksari M., Hojabri K. The effects of aqueous extracts of Echium amoenum and Citrus aurantiflia on blood pressure and heart rate before and after phynelephrine injection in rat. Journal of Kerman University of Medical Sciences. 2011; 18: 349-357.
  27. Miller N.J., Rice-Evans C., Davies M.J., Gopinathan V., Milner A.A novel method for measuring antioxidant capacity and its application to monitoring the antioxidant status in premature neonates. Clinical Science. 1993; 84:407–12.
  28. Arthur J.R., Boyne R. Superoxide dismutase and glutathione peroxidase activities in neutrophils from selenium deficient and copper deficient cattle. Life Sciences. 1985; 22: 36(16):1569-75.
  29. Paglia D.E., Valentine W.N. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. Journal of Laboratory and Clinical Medicine. 1967;70:158–169.
  30. Góth L.A simple method for determination of serum catalase activity and revision of reference range. Clinica Chimica Acta. 1991; 196 (2-3):143-51.
  31. Esterbauer H., Cheeseman K.H. Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal. Meth. Enzym. 1990;186:407-21.
  32. Norusis M.Y. Spss for windows base system user’s guide release 6.0, 1st ed. SPSS Inc, Michigan. 1993; 281-290.
  33. Gupta A., Chauhan N.R., Singh A., Chowdhury D., Meena R.C., Chakrabarti A., Singh S.B J.D.L.S.J. Heat induced oxidative stress and aberrations in liver function leading to hepatic injury in rats. Defence Life Science Journal. 2018; 4: 21-32. DOI:10.14429/dlsj.4.13174.
  34. Gaykwad C.J., Garkhal G.E., Chethan S.N., De U.K.: Stress using N‐acetylcysteine in canine parvoviral enteritis. Journal of Veterinary Pharmacology and Therapeutics. 2018; 41(1): 68–75.
  35. Fortunato S .Redox signaling in plant heat stress response .Antioxidants. 2023; 12(3): 605; https://doi.org/10.3390/antiox12030605 .
  36. Gonzalez-Rivas P.A., Chauhan S.S., Ha M., Fegan N., Dunshea F.R., Warner R.D. Effects of heat stress on animal physiology, metabolism, and meat quality: A review. Meat Science. 2019;162(2020): 108025. https://doi.org/10.1016/j.meatsci.2019.108025.
  37. Dou J., Khan A., Khan M.Z., Mi S., Wang Y., Yu Y., Wang Y.J.G. Heat stress impairs the physiological responses and regulates genes coding for extracellular exosomal proteins in rat.Gen. 2020;11(3):306. doi: 10.3390/genes11030306.
  38. Senturk E., Ustundag H.J.B.S. Heat Stress Alters oxidative and inflammatory responses in many tissues of male rats. Bezmialem Science. 2023; 11(4): 453-460.
  39. Bhat S., Rao G., Murthy K.D., Bhat P.G. Seasonal variations in markers of stress and oxidative stress in rats. Indian Journal of Clinical Biochemistry. 2008; 23, 191-194.
  40. Wang H.L., Xing G.D., Qian Y., Sun X.F., Zhong J.F., Chen K.L.J.E., Safety E. Dihydromyricetin attenuates heat stress-induced apoptosis in dairy cow mammary epithelial cells through suppressing mitochondrial dysfunction. Ecotoxicology and Environmental Safety. 2021; 214:112078. doi: 10.1016/j.ecoenv.2021.112078.
  41. Jin J., Boersch M., Nagarajan A., Davey A.K., Zunk M.J.A. Antioxidant properties and reported ethnomedicinal use of the genus Echium (Boraginaceae). Antioxidants. 2020; 9 (8): 722. https://doi.org/10.3390/antiox9080722 .
  42. Gutierres J.M., Carvalho F.B., Schetinger M.R.C., Agostinho P., Marisco P.C., Vieira J.M., Rosa M.M., Bohnert C., Rubin M.A., Morsch V.M., Spanevello R., Mazzanti C.M. Neuroprotective effect of anthocyanins on acetylcholinesterase activity and attenuation of scopolamine-induced amnesia in rats. International Journal of Developmental Neuroscience. 2014;33: 88-97.
  43. Min J., Yu S.W., Baek S.H., Nair K.M., Bae O.N., Bhatt A., Majid A.J.N.l. Neuroprotective effect of cyanidin-3-O-glucoside anthocyanin in mice with focal cerebral ischemia. Neuroscience Letters. 2011 18; 500(3):157-61. doi: 10.1016/j.neulet.2011.05.048.
  44. Mehrabani M., Ghassemi N., Ghannadi E.S.A., Shams-Ardakani M.J.D.J.O.P.S. Main phenolic compound of petals of Echium amoenum Fisch. and C.A. Mey., a famous medicinal plant of Iran. DARU Journal of Pharmaceutical Sciences. 2005; 13(2): 65-69.
  45. Bekhradnia S., Ebrahimzadeh M.A.J.R.C.J. Antioxidant activity of Echium amoenum. Review Chemistry. 2016; 67(2): 223-226.
  46. Friedman T.J.J.O.R.M. The effect of rosmarinic acid on immunological and neurological systems: A Basic Science and Clinical Research. 2015; 4(1): 50.
  47. Zeng H., Xi Y., Li Y., Wang Z., Zhang L., Han Z.J.A. Analysis of astragalus polysaccharide intervention in heat-stressed dairy cows’ serum metabolomics. Animals (Basel). 2020 29; 10(4):574. doi: 10.3390/ani10040574.
  48. Kra G., Daddam J.R., Gabay H., Yosefi S., Zachut M.J.A. Antioxidant resveratrol increases lipolytic and reduces lipogenic gene expression under in vitro heat stress conditions in dedifferentiated adipocyte-derived progeny cells from dairy cows. Antioxidants (Basel). 2021; 10(6):905.
  49. Wang M., Huang X., Liu Y., Zeng J. Effects of Macleaya cordata extract on blood biochemical indices and intestinal flora in heat-stressed mice. Animals. 2022; 12(19): 2589. https://doi.org/10.3390/ani12192589.
  50. Fang X., Nong K., Qin X., Liu Z. Effect of purple sweet potato-derived anthocyanins on heat stress response in Wenchang chickens and preliminary mechanism study. Poultry Science. 2023; 102(97): 102861. DOI:10.1016/j.psj.2023.102861.
  51. Abed A., Minaiyan M., Ghannadi A., Mahzouni P., Babavalian M.R. Effect of Echium amoenum Fisch. et Mey a traditional Iranian herbal remedy in an experimental model of acute pancreatitis. International Scholarly Research Notices (ISRN) Gastroenterol. 2012; 141548: 7. doi: 10.5402/2012/141548.
  52. Ranjbar A., Khorami S., Safarabadi M., Shahmoradi A., Malekirad A.A., Vakilian K.Medicine A. Antioxidant activity of Iranian Echium amoenum Fisch & CA Mey flower decoction in humans: a cross-sectional before/after clinical trial. Evidence-Based Complementary and Alternative Medicine. 2006;3(4):469-473. doi: 10.1093/ecam/nel03.
  53. Mehrabi A., Mahmoudi R., Khedmati Morasa H., Mosavi S., Kazeminia M., Attaran Rezaei F., Shahsavari S., Vahidi R. Study of chemical composition, antibacterial and antioxidant activity of thyme leaves and stems essential oil. Journal of Medicinal Plants and by-Prod. 2022; 2: 253-263.
  54. Mohammadzadeh M., Mahmoudi R., Ghajarbeigy P. Evaluation of chemical composition and antibacterial properties of Froriepia subpinnta essential oils from Guilan region: before and after flowering. Journal of Essential Oil-Bearing Plants. 21(4):1119-1127.
  55. Kazeminia M., Mehrabi A., Mahmoudi R. Chemical composition, biological activities, and nutritional application of Asteraceae family herbs: A systematic review. Trends in Phytochemical Research. 2022; 6(3):187-213.
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