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Kaempferol from Medicinal Plants: A Comprehensive Review of its Anti-Diabetic Effects | ||
| Journal of Medicinal plants and By-products | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 16 تیر 1404 اصل مقاله (886.91 K) | ||
| نوع مقاله: Full Issue File | ||
| شناسه دیجیتال (DOI): 10.22034/jmpb.2025.368448.1889 | ||
| نویسندگان | ||
| Wafaa M.A.Al-attar1؛ Khitam Ghazi Atiyah2؛ Hussein Aadi Ubaid3؛ Alaa Jawad Kadhim4؛ Sabah Abbas Ahmed1؛ Majeed M.A.ALI5؛ Behnam Barzgar6؛ Narges Shafie Masabi7؛ Hadi Ahmadi* 7، 6 | ||
| 1College of Nursing, Al-Bayan University, Baghdad, Iraq | ||
| 2Department of Psychiatric and mental health Nursing, College of Nursing, University of Baghdad, Baghdad, Iraq | ||
| 3Department of Nursing, Al-kut university college, Iraq | ||
| 4Department of Adult Nursing, College of Nursing, University of Baghdad, Iraq | ||
| 5Ibn Khaldun Private University College, Baghdad, Iraq | ||
| 6Department of Nursing, Ferdows Faculty of Medical Sciences, Birjand University of Medical Sciences, Birjand, Iran | ||
| 7Ferdows Rasoul Hospital ,Birjand University of Medical Sciences ,Ferdows ,Iran | ||
| چکیده | ||
| Due to the high prevalence of diabetes and the promising effects of Kaempferol, this review assesses its molecular, cellular, and metabolic effects relevant to diabetes. A comprehensive search of PubMed, Scopus, Web of Science, Science Direct, and Google Scholar was conducted for articles published between 2010 and 2023 using relevant keywords. Kaempferol modulates glucose metabolism, enhances hepatic enzyme activity, and improves lipid profiles through multiple mechanisms. Specifically, it protects pancreatic β-cells by inhibiting apoptosis, promoting proliferation, and increasing their number, which is valuable in preventing and treating type 2 Diabetes Mellitus. Studies show that kaempferol reduces serum HbA1c levels (by an average of 20% if used for more than six months (and fasting blood glucose while increasing insulin sensitivity. Oral administration of kaempferol (5 mg/Kg) reduced blood glucose levels as compared to metformin (50 mg/Kg), while it does not have the harmful effects of metformin and other medications. Meanwhile, another therapeutic difference between Kaempferol is that, compared to other supplements and medications, it has positive effects on other systems of the body rather than destructive and negative effects, including on the liver and kidney systems. However, effects on weight vary across studies, possibly due to differences in dosage and study duration. Kaempferol also plays a multi-target role in diabetic nephropathy therapy, primarily via anti-oxidative stress and anti-inflammatory effects. Further clinical trials are needed to clarify conflicting results and fully establish its therapeutic potential in diabetes management. | ||
| کلیدواژه‌ها | ||
| Kaempferol؛ Diabetes؛ Flavonoid؛ Insulin resistance؛ Diabetic nephropathy؛ Glucose metabolism؛ Inflammation؛ Metabolic effects | ||
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آمار تعداد مشاهده مقاله: 293 تعداد دریافت فایل اصل مقاله: 155 |
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