اخبار و اعلانات

 آمار

تعداد نشریات282
تعداد نشریات سازمان80
تعداد شماره‌ها3,188
تعداد مقالات35,336
تعداد مشاهده مقاله51,459,510
تعداد دریافت فایل اصل مقاله91,332,225
Rahmati-Holasoo, Hooman, Darabiyan, Ali, Shokrpoor, Sara, Rezaei, Alireza. (1404). The Study of the Effects of Menthol and Thymol on Kidney and Liver Lesions Caused by Chronic Mercury Poisoning in Zebrafish (Danio rerio). سامانه مدیریت نشریات علمی, 14(5), 484-488. doi: 10.22034/jmpb.2025.369444.1968
Hooman Rahmati-Holasoo; Ali Darabiyan; Sara Shokrpoor; Alireza Rezaei. "The Study of the Effects of Menthol and Thymol on Kidney and Liver Lesions Caused by Chronic Mercury Poisoning in Zebrafish (Danio rerio)". سامانه مدیریت نشریات علمی, 14, 5, 1404, 484-488. doi: 10.22034/jmpb.2025.369444.1968
Rahmati-Holasoo, Hooman, Darabiyan, Ali, Shokrpoor, Sara, Rezaei, Alireza. (1404). 'The Study of the Effects of Menthol and Thymol on Kidney and Liver Lesions Caused by Chronic Mercury Poisoning in Zebrafish (Danio rerio)', سامانه مدیریت نشریات علمی, 14(5), pp. 484-488. doi: 10.22034/jmpb.2025.369444.1968
Rahmati-Holasoo, Hooman, Darabiyan, Ali, Shokrpoor, Sara, Rezaei, Alireza. The Study of the Effects of Menthol and Thymol on Kidney and Liver Lesions Caused by Chronic Mercury Poisoning in Zebrafish (Danio rerio). سامانه مدیریت نشریات علمی, 1404; 14(5): 484-488. doi: 10.22034/jmpb.2025.369444.1968

The Study of the Effects of Menthol and Thymol on Kidney and Liver Lesions Caused by Chronic Mercury Poisoning in Zebrafish (Danio rerio)

Journal of Medicinal plants and By-products
مقاله 15، دوره 14، شماره 5، آذر و دی 2025، صفحه 484-488    اصل مقاله (997.67 K)
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22034/jmpb.2025.369444.1968
نویسندگان
Hooman Rahmati-Holasoo* 1؛ Ali Darabiyan2؛ Sara Shokrpoor3؛ Alireza Rezaei2
1Department of Aquatic Animal Health, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
2Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
3Department of Pathology and Clinical Pathology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
چکیده
Heavy metals represent a significant form of environmental pollution, accumulating over time and posing serious risks to human health. Among these, mercury is particularly concerning, as it primarily enters the human body through the consumption of contaminated aquatic animals. The ingestion of mercury-laden fish can lead to severe health issues. Therefore, it is essential to explore strategies to mitigate the adverse effects of this pollution. Natural plant compounds, known for their antioxidant and chelating properties as well as their biodegradability, offer promising solutions for addressing heavy metal contamination. Thymol and menthol are two such compounds that exhibit beneficial effects in this context. Zebrafish (Danio rerio) have gained significant attention as a model organism in biological research due to their genetic similarity to humans, ease of breeding, and high reproductive capacity. This study aimed to compare the protective effects of thymol and menthol against chronic mercury poisoning in the liver and kidney tissues of zebrafish. A group of zebrafish was exposed to 0.44 mg/L of mercury to assess the therapeutic effects of thymol and menthol on chronic mercury toxicity. Pathological sampling was performed, and tissue sections were examined microscopically. The findings revealed that the mercury-exposed group exhibited the highest level of tissue damage. While the severity of injuries in the mercury-thymol group was less pronounced than in the mercury-menthol group, neither treatment fully resolved the damage caused by mercury exposure. These results underscore the importance of investigating various substances to mitigate the effects of environmental pollutants. Notably, this study demonstrated that thymol was slightly more effective than menthol in reducing the severity of mercury-induced injuries.
کلیدواژه‌ها
Danio rerio؛ Histopathology؛ Mercuric chloride؛ Menthol؛ Thymol
مراجع
  1. Güven K., Özbay C., Ünlü E., Satar A. Acute Lethal Toxicity and Accumulation of Copper in Gammarus pulex (L.) (Amphipoda). Turkish Journal of Biology. 1999; 23(4): 513-522.
  2. Hedayati A., Hoseini S.M., Hoseinifar S.H. Response of plasma copper, ceruloplasmin, iron and ions in carp, Cyprinus carpio to waterborne copper ion and nanoparticle exposure. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology. 2016; 179:87-93.
  3. Hoseini S.M., Rajabiesterabadi H., Kordrostami S. Chronic exposure of Rutilus rutilus caspicus fingerlings to ambient copper: Effects on food intake, growth performance, biochemistry and stress resistance. Toxicology and Industrial Health. 2016; 32(2): 375-383.
  4. Rajabiesterabadi H., Hoseini S.M., Fazelan Z., Hoseinifar S.H., Doan H.V. Effects of dietary turmeric administration on stress, immune, antioxidant and inflammatory responses of common carp (Cyprinus carpio) during copper exposure. Aquaculture Nutrition. 2020; 26(4): 1143-1153.
  5. Hoseini S.M., Khalili M., Rajabiesterabadi H., Hoseinifar S.H., Van Doan H. Effects of dietary monoterpene, myrcene, administration on immune-and health-related genes expression in common carp gill following exposure to copper sulfate. Fish & Shellfish Immunology. 2020; 98: 438-445.
  6. Hoseini S.M., Sinha R., Fazel A., Khosraviani K., Hosseinpour Delavar F., Arghideh M., Sedaghat M., Paolucci M., Hoseinifar S.H., Van Doan H. Histopathological damage and stress‐and immune‐related genes' expression in the intestine of common carp, Cyprinus carpio exposed to copper and polyvinyl chloride microparticle. Journal of Experimental Zoology Part A: Ecological and Integrative Physiology. 2022; 337(2): 181-190.
  7. Esmaili Sari A. Pollution, health and environmental standards. Tehran: Naghsh Mehr Publications. 2002
  8. Clarkson T.W. The toxicology of mercury. Critical reviews in clinical laboratory sciences. 1997; 34(4): 369-403.
  9. Bosch A.C., O'Neill B., Sigge G.O., Kerwath S.E., Hoffman L.C. Heavy metals in marine fish meat and consumer health: a review. Journal of the Science of Food and Agriculture. 2016; 96(1): 32-48.
  10. de Almeida Rodrigues P., Ferrari R.G., Dos Santos L.N., Junior C. A.C. Mercury in aquatic fauna contamination: a systematic review on its dynamics and potential health risks. Journal of Environmental Sciences. 2019; 84: 205-218.
  11. Briggs J.P. The zebrafish: a new model organism for integrative physiology. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 2002; 282(1): R3-R9.
  12. Zhu F. A review on the application of herbal medicines in the disease control of aquatic animals. Aquaculture.2020; 526: 735422.
  13. Pu H., Li X., Du Q., Cui H., Xu Y. Research progress in the application of Chinese herbal medicines in aquaculture: a review. Engineering. 2017; 3(5), 731-737.
  14. Hoseini S.M., Yousefi M., Hoseinifar S.H., Van Doan H. Antioxidant, enzymatic and hematological responses of common carp (Cyprinus carpio) fed with myrcene-or menthol-supplemented diets and exposed to ambient ammonia. Aquaculture. 2019; 506, 246-255.
  15. Aanyu M., Betancor M.B., Monroig O. Effects of dietary limonene and thymol on the growth and nutritional physiology of Nile tilapia (Oreochromis niloticus). Aquaculture. 2018; 488: 217-226.
  16. Yousefi M., Hoseini S.M., Vatnikov Y.A., Karamyan A., Kulikov E.V. Dietary Thymol Supplementation Promotes Antioxidant Responses and Thermal Stress Resistance in Rainbow Trout, Oncorhynchus mykiss. Animals. 2024; 14(20): 2988.
  17. Yousefi M., Adineh H., Taheri Mirghaed A., Hoseini S.M. Co-Supplementation of Diet with Saccharomyces cerevisiae and Thymol: Effects on Growth Performance, Antioxidant and Immunological Responses of Rainbow Trout, Oncorhynchus mykiss. Animals. 2025; 15(3): 302.
  18. da Cunha J.A., Junior G.B., da Silva E.G., de Ávila Scheeren C., Fausto V.P., Salbego J., de Almeida Vaucher R., de Vargas A.C. Baldisserotto B. The survival and hepatic and muscle glucose and lactate levels of Rhamdia quelen inoculated with Aeromonas hydrophila and treated with terpinen-4-ol, carvacrol or thymol. Microbial Pathogenesis. 2019; 127: 220-224.
  19. Amer S.A., Metwally A.E., Ahmed S.A. The influence of dietary supplementation of cinnamaldehyde and thymol on the growth performance, immunity and antioxidant status of monosex Nile tilapia fingerlings (Oreochromis niloticus). The Egyptian Journal of Aquatic Research. 2018; 44(3): 251-256.
  20. Mazandarani M., Hoseini S.M. Menthol and 1, 8‐cineole as new anaesthetics in common carp, Cyprinus carpio (Linnaeus, 1758). Aquaculture Research. 2017; 48(6): 3041-3051.
  21. Yilmaz B.H., Yildiz H.Y. Anthelmintic effects of peppermint (Mentha piperita), lemon (Citrus limon), and tea tree (Melaleuca alternifolia) essential oils against Monogenean parasite (Dactylogyrus sp.) on carp (Cyprinus carpio). Helminthologia. 2023; 60(2):125.
  22. Dawood M.A., Metwally A.E.S., Elkomy A.H., Gewaily M.S., Abdo S.E., Abdel-Razek M.A., Soliman A.A., Amer A.A., Abdel-Razik N.I., Abdel-Latif H.M. Paray B.A. The impact of menthol essential oil against inflammation, immunosuppression, and histopathological alterations induced by chlorpyrifos in Nile tilapia. Fish & Shellfish Immunology. 2020; 102: 316-325.
  23. Rahmati-Holasoo H., Nassiri A., Soltani M., Shokrpoor S. Studying protective effects of thymol on the growth factors of juvenile common carp following chronic mercury (II) chloride exposure. Iranian Journal of Veterinary Medicine. 2025;19(1): 41-50
  24. Morselli M.B., Reis J.H., Baldissera M.D., Souza C.F., Baldisserotto B., Petrolli T.G., Paiano D., Lopes D.L., Da Silva A.S. Benefits of thymol supplementation on performance, the hepatic antioxidant system, and energetic metabolism in grass carp. Fish Physiology and Biochemistry. 2020; 46: 305-314.
  25. Rozza A.L., Beserra F.P., Vieira A.J., Oliveira de Souza E., Hussni C.A., Martinez E.R.M., Nóbrega R.H., Pellizzon C.H. The use of menthol in skin wound Healing-Anti-inflammatory potential, antioxidant defense system stimulation and increased epithelialization. Pharmaceutics. 2021; 13(11): 1902.
  26. de Almeida Rodrigues P., Ferrari R.G., Dos Santos L.N., Junior C.A.C. Mercury in aquatic fauna contamination: a systematic review on its dynamics and potential health risks. Journal of Environmental Sciences. 2019; 84: 205-218.
  27. Lateef, N.A. Toxicity of Anthracene on the function of the liver and kidney of the common carp Cyprinus carpio. Egyptian Journal of Aquatic Biology and Fisheries. 2021; 25(3): 831-840.
  28. Mieiro C.L., Pacheco M., Pereira M.E., Duarte A.C. Mercury distribution in key tissues of fish (Liza aurata) inhabiting a contaminated estuary-implications for human and ecosystem health risk assessment. Journal of Environmental Monitoring. 2009; 11(5): 1004-1012.
  29. Chen Q.L., Sun Y.L., Liu Z.H., Li Y.W. Sex-dependent effects of subacute mercuric chloride exposure on histology, antioxidant status and immune-related gene expression in the liver of adult zebrafish (Danio rerio). Chemosphere. 2017; 188: 1-9.
  30. Thoolen B., Maronpot R.R., Harada T., Nyska A., Rousseaux C., Nolte T., Malarkey D.E., Kaufmann, W., Küttler, K., Deschl U., Ward J.M. Proliferative and nonproliferative lesions of the rat and mouse hepatobiliary system. Toxicologic Pathology. 2010; 38(7_suppl), 5S-81S.
  31. Carmo N., Gringer C., Souza Neto J.B., França J.C., Victorino R., Pereira C.C.D.A. A importância da educação física escolar sobre aspectos de saúde: sedentarismo. Revista Educare CEUNSP.2013; 1(1), 21-29.
  32. Adams D.H., Sonne C., Basu N., Dietz R., Nam D.H., Leifsson P.S., Jensen A. L. Mercury contamination in spotted seatrout, Cynoscion nebulosus: an assessment of liver, kidney, blood, and nervous system health. Science of the Total Environment. 2010; 408(23), 5808-5816.
  33. Kaewamatawong T., Rattanapinyopituk K., Ponpornpisit A., Pirarat N., Ruangwises S., Rungsipipat A. Short-term exposure of Nile Tilapia (Oreochromis niloticus) to mercury: histopathological changes, mercury bioaccumulation, and protective role of metallothioneins in different exposure routes. Toxicologic Pathology. 2013; 41(3), 470-479.
  34. Closa D., Folch‐Puy E. Oxygen free radicals and the systemic inflammatory response. IUBMB life.2004; 56(4): 185-191.
  35. Zhang Q.F., Li Y.W., Liu Z.H., Chen Q.L. Exposure to mercuric chloride induces developmental damage, oxidative stress and immunotoxicity in zebrafish embryos-larvae. Aquatic Toxicology. 2016; 181: 76-85.
  36. Abou-Zeid S.M., Zheng C., Khalil S.R., Farag M.R., Elsabbagh H.S., Siddique M.S., Mawed S.A., Azzam M.M., Di Cerbo A. and Elkhadrawey B.A., Thymol-enriched diet alleviates the toxic impacts of zinc oxide nanoparticles on growth performance, blood biochemistry, oxidant/antioxidant status and stress-related genes and histology of liver and gills in Oreochromis niloticus. Aquaculture Reports. 2023; 33: 101750.
  37. El Euony O.I., Elblehi S.S., Abdel-Latif H.M., Abdel-Daim M.M., El-Sayed Y.S. Modulatory role of dietary Thymus vulgaris essential oil and Bacillus subtilis against thiamethoxam-induced hepatorenal damage, oxidative stress, and immunotoxicity in African catfish (Clarias garipenus). Environmental Science and Pollution Research.2020; 27: 23108-23128.
  38. Krishnan M., Kim D.K., Kim S.G., Kang S.C. Thymol exposure mediates pro-oxidant shift by regulating Nrf2 and apoptotic events in zebrafish (Danio rerio) embryos. Environmental Toxicology and Pharmacology. 2019; 65:1-8.
  39. Rocha C.A., Félix, L.M., Monteiro S.M., Venâncio C. Antinociceptive analysis of natural monoterpenes eugenol, menthol, carvacrol and thymol in a zebrafish larval model. Pharmaceuticals. 2024; 17(4): 457.
آمار
تعداد مشاهده مقاله: 451
تعداد دریافت فایل اصل مقاله: 341


counter
سامانه مدیریت نشریات علمی. طراحی و پیاده سازی از سیناوب