| The aim of this study was to evaluate the impact of PGF2α treatment administered after parturition on key reproductive parameters, the incidence of postpartum pathologies, and the resumption of ovarian cyclicity in dairy cows. The study involved two groups of dairy cows: a control group (C, n=20) and an experimental group (E, n=20) that received the PGF2α treatment. Postpartum pathologies, ovarian cyclicity, and reproductive performance indicators were compared between the groups. Postpartum pathologies were observed at a higher rate in the control group, with a 30% prevalence of retained placenta, 20% for both delayed uterine involution and clinical endometritis, and 5% for pyometra. In contrast, the experimental group exhibited a lower incidence, with 10% for retained placenta, 5% for delayed uterine involution, 5% for clinical endometritis, and 0% for pyometra. Although these results suggest a trend toward lower pathology incidence in treated cows, the differences were not statistically significant (p > 0.05). Regarding the resumption of ovarian cyclicity, the control group showed a resumption rate of only 15%, whereas 65% of the experimental group resumed cyclicity. This yielded an odds ratio of 10.52 and a highly significant p-value (< 0.01), indicating that PGF2α treatment effectively hastened the return to normal ovarian function. Reproductive performance also improved in the experimental group, with first insemination (AI1) success rates of 45% compared to 30% in the control group (OR = 1.93). The waiting period was significantly shorter in the experimental group (73 vs. 98 days, p < 0.001), and calving-to-fertilization and calving-to-calving intervals were reduced by approximately 31 days (p < 0.001). However, the overall reduction in the breeding period remained inconclusive. While PGF2α treatment did not significantly reduce postpartum pathologies, it markedly enhanced the resumption of ovarian cyclicity and improved reproductive intervals in dairy cows, leading to enhanced reproductive efficiency. |
- Inchaisri C, Jorritsma R, Vos P, Van der Weijden G, Hogeveen H. Analysis of the economically optimal voluntary waiting period for first insemination. Journal of dairy science. 2011;94(8):3811-23. DOI:
- Kok A, Lehmann J, Kemp B, Hogeveen H, Van Middelaar C, De Boer I, et al. Production, partial cash flows and greenhouse gas emissions of simulated dairy herds with extended lactations. Animal. 2019;13(5):1074-83. DOI:
- Ries J, Jensen KC, Müller KE, Thöne-Reineke C, Merle R. Impact of veterinary herd health management on German dairy farms: Effect of participation on farm performance. Frontiers in Veterinary Science. 2022;9:841405. DOI:
- Sammad A, Khan MZ, Abbas Z, Hu L, Ullah Q, Wang Y, et al. Major nutritional metabolic alterations influencing the reproductive system of postpartum dairy cows. Metabolites. 2022;12(1):60. DOI:
- Canadas ER, Lonergan P, Butler S. Effect of equine chorionic gonadotropin administration on day 8 post-partum on ovarian follicular development, uterine health and uterine involution in lactating dairy cows. Theriogenology. 2019;123:54-61. DOI:
- Enriquez MF, Pérez-Torres L, Orihuela A, Rubio I, Corro M, Galina CS. Relationship between protective maternal behavior and some reproductive variables in zebu-type cows (Bos indicus). Journal of Animal Behaviour and Biometeorology. 2021;9(2):2124-. DOI:
- PARKINSON T. Infertility in the cow due to functional and management deficiencies. NOAKES, DAVID; PARKINSON, TIMOTHY and ENGLAND, GARY Veterinary reproduction and obstetrics. 2018;10:361-407. DOI:
- Gordon C. Pregnancy and autoimmune diseases. Best Practice & Research Clinical Rheumatology. 2004;18(3):359-79. DOI:
- Damarany AI. IMPACT OF OXYTETRACYCLINE AND PROSTAGLANDIN F2α DURING PUERPERIUM PERIOD ON UTERINE RECOVERY AND POST-PARTURIENT REPRODUCTIVE CHARACTERISTICS IN BALADI COWS. Egyptian Journal of Animal Production. 2022;59(3):97-109. DOI:
- Ullah A, Muhammad R, Ali A, Raza HA, Abdul Q, Nargis A, et al. Comparative Efficacy of Antibiotics and PGF2α in the Treatment of Postpartum Endometritis in Nili-Ravi Buffaloes. Indus Journal of Bioscience Research. 2024;2(02):64-72. DOI:
- LeBlanc SJ. Postpartum uterine disease and dairy herd reproductive performance: a review. The Veterinary Journal. 2008;176(1):102-14. DOI:
- Masoumi R, Badiei A, Dirandeh E, Zhandi M, Mousakhani F, Stear M. Quantification of the uterine involution and dimensions, hormonal response and reproductive performance of pyometric and healthy dairy cows treated with Dinoprost. South African Journal of Animal Science. 2018;48(2):222-33. DOI:
- Abuelhamd M, Metwally AE-S, Ghallab Z, El-Diahy Y, Hegazy M, El-Ghamry Z. Effect of Using Low Doses of PGF2α and GnRH Hormones on Reproduction of Dairy Cows. Egyptian Journal of Veterinary Sciences. 2023;54(7):237-44. DOI:
- Zidane K, Niar A, Tainturier D. Comparative effect on clinical use of PGF2α and REPROCINE in the treatment of retained placenta in dairy cows at Tiaret region (Algeria). 2011. DOI:
- Elmetwally MA, Elshopakey GE, El-Desouky AM, Eldomany WB, Bazer FW. Serum biochemical profile in buffalo endometritis and impact of treatment with PGF2α and intrauterine gentamicin infusion on postpartum reproductive performance. Tropical Animal Health and Production. 2020;52(6):3697-706. DOI:
- Hirsbrunner G, Knutti B, Küpfer U, Burkhardt H, Steiner A. Effect of prostaglandin E2, DL-cloprostenol, and prostaglandin E2 in combination with D-cloprostenol on uterine motility during diestrus in experimental cows. Animal Reproduction Science. 2003;79(1-2):17-32. DOI:
- Hanzen C, Boudry B, Drion P. Induction etsynchronisation de l’œstrus par la PgF 2α. 2003. DOI:
- Elsheikh A, Ahmed F. Backing up postpartum dairy cows with PGF2α. 2005. DOI:
- Sheldon IM, Owens SE. Postpartum uterine infection and endometritis in dairy cattle. Animal Reproduction (AR). 2018;14(3):622-9. DOI:
- Lewis G. Steroidal regulation of uterine immune defenses. Animal Reproduction Science. 2004;82:281-94. DOI:
- Ingawale M, Bakshi S. Effect of GnRH and PGF2α administration in early post partum period on fertility in retained placenta buffaloes. Buffalo Bulletin. 2016;35(4):629-34. DOI:
- Lopez-Gatius F, Yaniz J, Santolaria P, Murugavel K, Guijarro R, Calvo E, et al. Reproductive performance of lactating dairy cows treated with cloprostenol at the time of insemination. Theriogenology. 2004;62(3-4):677-89. DOI:
- Ambrose DJ, Gobikrushanth M, Zuidhof S, Kastelic JP. Low-dose natural prostaglandin F2α (dinoprost) at timed insemination improves conception rate in dairy cattle. Theriogenology. 2015;83(4):529-34. DOI:
- Leonardi C, Pfeifer L, Rubin M, Singh J, Mapletoft R, Pessoa G, et al. Prostaglandin F2α promotes ovulation in prepubertal heifers. Theriogenology. 2012;78(7):1578-82. DOI:
- Cruz L, Do Valle E, Kesler D. Effect of prostaglandin F2α—and gonadotropin releasing hormone-induced luteinizing hormone releases on ovulation and corpus luteum function of beef cows. Animal reproduction science. 1997;49(2-3):135-42. DOI:
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