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Creation and implementation of the modern treatment in eimeria and esophagostomiasis invasion: Case report in the farms "Ulan", "Erlan", and "Balke" | ||
| Archives of Razi Institute | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 30 فروردین 1404 اصل مقاله (382.55 K) | ||
| نوع مقاله: Scientific Report | ||
| شناسه دیجیتال (DOI): 10.22092/ari.2025.368331.3506 | ||
| نویسندگان | ||
| Zhanat Nurzhumanova* 1؛ Assel Zhexenayeva2؛ Altyn Nurymovna Zhubantayeva3؛ Shyngys Suleimenov4؛ Nurlygul Yessengulova2؛ Leila Kassymbekova5 | ||
| 1NJSC Shakarim University of Semey, Shugaev 159, Faculty: Veterinary and Agricultural Management, Department: Veterinary Medicine | ||
| 2NJSC Shakarim University of Semey, Shugaev 159, Faculty: Veterinary and Agricultural Management, Department: Veterinary Medicine | ||
| 3the city of Uralsk. West Kazakhstan University of Innovation and Technology. Institute of Industrial Technologies Department of Veterinary Medicine and Technosphere Safety. | ||
| 4NJSC Shakarim University of Semey. Agrotechnopark | ||
| 5Pavlodar c. Innovative University of Eurasia Faculty Economics and Enqineerinq Department Veterinary Medicine and industrial Technoloqies | ||
| چکیده | ||
| Background: Parasitic diseases in sheep reduce sheep-breeding productivity and decrease the economic efficiency of the industry. Our research aim was a study of the dynamics of clinical sings development in manifestation of associated eimeriosis and esophagostomosis invasion, as well as concomitant immunodeficiency state in experimental infested lambs and efficiency of complex treatment approach at associated invasions. Materials and Methods: A prospective study using helminthoscopic methods with the subsequent calculation of indicators of extensiveness and intensity of infestation, as well as haematological studies with the determination of subpopulations of T- and B-lymphocytes was carried out by the author's team. Results: Due to more active development of protozoa, the main symptoms of associated invasion were those typical for acute eimeriosis. Progression of the disease was accompanied by an increase in the intensity of invasion both in relation to eimeria and esophagostomes. At the same time in animals with the development of invasion there was observed a decrease in the total number of leukocytes (up to 25%), including T- and B-lymphocytes, which indicates a decrease in humoral defence of the lambs' organism. On the 24th day after infection, an increase in the level of T-lymphocytes (by 0.8%) was observed due to an increase in T-helpers (by 2.0%). Sulfamonomethoxine in complex with niacid was used for treatment of associated infestation. The use of these drugs in recommended doses and according to the developed scheme allowed to reduce the intensity of eimeriosis invasion by 97-98% and esophagostomosis by 100 %. Conclusions: In the work data on eimerioses and eimeriosis-esophagostomosis infestation of sheep are given. At the description of eimerioses and helminthoses of sheep the species composition, distribution and seasonal - age dynamics of infestation were determined. The developed method of treatment showed high therapeutic effect and can be recommended for use in all sheep farms of the Republic of Kazakhstan. | ||
| کلیدواژه‌ها | ||
| associated parasitic disease؛ complex therapy؛ immunosuppression؛ lymphocyte subpopulations | ||
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