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Ghotbi Maleki, Vahid, Fathi, Faezeh, Behboudi, Hosein, Armand, Nezam, Nejad Ebrahimi, Samad. (1404). Fabrication of Pistacia atlantica Desf. Oil-Encapsulated Chitosan Nanoparticles in Polyvinyl Alcohol Nanofibers: Biocompatibility and Antioxidant Properties for Skin Care Applications. سامانه مدیریت نشریات علمی, 14(5), 441-449. doi: 10.22034/jmpb.2025.367910.1836
Vahid Ghotbi Maleki; Faezeh Fathi; Hosein Behboudi; Nezam Armand; Samad Nejad Ebrahimi. "Fabrication of Pistacia atlantica Desf. Oil-Encapsulated Chitosan Nanoparticles in Polyvinyl Alcohol Nanofibers: Biocompatibility and Antioxidant Properties for Skin Care Applications". سامانه مدیریت نشریات علمی, 14, 5, 1404, 441-449. doi: 10.22034/jmpb.2025.367910.1836
Ghotbi Maleki, Vahid, Fathi, Faezeh, Behboudi, Hosein, Armand, Nezam, Nejad Ebrahimi, Samad. (1404). 'Fabrication of Pistacia atlantica Desf. Oil-Encapsulated Chitosan Nanoparticles in Polyvinyl Alcohol Nanofibers: Biocompatibility and Antioxidant Properties for Skin Care Applications', سامانه مدیریت نشریات علمی, 14(5), pp. 441-449. doi: 10.22034/jmpb.2025.367910.1836
Ghotbi Maleki, Vahid, Fathi, Faezeh, Behboudi, Hosein, Armand, Nezam, Nejad Ebrahimi, Samad. Fabrication of Pistacia atlantica Desf. Oil-Encapsulated Chitosan Nanoparticles in Polyvinyl Alcohol Nanofibers: Biocompatibility and Antioxidant Properties for Skin Care Applications. سامانه مدیریت نشریات علمی, 1404; 14(5): 441-449. doi: 10.22034/jmpb.2025.367910.1836

Fabrication of Pistacia atlantica Desf. Oil-Encapsulated Chitosan Nanoparticles in Polyvinyl Alcohol Nanofibers: Biocompatibility and Antioxidant Properties for Skin Care Applications

Journal of Medicinal Plants and By-products
مقاله 7، دوره 14، شماره 5، آذر و دی 2025، صفحه 441-449    اصل مقاله (1.26 M)
نوع مقاله: Research Article
شناسه دیجیتال (DOI): 10.22034/jmpb.2025.367910.1836
نویسندگان
Vahid Ghotbi Maleki1؛ Faezeh Fathi1؛ Hosein Behboudi2؛ Nezam Armand3؛ Samad Nejad Ebrahimi* 1
1Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, Tehran, Iran
2Department of Biology, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, Tehran, Iran
3Evidence-based Phytotherapy and Complementary Medicine Research Center, Alborz University of Medical Sciences, Karaj, Iran
چکیده
This study provides a comprehensive nutritional and phytochemical analysis of Pistacia atlantica Desf. fruit (PAF), which revealed a high fat content (33.90%) and carbohydrate content (62.41%), identifying it as a significant energy source. Phytochemical profiling demonstrated notable levels of phenolics (17.70 ± 1.59 mg GAE/g dry weight) and flavonoids (6.46 ± 0.35 mg CE/g), contributing to substantial antioxidant properties. A novel nanocomposite was developed by encapsulating Pistacia atlantica oil (PAO) within chitosan nanoparticles (CNPs) using ionic gelation with sodium tripolyphosphate, followed by embedding these nanoparticles into polyvinyl alcohol (PVA) nanofibers. Characterization of the resulting nanocomposite revealed a mean particle size of 104.76 nm and a polydispersity index (PDI) of 0.41, indicating a uniform size distribution. The encapsulation efficiency (EE%) of PAO was consistent across formulations, while the loading capacity (LC%) increased with higher CNP content, achieving a maximum of 32.37% for a PVA ratio of 1:2. Antioxidant assays confirmed robust activity, with FRAP and DPPH values of 79.4 ± 2.1 µmol ESF/100g and an IC₅₀ of 7344.7 µg/mL, respectively. Cell viability assays demonstrated excellent biocompatibility, with CNP and PVA-CNP formulations maintaining over 82% viability in human dermal fibroblast cells. The CNP-PVA nanofiber system infused with PAO demonstrates controlled release, robust antioxidant properties, and superior biocompatibility, positioning it as a potential solution for wound healing and skin care needs
کلیدواژه‌ها
Pistacia atlantica؛ Chitosan nanocapsules؛ PVA nanofibers؛ Antioxidant؛ Wound healing؛ Biocompatibility
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