اخبار و اعلانات

 آمار

تعداد نشریات282
تعداد نشریات سازمان80
تعداد شماره‌ها3,196
تعداد مقالات35,423
تعداد مشاهده مقاله52,256,831
تعداد دریافت فایل اصل مقاله91,785,767
Poormasoumi, Hossein, Fazeli, Farzaneh, Mirshekari, Afsaneh, Heydari Sadegh, Batool, Ahmadi, Tayebeh, Mirzaei, Ali Reza, Fazeli-Nasab, Bahman. (1404). Exploring Ferula assa-foetida's Potential in Combating Helicobacter pylori and Gastric Cancer. سامانه مدیریت نشریات علمی, 14(4), 385-390. doi: 10.22034/jmpb.2024.367556.1807
Hossein Poormasoumi; Farzaneh Fazeli; Afsaneh Mirshekari; Batool Heydari Sadegh; Tayebeh Ahmadi; Ali Reza Mirzaei; Bahman Fazeli-Nasab. "Exploring Ferula assa-foetida's Potential in Combating Helicobacter pylori and Gastric Cancer". سامانه مدیریت نشریات علمی, 14, 4, 1404, 385-390. doi: 10.22034/jmpb.2024.367556.1807
Poormasoumi, Hossein, Fazeli, Farzaneh, Mirshekari, Afsaneh, Heydari Sadegh, Batool, Ahmadi, Tayebeh, Mirzaei, Ali Reza, Fazeli-Nasab, Bahman. (1404). 'Exploring Ferula assa-foetida's Potential in Combating Helicobacter pylori and Gastric Cancer', سامانه مدیریت نشریات علمی, 14(4), pp. 385-390. doi: 10.22034/jmpb.2024.367556.1807
Poormasoumi, Hossein, Fazeli, Farzaneh, Mirshekari, Afsaneh, Heydari Sadegh, Batool, Ahmadi, Tayebeh, Mirzaei, Ali Reza, Fazeli-Nasab, Bahman. Exploring Ferula assa-foetida's Potential in Combating Helicobacter pylori and Gastric Cancer. سامانه مدیریت نشریات علمی, 1404; 14(4): 385-390. doi: 10.22034/jmpb.2024.367556.1807

Exploring Ferula assa-foetida's Potential in Combating Helicobacter pylori and Gastric Cancer

Journal of Medicinal plants and By-products
مقاله 12، دوره 14، شماره 4، مهر و آبان 2025، صفحه 385-390    اصل مقاله (1.03 M)
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22034/jmpb.2024.367556.1807
نویسندگان
Hossein Poormasoumi1؛ Farzaneh Fazeli2؛ Afsaneh Mirshekari3؛ Batool Heydari Sadegh* 4؛ Tayebeh Ahmadi5؛ Ali Reza Mirzaei6؛ Bahman Fazeli-Nasab* 7
1Department of Infectious Diseases, School of Medicine, Zabol University of Medical Sciences, Zabol, Iran
2Department of Biology, Payame Noor University, Terhran, Iran
3Department of Pediatrics, School of Medicine, Amir Al Momenin Hospital, Zabol University of Medical Sciences, Zabol, Iran
4Department of Emergency Medicine, School of Medicine, Zabol University of Medical Sciences, Zabol, Iran
5Department of Medical Laboratory Science, College of Science, Knowledge University, Kirkuk Road, Erbil 44001, Iraq
6Department of Agronomy and Plant Breeding, Faculty of Agriculture and Natural Resources, University of Mohaghegh Ardabili, Ardabil, Iran
7Department of Agronomy and Plant Breeding, Agriculture Institute, Research Institute of Zabol, Zabol, Iran
چکیده
Helicobacter pylori is one of the most effective factors in digestive diseases. Infections caused by this bacterium are prevalent and affect many people worldwide yearly. The stages of the spread of this infection are as follows: first, the bacteria are concentrated in the area of ​​the cardia stomach valve and leads to irritation in this area. Then the proliferation of bacteria spreads and penetrates the lining tissues of the stomach, which leads to severe inflammation in the stomach. In the advanced stages of infection, it becomes cancerous and metastasized, so that even with surgery and removal of a part of the stomach, bacteria and secondary tumors grow, spread, and transfer aggressively. In general, this infection is directly related to economic, social, and health conditions. Today, many drugs are used by patients to treat these bacteria. But the point that should be paid attention to is the prevention of this infection. Observing health issues and benefiting from digestive medicinal plants can play a significant role in the recovery of patients. Therefore, we decided to investigate the potential and evaluation of the medicinal plant Ferula assa-foetida L., which is one of the suitable candidates for the prevention and treatment of this infection. The results of this research showed a promising perspective so it was found that the use of F. assa-foetida and its effective ingredients have a significant effect in controlling infection in patients. It was also found that the use of F. assa-foetida extract leads to an increase in apoptosis and necrosis in gastric cancer cells, especially in high concentrations of 1500 µg/ml. On the other hand, this study provided a wide field of pharmaceutical research related to drug production and treatment of gastrointestinal diseases. It is hoped that by focusing on this research and using the medicinal properties of these valuable plants, it will be possible to completely prevent the proliferation of these bacteria in the stomach and provide the basis for the treatment of patients.
کلیدواژه‌ها
Cardiovascular diseases؛ Ferutinin؛ Galbanic Acid؛ Peptic Ulcers؛ Umbelliprenin
مراجع
  1. Hamedi A., Bayat M., Asemani Y., Amirghofran Z. A review of potential anti-cancer properties of some selected medicinal plants grown in Iran. J. Herb. Med. 2022; 33: 100557.
  2. Elshafie H.S., Camele I., Mohamed A.A. A comprehensive review on the biological, agricultural and pharmaceutical properties of secondary metabolites based-plant origin. Int. J. Mol. Sci. 2023; 24(4): 3266.
  3. Khosravi H., Mehrabi A. Economic study of Ferula harvesting in Tabass Region. Iranian J. Natu.ral Res. 2005; 58(4): 933-944.
  4. Goudarzi S., Rassouli F.B., Kahrizi D., Shirkhani P., Mahdifar M., Iranshahi M., Rafatpanah H., Keramati M.R., Ayatollahi H. Comparing toxicity of galbanic acid, auraptene and umbelliprenin on adult T-cell leukaemia-lymphoma in normoxia and hypoxia. Cell. Mol. Biol. 2022; 68(12): 17-20.
  5. Golmohammadi F. Ferula assa-foetida as a main medical plant in east of Iran (harvesting, main characteristics and economical importance). Progress. agric. 2016; 7(2): 1-14.
  6. Raghavan S. Handbook of spices, seasonings, and flavorings: CRC press. 2006;
  7. Guclu G., Tas A., Dincer E., Ucar E., Kaya S., Berisha A., Dural E., Silig Y. Biological evaluation and in silico molecular docking studies of Abies cilicica (Antoine & Kotschy) Carrière) resin. J. Mol. Struct. 2023; 1288: 135740.
  8. Salehi M., Naghavi M.R., Bahmankar M. A review of Ferula species: Biochemical characteristics, pharmaceutical and industrial applications, and suggestions for biotechnologists. Ind. Crop Prod. 2019; 139: 111511.
  9. Sonigra P., Meena M. Metabolic profile, bioactivities, and variations in the chemical constituents of essential oils of the Ferula genus (Apiaceae). Front. pharmacol. 2021; 11: 608649.
  10. Wang J., Zheng Q., Wang H., Shi L., Wang G., Zhao Y., Fan C., Si J. Sesquiterpenes and Sesquiterpene Derivatives from Ferula: Their Chemical Structures, Biosynthetic Pathways, and Biological Properties. Antioxidants. 2023; 13(1): 7.
  11. Mahendra P., Bisht S. Ferula asafoetida: Traditional uses and pharmacological activity. Pharmacogn. Rev. 2012; 6(12): 141.
  12. Amalraj A., Gopi S. Biological activities and medicinal properties of Asafoetida: A review. J. Tradit. Med. Complement. 2017; 7(3): 347-359.
  13. Upadhyay P.K. Pharmacological activities and therapeutic uses of resins obtained from Ferula asafoetida Linn.: A Review. Int. J. Green Pharm. 2017; 11(02).
  14. Keyghobadi N., Bagheri V., Rahnamaii M.S., Sarab G.A. Evaluation of hydroalcoholic extract effects of Ferula assa-foetida on expression change of EMT and CD44-related genes in gastric cancer stem cell. Gene Rep. 2022; 27: 101535.
  15. Sirizi M.A.G., Ghalenoei J.A., Allahtavakoli M., Forouzanfar H., Bagheri S.M. Anticancer potential of Ferula assa-foetida and its constituents, a powerful plant for cancer therapy. World J. Biol. Chem. 2023; 14(2): 28.
  16. Mahboubi M. The beneficial effects of Ferula asafoetida oleo-gum resin in gastrointestinal disorders. Bull. Fac. Pharm. Cairo Univ. 2021; 59(1): 50-63.
  17. Ko K.-P. Risk factors of gastric cancer and lifestyle modification for prevention. J Gastric Cancer. 2024; 24(1): 99.
  18. Bagheri S., Javidmehr D., Ghaffari M., Ghoderti-Shatori E. Chemical compositions and antiproliferative effect of essential oil of asafoetida on MCF7 human breast cancer cell line and female wistar rats. Transl. Cancer Res. 2020; 6(2): 34-34.
  19. Alhashimi R.A.H., Mirzaei A.R., Alsaedy H.K. Molecular and clinical analysis of genes involved in gastric cancer. Cell. Mol. Biomed. Rep. 2021; 1(3): 138-146.
  20. Iranshahy M., Iranshahi M. Traditional uses, phytochemistry and pharmacology of asafoetida (Ferula assa-foetida oleo-gum-resin)—A review. J. Ethnopharmacol. 2011; 134(1): 1-10.
  21. Azani H., Homayouni Tabrizi M., Neamati A., Khadem F., Khatamian N. The Ferula assafoetida essential oil nanoemulsion (FAEO-NE) as the selective, apoptotic, and anti-angiogenic anticancer compound in human MCF-7 breast cancer cells and murine mammary tumor models. Nutr. Cancer. 2022; 74(6): 2196-2206.
  22. Reddy K.T.K., Reddy A.S. Recent Breakthroughs in Drug Delivery Systems for Targeted Cancer Therapy: An Overview. Cell. Mol. Biomed. Rep. 2025; 5(1): 13-27.
  23. Linz B., Sticht H., Tegtmeyer N., Backert S. Cancer-associated SNPs in bacteria: lessons from Helicobacter pylori. Trends Microbiol. 2024; 32(9): 847-857.
  24. Polk D.B., Peek Jr R.M. Helicobacter pylori: gastric cancer and beyond. Nat. Rev. Cancer. 2010; 10(6): 403-414.
  25. Tran S.C., Bryant K.N., Cover T.L. The Helicobacter pylori cag pathogenicity island as a determinant of gastric cancer risk. Gut. Microbes. 2024; 16(1): 2314201.
  26. Fazeli-Nasab B. In Silico Analysis of the Effect of Scrophularia striata Linalool on VacA Protein of Helicobacter Pylori. scientific journal of ilam university of medical sciences. 2021; 29(1): 50-64.
  27. Valizadeh M., ur Rehman F., Hassanzadeh M.A., Beigomi M., Fazeli-Nasab B. Investigating the Antimicrobial Effects of Glycyrrhiza glabra and Salvia officinalis Ethanolic Extract Against Helicobacter pylori. [Research Article]. Int. J. Infect. 2021; 8(4): e114563.
  28. Magdy H., Rady M.H., Salama M.S., Sayed H.A.E., Hamza D., Azzam M., Essa E.E. Isolation of Multidrug-Resistant Helicobacter pylori from Wild Houseflies Musca domestica with a New Perspective for the Treatment. Vector Borne. Zoonotic. Dis. 2023; 23(2): 63-74.
  29. Norouzi R., Abedi Maleki R., Siyadatpanah A., Fiad A., El Zowalaty M.E. In vitro scolicidal effect of Calendula officinalis, Artemisia dracunculus, Artemisia absinthium, and Ferula assafoetida extracts against hydatid cyst protoscolices. Ann. Parasitol. 2022; 68(3): 543-551.
  30. Saber M., Mokhtari B. Effect of Eucalyptus globulus and Ferula assafoetida essential oils and their nanoformulations on the life table parameters of Tetranychus urticae (Acari: Tetranychidae). Exp. Appl. Acarol. 2024; 93(2): 297-315.
  31. Xia H.H.-X., Talley N.J. Apoptosis in Gastric Epithelium Induced by Helicobacter PyloriInfection: Implications in Gastric Carcinogenesis. Am. J. Gastroenterol. 2001; 96(1): 16-26.
  32. Song Y., Liu P., Qi X., Shi X.-L., Wang Y.-S., Guo D., Luo H., Du Z.-J., Wang M.-Y. Helicobacter pylori infection delays neutrophil apoptosis and exacerbates inflammatory response. Future Microbiol. 2024; 19(13): 1145-1156.
  33. Radin J.N., González-Rivera C., Ivie S.E., McClain M.S., Cover T.L. Helicobacter pylori VacA Induces Programmed Necrosis in Gastric Epithelial Cells. Infect. Immun. 2011; 79(7): 2535-2543.
آمار
تعداد مشاهده مقاله: 1,081
تعداد دریافت فایل اصل مقاله: 607


counter
سامانه مدیریت نشریات علمی. طراحی و پیاده سازی از سیناوب