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Patel, Dr. Ruchi, Metgud, Dr. Renuka, Dodamani, Dr. Suneel, Nadaf, Dr. Rubeen, Patil, Dr. Archana. (1403). Comparative Evaluation of the Antimicrobial Efficacy of Anethum Graveolens Gel with Chlorhexidine Gel against Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis and Fusobacterium nucleatum- an in vitro study. سامانه مدیریت نشریات علمی, 80(1), 225-232. doi: 10.32592/ARI.2025.80.1.225
Dr. Ruchi Patel; Dr. Renuka Metgud; Dr. Suneel Dodamani; Dr. Rubeen Nadaf; Dr. Archana Patil. "Comparative Evaluation of the Antimicrobial Efficacy of Anethum Graveolens Gel with Chlorhexidine Gel against Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis and Fusobacterium nucleatum- an in vitro study". سامانه مدیریت نشریات علمی, 80, 1, 1403, 225-232. doi: 10.32592/ARI.2025.80.1.225
Patel, Dr. Ruchi, Metgud, Dr. Renuka, Dodamani, Dr. Suneel, Nadaf, Dr. Rubeen, Patil, Dr. Archana. (1403). 'Comparative Evaluation of the Antimicrobial Efficacy of Anethum Graveolens Gel with Chlorhexidine Gel against Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis and Fusobacterium nucleatum- an in vitro study', سامانه مدیریت نشریات علمی, 80(1), pp. 225-232. doi: 10.32592/ARI.2025.80.1.225
Patel, Dr. Ruchi, Metgud, Dr. Renuka, Dodamani, Dr. Suneel, Nadaf, Dr. Rubeen, Patil, Dr. Archana. Comparative Evaluation of the Antimicrobial Efficacy of Anethum Graveolens Gel with Chlorhexidine Gel against Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis and Fusobacterium nucleatum- an in vitro study. سامانه مدیریت نشریات علمی, 1403; 80(1): 225-232. doi: 10.32592/ARI.2025.80.1.225

Comparative Evaluation of the Antimicrobial Efficacy of Anethum Graveolens Gel with Chlorhexidine Gel against Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis and Fusobacterium nucleatum- an in vitro study

Archives of Razi Institute
مقاله 27، دوره 80، شماره 1، فروردین و اردیبهشت 2025، صفحه 225-232    اصل مقاله (551.89 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.32592/ARI.2025.80.1.225
نویسندگان
Dr. Ruchi Patel* 1؛ Dr. Renuka Metgud2؛ Dr. Suneel Dodamani3؛ Dr. Rubeen Nadaf3؛ Dr. Archana Patil4
1Department of Periodontics, KAHER KLE VK Institute of dental sciences, Belagavi
2Department of Periodontics, KAHER’s KLE VK Institute of Dental Sciences, Nehru Nagar, JNMC Campus, Belagavi, Karnataka.
3KAHER’s Dr. Prabhakar Kore Basic Science Research Centre, Nehru Nagar, JNMC Campus, Belagavi, Karnataka
4Department of Pharmaceutics, KLE Academy of Higher Education and Research’s College of Pharmacy, Nehru Nagar, JNMC Campus, Belagavi, Karnataka
چکیده
Periodontitis is an infection of the periodontium caused by group of specific
microorganisms, resulting in progressive destruction of the periodontal ligament
and alveolar bone. Initial treatment for periodontitis is mechanical scaling and root planing, but it does not cause sufficient reduction of the bacterial load due to lack of accessibility to microorganisms. Hence, the incorporation of adjunctive chemotherapeutic agent enhances the outcome at sites which are not responsive to conventional therapy. Chlorhexidine is considered the gold standard for local drug delivery system but it has side effects like tooth staining, xerostomia and calculus formation. This has led to increasing demand for herbal medicine as they show fewer side effects and are cost effective. Among these herbal remedies Anethum graveolens, which contains natural phytochemicals is known for its therapeutic properties. Hence the present in-vitro microbiological study was undertaken to evaluate and compare the antimicrobial activity of Anethum graveolens gel with Chlorhexidine gel for Aa,Pg and Fn. MIC and MBC of the ethanolic extract of Anethum graveolens against standard ATCC bacterial strains of A.a, P.g and F.n were determined using broth dilution method and streaking on blood agar plates. The antimicrobial activity of the
prepared Anethum graveolens gel was evaluated and compared with Chlorhexidine gel using the agar well diffusion assay. The zone of inhibition for Chlorhexidine gel was 15.6 mm, 17mm and 15.3mm for A.a, P.g and F.n respectively, whereas for A. graveolens gel it was 12.6mm 13mm and 12mm for 24. A.a, P.g and F.n respectively.
The results obtained suggested that Chlorhexidine gel showed a slightly better antimicrobial activity as compared to the Anethum graveolens gel against Aa, Pg and Fn.
کلیدواژه‌ها
Anethum graveolens؛ Dental plaque؛ Chlorhexidine؛ Herbal extract؛ Periodontal disease
مراجع
  1. Listgarten MA. Pathogenesis of periodontitis. Journal of clinical periodontology. 1986 May;13(5):418-25.
  2. Papapanou PN, Sanz M Et al. Periodontitis: Consensus report of Workgroup 2 of the 2017 World Workshop on the Classification of Periodontal and Peri Implant Diseases and Conditions. J Clin Periodontol 2018;45 (20): S162–S170.
  3. Mehrotra N, Singh S. Periodontitis. InStatPearls. StatPearls Publishing. 2022.
  4. Rajeshwari HR, Dhamecha D, Jagwani S, Patil D, Hegde S, Potdar R, Metgud R, Jalalpure S, Roy S, Jadhav K, Tiwari NK. Formulation of thermoreversible gel of cranberry juice concentrate: Evaluation, biocompatibility studies and its antimicrobial activity against periodontal pathogens. Materials Science and Engineering: C. 2017;75:1506-14.
  5. Hajishengallis G, Darveau RP, Curtis MA. The keystone-pathogen hypothesis. Nature Reviews Microbiology. 2012;10(10):717-25
6.Signat B, Roques C, Poulet P, Duffaut D. Role of Fusobacterium nucleatum in periodontal health and disease. Current issues in molecular biology. 2011;13(2):25-36.

  1. Szulc M, Zakrzewska A, Zborowski J. Local drug delivery in periodontitis treatment: A review of contemporary literature. Dental and medical problems. 2018;55(3):333-42.
  2. Greenstein G. Local drug delivery in the treatment of periodontal diseases: assessing the clinical significance of the results. Journal of periodontology. 2006;77(4):565-78.
  3. Jones CG. Chlorhexidine: is it still the gold standard? Periodontology. 2000;15:55-62.
  4. Kazemi M, Abdossi V. Chemical composition of the essential oils of Anethum graveolens L. Bangladesh Journal of Botany. 2015;44(1):159-61.
  5. Al-Snafi AE. The pharmacological importance of Anethum graveolens–A review. International Journal of Pharmacy and Pharmaceutical Sciences. 2014;6(4):11-3.
  6. Marsh PD. Dental plaque as a biofilm and a microbial community - implications for health and disease. BMC Oral Health. 2006;6(1):S14.
  7. Dental Scaling and Root Planing for Periodontal Health: A Review of the Clinical Effectiveness, Cost-effectiveness, and Guidelines [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2016.
  8. Steinberg D, Friedman M. Sustained‐release delivery of antimicrobial drugs for the treatment of periodontal diseases: Fantasy or already reality? Periodontology 2000. 2020;84(1):176-87.
  9. Poppolo Deus F, Ouanounou A. Chlorhexidine in Dentistry: Pharmacology, Uses, and Adverse Effects. Int Dent J. 2022;72(3):269-277.
  10. Jana S, Shekhawat GS. Anethum graveolens: An Indian traditional medicinal herb and spice. Pharmacogn Rev. 2010;4(8):179-84.
  11. Derakhshan S, Navidinia M, Ahmadi A. Antibacterial activity of Dill (Anethum graveolens) essential oil and antibiofilm activity of Cumin (Cuminum cyminum) alcoholic extract. Infection Epidemiology and Microbiology. 2017;3(4):122-6.
  12. Chahal KK, Kumar A, Bhardwaj U, Kaur R. Chemistry and biological activities of Anethum graveolens L.(dill) essential oil: A review. Journal of Pharmacognosy and Phytochemistry. 2017;6(2):295-306.
  13. Eshwar S, Rekha K, Jain V, Manvi S, Kohli S, Bhatia S. Suppl-1, M8: Comparison of Dill Seed Oil Mouth Rinse and Chlorhexidine Mouth Rinse on Plaque Levels and Gingivitis-A Double Blind Randomized Clinical Trial. The open dentistry journal. 2016;10:207.
  14. Badar NA, Arshad MU, Farooq UM. Characteristics of Anethum graveolens (Umbelliferae) seed oil: Extraction, composition and antimicrobial activity. International Journal of Agriculture and Biology. 2008;10(3):329-32.
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