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Silent Threat: Investigating the Prevalence of Cytomegalovirus in Expectant Mothers in Northern Iran, Gorgan | ||
| Archives of Razi Institute | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 21 آبان 1403 اصل مقاله (609.71 K) | ||
| نوع مقاله: Original Articles | ||
| شناسه دیجیتال (DOI): 10.22092/ari.2024.366657.3282 | ||
| نویسندگان | ||
| Alijan Tabarraei* 1؛ Seyedeh Delafruz Hosseini2؛ Mohammad Yasaghi2؛ Homina Saffar3؛ Fatemeh Nassaj Torshizi4؛ Ali Vaez5؛ Elham Mobasheri6 | ||
| 1Golestan University of medical Sciences | ||
| 2Infectious Research Center, Golestan University of Medical Sciences, Gorgan, Iran. | ||
| 3Student Research Committee, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. | ||
| 4Student research committee, Golestan University of Medical Sciences, Gorgan, Iran. | ||
| 5Department of Microbiology, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran. | ||
| 6Gorgan Congenital Malformations Research Center, Golestan University of Medical Sciences, Gorgan, Iran | ||
| چکیده | ||
| Cytomegalovirus (CMV) infection during pregnancy is the leading cause of congenital infections globally, often resulting in significant health issues in newborns. These issues include sensorineural hearing loss, which can affect communication and language development, and neurodevelopmental delays that manifest as cognitive impairments, motor dysfunction, and behavioral challenges. The virus can be transmitted from the mother to the fetus, particularly if the mother experiences a primary infection during pregnancy. Early detection through maternal screening and fetal diagnostic tests, such as polymerase chain reaction (PCR) analysis of amniotic fluid, is crucial. Prompt management strategies, including antiviral therapies and immunoglobulin treatments, are essential to reduce viral load and mitigate these risks, thereby improving outcomes for affected infants. Vaginal secretions and blood specimens of 315 pregnant women referred to an educational hospital in the North east of Iran were tested for HCMV using PCR and ELISA assays. Chi-Square test was utilized to evaluate the association of qualitative variables and the level of significance was set at p≤0.05. Moreover, statistical analysis was performed using SPSS Statistics V.26.0. The findings of the molecular and serological investigation of cytomegalovirus (CMV) in the current population revealed that 16.2% (51/315) of the individuals tested positive for DNA-CMV, 87.6% (276/315) displayed IgG antibodies, and 3.2% (10/315) had IgM antibodies. Studying the prevalence of CMV in pregnant women is crucial to understand the extent of maternal and fetal exposure to this virus, which can lead to significant congenital disabilities and developmental issues in newborns. This data is essential for developing effective screening protocols and preventive measures to mitigate the health risks associated with CMV infections during pregnancy. | ||
| کلیدواژه‌ها | ||
| Human Cytomegalovirus؛ HHV-5؛ Pregnant women؛ Iran | ||
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آمار تعداد مشاهده مقاله: 97 تعداد دریافت فایل اصل مقاله: 74 |
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