اخبار و اعلانات

 آمار

تعداد نشریات284
تعداد نشریات سازمان82
تعداد شماره‌ها3,049
تعداد مقالات34,082
تعداد مشاهده مقاله46,535,736
تعداد دریافت فایل اصل مقاله77,585,295
Shabani, Alireza, Zaefizadeh, Mohammad, Farhadpour, Mohsen, Soheila s\Soheili, Zahra, Esfahani, Kasra. (1403). Phytochemical and Biomedical Analysis of β-cyclocitral Extracted from Galium mite (Medicinal Herb), and its Effects on Breast Cancer Targeted Proteins. سامانه مدیریت نشریات علمی, 14(3), 238-244. doi: 10.22034/jmpb.2024.366588.1732
Alireza Shabani; Mohammad Zaefizadeh; Mohsen Farhadpour; Zahra Soheila s\Soheili; Kasra Esfahani. "Phytochemical and Biomedical Analysis of β-cyclocitral Extracted from Galium mite (Medicinal Herb), and its Effects on Breast Cancer Targeted Proteins". سامانه مدیریت نشریات علمی, 14, 3, 1403, 238-244. doi: 10.22034/jmpb.2024.366588.1732
Shabani, Alireza, Zaefizadeh, Mohammad, Farhadpour, Mohsen, Soheila s\Soheili, Zahra, Esfahani, Kasra. (1403). 'Phytochemical and Biomedical Analysis of β-cyclocitral Extracted from Galium mite (Medicinal Herb), and its Effects on Breast Cancer Targeted Proteins', سامانه مدیریت نشریات علمی, 14(3), pp. 238-244. doi: 10.22034/jmpb.2024.366588.1732
Shabani, Alireza, Zaefizadeh, Mohammad, Farhadpour, Mohsen, Soheila s\Soheili, Zahra, Esfahani, Kasra. Phytochemical and Biomedical Analysis of β-cyclocitral Extracted from Galium mite (Medicinal Herb), and its Effects on Breast Cancer Targeted Proteins. سامانه مدیریت نشریات علمی, 1403; 14(3): 238-244. doi: 10.22034/jmpb.2024.366588.1732

Phytochemical and Biomedical Analysis of β-cyclocitral Extracted from Galium mite (Medicinal Herb), and its Effects on Breast Cancer Targeted Proteins

Journal of Medicinal plants and By-products
مقاله 4، دوره 14، شماره 3، مرداد و شهریور 2025، صفحه 238-244    اصل مقاله (1001.25 K)
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22034/jmpb.2024.366588.1732
نویسندگان
Alireza Shabani1؛ Mohammad Zaefizadeh* 2؛ Mohsen Farhadpour1؛ Zahra Soheila s\Soheili3؛ Kasra Esfahani* 1
1Plant Bioproducts Department, National Institute of Genetic Engineering and Biotechnology (NIGEB), Tehran, Iran
2Biology Department, Ardabil Branch, Islamic Azad University, Ardabil, Iran
3Molecular Medicine Department, National Institute of Genetic Engineering and Biotechnology (NIGEB), Tehran, Iran
چکیده
Molecular docking PyRx software coupled with gas chromatography/mass spectrometry (GC-MS) was used to identify predicted proteins which were targeted by β-cyclocitral derived from Galium mite var. roseum Ghahr. Twenty-four phytochemical compounds were detected using the GC-MS technique. Physiochemical qualities of β-cyclocitral were done using Pubchem database. Pharmaceutical and pharmacokinetic properties of the extracted β-cyclocitral were evaluated using SwissADME and GeneCards databases. One hundred entries were determined in this query. Molecular docking properties were implemented using PyRx software. Results indicated that twenty-two of these entries were predicted to be candidate as target proteins in breast cancer treatment. Catepsin k, Andregone receptor, Alcohol dehydrogenase alpha chain, Cytochrome P450 17A1 and Prostaglandin E synthase with binding affinity of 6.5, 6.2, 6, 5.7, and 5.7kcal/mol, exhibited the highest binding affinity with target proteins respectively. The project results revealed that β-cyclocitral could be used as a ligand in targeting proteins evolved in breast cancer.
کلیدواژه‌ها
Breast cancer؛ Galium mite؛ B-cyclocitral؛ Molecular docking
مراجع
  1. . Harirchi I., Kolahdoozan S., Karbakhsh M., Chegini N., Mohseni S.M., Montazeri A., Momtahen A.J., Kashefi A., Ebrahimi M. Twenty years of breast cancer in Iran: down staging without a formal screening program. Ann Oncol. 2011; 22: 93-97.
  2. Ferlay J., Colombet M., Soerjomataram I., Mathers C., Parkin D., Pineros M., Znaor A., & Bray F. Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods. Int J Cancer. 2019; 144:1941–1953.
  3. Lester J. Breast cancer in 2007: Incidence, risk assessment and risk reduction strategies. Clinical J Oncology Nursing. 2007; 11:619–622.
  4. Singh P., Raj R., Kumar V., Mahjan M.P., Bedi PMS., Kaur T. 1, 2, 3-Triazole tethered b-lactam-chalconebifunctional hybrids:synthesis and anticancer evaluation. Eur J Med Chem. 2012; 47:594-600.
  5. Sirvastava V., Negi A.S., Kumar J.K., Gupta M.M., Khanuja S.P. Plant-based anticancer molecules: achemical and biological profile of some importantleads. Bioorg Med Chem. 2005; 13:5892-5908.
  6. Javidnia K., Jafari A., Shahabipour S., Afshaki S. Chemical constituents of the essential oil of Galium mite var. roseum ghahramaninejad. Chem Natural Compounds. 2014. DOI: 10.1007/s10600-014-1119-1.
  7. Gambliel H.A., Cates R.G. Terpene changes due to maturation and canopy level in Douglas-fir (Pseudotsugamenziesii) flush needle oil. Biochem. Syst. Ecol. 1995; 23:469–476.
  8. Guimarães A.G., Quintans J.S., Quintans, L.J. Monoterpenes with analgesic activity-a systematic review. Phytother, 2013; 27: pp.1–15.
  9. Turek C., Stintzing F.C. Stability of Essential Oils: A Review. Compr. Rev. Food Sci. Food Saf. 2013;12:40–53.
  10. Bardon S., Foussard V., Fournel S., Loubat A. Monoterpenes inhibit proliferation of human colon cancer cells by modulating cell cycle-related protein expression. Cancer Lett. 2002; 181: 187–94.
  11. Havaux M. Carotenoid oxidation products as stress signals in plants. The plant journal. 2013; 79:597-606.
  12. Zhao C., Song X., Liu Y. Synthesis of graphene quantum dots and their applications in drug delivery. J Nanobiotechnol. 2020. Doi: 10.1186/s12951-020-00698-z.
  13. Gilardi G. Impact of R264C and R264H polymorphisms in human aromatase function. The Journal of Steroid Biochemistry and Molecular Biology. 2017; 167:23-32.
  14. Anderson S., Russell D.W. Structural and biochemical properties of cloned and expressed human and rat steroid 5alpha-reductases. Biochemistry Proc. Natl. Acad. Sci. USA. 1990; 87: 3640-3644.
  15. McDonell P.B. The Opposing Transcriptional Activities of the Two Isoforms of the Human Progesterone Receptor Are Due to Differential Cofactor Binding. Molecular and Cellular Biology. 2000; 20:3102-15.
  16. Gaudet P. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Briefings in Bioinformatics. 2011;12:449-462.
  17. Yang J. The single-macro domain protein LRP16 isan essential cofactor of androgen receptor. Endocrine related cancer. 2009; 16: 139-153.
  18. Ston C.L., Li T., Bosron W.F. Stereospecific Oxidation of Secondary Alcohols by Human Alcohol Dehydrogenase. Journal of biological chemistry. 1989; 264:11112-11116.
  19. Jegerschoold C. Structural basis for induced formation of theinflammatory mediator prostaglandin E2. 2008. Doi:10.1073/pnas.0802894105.
  20. Miller W.L. Cytochrome b5 augments the 17, 20-Lyase Activity of Human P450c17 without Direct Electron Transfer. J Biological Chem.1998; 273:3158–3165.
  21. Wang B. Activation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylation. Nature Cell Biology. 2000; 2: pp.62–69.
  22. Barnett J. Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system. Biochimica et BiophysicaActa (BBA)- Protein Structure and Molecular Enzymology. 1994; 1209:130-139.
  23. Lambert J.C. ADAM30 Downregulates APP-Linked Defects ThroughCathepsin D Activation in Alzheimer's disease. EbioMedicine. 2016; 9:278-292.
  24. Molli P.R., Singh R.R., Lee S.W., Kumar R. MTA1-mediated transcriptional repression of BRCA1 tumor suppressor gene. Nature. 2008; 14:1971–1980.
  25. Koyama S. Repression of estrogen receptor β function by putative tumor suppressor DBC1. Biochemical and Biophysical Research Communications. 2010; 392:357-362.
  26. Drake R.R. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics, 2013; 13:1667-1671.
  27. Sacchettini J.C. Structural studies on human muscle fatty acid binding protein at 1.4A resolution: binding interactions with three C18 fatty acids. Structure.1994; 2:523-534.
  28. Maryuma T., Nara K., Yoshikawa H., Suzuki N. Txk, a member of the non-receptor tyrosine kinase of the Tec family, forms a complex with poly (ADP-ribose) polymerase 1 and elongation factor 1α and regulates interferon-γ gene transcription in Th1 cells. Clinical and Experimental Immunology. 2007; 147:164–175.
  29. Tepel C., Bromme D., Herzog V., Brix K. Cathepsin K in thyroid epithelial cells: sequence, localization and possible function in extracellular proteolysis of thyroglobulin. J Cell Sci. 2000; 113 (24):4487–4498.
  30. De Simone, G. Carbonic anhydrase inhibitors: Binding of an antiglaucomaglycosyl-sulfanilamide derivative to human isoform II and its consequences for the drug design of enzyme inhibitors incorporating sugar moieties. Bioorganic & Med Chem Letters. 2007; 17:1726-1731.
  31. Lebioda L. Structure of Human Thymidylate Synthase Suggests Advantages of Chemotherapy with Noncompetitive Inhibitors. Biology Chem. 2001; 276:14170–14177.
  32. Ojala P. Application of Active and Kinase-Deficient Kinome Collection for Identification of Kinases Regulating Hedgehog Signaling. Cell. 2008; 133:537-548.
  33. Demple, B. Covalent Trapping of Human DNA polymerase by the Oxidative DNA Lesion 2-Deoxyribonolactone. Journal of biological chemistry. 2002; 277:7637-7640.
  34. Decarolis E., Denis D., Riendeau D. Oxidative Inactivation of Human 5-Lipoxygenase in Phosphatidylcholine vesicles. Eur. J. Biochem, 1996; 235: 416-423.
آمار
تعداد مشاهده مقاله: 306
تعداد دریافت فایل اصل مقاله: 322


counter
سامانه مدیریت نشریات علمی. طراحی و پیاده سازی از سیناوب