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Fah, Lauris, Klotoé, Jean Robert, Agbodjento, Eric, Tamègnon Dougnon, Victorien, Kitchey, Alice, Sintondji, Kévin, Déguénon, Esther, Atègbo, Jean Marc. (1403). Evaluation of the Anti-inflammatory and Immunomodulatory Properties of Jatropha multifida stem sap. سامانه مدیریت نشریات علمی, 13(3), 680-690. doi: 10.22034/jmpb.2024.363925.1622
Lauris Fah; Jean Robert Klotoé; Eric Agbodjento; Victorien Tamègnon Dougnon; Alice Kitchey; Kévin Sintondji; Esther Déguénon; Jean Marc Atègbo. "Evaluation of the Anti-inflammatory and Immunomodulatory Properties of Jatropha multifida stem sap". سامانه مدیریت نشریات علمی, 13, 3, 1403, 680-690. doi: 10.22034/jmpb.2024.363925.1622
Fah, Lauris, Klotoé, Jean Robert, Agbodjento, Eric, Tamègnon Dougnon, Victorien, Kitchey, Alice, Sintondji, Kévin, Déguénon, Esther, Atègbo, Jean Marc. (1403). 'Evaluation of the Anti-inflammatory and Immunomodulatory Properties of Jatropha multifida stem sap', سامانه مدیریت نشریات علمی, 13(3), pp. 680-690. doi: 10.22034/jmpb.2024.363925.1622
Fah, Lauris, Klotoé, Jean Robert, Agbodjento, Eric, Tamègnon Dougnon, Victorien, Kitchey, Alice, Sintondji, Kévin, Déguénon, Esther, Atègbo, Jean Marc. Evaluation of the Anti-inflammatory and Immunomodulatory Properties of Jatropha multifida stem sap. سامانه مدیریت نشریات علمی, 1403; 13(3): 680-690. doi: 10.22034/jmpb.2024.363925.1622

Evaluation of the Anti-inflammatory and Immunomodulatory Properties of Jatropha multifida stem sap

Journal of Medicinal plants and By-products
مقاله 24، دوره 13، شماره 3، آذر 2024، صفحه 680-690    اصل مقاله (891.47 K)
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22034/jmpb.2024.363925.1622
نویسندگان
Lauris Fah1، 2؛ Jean Robert Klotoé* 1، 3؛ Eric Agbodjento1؛ Victorien Tamègnon Dougnon1؛ Alice Kitchey1؛ Kévin Sintondji1؛ Esther Déguénon1؛ Jean Marc Atègbo4
1Research Unit in Applied Microbiology and Pharmacology of natural substances, Polytechnic school of Abomey-Calavi, University of Abomey-Calavi
2National Medico-Sanitary Institute (INMeS), University of Abomey-Calavi
3Multidisciplinary Research Laboratory for Technical Education (LARPET) of the National Higher School for Technical Education (ENSET) of Lokossa; National University of Science, Technology, Engineering and Mathematics (UNSTIM), Abomey, Benin
4Faculty of Science and Technology, University of Abomey-Calavi
چکیده
Inflammatory diseases remain a significant public health issue, posing challenges in their management due to the adverse effects associated with conventional anti-inflammatory drugs. Exploring medicinal plants as a viable avenue for researching novel anti-inflammatory drugs offers a promising alternative. Jatropha multifida is a well-known traditional plant of the Euphorbiaceae family with undisputed medicinal properties, both haemostatic and antimicrobial. Very little data exists on its anti-inflammatory properties. This study aimed to assess the anti-inflammatory and immunomodulatory properties of Jatropha multifida stem sap
The anti-inflammatory activity of the stem sap was evaluated in vitro by the anti-hemolytic activity assessment method, in vivo by the paw edema test in rats. The immunomodulatory potential was determined using a chemical mediator of inflammation, TNFα. Its antioxidant activity by the DPPH method was evaluated.
The results of this study revealed that Jatropha multifida sap with an LC50 of 0.604 mg/mL, is non-toxic and showed a 66.21% higher anti-hemolytic effect than Diclofenac (25.94 %) and Ibuprofen (40 %). It also has a high DPPH inhibitory power (86.61 %) at 0.5 mg/mL similar to that of vitamin C. Sap at the concentration of 800 mg/Kg has overall the same effects on paw inflammation as Diclofenac and results in a greater decrease in TNFα (286.15) at values similar to those of normal control rats.
The therapeutic use of this sap in a traditional setting is therefore once again justified due to its proven anti-inflammatory and immunomodulatory properties.
کلیدواژه‌ها
Jatropha multifida؛ Anti-inflammatory؛ Rat؛ TNFα
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