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Arzani, Maya, Mostofi Fakhrani, Zahra, Omranzadeh, Alireza, Safarian, Samin, Soltani, Danial, Soroushianfar, Mahdi. (1404). Harnessing Listeria monocytogenes: A Promising Approach to Cancer Treatment. سامانه مدیریت نشریات علمی, 80(2), 375-384. doi: 10.32592/ARI.2025.80.2.375
Maya Arzani; Zahra Mostofi Fakhrani; Alireza Omranzadeh; Samin Safarian; Danial Soltani; Mahdi Soroushianfar. "Harnessing Listeria monocytogenes: A Promising Approach to Cancer Treatment". سامانه مدیریت نشریات علمی, 80, 2, 1404, 375-384. doi: 10.32592/ARI.2025.80.2.375
Arzani, Maya, Mostofi Fakhrani, Zahra, Omranzadeh, Alireza, Safarian, Samin, Soltani, Danial, Soroushianfar, Mahdi. (1404). 'Harnessing Listeria monocytogenes: A Promising Approach to Cancer Treatment', سامانه مدیریت نشریات علمی, 80(2), pp. 375-384. doi: 10.32592/ARI.2025.80.2.375
Arzani, Maya, Mostofi Fakhrani, Zahra, Omranzadeh, Alireza, Safarian, Samin, Soltani, Danial, Soroushianfar, Mahdi. Harnessing Listeria monocytogenes: A Promising Approach to Cancer Treatment. سامانه مدیریت نشریات علمی, 1404; 80(2): 375-384. doi: 10.32592/ARI.2025.80.2.375

Harnessing Listeria monocytogenes: A Promising Approach to Cancer Treatment

Archives of Razi Institute
مقاله 2، دوره 80، شماره 2، خرداد و تیر 2025، صفحه 375-384    اصل مقاله (597.51 K)
نوع مقاله: Review Article
شناسه دیجیتال (DOI): 10.32592/ARI.2025.80.2.375
نویسندگان
Maya Arzani1؛ Zahra Mostofi Fakhrani2؛ Alireza Omranzadeh* 3؛ Samin Safarian4؛ Danial Soltani4؛ Mahdi Soroushianfar5
1Graduate student of the Plant Biology Department, University of Nazlu Urmia, Iran
2Islamic Azad University of Shoushtar, Khuzestan, Iran
3Medical doctor, Mashhad University of Medical Sciences, Mashhad, Iran
4Mashhad University of Medical Sciences, Mashhad, Iran
5Department of Pathobiology, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran
چکیده
Increasing mortality and morbidity rates have drawn global attention to cancer, prompting the exploration of new treatment options. The use of immunotherapy for recurrent or metastatic cancer has emerged as a promising option over the years despite its limitations as compared to traditional treatment options. Among the various immunotherapeutic approaches, bacterial-based vectors like Listeria monocytogenes (Lm) have garnered attention for their unique characteristics. Utilizing these vectors involves leveraging their ability to invade Antigen-Presenting Cells (APCs), grow intracellularly within immune cells, and spread intracellularly, enhancing their efficacy in tailoring immune responses. It is important to note that the use of bacterial vectors significantly minimizes the risks associated with off-target effects. The antitumor effects of Lm can be observed through the reduction of immunosuppressive cells in the tumor microenvironment as well as the stimulation of T cells. Various types of tumor cells can be targeted by modified Lm vaccines, according to research. However, it is recognized that Lm vaccines alone may not suffice for comprehensive cancer treatment. Therefore, using Lm vaccines in combination with other therapeutic modalities like radiotherapy, reactivated adoptive cell therapy, and immune checkpoint inhibitors could result in superior results. As a result of these developments, the current review aims to elaborate on recent developments in the understanding of how Lm vaccines perform their antitumor properties. This review aims to provide insights into optimizing the therapeutic potential of Lm vaccines by comprehensively examining their interplay with the immune system. In order to harness the full therapeutic potential of Lm vaccines for fighting cancer, researchers and clinicians need to gain a deeper understanding of these mechanisms.
کلیدواژه‌ها
Listeria monocytogenes؛ Cancer؛ Cancer vaccine؛ Immunotherapy؛ Tumor
عنوان مقاله [English]
لیستریا مونوسیتوژنز به عنوان یک عامل پاتوژن دامپزشکی برای مبارزه با سرطان‌ها
چکیده [English]
چشم‌انداز جهانی به سرطان به دلیل نرخ مرگ و میر چشمگیر آن تشدید شده است که منجر به بررسی روش‌های درمانی نوآورانه شده است. ایمونوتراپی به عنوان یک گزینه امیدبخش برای بیماران مبتلا به سرطان متاستاتیک به وجود آمده است که محدودیت‌های درمان‌های سنتی را برطرف می‌کند. از میان رویکردهای ایمونوتراپی مختلف، درمان بر پایه باکتری مانند لیستریا مونوسیتوژنز (Lm) به دلیل ویژگی‌های منحصر به فرد خود، توجه بسیاری را به خود جلب کرده‌اند. استفاده از این باکتری شامل بهره‌گیری از توانایی آن‌ها برای تهاجم به سلول‌های آنتی‌ژن‌پرداز (APC)، رشد در داخل سلول‌های ایمنی و گسترش درون‌سلولی است، که بهبود کارآیی آن‌ها در سازماندهی پاسخ‌های ایمنی منجر می‌شود. از اهمیت ویژه استفاده از باکتریایی میتوان به کم کردن خطر اثرات جانبی شیمی درمانی یا پرتودرمانی و جراحی اشاره کرد. لیستریا مونوسیتوژنز اثرات ضد توموری قوی را با کاهش سلول‌های ایمنی‌ساز، افزایش فعالیت سلول‌های T در محیط تومور نشان می‌دهد. تحقیقات نشان می‌دهد که واکسن‌های Lm تغییر یافته می‌توانند پاسخ‌های ایمنی متنوعی را به سلول‌های مختلف توموری القا کنند. با این حال، واکسن‌های Lm به تنهایی ممکن است برای درمان جامع سرطان کافی نباشند. بنابراین، ترکیب واکسن‌های Lm با سایر روش‌ها مانند درمان سلول‌های بیماری‌ای بازفعال‌شده، رادیوتراپی و مهارکننده‌های چک‌پوینت ایمنی امیدواری به بهبود نتایج درمانی دارد. با توجه به این پیشرفت‌ها، بررسی حاضر به بررسی پیشرفت‌های اخیر در درک مکانیسم‌های مولکولی در پایگاه ضد توموری واکسن‌های Lm می‌پردازد. با بررسی جامع تعامل پیچیده بین واکسن‌های Lm و سیستم ایمنی، این بررسی به هدف ارائه بینش‌ها در بهینه‌سازی قدرت درمانی آن‌ها در زمینه درمان سرطان می‌پردازد. از طریق درک عمیق‌تر این مکانیسم‌ها، پژوهشگران و پزشکان می‌توانند استراتژی‌های نوآورانه‌ای را برای بهره‌گیری از مزایای کامل درمانی واکسن‌های Lm در مبارزه با سرطان ارائه دهند.
کلیدواژه‌ها [English]
لیستریا مونوسیتوژنز, سرطان، واکسن سرطان، ایمونوتراپی، تومور
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آمار
تعداد مشاهده مقاله: 231
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