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hosseinzadeh, Mehri, Titidej, Azadeh Zeinab, Mokhlesi, Aida, Yazdi, Zohreh, Azmoudeh, Faezeh, Samani, Simin, Saffar, Hana. (1403). Tumor-Associated Tissue Eosinophilia in Oral Squamous Cell Carcinoma: Implications for Histopathologic Grading. سامانه مدیریت نشریات علمی, 79(6), 1345-1351. doi: 10.32592/ARI.2024.79.6.1345
Mehri hosseinzadeh; Azadeh Zeinab Titidej; Aida Mokhlesi; Zohreh Yazdi; Faezeh Azmoudeh; Simin Samani; Hana Saffar. "Tumor-Associated Tissue Eosinophilia in Oral Squamous Cell Carcinoma: Implications for Histopathologic Grading". سامانه مدیریت نشریات علمی, 79, 6, 1403, 1345-1351. doi: 10.32592/ARI.2024.79.6.1345
hosseinzadeh, Mehri, Titidej, Azadeh Zeinab, Mokhlesi, Aida, Yazdi, Zohreh, Azmoudeh, Faezeh, Samani, Simin, Saffar, Hana. (1403). 'Tumor-Associated Tissue Eosinophilia in Oral Squamous Cell Carcinoma: Implications for Histopathologic Grading', سامانه مدیریت نشریات علمی, 79(6), pp. 1345-1351. doi: 10.32592/ARI.2024.79.6.1345
hosseinzadeh, Mehri, Titidej, Azadeh Zeinab, Mokhlesi, Aida, Yazdi, Zohreh, Azmoudeh, Faezeh, Samani, Simin, Saffar, Hana. Tumor-Associated Tissue Eosinophilia in Oral Squamous Cell Carcinoma: Implications for Histopathologic Grading. سامانه مدیریت نشریات علمی, 1403; 79(6): 1345-1351. doi: 10.32592/ARI.2024.79.6.1345

Tumor-Associated Tissue Eosinophilia in Oral Squamous Cell Carcinoma: Implications for Histopathologic Grading

Archives of Razi Institute
مقاله 27، دوره 79، شماره 6، بهمن و اسفند 2024، صفحه 1345-1351    اصل مقاله (326.24 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.32592/ARI.2024.79.6.1345
نویسندگان
Mehri hosseinzadeh1؛ Azadeh Zeinab Titidej2؛ Aida Mokhlesi3؛ Zohreh Yazdi4؛ Faezeh Azmoudeh* 2؛ Simin Samani5؛ Hana Saffar6
1Student Research Committee, Qazvin University of Medical Sciences, Qazvin, Iran
2Dental Caries Prevention Research Center, Qazvin University of Medical Sciences, Qazvin, Iran.
3Student Research Committee, Qazvin University of Medical Sciences, Qazvin, Iran USERN Office, Qazvin University of Medical Sciences, Qazvin, Iran Network of Interdisciplinarity in Neonates and Infants (NINI), Universal Scientific
4Metabolic Diseases Research Center, Research Institute for Prevention of Non-Communicable Diseases, Qazvin University Of Medical Sciences, Qazvin, Iran
5Qazvin University of Medical Sciences, Qazvin, Iran.
6Tehran University of Medical Sciences, Tehran, Iran.
چکیده
Tumor-associated tissue eosinophilia (TATE) has been associated with various tumors, including Oral squamous cell carcinoma, but its role has not been precisely elucidated. This research aimed to investigate the presence of tumor-associated tissue eosinophilia in oral squamous cell carcinomas (OSCCs) and its correlation with histopathologic grading. 70 OSCC tissue samples collected between 2016 and 2020 were examined. The samples comprised 60 previously diagnosed cases of OSCC, classified as well-differentiated squamous cell carcinoma (WDSCC), moderately differentiated squamous cell carcinoma (MDSCC), and poorly differentiated squamous cell carcinoma (PDSCC). Two observers assessed TATE using Sirius red stain, with the average eosinophil count evaluated in 10 fields under the ×40 objective lens. Statistical analysis involved the Student t-test, One-way ANOVA, and chi-square test. The study encompassed 70 OSCC samples and corresponding healthy tissue, with OSCC predominantly found in the tongue, representing 61.4% of cases. The total eosinophil count per high-power field (HPF10) was significantly higher in OSCC compared to healthy tissue. Moreover, the mean TATE score was notably elevated in OSCC tissue. One-way ANOVA revealed a lack yet statistically significant association between different OSCC grades and eosinophil counts. However, the chi-square test did not indicate a significant association between eosinophil count and gender or age group. This study underscores that cancerous tissues exhibit a heightened eosinophil count compared to healthy tissues. Nonetheless, the variability in eosinophil counts across distinct OSCC grades remains ambiguous. Further investigation is recommended to delve into the infiltration of eosinophils in solid tumors and their potential role in predicting malignancies, particularly in OSCC.
کلیدواژه‌ها
oral squamous cell carcinoma؛ Sirius red؛ Eosinophils؛ Stains؛ Tumor-associated tissue eosinophilia
عنوان مقاله [English]
ائوزینوفیلی بافتی مرتبط با تومور در کارسینوم سلول سنگفرشی دهان: پیامدهایی برای درجه بندی هیستوپاتولوژیک
چکیده [English]
مقدمه : با وجود اینکه Tumor associated tissue eosinophilia(TATE) همراه با تومورهای مختلف از جمله Oral Squammous Cell Carcinoma (OSCC) دیده شده ، اما نقش آن به طور دقیق مشخص نشده است. هدف این مطالعه تعیین تعداد TATE در شرایط بدخیم نسبت به بافت سالم و بین درجات مختلف هیستوپاتولوژیکی OSCC می باشد. مواد و روش ها : در این مطالعه توصیفی_تحلیلی، از بین پرونده های موجود در بایگانی انستیتو سرطان بیمارستان امام خمینی، 10 نمونه بافت سالم و 60 نمونه OSCC با درجه هیستوپاتولوژیکی مختلف ( 20مورد Well-Differentiated،20مورد Moderately-Differentiatedو20مورد Poorly-Differentiated ) انتخاب گردید و بررسی اینفیلتراسیون ائوزینوفیل ها در نمونه ها با استفاده از روش رنگ‌آمیزی Sirius red انجام شد و ائوزینوفیل ها در 10 ناحیه تصادفی با بزرگنمایی 400 شمارش شده و میانگین تعداد آن ها بین درجات 4-0 گزارش شد. جهت آنالیز آماری نتایج از نسخه 22 نرم افزار SPSS و آزمون های Student t-test One-way ANOVA ، chi-square استفاده شد. یافته ها : میانگین TATE در OSCC 27/5 و در بافت سالم 05/2 بود و TATE، در OSCC به طور معنی داری بیشتر از بافت سالم بود.( 026/0=P) بین TATE با درجات مختلف هیستوپاتولوژیکی تومور ارتباط معنی دار ضعیفی مشاهده شد، اما روند تغییرات آن در درجات مختلف به طور دقیق مشخص نشد. (048/0=P) هم چنین رابطه ی معناداری بین TATE با سن و جنس افراد وجود نداشت.
نتیجه گیری : حضور بیشتر TATE در ضایعات OSCC نسبت به بافت سالم مشاهده شد، اما نقش آن در درجات مختلف هیستولوژیکی OSCC مشخص نشد.
واژگان کلیدی : ائوزینوفیل _ رنگ آمیزی Sirius Red _کارسینوم سلول سنگفرشی دهان
کلیدواژه‌ها [English]
کارسینوم سلول سنگفرشی دهان, سیریوس قرمز, ائوزینوفیل ها, استین هاا, ائوزینوفیلی بافت مرتبط با تومور
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مراجع
  1. Tan, Y., et al., Oral squamous cell carcinomas: state of the field and emerging directions. International Journal of Oral Science, 2023. 15(1): p. 44.
  2. Azmoudeh, F., et al., Molecular prevalence of human papillomavirus types 16 and 18 in Oral squamous cell carcinoma using real-time PCR. Archives of Razi Institute, 2023.
  3. Keshani, F., et al., Assessment of biochemical factors in blood serum of patients with oral squamous cell carcinoma. Dental Research Journal, 2023. 20(1): p. 81.
  4. Azmoodeh, F., et al., Frequency of Oral and Maxillofacial Tumors in the Samples Referred to the Pathology Department of Qazvin University of Medical Sciences. 2023.
  5. Badwelan, M., et al., Oral Squamous Cell Carcinoma and Concomitant Primary Tumors, What Do We Know? A Review of the Literature. Curr Oncol, 2023. 30(4): p. 3721-3734.
  6. Mauceri, R., et al., Diagnostic delay of oral squamous cell carcinoma and the fear of diagnosis: A scoping review. Front Psychol, 2022. 13: p. 1009080.
  7. Venkatesiah, S.S., et al., Immunology of Oral Squamous Cell Carcinoma-A Comprehensive Insight with Recent Concepts. Life (Basel), 2022. 12(11).
  8. Sathiyasekar, A.C., et al., Overview of immunology of oral squamous cell carcinoma. J Pharm Bioallied Sci, 2016. 8(Suppl 1): p. S8-s12.
  9. Ghaffari, S. and N. Rezaei, Eosinophils in the tumor microenvironment: implications for cancer immunotherapy. J Transl Med, 2023. 21(1): p. 551.
  10. Labani-Motlagh, A., M. Ashja-Mahdavi, and A. Loskog, The tumor microenvironment: a milieu hindering and obstructing antitumor immune responses. Frontiers in immunology, 2020. 11: p. 940.
  11. Rakesh, N., et al., Tumour associated tissue eosinophilia as a predictor of locoregional recurrence in oral squamous cell carcinoma. J Clin Exp Dent, 2015. 7(1): p. e1-6.
  12. Deepthi, G., P.G. Kulkarni, and K.N. SR, Eosinophils: An imperative histopathological prognostic indicator for oral squamous cell carcinoma. J Oral Maxillofac Pathol, 2019. 23(2): p. 307.
  13. Choudhary, N., et al., Tumor associated tissue eosinophilia in oral squamous cell carcinoma: A systematic review and meta-analysis. J Oral Biol Craniofac Res, 2021. 11(1): p. 33-39.
  14. Wabinga, H.R., Comparison of immunohistochemical and modified Giemsa stains for demonstration of Helicobacter pylori infection in an African population. Afr Health Sci, 2002. 2(2): p. 52-5.
  15. Lee, T.-L., et al., Tumor-associated tissue eosinophilia promotes angiogenesis and metastasis in head and neck squamous cell carcinoma. Neoplasia, 2023. 35: p. 100855.
  16. Kaur, N., et al., To evaluate eosinophilia (tissue eosinophilia, blood eosinophilia and tissue eosinophilia/blood eosinophilia ratio) in increasing grades/severity of oral neoplastic lesions. Journal of Cancer Research and Therapeutics, 2023. 19(Suppl 1): p. S206-S211.
  17. Alkhabuli, J.O. and A.S. High, Significance of eosinophil counting in tumor associated tissue eosinophilia (TATE). Oral Oncol, 2006. 42(8): p. 849-50.
  18. Majumdar, B., et al., Tumor associated tissue eosinophilia as a potential predictor in the invasion patterns of oral squamous cell carcinoma. Journal of International Oral Health, 2016. 8(11): p. 1026.
  19. Yellapurkar, S., et al., Tumour-associated tissue eosinophilia in oral squamous cell carcinoma-a boon or a bane? Journal of Clinical and Diagnostic Research: JCDR, 2016. 10(4): p. ZC65.
  20. Beunk, L., et al., Cancer invasion into musculature: Mechanics, molecules and implications. Semin Cell Dev Biol, 2019. 93: p. 36-45.
  21. Quintero-Fabián, S., et al., Role of Matrix Metalloproteinases in Angiogenesis and Cancer. Front Oncol, 2019. 9: p. 1370.
  22. Martinelli-Kläy, C., B. Mendis, and T. Lombardi, Eosinophils and oral squamous cell carcinoma: a short review. Journal of oncology, 2009. 2009.
  23. Jain, M., et al., Tissue eosinophilia in head and neck squamous neoplasia: an update. Experimental oncology, 2014(36,№ 3): p. 157-161.
  24. Sahni, P., et al., Tumor associated tissue eosinophilia in oral squamous cell carcinoma: A histo-chemical analysis. The Malaysian Journal of Medical Sciences: MJMS, 2015. 22(6): p. 21.
  25. Van Zyl, A.W. and B.K. Bunn, Clinical features of oral cancer: clinical review. South African Dental Journal, 2012. 67(10): p. 566-569.
  26. Shrestha, P., et al., Tumor-associated tissue eosinophilia in oral squamous cell carcinoma–A predictable biological behavior. J Global Oral Health, 2020. 3: p. 3-8.
  27. Saravani, S., H. Kadeh, and A. Abilnajafzade, Tissue eosinophils as a histopathological marker in oral premalignant and malignant lesions: a histochemical study. Caspian Journal of Dental Research, 2017. 6(2): p. 8-14.
  28. Razavi, S.M., P. Deyhimi, and S. Homayouni, Comparative evaluation of eosinophils in normal mucosa, dysplastic mucosa and oral squamous cell carcinoma with hematoxylin-eosin, Congo red, and EMR1 immunohistochemical staining techniques. Electronic physician, 2015. 7(2): p. 1019.
  29. Bhargava, A., S. Saigal, and M. Chalishazar, Histopathological grading systems in oral squamous cell carcinoma: A review. J Int Oral Health, 2010. 2(4): p. 1-10.
  30. Jain, M., et al., Assessment of tissue eosinophilia as a prognosticator in oral epithelial dysplasia and oral squamous cell carcinoma—an image analysis study. Pathology research international, 2014. 2014.
  31. Vaibhav, S.L., et al., Evaluation of Tumor-associated Tissue Eosinophilia in Different Stages of Oral Squamous Cell Carcinoma using Special Stains: An in vitro Histopathological Study. The Journal of Contemporary Dental Practice, 2018. 19(5): p. 579-586.
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