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(2025). استفاده از قارچ‌های آسپرژیلوس، یک پاتوژن مهم در حوزه دامپزشکی، در درمان سرطان ریه: یک رویکرد نوین. , 80(1), 1-10. doi: 10.32592/ARI.2025.80.1.1
. "استفاده از قارچ‌های آسپرژیلوس، یک پاتوژن مهم در حوزه دامپزشکی، در درمان سرطان ریه: یک رویکرد نوین". , 80, 1, 2025, 1-10. doi: 10.32592/ARI.2025.80.1.1
(2025). 'استفاده از قارچ‌های آسپرژیلوس، یک پاتوژن مهم در حوزه دامپزشکی، در درمان سرطان ریه: یک رویکرد نوین', , 80(1), pp. 1-10. doi: 10.32592/ARI.2025.80.1.1
استفاده از قارچ‌های آسپرژیلوس، یک پاتوژن مهم در حوزه دامپزشکی، در درمان سرطان ریه: یک رویکرد نوین. , 2025; 80(1): 1-10. doi: 10.32592/ARI.2025.80.1.1

استفاده از قارچ‌های آسپرژیلوس، یک پاتوژن مهم در حوزه دامپزشکی، در درمان سرطان ریه: یک رویکرد نوین

Archives of Razi Institute
Article 2, Volume 80, Issue 1, January and February 0, Pages 1-10    PDF (374.26 K)
Document Type: مقاله مروری
DOI: 10.32592/ARI.2025.80.1.1
Abstract
سرطان به عنوان یک چالش مهم در حوزه سلامت جهانی باقی مانده است که نیاز به راهکارهای درمانی نوآورانه برای مداخله مؤثر دارد. در سال‌های اخیر، تحقیقات گسترده‌ای در زمینه خصوصیات ضد سرطانی احتمالی قارچ آسپرژیلوس انجام شده است. این مطالعه مروری سعی در انجام ارزیابی جامع از شواهد علمی مربوط به اثرات ضد تومور پتانسیلی انواع مختلف آسپرژیلوس و متابولیت‌های ثانویه آنها در برابر سرطان ریه دارد. تعداد زیادی از گونه‌های آسپرژیلوس، با Aspergillus fumigatus در رأس، توانایی تولید ترکیباتی را که در زمینه درمان ضد سرطان قابل توجهی دارند، اثبات کرده‌اند. گلایوتوکسین، یکی از این ترکیبات، به عنوان یک عامل قابل توجه در ایجاد آپوپتوز در سلول‌های سرطان ریه و مهار رشد تومور ظاهر می‌شود. علاوه بر این، امریسلامید A، مشتق از Aspergillus nidulans، سمیت سلولی قابل توجهی را در برابر سلول‌های سرطان ریه نشان می‌دهد. همچنین، سروتونین، مشتق از Aspergillus terreus، اثرات سمیت سلولی را در برابر سلول‌های سرطان ریه نشان داده است. ترکیب اسید سایکلوپیازونیک، شناخته شده در Aspergillus flavus، نیز سمیت سلولی را در برابر سلول‌های سرطان ریه نشان داده است. تأثیرات مهاری بر روی سلول‌های سرطان به تنهایی به سمت سمیت سلولی گسترش نمی‌یابد و شامل فرآیندهایی نظیر آپوپتوز، تنظیم آنژیوژنز، تنظیم ایمنی، و مهار افزایش تقسیم میتواند باشد. حل چالش‌های درمان سرطان نیاز به تلاش‌های مشترک دارد که همکاری بین پژوهشگران، پزشکان و مخصوصا دامپزشکان را ترویج می‌دهد. دامپزشکان می‌توانند راهی را برای درمان‌های بهتر و مؤثر و قابل استفاده برای سرطان ریه، با بهره‌گیری از تنوع غنی ترکیبات فارماکولوژیکی قارچ‌های آسپرژیلوس، به‌وجود بیاورند.
Keywords
قارچ‌های آسپرژیلوس; سرطان; سرطان ریه; متابولیت‌های ثانویه; پاتوژن‌های دامپزشکی
Supplementary Files
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