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Karimi shayan, Tahereh, Abdolmaleki, Arash, asadi, asadollah, Hassanpour, Hossein. (1403). Piracetam as Neuroprotective, Anticonvulsant, and Anti-Anxiety Agent: An In Vivo Study on Ptz Epileptic Rats. سامانه مدیریت نشریات علمی, 79(5), 1057-1064. doi: 10.32592/ARI.2024.79.5.1057
Tahereh Karimi shayan; Arash Abdolmaleki; asadollah asadi; Hossein Hassanpour. "Piracetam as Neuroprotective, Anticonvulsant, and Anti-Anxiety Agent: An In Vivo Study on Ptz Epileptic Rats". سامانه مدیریت نشریات علمی, 79, 5, 1403, 1057-1064. doi: 10.32592/ARI.2024.79.5.1057
Karimi shayan, Tahereh, Abdolmaleki, Arash, asadi, asadollah, Hassanpour, Hossein. (1403). 'Piracetam as Neuroprotective, Anticonvulsant, and Anti-Anxiety Agent: An In Vivo Study on Ptz Epileptic Rats', سامانه مدیریت نشریات علمی, 79(5), pp. 1057-1064. doi: 10.32592/ARI.2024.79.5.1057
Karimi shayan, Tahereh, Abdolmaleki, Arash, asadi, asadollah, Hassanpour, Hossein. Piracetam as Neuroprotective, Anticonvulsant, and Anti-Anxiety Agent: An In Vivo Study on Ptz Epileptic Rats. سامانه مدیریت نشریات علمی, 1403; 79(5): 1057-1064. doi: 10.32592/ARI.2024.79.5.1057

Piracetam as Neuroprotective, Anticonvulsant, and Anti-Anxiety Agent: An In Vivo Study on Ptz Epileptic Rats

Archives of Razi Institute
مقاله 23، دوره 79، شماره 5، آذر و دی 2024، صفحه 1057-1064    اصل مقاله (763.95 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.32592/ARI.2024.79.5.1057
نویسندگان
Tahereh Karimi shayan1؛ Arash Abdolmaleki2؛ asadollah asadi* 1؛ Hossein Hassanpour3
1Department of Biology, Faculty of Science, University of Mohaghegh Ardabili, Ardabil, Iran.
2Department of Biophysics, Faculty of Advanced Technologies, University of Mohaghegh Ardabili, Namin, Iran.
3Department of Basic Science, Faculty of Veterinary Medicine Shahrekord University, Saman Road P.O.115, Shahrekord, Iran.
چکیده
Recurrent seizures characterize epilepsy, a category of neurological disorder. Epileptic seizures can result in sudden changes in brain electrical activity. Piracetam is a cyclic aminobutyric acid derivative with neuroprotective effects. We aimed to evaluate piracetam's neuroprotective, anticonvulsant, and anti-anxiety effects in the pentylenetetrazole (PTZ) seizure rat model. To assess piracetam's anticonvulsant properties in the PTZ seizure model, the experimental groups received Piracetam at 30 or 100 mg/kg. The positive control group received diazepam (2 mg/kg), and the negative control group received only PTZ. Elevated plus maze and open field tests evaluated the anti-anxiety effects. The antioxidant effects of Piracetam on brain tissues were also examined. Open field test results revealed that crossing the line increased significantly in the Piracetam (30 and 100 mg/kg) and diazepam groups compared to the negative control group. In the plus maze test, the Piracetam groups showed more time spent in open arms than the control group. Also, diazepam significantly increased the time spent in open arms compared to the negative control group. Histological results showed structural changes in hippocampal neurons. Also, the antioxidant test showed Piracetam's antioxidant properties compared to the negative control group. Piracetam had anticonvulsant and neuroprotective effects in PTZ epileptic rats and inhibited or reduced seizures. Also, it had anti-anxiety and sedative effects. Neuroprotective effects of Piracetam may be due to the control of neurotransmitters such as cholinergic, serotonergic, noradrenergic, and glutamatergic systems. Piracetam might have neuroprotective, anti-epileptic, anti-anxiety, and antioxidant properties in PTZ epileptic rats. However, further studies are needed to confirm these results.
کلیدواژه‌ها
Antioxidant؛ Epilepsy؛ Piracetam؛ Plus Maze
مراجع
  1. Darch H, McCafferty CP. Gut microbiome effects on neuronal excitability & activity: implications for epilepsy. Neurobiology of Disease. 2022;65(13): 1-9.
  2. Kanner AM, Bicchi MM. Antiseizure medications for adults with epilepsy: a review. Jama. 2022;327(13):1269-81.
  3. Eadie MJ. Shortcomings in the current treatment of epilepsy. Expert review of neurotherapeutics. 2012;12(12):1419-27.
  4. Ghanimi HA, Albahadly WKY, Abdolmaleki A, Roohbakhsh A, Zaniani NR. Assessment of Hippocampal Cell Death and Memory Deficits in Rats Following Neonatal Stress. NeuroQuantology. 2022;20(4):434-42.
  5. Fisher RS, Boas WVE, Blume W, Elger C, Genton P, Lee P, et al. Epileptic seizures and epilepsy: definitions proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE). Epilepsia. 2005;46(4):470-2.
  6. Abdolmaleki A, Moghimi A, Ghayour MB, Rassouli MB. Evaluation of neuroprotective, anticonvulsant, sedative and anxiolytic activity of citicoline in rats. European journal of pharmacology. 2016;789:275-9.
  7. Goldberg EM, Coulter DA. Mechanisms of epileptogenesis: a convergence on neural circuit dysfunction. Nature Reviews Neuroscience. 2013;14(5):337-49.
  8. Hebbar M, Mefford HC. Recent advances in epilepsy genomics and genetic testing. F1000Research. 2020;9(F1000 Faculty Rev):1-9.
  9. Tuncer E, Bolat ED. Classification of epileptic seizures from electroencephalogram (EEG) data using bidirectional short-term memory (Bi-LSTM) network architecture. Biomedical Signal Processing and Control. 2022;73(3):103462.
  10. Duncan JS, Sander JW, Sisodiya SM, Walker MC. Adult epilepsy. The Lancet. 2006;367(9516):1087-100.
  11. Asadi A, Abdolmaleki A. New Drugs and their Mechanism in the Treatment of Epilepsy. The Neuroscience Journal of Shefaye Khatam. 2022;10(2):104-10.
  12. Al-Mosawi A. Recent uses of piracetam in pediatric neurology. SunKrist Neurology, Neurosurgery and Stroke Journal. 2020;2(1):1002.
  13. Grover S, Jain S. Current Trends in the Animal Models for Screening of Nootropic Agents. Current Reviews in Clinical and Experimental Pharmacology. 2023;18(3):255-26914.
  14. Ferdowsi S, Abdolmaleki A, Asadi A, Zahri S. Effect of Azithromycin on Sciatic Nerve Injury in the Wistar Rats. Neurochemical Research. 2022;48(1):161-171.
  15. Nasr M, Wahdan SA. Neuroprotective effects of novel nanosystems simultaneously loaded with vinpocetine and piracetam after intranasal administration. Life sciences. 2019;226:117-29.
  16. Fayez AM, Elnoby AS, Bahnasawy NH, Hassan O. Neuroprotective effects of zafirlukast, piracetam and their combination on L‐Methionine‐induced vascular dementia in rats. Fundamental & Clinical Pharmacology. 2019;33(6):634-48.
  17. Winblad B. Piracetam: a review of pharmacological properties and clinical uses. CNS drug reviews. 2005;11(2):169-82.
  18. Van Erum J, Van Dam D, De Deyn PP. PTZ-induced seizures in mice require a revised Racine scale. Epilepsy & Behavior. 2019;95:51-5.
  19. Daldegan-Bueno D, Favaro VM, Morais PR, Sussulini A, Oliveira MGM. Effects of repeated ayahuasca administration on behaviour and c-Fos expression in male rats exposed to the open field. Behavioural brain research. 2022;427(3):113878.
  20. Hogg S. A review of the validity and variability of the elevated plus-maze as an animal model of anxiety. Pharmacology Biochemistry and Behavior. 1996;54(1):21-30.
  21. Kraeuter A-K, Guest PC, Sarnyai Z. The elevated plus maze test for measuring anxiety-like behavior in rodents. Pre-Clinical Models: Techniques and Protocols. 2019; 1916:69-74.
  22. Gaudette F, Bedard D, Kwan C, Frouni I, Hamadjida A, Beaudry F, et al. Highly sensitive HPLC-MS/MS assay for the quantitation of ondansetron in rat plasma and rat brain tissue homogenate following administration of a very low subcutaneous dose. Journal of Pharmaceutical and Biomedical Analysis. 2019;175:112766.
  23. Li J, Gibbs RB. Detection of estradiol in rat brain tissues: Contribution of local versus systemic production. Psychoneuroendocrinology. 2019;102:84-94.
  24. Bartos M, Gumilar F, Gallegos CE, Bras C, Dominguez S, Cancela LM, et al. Effects of perinatal fluoride exposure on short-and long-term memory, brain antioxidant status, and glutamate metabolism of young rat pups. International Journal of Toxicology. 2019;38(5):405-14.
  25. Abdel-Wahab WM, Moussa FI. Neuroprotective effect of N-acetylcysteine against cisplatin-induced toxicity in rat brain by modulation of oxidative stress and inflammation. Drug design, development and therapy. 2019;13:1155–1162.
  26. Luo Z, Fang Y, Zhang L. The effects of antiepileptic drug valproic acid on apoptosis of hippocampal neurons in epileptic rats. Pakistan Journal of Pharmaceutical Sciences. 28(1):319-24.
  27. Aydin S, Kuloglu T, Aydin Y, Yalcin M, Ugur K, Albayrak S, et al. Effects of iloprost and sildenafil treatment on elabela, apelin-13, nitric oxide, and total antioxidant and total oxidant status in experimental enzyme-positive acute coronary syndrome in rats. Biotechnic & Histochemistry. 2020;95(2):145-51.
  28. Erel O. A new automated colorimetric method for measuring total oxidant status. Clinical biochemistry. 2005;38(12):1103-11.
  29. Aslankoc R, Ozmen O, Yalcın A. Astaxanthin ameliorates damage to the cerebral cortex, hippocampus and cerebellar cortex caused by methotrexate. Biotechnic & Histochemistry. 2022;97(5):382-93.
  30. Ghanimi HA, Kadhim HM, Hussein HH, Abdolmaleki A, Moghimi A. Neonatal isolation provokes hippocampal apoptosis and recognition memory impairment in rats. 2022;6(S2):2811–2823.
  31. Aran S, Zahri S, Asadi A, Khaksar F, Abdolmaleki A. Hair follicle stem cells differentiation into bone cells on collagen scaffold. Cell and Tissue Banking. 2020;21:181-8.
  32. Wang Y, Wei P, Yan F, Luo Y, Zhao G. Animal models of epilepsy: A phenotype-oriented review. Aging and disease. 2022;13(1):215.
  33. Łukawski K, Czuczwar SJ. Developing precision treatments for epilepsy using patient and animal models. Expert Review of Neurotherapeutics. 2021;21(11):1241-50.
  34. Alavi K, Shirazi E, Akbari M, Shahrivar Z, Noori F-S, Shirazi S. Effects of piracetam as an adjuvant therapy on Attention-Deficit/Hyperactivity Disorder: A randomized, double-blind, placebo-controlled trial. Iranian Journal of Psychiatry and Behavioral Sciences. 2021;15(2).
  35. Naik RA, Rawat D, Ahi JD, Koiri RK. Ameliorative effect of piracetam on emamectin benzoate induced perturbations in the activity of lactate dehydrogenase in murine system. Advances in Redox Research. 2021;3:100019.
  36. Malík M, Tlustoš P. Nootropics as cognitive enhancers: types, dosage and side effects of smart drugs. Nutrients. 2022;14(16):3367.
  37. Malykh AG, Sadaie MR. Piracetam and piracetam-like drugs. Drugs. 2010;70(3):287-312.
  38. Lou S, Cui S. Drug Treatment of Epilepsy: From Serendipitous Discovery to Evolutionary Mechanisms. Current Medicinal Chemistry. 2022;29(19):3366-91.
  39. Tortiglione A, Minale M, Pignataro G, Amoroso S, DiRenzo G, Annunziato L. The 2-oxopyrrolidinacetamide piracetam reduces infarct brain volume induced by permanent middle cerebral artery occlusion in male rats. Neuropharmacology. 2002;43(3):427-33.
  40. Łukawski K, Czuczwar SJ. Oxidative Stress and Neurodegeneration in Animal Models of Seizures and Epilepsy. Antioxidants. 2023;12(5):1049.
  41. Sheref A, Naguib Y, Abouelnour E, Salem H, Hassan M, Abdel-Razek H. Neuroprotective Effect of Piracetam and Vincamine in a Rat Model of Haloperidol-induced Parkinson's Disease. Bulletin of Egyptian Society for Physiological Sciences. 2022;42(1):11-26.
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