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Khdhir, Chrakhan, Raouf, Chro, shakor, Jamal, Mohammed, Saman, Karim, Dyar, Muhammd, Shagul, Salih, Mohsin. (1403). Effect of Beta Vulgaris and Laurus Nobitis on Lipid Profile and Kidney in Hyperuricemia Rat. سامانه مدیریت نشریات علمی, 79(5), 1005-1012. doi: 10.32592/ARI.2024.79.5.1005
Chrakhan J Khdhir; Chro Ghafoor Raouf; Jamal shakor; Saman H Mohammed; Dyar Hamid Karim; Shagul Jalal Muhammd; Mohsin Ahmed Salih. "Effect of Beta Vulgaris and Laurus Nobitis on Lipid Profile and Kidney in Hyperuricemia Rat". سامانه مدیریت نشریات علمی, 79, 5, 1403, 1005-1012. doi: 10.32592/ARI.2024.79.5.1005
Khdhir, Chrakhan, Raouf, Chro, shakor, Jamal, Mohammed, Saman, Karim, Dyar, Muhammd, Shagul, Salih, Mohsin. (1403). 'Effect of Beta Vulgaris and Laurus Nobitis on Lipid Profile and Kidney in Hyperuricemia Rat', سامانه مدیریت نشریات علمی, 79(5), pp. 1005-1012. doi: 10.32592/ARI.2024.79.5.1005
Khdhir, Chrakhan, Raouf, Chro, shakor, Jamal, Mohammed, Saman, Karim, Dyar, Muhammd, Shagul, Salih, Mohsin. Effect of Beta Vulgaris and Laurus Nobitis on Lipid Profile and Kidney in Hyperuricemia Rat. سامانه مدیریت نشریات علمی, 1403; 79(5): 1005-1012. doi: 10.32592/ARI.2024.79.5.1005

Effect of Beta Vulgaris and Laurus Nobitis on Lipid Profile and Kidney in Hyperuricemia Rat

Archives of Razi Institute
مقاله 17، دوره 79، شماره 5، آذر و دی 2024، صفحه 1005-1012    اصل مقاله (629.15 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.32592/ARI.2024.79.5.1005
نویسندگان
Chrakhan J Khdhir1؛ Chro Ghafoor Raouf2؛ Jamal shakor* 3؛ Saman H Mohammed3؛ Dyar Hamid Karim4؛ Shagul Jalal Muhammd5؛ Mohsin Ahmed Salih6
1College of nursing, University of Human Development, Sulaimani, KRG, Iraq
2College of Health science, University of Human Development, Sulaimani, KGR, Iraq
3Nursing Department, Darbandikhan Technical Institute, Sulaimani Polytechnic University, Sulaimani, KGR, Iraq
4department of biology, college of science, University of Sulaimani, Sulaimani, KRG, Iraq
5Department of animal science, college of agriculture engineering science, University of Sulaimani, Sulaimani, KRG, Iraq
6Department of nursing, college of health and medical technology, Sulaimani Polytechnic University, Sulaimani, KGR, Iraq
چکیده
Abstract
Background: Hyperuricemia is considered the main cause of many chronic and metabolic diseases. Hyperuricemia causes hyperlipidemia, increased serum creatinine, hyperglycemia, and weight gain through different pathways and mechanisms. The aim of this study was to investigate the effect of Beta vulgaris and Laurus nobilis on reducing the risk of hyperuricemia in developing metabolic disorders and kidney damage in a rat model. Methods: Twenty-four adult male albino rats of about 200–220 g body weight and 8–12 weeks old were kept in the animal house. The hyperuricemia rats, model group were given oxonic acid (250 mg/kg/bw). Treatment groups were administered either Beta vulgaris or Laurus nobilis after induced hyperuricemia. Histopathological examination of kidney tissue and biochemical tests were done for all groups of rats. Results: Except for HDL, all biochemical parameters, including cholesterol (49.00±6.48), triglyceride (47.25±2.22), LDL (34.50±3.11), uric acid (4.90±0.22), urea (46.00±0.82), creatinine (0.35±0.03), blood sugar (193.00±11.20), and weight gain (77.75±2.06), were significantly decreased in the rats administered Laurus nobilis and Beta vulgaris treatments compared to hyperuricemia model rat (P. value ≤0.01). Nephron structure in Beta vulgaris and Laurus nobilis rat was less damaged. Conclusion: This study found hyperuricemia induces kidney damage and several metabolic disorders such as dyslipidemia, hyperglycemia, increased serum creatinine and urea, and weight gain in model rats. Beta vulgaris and Laurus nobilis decrease the biochemical parameters, and ameliorate the histopathological effects of hyperuricemia, such as atrophy of glomeruli and hydropic changes in the epithelial lining of proximal convoluted tubules. Laurus nobilis physiologically has a greater effect on lipid profile, blood glucose, serum creatinine, weight, and urea compared to Beta vulgaris.
کلیدواژه‌ها
Hyperuricemia؛ Metabolic disorder؛ Beta vulgaris؛ Laurus nobilis؛ Kidney damage
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مراجع
  1. Yang W, Ma Y, Hou Y, Wang Y GY C. Prevalence of Hyperuricemia and its Correlation with Serum Lipids and Blood Glucose in Physical Examination Population in 2015-2018: a Retrospective Study. Clin lab. 2019;1(65):8.
  2. Gherghina M, Peride I, Tiglis M, Neagu TP, Niculae A, Checherita IA. Uric Acid and Oxidative Stress — Relationship with Cardiovascular , Metabolic , and Renal Impairment. 2022; 23(6), 3188
  3. Wu M, Ma Y, Chen X, Liang N, Qu S, Chen H. Hyperuricemia causes kidney damage by promoting autophagy and NLRP3-mediated inflammation in rats with urate oxidase deficiency. 2021;1–9.
  4. Suneja S, Kumawat R, Saxena R. Internet Journal of Medical Update Correlation between hyperuricemia and lipid profile in untreated dyslipidemic patients. 2018;13(1):3–9.
  5. Maiuolo J, Oppedisano F, Gratteri S, Muscoli C, Mollace V. Regulation of uric acid metabolism and excretion. 2016;213:8–14.
  6. El R, Tallima H. Physiological functions and pathogenic potential of uric acid : A review. J Adv Res. 2017;8(5):487–93.
  7. Yanai H, Adachi H, Hakoshima M, Katsuyama H. Molecular Biological and Clinical Understanding of the Pathophysiology and Treatments of Hyperuricemia and Its Association with Metabolic Syndrome , Cardiovascular Diseases and Chronic Kidney Disease. 2021;22(17), 9221
  8. Batchu U, Mandava K. Biochemical role of xanthine oxidoreductase and its natural inhibitors : an overview. 2016;8(10).
  9. Ali N, Rahman S, Islam S, Haque T, Molla NH, Sumon AH, et al. The relationship between serum uric acid and lipid profile in Bangladeshi adults. 2019;(19)1–8.
  10. Peng T, Wang C, Kao T, Chan JY, Yang Y, Chang Y, et al. Relationship between Hyperuricemia and Lipid Profiles in US Adults. 2015(1), 127596
  11. Kumar S, Banerjee A, Mahto M, Ranjan A. Evaluation of relationship between hyperuricemia and lipid profile. 2018;(June).4(6).
  12. Wulandari A, Dirgahayu P, Wiboworini B. Anti-hyperurisemic Activity of Combination of Beetroot Powder ( Beta vulgaris L) And Allopurinol in Potassium Oxonate-Induced White Rats. 2021;15(2):164–8.
  13. Spiegel M, Gamian A, Sroka Z. Antiradical Activity of Beetroot ( Beta vulgaris L.) Betalains. 2021;1–20.
  14. Article O. In vitro study of red beetroot ethanol extract ( Beta vulgaris L . ) as xanthine oxidase inhibitor. 2021;12(1):414–9.
  15. Review U, Universite CC, Orcid CA. Evaluation of Impact of Daily Laurus Nobilis Tea Consumption on the Lipid Profile and on the Increased Anti- Oxidant Activity In Healthy Volunteers. :1–16.
  16. Chbili C, Maoua M, Selmi M, Mrad S, Khairi H, Limem K, et al. Evaluation of Daily Laurus nobilis Tea Consumption on Lipid Profile Biomarkers in Healthy Volunteers Evaluation of Daily Laurus nobilis Tea Consumption on Lipid Profile Biomarkers in Healthy Volunteers. J Am Coll Nutr. 2020;0(0):1–6.
  17. Acqua SD, Cervellati R, Speroni E, Costa S, Uniti CS. Phytochemical Composition and Antioxidant Activity of Laurus nobilis L. Leaf Infusion. J Med food. 2009;12(4):869–76.
  18. Khdhir C, Hussein RH, Azeez HA. Effect of Cherry Extract and Almond Oil on Oxonic cid-Induced Hyperuricemia in Male Albino Rats. 2019;22(4):59–67.
  19. Irannejad A, Khatamsaaz S, Mokhtari MJ, Branch S, Branch K, Branch Z. Effect of Hydro-Alcoholic Extract of Rosemary on Lipid Profile and Liver Enzymes in Male Wistar Rats Fed with High-Fat Diet. 2022;may,1–21.
  20. Abbasi M, Katadj JK, Cheraghi J, Zendehdel M. Antihyperglycemic and antihyperlipidemic effects of hydroalcoholic extract of Ferulago angulta in experimental hyperlipidemic rats. Iran J Vet Med. 2021;15(2):208–20.
  21. Alp H, Aytekin I, Hatipoglu NK, Alp A, Ogun M. Effects of sulforophane and curcumin on oxidative stress created by acute malathion toxicity in rats. 2012 Jun 2;16.
  22. Lu W, Xu Y, Shao X, Gao F, Li Y, Hu J, et al. Uric Acid Produces an Inflammatory Response through Activation of NF- κ B in the Hypothalamus : Implications for the Pathogenesis of Metabolic Disorders. Nat Publ Gr. 2015;(June):1–15.
  23. Johnson RJ, Nakagawa T, Jalal D, Sánchez-lozada LG, Kang D, Ritz E. Full Reviews Uric acid and chronic kidney disease : which is chasing which ?. 2013;(March):2221–8.
  24. Wang H, Wang L, Xie R, Dai W, Gao C, Huang X, et al. Association of Serum Uric Acid with Body Mass Index : A Cross- Sectional Study from Jiangsu Province , China. 2014;43(11):1503–9.
  25. Bolea CA, Cantaragiu A, Andronoiu DG, Bahrim GE, Enachi E. Three Types of Beetroot Products Enriched with Lactic. 2020;9(6):786.
  26. Kundakovic T, Kovacevic N, Simic M. Preliminary assay on the antioxidative activity of Laurus nobilis extracts. 2003;74(03):613–6.
  27. Asgary S, Afshani M R, Sahebkar A, Keshvari M, Taheri M, Jahanian E, Rafieian-Kopaei M & NS. improvement of hypertension, endothelial function and systemic inflammation following short-term supplementation with red beet (Beta vulgaris L.) juice: a randomized crossover pilot study. J Hum Hypertens Vol. 2016;30:627–632.
  28. Bourebaba N, Kornicka-garbowska K, Marycz K. Mitochondrion Laurus nobilis ethanolic extract attenuates hyperglycemia and hyperinsulinemia-induced insulin resistance in HepG2 cell line through the reduction of oxidative stress and improvement of mitochondrial biogenesis – Possible implication in phar. Mitochondrion. 2021;59:190–213.
  29. Kaurinovic B, Popovic M, Vlaisavljevic S. In Vitro and in Vivo Effects of Laurus nobilis L. Leaf Extracts. 2010;3378–90.
  30. Amirpoor A, Zavar R, Amerizadeh A, Asgary S, Moradi S, Farzaei MH, et al. Effect of Beetroot Consumption on Serum Lipid Profile: A Systematic Review and Meta-Analysis. Curr Probl Cardiol. 2022;47(7):100887.
  31. Albasher G, Almeer R, Alarifi S, Alkhtani S, Farhood M, Al-otibi FO, et al. Nephroprotective Role of Beta vulgaris L . Root Extract against Chlorpyrifos-Induced Renal Injury in Rats. 2019(1):3595761.
  32. Fan S, Zhang P, Wang AY, Wang X, Wang L, Li G, et al. Hyperuricemia and its related histopathological features on renal biopsy. 2019 Dec;20:1-8.
  33. Rafaat R, Khalid A, Yener Z, Uyar A, Kawa A. Biomedical effects of Laurus nobilis L . leaf extract on vital organs in streptozotocin-induced diabetic rats : Experimental research. Ann Med Surg. 2021;61(November 2020):188–97.
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