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Mirzania, Foroogh, Salimikia, Iraj, Ghasemian Yadegari, Javad, Nazarzadeh, Alireza, Najmaddini, Hossein. (1403). Investigating the Effect of Acute and Subacute Toxicity of Ferula macrocolea (Boiss.) Boiss Essential Oil in BALB/c Mice. سامانه مدیریت نشریات علمی, 13(4), 1111-1117. doi: 10.22034/jmpb.2024.363350.1598
Foroogh Mirzania; Iraj Salimikia; Javad Ghasemian Yadegari; Alireza Nazarzadeh; Hossein Najmaddini. "Investigating the Effect of Acute and Subacute Toxicity of Ferula macrocolea (Boiss.) Boiss Essential Oil in BALB/c Mice". سامانه مدیریت نشریات علمی, 13, 4, 1403, 1111-1117. doi: 10.22034/jmpb.2024.363350.1598
Mirzania, Foroogh, Salimikia, Iraj, Ghasemian Yadegari, Javad, Nazarzadeh, Alireza, Najmaddini, Hossein. (1403). 'Investigating the Effect of Acute and Subacute Toxicity of Ferula macrocolea (Boiss.) Boiss Essential Oil in BALB/c Mice', سامانه مدیریت نشریات علمی, 13(4), pp. 1111-1117. doi: 10.22034/jmpb.2024.363350.1598
Mirzania, Foroogh, Salimikia, Iraj, Ghasemian Yadegari, Javad, Nazarzadeh, Alireza, Najmaddini, Hossein. Investigating the Effect of Acute and Subacute Toxicity of Ferula macrocolea (Boiss.) Boiss Essential Oil in BALB/c Mice. سامانه مدیریت نشریات علمی, 1403; 13(4): 1111-1117. doi: 10.22034/jmpb.2024.363350.1598

Investigating the Effect of Acute and Subacute Toxicity of Ferula macrocolea (Boiss.) Boiss Essential Oil in BALB/c Mice

Journal of Medicinal plants and By-products
مقاله 21، دوره 13، شماره 4، اسفند 2024، صفحه 1111-1117    اصل مقاله (928.44 K)
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22034/jmpb.2024.363350.1598
نویسندگان
Foroogh Mirzania* 1، 2؛ Iraj Salimikia* 2؛ Javad Ghasemian Yadegari2؛ Alireza Nazarzadeh3؛ Hossein Najmaddini3
1Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran
2Department of Pharmacognosy, Faculty of Pharmacy, Lorestan University of Medical Sciences, Khorramabad, Lorestan, Iran
3Faculty of Pharmacy, Lorestan University of Medical Sciences, Lorestan, Iran
چکیده
This research was conducted to evaluate the acute and subacute toxicity of Ferula macrocolea essential oil on blood and serum biochemical parameters in BALB/c mice. To determine acute toxicity, four groups of mice (each comprising 6 mice) received a single oral dose of 1.24 ml/kg of F. macrocolea essential oil. Subacute toxicity was assessed by examining vital organs such as the liver, kidneys, and blood parameters after administering doses (0.1, 0.2, 0.4, and 0.6 ml/kg) of the plant essential oil orally for 28 days. The results of acute toxicity studies, where a single dose of 1.24 ml/kg of plant essential oil was orally administered to the mice, were monitored for 28 days. The median lethal dose (LD50) of this compound was determined to be 1.79 ml/kg. In the study of acute toxicity, conducted with a dose of 1.24 ml/kg, no cases of animal death were observed. Additionally, in the study of subacute toxicity with doses of (0.1, 0.2, 0.4, and 0.6 ml/kg), no toxic effects on vital organs such as the liver and kidneys, as well as blood parameters, were observed. Finally, none of the blood parameters and histological characteristics of the studied organs were altered by the consumption of F. macrocolea essential oil. Therefore, it exhibits no significant toxicity and can be considered for potential effects on various diseases in future studies.
کلیدواژه‌ها
Ferula macrecolea (Boiss.) Boiss؛ Toxicity؛ Acute toxicity؛ Subacute toxicity؛ LD50
مراجع
  1. Tanaka N., Kashiwada Y. Phytochemical studies on traditional herbal medicines based on the ethnopharmacological information obtained by field studies. J. Nat. Med. 2021; 75:762-83.
  2. Zhu F. A review on the application of herbal medicines in the disease control of aquatic animals. Aquac. 2020; 526:735422-735431.
  3. Akinyemi O., Oyewole S.O., Jimoh K.A. Medicinal plants and sustainable human health: a review. Hortic. Int. J. 2018; 2(4):194-198.
  4. Bateman J., Chapman R.D., Simpson D. Possible toxicity of herbal remedies. Scott. Med. J. 1998; 43(1):7-15.
  5. Bamola N., Verma P., Negi C. A review on some traditional medicinal plants. Int. J. Life-sci. 2018; 4(1):1550-1556.
  6. Mirzania F, Farimani M.M. Biochemical evaluation of antioxidant activity, phenol and flavonoid contents of dracocephalum kotschyi boiss extracts obtained with different solvents. HBB. 2018; 1: 32-44.
  7. Jamshidi-Kia F., Lorigooini Z., Amini-Khoei H. Medicinal plants: Past history and future perspective. J. Herb. Med. Pharmacol. 2017; 7(1):1-7.
  8. Uchimiya M., Bannon D., Nakanishi H., McBride M.B., Williams M.A., Yoshihara T. Chemical speciation, plant uptake, and toxicity of heavy metals in agricultural soils. J. Agric. Food Chem. 2020; 68(46):12856-12869.
  9. Salimikia I., Mirzania F. A Review of Traditional Uses, Phytochemistry, and Pharmacology of Salvia chloroleuca Rech. f. & Aellen. Curr. Tradit. Med. 2022; 8(6):50-59.
  10. Macrì R., Musolino V., Gliozzi M., Carresi C., Maiuolo J., Nucera S., Scicchitano M., Bosco F., Scarano F., Ruga S., Zito M.C. Ferula L. Plant extracts and dose-dependent activity of natural sesquiterpene ferutinin: from antioxidant potential to cytotoxic effects. Molecules. 2020; 25(23):5768-5775.
  11. Ghasemi Z., Rezaee R., Aslani M.R., Boskabady M.H. Anti-inflammatory, anti-oxidant, and immunomodulatory activities of the genus Ferula and their constituents: A review. Iran. J. Basic Med. Sci. 2021; 24(12):1613-1622.
  12. Karimi A., Krahmer A., Herwig N., Hadian J., Schulz H., Meiners T. Metabolomics approaches for analyzing effects of geographic and environmental factors on the variation of root essential oils of Ferula assa-foetida L. J. Agric. Food Chem. 2020; 68(37):9940-9952.
  13. Panahi M., Rezaee M.B., Jaimand K. A review of phytochemistry and phylogeny that aid bio-prospecting in the traditional medicinal plant genus Ferula L. (Apiaceae) in Iran. J. Med. Plants By-Prod. 2020; 9(2):133-148.
  14. Hosseinzadeh N., Shomali T., Hosseinzadeh S., Raouf F. F., Jalaei J., Fazeli M. Cytotoxic activity of Ferula persica gum essential oil on murine colon carcinoma (CT26) and Vero cell lines. J. Essent. Oil Res. 2020; 32(2):169-177.
  15. Alyousif M.S., Al-Abodi H.R., Almohammed H., Alanazi A.D., Mahmoudvand H., Shalamzari M.H., Salimikia I. Chemical composition, apoptotic activity, and antiparasitic effects of Ferula macrecolea essential oil against Echinococcus granulosus protoscoleces. Molecules. 2021; 26(4):888-895.
  16. Baccari W., Znati M., Zardi-Bergaoui A., Chaieb I., Flamini G., Ascrizzi R., Jannet H.B. Composition and insecticide potential against Tribolium castaneum of the fractionated essential oil from the flowers of the Tunisian endemic plant Ferula tunetana Pomel ex Batt. Ind. Crops Prod. 2020; 143:111888-111899.
  17. Mirzania F., Moridi Farimani M., Sarrafi Y., Nejad Ebrahimi S., Troppmair J., Kwiatkowski M., Stuppner H., Alilou M. New Sesterterpenoids from Salvia mirzayanii Rech. f. and Esfand. Stereochemical Characterization by Computational Electronic Circular Dichroism. Front. Chem. 2022; 9:783292-783305.
  18. Sonboli A., Mirzania F., Aliahmadi A., Amiri M.S. Composition and antibacterial activity of the essential oil of Phlomidoschema parviflorum from Iran. Chem. Nat. Compd. 2015; 51:366-368.
    1. Akçay, Te calculation of LD50 using probit analysis. Te FASEB J., 2013; 27: 1217-1228.
  19. Hosseinzadeh H., Shakib S.S., Sameni A.K., Taghiabadi E. Acute and subacute toxicity of safranal, a constituent of saffron, in mice and rats. IJPR. 2013; 12(1):93-99.
  20. Ghorbani A., Mohebbati R., Jafarian A.H., Vahedi M.M., Hosseini S.M., Soukhtanloo M., Sadeghnia H.R. Toxicity evaluation of hydroalcoholic extract of Ferula gummosa root. RTP. 2016; 77:35-41.
  21. Venkatachalam U., Muthukrishnan S. Hepatoprotective activity of Desmodium gangeticum in paracetamol induced liver damage in rats. Biomed. Prev. Nutr. 2013; 3(3):273-277.
  22. Rustaiyan A., Nadimi M., Mazloomifar H., Massudi S. Composition of the essential oil of Ferula macrocolea (Boiss.) Boiss. from Iran. J. Essent. Oil Res. 2005; 17(1):55-56.
  23. Alyousif M.S., Al-Abodi H.R., Almohammed H., Alanazi A.D., Mahmoudvand H., Shalamzari M.H., Salimikia I. Chemical composition, apoptotic activity, and antiparasitic effects of Ferula macrecolea essential oil against Echinococcus granulosus protoscoleces. Molecules. 2021; 26(4):888-899.
  24. Mahmoudvand H., Yadegari J.G., Khalaf A.K., Hashemi M.J., Dastyarhaghighi S., Salimikia I. Chemical composition, antileishmanial, and cytotoxic effects Ferula macrecolea essential oil against Leishmania tropica. Parasite Epidemiol. Control. 2022; 19:e00270.
  25. Naderi M.A., Afkhami H., Ghaffarian F., Rahimi M., Sameni F., Khorshidi N., Akbari A. Investigation of Antibacterial Effect of Ferula macrocolea Extract and Quantity Determination of Inhibitory Effect on 4 Standard Strains of Gram Positive and Gram Negative Bacteria. PBP. 2022; 4(1):97-102.
  26. Goudah A., Abdo-El-Sooud K., Yousef M.A. Acute and subchronic toxicity assessment model of Ferula assa-foetida gum in rodents. Vet. World. 2015; 8(5):584-594.
  27. Fraigui O., Lamnaouer D., Faouzi M.Y., Cherrah Y., Tijjane M. Acute and chronic toxicity of fessoukh, the resinous gum of Ferula communis L, compared to warfarin. VHTOD. 2001; 43(6):327-330.
  28. Aragno M., Tagliapietra S., Nano G.M., Ugazio G. Experimental studies on the toxicity of Ferula communis in the rat. Res. Commun. Chem. Pathol. Pharmacol. 1988; 59(3):399-402.
  29. Vahedi M.M., Mahdian D., Jafarian A.H., Iranshahi M., Esmaeilizadeh M., Ghorbani A. Toxicity assessment of Ferula gummosa administration during pregnancy, lactation, and juvenile period in rat. Drug Chem. Toxicol. 2018; 41(2):199-205.
  30. Soleimani F.M., Mojab F., Arbabi B.S. Acute and subchronic toxicity assessment of aerial parts of Ferula persica in female mice. J. Med. Plant Res. 2019; 18(69): 47-58.
  31. Illuri R., Venkataramana S.H., Daguet D., Kodimule S. Sub-acute and acute toxicity of Ferula asafoetida and Silybum marianum formulation and effect of the formulation on delaying gastric emptying. BMC Complement Altern. Med. 2019; 19(1): 1-3.
  32. Mirzania F., Sonboli A. Chemical diversity of essential oil composition from five populations of Dracocephalum Kotschyi Boiss. HBB. 2021; 5(1):39-50.
  33. Ebrahimi S., Farimani M.M., Mirzania F., Hamburger M. New sesterterpenoids from Salvia mirzayanii-stereochemical characterization by computational electronic circular dichroism. Planta Med. 2013; 79(13):PG2.
  34. Keypour S., Mirzania F., Farimani M.M. Antioxidant activity, total flavonoid and phenolic contents of three different extracts of Hyrcanian reishi. Curr. Bioact. Compd. 2019; 15(1):109-113.
  35. Khorshidi N., Rahimi M., Salimikia I. Application of aeration‐assisted homogeneous liquid–liquid microextraction procedure using Box-Behnken design for determination of curcumin by HPLC. J. Sep. Sci. 2020; 43(13):2513-2520.
  36. Mahmoudi R., Kosari M., Barati S. Phytochemical and biological properties of Ferula sharifi essential oil. JBAPN. 2013; 3(5-6):331-338.
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