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Torkian, Fatemeh, Saadati, Fariba, kheiry, Azizollah, Zamani, Abbasali. (1403). Importance of Opium Alkaloids of Papaveraceae Family in Iran. سامانه مدیریت نشریات علمی, 14(1), 98-104. doi: 10.22034/jmpb.2024.364461.1640
Fatemeh Torkian; Fariba Saadati; Azizollah kheiry; Abbasali Zamani. "Importance of Opium Alkaloids of Papaveraceae Family in Iran". سامانه مدیریت نشریات علمی, 14, 1, 1403, 98-104. doi: 10.22034/jmpb.2024.364461.1640
Torkian, Fatemeh, Saadati, Fariba, kheiry, Azizollah, Zamani, Abbasali. (1403). 'Importance of Opium Alkaloids of Papaveraceae Family in Iran', سامانه مدیریت نشریات علمی, 14(1), pp. 98-104. doi: 10.22034/jmpb.2024.364461.1640
Torkian, Fatemeh, Saadati, Fariba, kheiry, Azizollah, Zamani, Abbasali. Importance of Opium Alkaloids of Papaveraceae Family in Iran. سامانه مدیریت نشریات علمی, 1403; 14(1): 98-104. doi: 10.22034/jmpb.2024.364461.1640

Importance of Opium Alkaloids of Papaveraceae Family in Iran

Journal of Medicinal plants and By-products
مقاله 13، دوره 14، شماره 1، فروردین و اردیبهشت 2025، صفحه 98-104    اصل مقاله (1 M)
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22034/jmpb.2024.364461.1640
نویسندگان
Fatemeh Torkian* 1؛ Fariba Saadati1؛ Azizollah kheiry2؛ Abbasali Zamani3
1Department of Chemistry, Zanjan University, Zanjan, Iran
2Department of Horticultural Sciences, Zanjan University, Zanjan, Iran
3Department of Environmental Sciences, Zanjan University, Zanjan, Iran
چکیده
The Papaveraceae family comprises more than 40 genera and 760 species. Papaver alkaloids have significant therapeutic importance in the treatment of various diseases and exhibit some antimicrobial properties. These alkaloids have been used in cancer medicine, cough, and hypertension. The main goal of this study is to determine the amounts of various alkaloids in samples collected from different regions of Iran. The findings of this research could provide valuable insights for the pharmaceutical industry. Two grams of dried and powdered plant material were extracted with 30 ml chloroform and 15 ml of 99% acetic acid for 30 minutes under sonication. The change in the pH of the sample was revealed by 10 through gradually adding ammonia. The mobile phases consisted of phosphoric acid and acetonitrile. The analysis of the Papaveraceae family in Iran was performed using high-performance liquid chromatography-ultraviolet detection. This paper focuses on the Papaver alkaloids (noscapine, morphine, thebaine, papaverine, and codeine) found in three species of Papaver and four species of Glaucium. The maximum contents of noscapine (21.02 mg/kg DW), morphine (34.51 mg/kg DW), thebaine (6.96 mg/kg DW), papaverine (103.76 mg/kg DW), and codeine (3.63 mg/kg DW) were reported in Papaver rhoeas L., Papaver fugax Poir and., Glaucium oxylobum Boiss. & Buhse, respectively.
کلیدواژه‌ها
Noscapine؛ Morphine؛ Thebaine؛ Papaverine؛ Codeine؛ Pharmaceutical industries
مراجع
  1. Langlois A., Mulholland D.A., Crouch N.R., Grace O.M. Aporphine alkaloid from Papaver aculeatum (sect. Horrida; Papaveraceae) of southern Africa. Biochem. Syst. Ecol. 2004; 32, 1087–1990.
  2. Yu X., Gao X., Zhu Z., Cao Y., Zhang Q., Tu P, Chai X. Alkaloids from the tribe Bocconieae (Papaveraceae): a chemical and biological review. Molecules 2014; 19.
  3. Roberts M.F., Wink M. Alkaloids biochemistry, ecology, and medicinal application Plenum Press New York and London. 1998.
  4. Alves De Almeida A.C., De-Faria F.M., Dunder R.J., Manzo L.P.B., Souza-Brito A.R.M., Luiz-Ferreira A. Recent trends in pharmacological activity of alkaloids in animal colitis: potential use for inflammatory bowel disease. Evid-based Complement. Altern. Med. 2017; 8528210.
  5. Pienkny S., Brandt W., Schmidt J., Kramell R., Ziegler J. Functional characterization of a novel benzylisoquinoline O-methyltransferase suggests its involvement in papaverine biosynthesis in opium poppy (Papaver somniferum L.). Plant J. 2009; 60, 56–67.
  6. Lal R.K., Gupta V., Gupta P., Sarkar S., Singh S. Genetics and inheritance pattern of heterosis in impact of genetic divergence in opium poppy (Papaver somniferum L.). J. Herbs Spices Med. Plants. 2014; 20: 70–82.
  7. Stranska I., Skalicky M., Novak, J., Matyasova E., Hejnak V. Analysis of selected poppy (Papaver somniferum L.) cultivars: Pharmaceutically important alkaloids. Ind. Crop. Prod. 2013; 41: 120–126.
  8. Verma N., Jena S.N., Shukla S., Yadav K. Genetic diversity, population structure and marker trait associations for alkaloid content and licit opium yield in India-wide collection of poppy (Papaver somniferum L.). Plant Gene 2016; 7: 26–41.
  9. Yadav H.K., Shukla S., Singh S.P. Genetic variability and interrelationship among opium and its alkaloids in opium poppy (Papaver somniferum L.). Euphytica 2006; 150: 207–214.
  10. Lalezari I., Nasseri P., Asgharian R. Papaver bracteatum lindl: population arya II. J. Pharm. Sci. 1974; 63: 1331.
  11. Bulduk I., Taktak F. Isolation and characterization of antitumor alkaloid from poppy capsules (Papaver somniferum), J. Chem. 2013; 1-4.
  12. Lošák T., Hlusek J., Popp T. Potassium sulphate and potassium chloride in the nutrition of poppy (Papaver somniferum L.) in relation to nitrogen supply E-IFC. 2009; 19.
  13. Hazum E., Sabatka J.J., Chang K.J., Brent D.A., Findlay J.W.A., Cuatrecasas P. Morphine in cow and human milk: Could dietary morphine constitute a ligand for specific morphine (mu) receptors? Science 1981; 213: 1010-1012.
  14. Hosztafi S., Furst Z. Endogenous morphine. Pharm. Res. 1995;32: 15-20.
  15. Novak V., Dolejs L., Slavik J. Alkaloids of the Papaveraceae. XLVIII. (-)-Stylopine methohydroxide, a new alkaloid from Glaucium corniculatum CURT. Collect. Czezh. Chem. Commun. 1972; 37(10): 3346.
  16. Facchini P.J., Hagel J.M., Liscombe D.K., Loukanina N., MacLeod B.P., Samanani N., Zulak K.G. Opium poppy: blueprint for an alkaloid factory. Phytochem. Rev. 2007; 6: 97–124.17.
  17. Yang L., Wen K.S., Ruan X., Zhao Y.X., Wei F., Wang Q. Response of plant secondary metabolites to environmental factors. Molecules 2018; 27 (4): 23.
  18. Bernath J., Tetenyi P. The Effect of environmental factors on growth. Development and alkaloid production of Poppy (Papaver somniferum L.): I. Responses to day-length and light intensity. Biochem. Physiol. Pflanz. 1979; 174: 468–478.
  19. Barlog P.K. Effect of magnesium and nitrogenous fertilisers on the growth and alkaloid content in Lupinus angustifolius L. Aust. J. Agric. Res. 2002; 53: 671–676.
  20. Gurkok T., Ozhuner E., Parmaksiz I., Ozcan S., Turktas M., İpek A., Demirtas I., Okay S., Unver T. Functional Characterization of 4′OMT and 7OMT Genes in BIA Biosynthesis. Front. Plant Sci. 2016; 16 (7): 98.
  21. Turhede B.B., R. De, Singh R.K., Indian J. Agric. Sci. 1981; 51(2): 102-107.
  22. Shaghaghi A., Alirezalu A., Nazarianpour E., Sonboli A., Nejad-Ebrahimi S. Opioid alkaloids profiling and antioxidant capacity of Papaver species from Iran. Ind. Crops Prod. 2019; 142: 111870.
  23. Karajibani M., Montazerifar F., Feizabad A.K. Study of oxidants and antioxidants in addicts. Int. J. High Risk Behav. Addict. 2016; 101: 657–660.
  24. Materska M., Perucka I. Antioxidant activity of the main phenolic compounds isolated from hot pepper fruit (Capsicum annuum L.). J. Agric. Food Chem. 2005; 53: 1750–1756.
  25. Belyagoubi-Benhammou N., Belyagoubi L., Gismondi A., Di Marco G., Canini A., Atik Bekkara F. GC/MS analysis, and antioxidant and antimicrobial activities of alkaloids extracted by polar and apolar solvents from the stems of Anabasis articulata. Med. Chem. Res. 2019; 28: 754–767.
  26. Alagoz Y., Gurkok T., Zhang B., Unver T. Manipulating the biosynthesis of bioactive compound alkaloids for next-generation metabolic engineering in opium poppy using CRISPR-Cas 9 genome editing technology. Sci. Rep. 2016; 6, 30910.
  27. Hosseini B. Overexpression of sat and cor genes in Papaver somniferum. PhD thesis, Ferdowsi University of Mashhad, Iran. 48. Hosseini B. Overexpression of sat and cor genes in Papaver somniferum. PhD thesis, Ferdowsi University of Mashhad, Iran. 2009.
  28. Kaya N., Lockwood B. A Study of the alkaloids in callusing plant tissues from a range of Turkish cultivars of Papaver somniferum. Tr. J. Agric. Forest. 1999; 23: 377-381.
  29. Chitty J.A., Allen R.S., Fist A.J., Larkin P.J. Genetic transformation in commercial Tasmanian cultivars of opium poppy, Papaver somniferum, and movement of transgenic pollen in the field. Func. Plant Biol. 2003; 30: 1045-1058.
  30. Chauhan S.P., Patra N.K., Srivastava N.K. Dwarf mutant of Papaver somniferum with high morphine content. Mutation Breeding Newsl. 1987; 30: 6-31.
  31. Memelink J. Putting the opium in poppy to sleep. Nat. Biotechnol. 2004; 22: 1526-1527.
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