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Lotfaliani, Mohamad Reza, Emami, Azadeh, Moazzen, Hamid Reza, Tavakoli, Fatemeh, Zarei, Mahtab. (1403). Anti-aging Effects and Chemical Composition of Dorema ammoniacum Gum Essence and Lonicera caprifolium Extract. سامانه مدیریت نشریات علمی, 13(Special), 780-790. doi: 10.22034/jmpb.2023.364088.1626
Mohamad Reza Lotfaliani; Azadeh Emami; Hamid Reza Moazzen; Fatemeh Tavakoli; Mahtab Zarei. "Anti-aging Effects and Chemical Composition of Dorema ammoniacum Gum Essence and Lonicera caprifolium Extract". سامانه مدیریت نشریات علمی, 13, Special, 1403, 780-790. doi: 10.22034/jmpb.2023.364088.1626
Lotfaliani, Mohamad Reza, Emami, Azadeh, Moazzen, Hamid Reza, Tavakoli, Fatemeh, Zarei, Mahtab. (1403). 'Anti-aging Effects and Chemical Composition of Dorema ammoniacum Gum Essence and Lonicera caprifolium Extract', سامانه مدیریت نشریات علمی, 13(Special), pp. 780-790. doi: 10.22034/jmpb.2023.364088.1626
Lotfaliani, Mohamad Reza, Emami, Azadeh, Moazzen, Hamid Reza, Tavakoli, Fatemeh, Zarei, Mahtab. Anti-aging Effects and Chemical Composition of Dorema ammoniacum Gum Essence and Lonicera caprifolium Extract. سامانه مدیریت نشریات علمی, 1403; 13(Special): 780-790. doi: 10.22034/jmpb.2023.364088.1626

Anti-aging Effects and Chemical Composition of Dorema ammoniacum Gum Essence and Lonicera caprifolium Extract

Journal of Medicinal plants and By-products
مقاله 7، دوره 13، Special، بهمن 2024، صفحه 780-790    اصل مقاله (1.09 M)
نوع مقاله: Research Article
شناسه دیجیتال (DOI): 10.22034/jmpb.2023.364088.1626
نویسندگان
Mohamad Reza Lotfaliani1، 2؛ Azadeh Emami3؛ Hamid Reza Moazzen4؛ Fatemeh Tavakoli* 2، 4؛ Mahtab Zarei5
1Department of Pharmacognosy, Faculty of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
2Traditional Pharmacy and Pharmaceutical Sciences Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
3Department of Pharmaceutics, Faculty of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
4Department of Toxicology and Pharmacology, Faculty of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
5Avicenna Infertility Clinic, Avicenna Research Institute, ACECR, Tehran, Iran
چکیده
The aging process is a multifactorial phenomenon that results from various diseases and abnormalities in living systems. Oxidative stress is a critical factor in aging, and it accelerates the aging process through different mechanisms. This study aims to explore the potential anti-aging effects of Dorema ammoniacum D.Don gum essence and Lonicera caprifolium L. plant extract in slowing down the aging process by using the antioxidant properties of these plants. Following preparation, the plants underwent analysis to identify their compounds. 42 male mice aged between 6-8 weeks and weighing 22-30 grams were divided into seven groups of six and treated by gavage for six weeks. The control group received sesame oil and DMSO 10%, which were the solvents, D-galactose (500 mg/kg/day), Vitamin E (200 mg/kg/day), and D-galactose with E. The other groups received D. ammoniacum gum essence (200 mg/kg/day) and L. caprifolium extract (200 mg/kg/day) and their combination. At the end of the treatment, the researchers measured the oxidative stress parameters such as malondialdehyde (MDA) level and glutathione content (GSH), catalase (CAT), and superoxide dismutase (SOD) activities, as well as sex hormones levels including testosterone and dehydroepiandrosterone sulfate (DHEA-S) and pro-inflammatory markers such as tumor necrosis factor-alpha (TNF-α) and Interleukin-1 beta (IL-1β) in serum by ELISA. The use of D-galactose with a concentration of 500 mg/kg in 42 days induced aging. However, the group treated with D. ammoniacum gum essence alone or in combination with L. caprifolium extract showed a significant reduction in lipid peroxidation (P< 0.05) and a significant increase in catalase enzyme activity (P< 0.05). The group treated with the combination of these two plants also showed a significant increase in glutathione content (P<0.05). These plants are rich sources of antioxidant compounds and could potentially improve the aging process induced by D-galactose.
کلیدواژه‌ها
D. ammoniacum gum؛ L.caprifolium؛ D-galactose؛ Anti-Aging؛ Antioxidant
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