اخبار و اعلانات

 آمار

تعداد نشریات282
تعداد نشریات سازمان80
تعداد شماره‌ها3,219
تعداد مقالات35,690
تعداد مشاهده مقاله53,562,479
تعداد دریافت فایل اصل مقاله92,842,720
Lotfaliani, Mohamad Reza, Emami, Azadeh, Moazzen, Hamid Reza, Tavakoli, Fatemeh, Zarei, Mahtab. (1403). Anti-aging Effects and Chemical Composition of Dorema ammoniacum Gum Essence and Lonicera caprifolium Extract. سامانه مدیریت نشریات علمی, 13(Special), 780-790. doi: 10.22034/jmpb.2023.364088.1626
Mohamad Reza Lotfaliani; Azadeh Emami; Hamid Reza Moazzen; Fatemeh Tavakoli; Mahtab Zarei. "Anti-aging Effects and Chemical Composition of Dorema ammoniacum Gum Essence and Lonicera caprifolium Extract". سامانه مدیریت نشریات علمی, 13, Special, 1403, 780-790. doi: 10.22034/jmpb.2023.364088.1626
Lotfaliani, Mohamad Reza, Emami, Azadeh, Moazzen, Hamid Reza, Tavakoli, Fatemeh, Zarei, Mahtab. (1403). 'Anti-aging Effects and Chemical Composition of Dorema ammoniacum Gum Essence and Lonicera caprifolium Extract', سامانه مدیریت نشریات علمی, 13(Special), pp. 780-790. doi: 10.22034/jmpb.2023.364088.1626
Lotfaliani, Mohamad Reza, Emami, Azadeh, Moazzen, Hamid Reza, Tavakoli, Fatemeh, Zarei, Mahtab. Anti-aging Effects and Chemical Composition of Dorema ammoniacum Gum Essence and Lonicera caprifolium Extract. سامانه مدیریت نشریات علمی, 1403; 13(Special): 780-790. doi: 10.22034/jmpb.2023.364088.1626

Anti-aging Effects and Chemical Composition of Dorema ammoniacum Gum Essence and Lonicera caprifolium Extract

Journal of Medicinal plants and By-products
مقاله 7، دوره 13، Special، بهمن 2024، صفحه 780-790    اصل مقاله (1.09 M)
نوع مقاله: Research Article
شناسه دیجیتال (DOI): 10.22034/jmpb.2023.364088.1626
نویسندگان
Mohamad Reza Lotfaliani1، 2؛ Azadeh Emami3؛ Hamid Reza Moazzen4؛ Fatemeh Tavakoli* 2، 4؛ Mahtab Zarei5
1Department of Pharmacognosy, Faculty of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
2Traditional Pharmacy and Pharmaceutical Sciences Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
3Department of Pharmaceutics, Faculty of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
4Department of Toxicology and Pharmacology, Faculty of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
5Avicenna Infertility Clinic, Avicenna Research Institute, ACECR, Tehran, Iran
چکیده
The aging process is a multifactorial phenomenon that results from various diseases and abnormalities in living systems. Oxidative stress is a critical factor in aging, and it accelerates the aging process through different mechanisms. This study aims to explore the potential anti-aging effects of Dorema ammoniacum D.Don gum essence and Lonicera caprifolium L. plant extract in slowing down the aging process by using the antioxidant properties of these plants. Following preparation, the plants underwent analysis to identify their compounds. 42 male mice aged between 6-8 weeks and weighing 22-30 grams were divided into seven groups of six and treated by gavage for six weeks. The control group received sesame oil and DMSO 10%, which were the solvents, D-galactose (500 mg/kg/day), Vitamin E (200 mg/kg/day), and D-galactose with E. The other groups received D. ammoniacum gum essence (200 mg/kg/day) and L. caprifolium extract (200 mg/kg/day) and their combination. At the end of the treatment, the researchers measured the oxidative stress parameters such as malondialdehyde (MDA) level and glutathione content (GSH), catalase (CAT), and superoxide dismutase (SOD) activities, as well as sex hormones levels including testosterone and dehydroepiandrosterone sulfate (DHEA-S) and pro-inflammatory markers such as tumor necrosis factor-alpha (TNF-α) and Interleukin-1 beta (IL-1β) in serum by ELISA. The use of D-galactose with a concentration of 500 mg/kg in 42 days induced aging. However, the group treated with D. ammoniacum gum essence alone or in combination with L. caprifolium extract showed a significant reduction in lipid peroxidation (P< 0.05) and a significant increase in catalase enzyme activity (P< 0.05). The group treated with the combination of these two plants also showed a significant increase in glutathione content (P<0.05). These plants are rich sources of antioxidant compounds and could potentially improve the aging process induced by D-galactose.
کلیدواژه‌ها
D. ammoniacum gum؛ L.caprifolium؛ D-galactose؛ Anti-Aging؛ Antioxidant
مراجع
  1. Momtaz S., Abdollahi M. A Comprehensive Review of Biochemical and Molecular Evidences from Animal and Human Studies on the Role of Oxidative Stress in Aging: An Epiphenomenon or the Cause. Asian J. Anim. Vet. Adv. 2012;7:1-19.
  2. Ghanbari S., Yonessi M., Mohammadirad A., Gholami M., Baeeri M., Khorram-Khorshid H.R., Gharibdoost F., Abdollahi M. Effects of IMOD™ and Angipars™ on mouse D-galactose-induced model of aging. Daru. 2012 ;20(1):68.
  3. Mohseni Salehi Monfared S.S., Larijani B., Abdollahi M. Islet transplantation and antioxidant management: a comprehensive review. World J Gastroenterol. 2009;15(10):1153-61.
  4. Abizadeh M., Hosseinmardi N., Ebrahimi S., Janahmadi M., Shojaii A., Motamedi F. The effect of Dorema ammoniacum pretreatment on the progression of seizures induced by chemical kindling in rats. Pajoohande. 2014;19(5):228-34.
  5. Mobeen A., Siddiqui M.A., Quamri M.A., Itrat M., Imran Khan M.D. Therapeutic potential of Ushaq (Dorema ammoniacum D. Don): A unique drug of Unani medicine. Int. J. Unani Integr. Medicine. 2018; 2(1): 11-16.
  6. Delnavazi1 M.R., Tavakoli S., Rustaie A., Batooli H., Yassa N. Antioxidant and antibacterial activities of the essential oils and extracts of Dorema ammoniacum roots and aerial parts. Res. J. Pharmacogn. 2014;1(4): 11-18.
  7. Jahani R., Khoramjouy M., Nasiri A., Sojoodi Moghaddam M., Asgharzadeh Salteh Y., Faizi M. Neuro-Behavioral Profile and Toxicity of the Essential Oil of Dorema ammoniacum Gum as an Anti-seizure, Anti-nociceptive, and Hypnotic Agent with Memory-enhancing Properties in D-galactose Induced Aging Mice. Iran J Pharm Res. 2020;19(3):110-121.
  8. Pandpazir M., Kiani A., Fakhri S., Mousavi Z. Anti-Inflammatory Effect and Skin Toxicity of Aqueous Extract of Dorema ammoniacum Gum in Experimental Animals. Res. J. Pharmacogn. 2018; 5(4): 1-8.
  9. Jalili S., Hamdi S.M.M., Oraghiardebili Z. Anatomical characteristics of the leaves and stems of 9 species of the genus Lonicera from Caprifoliaceae family in Iran. J Plant Res. (Iranian J. Biology). 2017; 29(4):751-65.
  10. Ilie D., Radulescu V., Dutu L. Volatile constituents from the flowers of two species of honeysuckle (Lonicera japonica and Lonicera caprifolium). Farmacia. 2014;62(1):194-201.
  11. Herman A., Herman A.P., Domagalska B.W., Młynarczyk A. Essential Oils and Herbal Extracts as Antimicrobial Agents in Cosmetic Emulsion. Indian J. Microbiol. 2013; 53:232–237.
  12. Bo-Htay C., Palee S., Apaijai N., Chattipakorn S.C., Chattipakorn N. Effects of d-galactose-induced ageing on the heart and its potential interventions. J. Cell. Mol. Med. 2018;22(3):1392-1410.
  13. Azman K.F., Zakaria R. D-Galactose-induced accelerated aging model: an overview. Biogerontology. 2019;20(6):763-782.
  14. Chandrasekaran A., Idelchik M.D.P.S., Melendez J.A. Redox control of senescence and age-related disease. Redox Biol. 2017;11:91-102.
  15. Brüünsgaard H., Pedersen B.K. Age-related inflammatory cytokines and disease. Immunol Allergy Clin North Am. 2003;23(1):15-39.
  16. Khan ST., Khan M., Ahmad J., Wahab R., Abd-Elkader OH., Musarrat J., Alkhathlan HZ., Al-Kedhairy AA. Thymol and carvacrol induce autolysis, stress, growth inhibition and reduce the biofilm formation by Streptococcus mutans. AMB Express. 2017;7(1):49.
  17. Mastelic J., Jerkovic I., Blazevic I., Poljak-Blazi M., Borovic S., Ivancic-Bace I., Smrecki V., Zarkovic N., Brcic-Kostic K., Vikic-Topic D., Mueller N.Comparative study on the antioxidant and biological activities of carvacrol, thymol, and eugenol derivatives. J Agr Food Chem. 2008; 56: 3989-3996.
  18. Güvenç M., Cellat M., Gökçek İ., Yavaş İ., Yurdagül Özsoy Ş. Effects of thymol and carvacrol on sperm quality and oxidant/antioxidant balance in rats. Arch Physiol Biochem. 2019;125(5):396-403.
  19. Xiao Y., Li B., Liu J., Ma X. Carvacrol ameliorates inflammatory response in interleukin 1β-stimulated human chondrocytes. Mol. Med. Rep. 2018; 17 (3): 3987-3992.
  20. Ozer E.K., Goktas M.T., Toker A., Bariskaner H., Ugurluoglu C., Iskit AB. Effects of Carvacrol on Survival, Mesenteric Blood Flow, Aortic Function and Multiple Organ Injury in a Murine Model of Polymicrobial Sepsis. Inflammation. 2017;40(5):1654-1663.
  21. Liang N., Kitts D.D. Role of Chlorogenic Acids in Controlling Oxidative and Inflammatory Stress Conditions. Nutrients. 2015;8(1):16.
  22. Kannan R.R.R., Arumugam R., Thangaradjou T., Anantharaman P. Phytochemical constituents, antioxidant properties and p-coumaric acid analysis in some seagrasses. Food Res Int. 2013;54(1):1229-36.
  23. Al-Dhabi N.A., Arasu M.V., Park CH., Park SU. An up-to-date review of rutin and its biological and pharmacological activities. EXCLI J. 2015;14: 59-63.
  24. Guan H., Luo W., Bao B., Cao Y., Cheng F., Yu S., Fan Q., Zhang L., Wu Q., Shan M. A Comprehensive Review of Rosmarinic Acid: From Phytochemistry to Pharmacology and Its New Insight. Molecules. 2022;27(10):3292.
  25. Shukla R., Pandey V., Vadnere G.P., Lodhi S. Role of Flavonoids in Management of Inflammatory Disorders. In: Watson RR, Preedy VR (eds.) Bioactive Food as Dietary Interventions for Arthritis and Related Inflammatory Diseases. 2end edition, Academic Press. 2019; 293-322.
  26. Venigalla M., Gyengesi E., Münch G. Curcumin and Apigenin - novel and promising therapeutics against chronic neuroinflammation in Alzheimer's disease. Neural Regen Res. 2015;10(8):1181-5.
  27. Kumar A., Prakash A., Dogra S. Protective effect of curcumin (Curcuma longa) against D-galactose-induced senescence in mice. J. Asian Nat. Prod. Res. 2011;13(1):42-55.
  28. Vaca C., Wilhelm J., Harms-Ringdahl M. Interaction of lipid peroxidation products with DNA. A review. Mutat Res Rev Genet Toxicol. 1988;195(2):137-49.
  29. Anand K.V., Anandhi R., Pakkiyaraj M., Geraldine P. Protective effect of chrysin on carbon tetrachloride (CCl4)-induced tissue injury in male Wistar rats. Toxicol. Ind. Health. 2011;27(10):923-33
  30. Veerappan R., Senthilkumar R. Chrysin enhances antioxidants and oxidative stress in L-NAME-induced hypertensive rats. Int J Nutr Pharmacol Neurol Dis. 2015; 5(1): 20-27.
  31. Pitti-Ferrandi H. DHEA et vieillissement [DHEA and aging]. Psychol Neuropsychiatr Vieil. 2003;1(2):111-9.
  32. Samaras N., Samaras D., Frangos E., Forster A., Philippe J. A review of age-related dehydroepiandrosterone decline and its association with well-known geriatric syndromes: is treatment beneficial? Rejuvenation Res. 2013;16(4):285-94.
  33. Mohammadi E., Mehri S., Badie Bostan H., Hosseinzadeh H. Protective effect of crocin against d-galactose-induced aging in mice. Avicenna J. Phytomed. 2018;8(1):14-23.
  34. Maggio M., Basaria S., Ceda G.P., Ble A., Ling S.M., Bandinelli S., Valenti G., Ferrucci L. The relationship between testosterone and molecular markers of inflammation in older men. J. Endocrinol. Invest. 2005;28(11):116-9.
  35. Badibostan H, Mehri S, Mohammadi E, Hosseinzadeh H. Protective effect of Thymoquinone on D-galactose-induced aging in mice. Jundishapur J. Nat. Pharm. Prod. 2019;14(1).
  36. Hadzi-Petrushev N, Stojkovski V, Mitrov D, Mladenov M. D-galactose induced inflammation lipid peroxidation and platelet activation in rats. Cytokine. 2014;69(1):150-3.
  37. Michaud M., Balardy L., Moulis G., Gaudin C., Peyrot C., Vellas B., Cesari M., Nourhashemi F. Proinflammatory cytokines, aging, and age-related diseases. J. Am. Med. Dir. Assoc. 2013;14(12):877-82.
  38. Umare V., Pradhan V., Nadkar M., Rajadhyaksha A., Patwardhan M., Ghosh K.K., Nadkarni A.H. Effect of proinflammatory cytokines (IL-6, TNF-α, and IL-1β) on clinical manifestations in Indian SLE patients. Mediators inflamm. 2014;2014: 385297.
آمار
تعداد مشاهده مقاله: 585
تعداد دریافت فایل اصل مقاله: 600


counter
سامانه مدیریت نشریات علمی. طراحی و پیاده سازی از سیناوب