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Banan Khojasteh, Seyed Mahdi, Javanmard Khameneh, Reihaneh. (1403). Sophora pachycarpa Root Extract has Ameliorative Effects on Testicular Injury but is Hepatotoxic in Carbon Tetrachloride Intoxicated Rats. سامانه مدیریت نشریات علمی, 13(2), 447-452. doi: 10.22034/jmpb.2023.361136.1522
Seyed Mahdi Banan Khojasteh; Reihaneh Javanmard Khameneh. "Sophora pachycarpa Root Extract has Ameliorative Effects on Testicular Injury but is Hepatotoxic in Carbon Tetrachloride Intoxicated Rats". سامانه مدیریت نشریات علمی, 13, 2, 1403, 447-452. doi: 10.22034/jmpb.2023.361136.1522
Banan Khojasteh, Seyed Mahdi, Javanmard Khameneh, Reihaneh. (1403). 'Sophora pachycarpa Root Extract has Ameliorative Effects on Testicular Injury but is Hepatotoxic in Carbon Tetrachloride Intoxicated Rats', سامانه مدیریت نشریات علمی, 13(2), pp. 447-452. doi: 10.22034/jmpb.2023.361136.1522
Banan Khojasteh, Seyed Mahdi, Javanmard Khameneh, Reihaneh. Sophora pachycarpa Root Extract has Ameliorative Effects on Testicular Injury but is Hepatotoxic in Carbon Tetrachloride Intoxicated Rats. سامانه مدیریت نشریات علمی, 1403; 13(2): 447-452. doi: 10.22034/jmpb.2023.361136.1522

Sophora pachycarpa Root Extract has Ameliorative Effects on Testicular Injury but is Hepatotoxic in Carbon Tetrachloride Intoxicated Rats

Journal of Medicinal plants and By-products
مقاله 19، دوره 13، شماره 2، شهریور 2024، صفحه 447-452    اصل مقاله (1.02 M)
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22034/jmpb.2023.361136.1522
نویسندگان
Seyed Mahdi Banan Khojasteh1؛ Reihaneh Javanmard Khameneh* 2
1Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran
2Department of Biology, Faculty of Sciences, University of Urmia, Urmia, Iran
چکیده
Background: Carbon tetrachloride (CCl4) causes damages to the testicles, liver, kidneys, lungs and brain. In the present study, we investigated protective effects of Sophora pachycarpa Schrenk ex C.A.Mey. root extract on testicular damage, liver histopathology and sex hormone levels in CCl4 intoxicated male rats.
Methods: In present study the rats were divided into 6 experimental groups (n=6): 3 groups as pre-treatment groups that received doses of 50, 100 and 250 mg/kg/days of S. pachycarpa extract respectively by gavage for 21 days before intraperitoneal injection of 500µl/kg CCl4. CCl4 group received 500µl/kg CCl4 on the day of 21. Post-treatment group received 100 mg/kg/day S. pachycarpa for 10 days and 12h after injection of 250 µl/kg CCl4. Control group received 1ml distilled water for 21 days. Liver and testis tissues were sampled for microscopic examination and sex hormone levels in the serum were evaluated.
Results: Treatment of S. pachycarpa root extract (250 mg/kg) lead to a considerable improvement in the histopathological changes caused by CCl4 in the testis. However, the extract (250 mg/kg) caused inflammation and adverse tissue effects in liver. Serum levels of hormones also increased significantly in pre-treatment groups.
Conclusion: Based on the results, the S. pachycarpa extract can improve the changes caused by CCl4 in the testis and sex hormones levels. But its higher doses can cause adverse effects in liver tissue. 
کلیدواژه‌ها
Carbon tetrachloride؛ Sophora pachycarpa root extract؛ Liver؛ Testis
مراجع
  1. Bahashwan S., et al. cronic mitigates carbon tetrachloride-induced liver toxicity in rats. J. Taibah University Medical Sci. 2015; 140-149.
  2. Al Amin A., Menezes R.G. Carbon tetrachloride toxicity. StatPearls. 2020.
  3. Torres-González L., Muñoz-Espinosa L.E., Rivas-Estilla A.M., Trujillo-Murillo K., Salazar-Aranda R., De Torres N.W., et al. Protective efect of four Mexican plants against CCl4-induced damage on the Huh7 human hepatoma cell line. Ann Hepatol. 2016;10(1):73–9.
  4. Manibusan M.K., Odin M., Eastmond DA. Postulated carbon tetrachloride mode of action: a review. J Environ Sci Health C. 2007;25(3):185–209
  5. Hashem A.S. Defensive impact of propolis against CCl4 actuated rats testicular damage. J Adv Vet Anim Res. 2021; 8:70-77.
  6. Unsal V., Cicek M., Sabancilar I. Toxicity of carbon tetrachloride, free radicasl and role of antioxidants. Rev Environ Health. 2020; 36: 279-295.
  7. Yang al et al. The Role of Oxidative Stress and Natural Antioxidants in Ovarian Aging: A Review. Front Pharmacol. 2021; 11: 1-18.
  8. Di Meo S., Venditti P. Evolution of the Knowledege of Free Radicals and Other Oxidants. Oxid Med Cell longev. 2020; 1-32.
  9. Sydney J. Aprioku. Pharmacology of free radicals and the impact of Reactive oxygen species on the testis. J. Reprod infertil. 2013; 14: 158-172.
  10. Sadasivam N., et al. Oxidative stress, Genomic integrity and Liver Diseases. Molecules., 2022, 27.
  11. Lutz W D Weber et al. hepatotoxicity and mechanism of action of haloalkanes: carbon tetrachloride as a toxicologinal model: A Review. Crit Rev Toxicol. 2008; 33: 105-136.
  12. Gehan M., et al. Antioxidant Potential of Parsley Leaf (Petroselinum crispum) essential oil on hypothyroidism and testicular injury in mice intoxicated by carbon tetrachloride. Biomed Res Int. 2021.
  13. Harish Nayaka M.A., Sathisha U.V., Dharmesh S.M. Cytoprotective and antioxidant activity of free, conjugated and insoluble-bound phenolic acids fromswallow root (Decalepis hamiltonii). Food Chem. 2010; 119: 1307-12.
  14. Shukla S., Mehta A., Bajpai V.K., Shukla S. In vitro antioxidant activity and total phenolic content of ethanolic leaf extract of Stevia rebaudiana Bert. Food and Chemical Toxicology. 2009; 47: 2338- 43.
  15. Eisenman S.W., Zaurov D.E., Struwe L. Medicinal plants of Central Asia: Uzbekistan and Kyrgyzstan. New York: Springer. 2013; pp.203-60.
  16. Muosavi SH., et al. In vitro Evaluation of Cytotoxic and Apoptogenic Properties of Sophora pachycarpa: Iranian J. Pharmaceutical Res. 2014; 2: 73-665.
  17. Es.Haghi M etal. Protective effects of Cornus mas fruit extract on carbon tetrachloride induced neohrotoxicity in rats. 2014; 24(5):291-296.
  18. Kumar Sh. Chemistry and Biological Activities of Flavonoids: An Overview. The Sci World J. 2016; 16: 1-16.
  19. Meng Y., et al. Enhannced degradation of carbon tetrachloride by surfactant-modified zero-valant iron. J Zhejiang Univ Sci B, 2006; 7: 702-707.
  20. Turner T., lysiak J. oxidative stress: a common factor in testicular dysfunction. J. Andrology. 2008; 29: 488-489.
  21. Malik R., Hodgson H. The relationship between thyroid gland and liver. QJM. 2002; 95: 559-569.
  22. Abalovich M., et al. Hypothalamic-Pituitary-Testicular axis and seminalo parameters in hyperthyroidism males. Thyroid. 1999; 9: 857-63.
  23. Sajjad M., et al. Phytochemical, antioxidant and hepatoprotective effects of Alnus nitida bark in carbontetrachloride challenged Sprague Dawley rats. BMC Complementary and Alternative Medicine. 2016; 16. 268.
  24. Roy A., et al. in vitro antioxidant and free radical scavenging activity of the ethanolicextract of dioscoreavillosa (wild yam) tubers. Drug Invent. 2011; 3: 214-5.
  25. Halliwell B., Gutteridge J. Cellular responses to Oxidative stress adaptation damage, repair, senescence and death. Free radicals in Biology and Medicine. NewYork: Owford University Press. 2015.
  26. Sahreen S., Rashid Khan M., Ali Khan R. Ameliorating effect of various fractions of Rumex hastatus roots against hepato- and Testicular toxicity caused by CCl4. 2013.
  27. Banan Khojasteh S.M., Javanmard Khameneh R. Sophora pachycarpa root extract improves testicular damage in carbon-tetrachloride intoxicated rats. 2018; 20(8):e 64950.
  28. Xiaohe Li., et al. Byakangelingelicine protects against carbon tetrachloride-induced liver injury and fibrosis in mice. J Cell Mol Med. 2020; 24: 8623-8635.
  29. Aramjoo H., et al. Protective effect of Sophora pachycarpa seed extract on carbon tetrachloride-induced toxicity in rats. BMC Complementary Medicine and Therapies. 2022; 22: 76-88.
  30. Ganeshpurkar A., Saluja A.K. The pharmacological potential of rutin. Saudi Pharmaceutical J. 2017; 25(2):149_164.
  31. Erdogan E., Ilgaz Y., Gurgor P.N., Oztas Y., Topal T., Oztas E. Rutin ameliorates methotrexate induced hepatic injury in rats. Acta Cirurgica Brasileira. 2015; 30(11):778-784.
  32. Mehfooz A., Wei Q., Zheng K., Fadlalla M.B., Maltasic G., Shi F. Protective roles of Rutin against restraint stress on spermatogenesis in testes of adult mice. Tissue and Cell. 2018; 50:133-143.
  33. Elsawy H., Badr G.M., Sedky A., Abdallah B.M., Alzahrani A.M., Abdel-Moneim AM. Rutin ameliorates carbon tetrachloride (CCl4)-induced hepatorenal toxicity and hypogonadism in male rats. 2019; PeerJ 7:e7011.
  34. Okolo K.O., Siminialayi I.M., Orisakwe O.E. Protective effects of Pleurotus tuberregium on carbon-tetrachloride induced testicular injury in Sprague Dawley rats. Frontiers in Pharmacology. 2016; 7:Article 480.
  35. Khorrami A., Ghanbarzadeh S., Ziaee M., Arami S., Vajdi R., Garjani A. Dietary cholesterol and oxidised cholesterol: effects on sperm characteristics, antioxidant status and hormonal profile in rats. Andrologia. 2015; 47(3):310-317.
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