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Zabihi, Mohsen, Mousavi, Hamideh Sadat, Mohammadi Hamaneh, Amirabbas, Mirzaei, Farzaneh. (1403). The Effect of Fig Leaves on Trichomonas vaginalis and Macrophages In-vitro. سامانه مدیریت نشریات علمی, 13(3), 661-668. doi: 10.22034/jmpb.2023.361502.1532
Mohsen Zabihi; Hamideh Sadat Mousavi; Amirabbas Mohammadi Hamaneh; Farzaneh Mirzaei. "The Effect of Fig Leaves on Trichomonas vaginalis and Macrophages In-vitro". سامانه مدیریت نشریات علمی, 13, 3, 1403, 661-668. doi: 10.22034/jmpb.2023.361502.1532
Zabihi, Mohsen, Mousavi, Hamideh Sadat, Mohammadi Hamaneh, Amirabbas, Mirzaei, Farzaneh. (1403). 'The Effect of Fig Leaves on Trichomonas vaginalis and Macrophages In-vitro', سامانه مدیریت نشریات علمی, 13(3), pp. 661-668. doi: 10.22034/jmpb.2023.361502.1532
Zabihi, Mohsen, Mousavi, Hamideh Sadat, Mohammadi Hamaneh, Amirabbas, Mirzaei, Farzaneh. The Effect of Fig Leaves on Trichomonas vaginalis and Macrophages In-vitro. سامانه مدیریت نشریات علمی, 1403; 13(3): 661-668. doi: 10.22034/jmpb.2023.361502.1532

The Effect of Fig Leaves on Trichomonas vaginalis and Macrophages In-vitro

Journal of Medicinal plants and By-products
مقاله 22، دوره 13، شماره 3، آذر 2024، صفحه 661-668    اصل مقاله (867.79 K)
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22034/jmpb.2023.361502.1532
نویسندگان
Mohsen Zabihi1؛ Hamideh Sadat Mousavi1؛ Amirabbas Mohammadi Hamaneh2؛ Farzaneh Mirzaei* 3
1Department of Pharmacology, School of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
2Department of Pharmacology, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
3Department of Medical Parasitology and Mycology, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
چکیده
Trichomonas vaginalis, an anaerobic flagellated protozoan, can infect the cervix, vagina, pelvis, urethra, and epididymis. The development of microbial resistance and the occurrence of side effects with synthetic anti-trichomonas drugs, such as metronidazole, requires the need to expand research on the use of natural medicines in the control of this infection. The present study was conducted to investigate the effect of hydroalcoholic and aqueous extracts of fig leaves on the viability of Trichomonas vaginalis in vitro. Hydroalcoholic and aqueous extracts of fig leaves were obtained by percolation and perfusion, respectively. The effect of the hydroalcoholic extract (2000, 1000, 500, 250, 125, 62.5, 31.2, 15.6, 7.8, 3.9 µg/ml) and the aqueous extract (3000, 1500, 750, 375, 187.5, 93.7, 46.8, 23.4, 11.7, 5.8 µg/ml) were evaluated on T. vaginalis cells in-vitro. Otherwise, the effect of the hydroalcoholic and aqueous extracts (3200, 1600, 800, 400, 200, 100, and 50 µg/ml) was studied on J774 macrophage cells. Using the hemocytometry method, the cell growth inhibition in different concentrations was calculated after three times incubation (24, 48, and 72 hrs). Fig leaves' hydroalcoholic and aqueous extracts could inhibit the growth of T. vaginalis and macrophage cells in-vitro. The cell growth inhibition in different concentrations and incubation times were significantly different. The anti-trichomonas activity of fig leaves' extracts allows their use in treating trichomoniasis.
کلیدواژه‌ها
Trichomonas vaginalis؛ Parabasalidea؛ Metronidazole؛ Ficus carica؛ Fig
مراجع
  1. Valadkhani Z., Kazemi F., Assmar M., Amirkhani A., Esfandeari B., Lotfi M., et al. Molecular diagnosis of trichomoniasis in negative samples examined by direct smear and culture. Iranian journal of parasitology. 2010;5(4):31-6.
  2. Fakhrieh Kashan Z., Delavari M., Arbabi M., Hooshyar H. Therapeutic effects of Iranian herbal extracts against Trichomonas vaginalis. Iranian biomedical J. 2017;21(5):285-93.
  3. Hezarjaribi HZ., Fakhar M., Shokri A., Teshnizi SH., Sadough A., Taghavi M. Trichomonas vaginalis infection among Iranian general population of women: a systematic review and meta-analysis. Parasitology research. 2015;114(4):1291-300.
  4. Niyati M., Joneidi Z., Kamalinejad M., Haghighi A., Valaei N., Abdi A.R., et al. Anti-trichomonas effect of Rheum ribes and Foeniculum vulgare extracts on Trichomonas vaginalis invitro. Journal of Islamic and Iranian Traditional Medicine. 2015;6(3):198-208.
  5. Arbabi M., Delavari M., Fakhrieh-Kashan Z., Hooshyar H. Review of Trichomonas vaginalis in Iran, Based on Epidemiological Situation. J reproduction & infertility. 2018;19(2):82-8.
  6. Vos T., Flaxman A.D., Naghavi M., Lozano R., Michaud C., Ezzati M., et al. Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet (London, England). 2012;380(9859):2163-96.
  7. Narcisi E.M., Secor W.E. In vitro effect of tinidazole and furazolidone on metronidazole-resistant Trichomonas vaginalis. Antimicrobial Agents and Chemotherapy. 1996;40(5):1121-5.
  8. Secor W.E., Meites E., Starr M.C., Workowski KA. Neglected parasitic infections in the United States: trichomoniasis. The American J Tropical Mmedicine and Hygiene. 2014;90(5):800-4.
  9. Sofowora A., Ogunbodede E., Onayade A. The role and place of medicinal plants in the strategies for disease prevention. African J Traditional, complementary, and alternative medicines : AJTCAM. 2013;10(5):210-29.
  10. Bouyahya A., Ben Said M., Bakri Y., Dakka N. Phytochemistry and Ethnopharmacology of Ficus carica. International J Biochemistry Res & Review. 2016;14:1-12.
  11. Mawa S., Husain K., Jantan I. Ficus carica L. (Moraceae): Phytochemistry, Traditional Uses and Biological Activities. Evidence-based complementary and alternative medicine : eCAM. 2013;2013:974256.
  12. Oktavia Tri W., Triana H. Dpph Radical Scavenging Activity, Total Phenolics and Flavonoids of Water Soluble Extracts Derived From Leaves and Fruit of Ficus Carica L. and Ficus Parietalis Bl. Traditional Medicine J. 2016;21(2):86-92.
  13. Pękal A., Pyrzynska K. Evaluation of aluminium complexation reaction for flavonoid content assay. Food Analytical Methods. 2014;7:1776-82.
  14. Garza-González, J.N. V-V., J. V-S., M.J., Rivas-Morales, C. O-C, A.,, Hernandez-García ME, De La GarzaSalinas, L. and González-Salazar, F. Antiprotozoal Activity of a Thymus vulgaris Methanol Extract and Its Fractions. Health. 2017;9:1081-94.
  15. Khanmohammadi M., Ganji S., Reyhani-Rad S. Anti-protozoan Effects of Methanol Extracts of the Ferula szowitsiana on the Trichomonas Vaginalis Trophozoites in vitro. International J Women's Health and Reproduction Sci. 2014;2:301-6.
  16. Sobel J.D., Nagappan V., Nyirjesy P. Metronidazole-resistant vaginal trichomoniasis--an emerging problem. The New England J Medicine. 1999;341(4):292-3.
  17. Ahmad J., khan I. Evaluation of Antioxidant and Antimicrobial Activity of Ficus Carica Leaves: an In Vitro Approach. Plant Pathology & Microbiology. 2013;4.
  18. Rocha V.P.C., Quintino da Rocha C, Ferreira Queiroz E, Marcourt L, Vilegas W, Grimaldi GB, et al. Antileishmanial Activity of Dimeric Flavonoids Isolated from Arrabidaea brachypoda. Molecules (Basel, Switzerland). 2018;24(1).
  19. Mamoona Rauf H.G., Begum H.A., Hamayun M., Waqar Khan K.A., Schulze M., Shah M. 94. Antimicrobial, antioxidant, phytochemical and pharmacognostic study of the leaf powder of Ficus carica L. Pure and Applied Biology (PAB). 2020(1):999-1008%V 9.
  20. Amol P.V.V., Vijay R., Rajesh Y. Anthelmintic and preliminary phytochemical screening of leaves of Ficus carica Linn against intestinal helminthiasis. International J Res in Ayurveda and Pharmacy (IJRAP). 2010;1(2):601-5.
  21. Elizondo-Luevano J.H., Verde-Star J., González-Horta A., Castro-Ríos R., Hernández-García M.E., Chávez-Montes A. In Vitro Effect of Methanolic Extract of Argemone mexicana against Trichomonas vaginalis. The Korean J Parasitology. 2020;58(2):135-45.
  22. Fakhrie-Kashan Z., Arbabi M., Delavari M., Taghi-Zadeh M., Hooshyar H., Solaymani F. The effect of aqueous and alcoholic extracts of Pelarqonium roseum on the growth of Trichomonas vaginalis in vitro. Feyz Journal of Kashan University of Medical Sciences. 2014;18(4):369-75.
  23. Nwodo N., Okoye F., Lai D., Debbab A., Kaiser M., Brun R., et al. Evaluation of the in vitro trypanocidal activity of methylated flavonoid constituents of Vitex simplicifolia leaves. BMC Complementary and Alternative Medicine. 2015;15:82.
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