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Maleki, Mahmood, Yousefi, Karim, Asadi, Malek Hossein, Mirtajadini, Seyed Mansour. (1403). Seseli transcaucasicum (Schischk.) Pimenov & Sdobnina Leaf and Seed Ethanolic and Methanolic Extracts: Cytotoxic Activity on MCF7 Cell Line and Antioxidant Properties. سامانه مدیریت نشریات علمی, 13(2), 459-467. doi: 10.22034/jmpb.2023.362345.1562
Mahmood Maleki; Karim Yousefi; Malek Hossein Asadi; Seyed Mansour Mirtajadini. "Seseli transcaucasicum (Schischk.) Pimenov & Sdobnina Leaf and Seed Ethanolic and Methanolic Extracts: Cytotoxic Activity on MCF7 Cell Line and Antioxidant Properties". سامانه مدیریت نشریات علمی, 13, 2, 1403, 459-467. doi: 10.22034/jmpb.2023.362345.1562
Maleki, Mahmood, Yousefi, Karim, Asadi, Malek Hossein, Mirtajadini, Seyed Mansour. (1403). 'Seseli transcaucasicum (Schischk.) Pimenov & Sdobnina Leaf and Seed Ethanolic and Methanolic Extracts: Cytotoxic Activity on MCF7 Cell Line and Antioxidant Properties', سامانه مدیریت نشریات علمی, 13(2), pp. 459-467. doi: 10.22034/jmpb.2023.362345.1562
Maleki, Mahmood, Yousefi, Karim, Asadi, Malek Hossein, Mirtajadini, Seyed Mansour. Seseli transcaucasicum (Schischk.) Pimenov & Sdobnina Leaf and Seed Ethanolic and Methanolic Extracts: Cytotoxic Activity on MCF7 Cell Line and Antioxidant Properties. سامانه مدیریت نشریات علمی, 1403; 13(2): 459-467. doi: 10.22034/jmpb.2023.362345.1562

Seseli transcaucasicum (Schischk.) Pimenov & Sdobnina Leaf and Seed Ethanolic and Methanolic Extracts: Cytotoxic Activity on MCF7 Cell Line and Antioxidant Properties

Journal of Medicinal plants and By-products
مقاله 21، دوره 13، شماره 2، شهریور 2024، صفحه 459-467    اصل مقاله (837.52 K)
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22034/jmpb.2023.362345.1562
نویسندگان
Mahmood Maleki* 1؛ Karim Yousefi2؛ Malek Hossein Asadi1؛ Seyed Mansour Mirtajadini3
1Department of Biotechnology, Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman, Iran
2MSc student of agricultural biotechnology, Graduate University of Advanced Technology, Kerman, Iran
3Department of Biology, Faculty of Sciences, Shahid Bahonar University, Kerman, Iran
چکیده
Seseli is an important genus of the Apiaceae family with many aromatic species. These plants are widely used in traditional medicine, but there is little information about their phytochemical compositions and biological activities. An ecotype of Seseli transcaucasicum (Schischk.) Pimenov & Sdobnina, about which there is little phytochemical information, grows in the Hezar-Masjed Mountains of northeastern Iran. The aim of this study was to investigate the anticancer activity and antioxidant properties of ethanolic and methanolic extracts from the leaves and seeds of this plant. Cytotoxic activity against MCF7 and HSkMC was determined by the MTT method, and the antioxidant properties of the extracts were evaluated by the DPPH and PFRAP methods. The results showed that the methanolic extract of seeds had the greatest effect on inhibiting the growth of cancer cells at 48 and 72 hours, with IC50 values of 54.35 and 50.52 μg/ml, respectively. Moreover, the methanolic extract of the seeds had the greatest effect on the degradation of DPPH free radicals with an IC50 value of 44.64 μg/ml, and this inhibitory effect was comparable to the effect of ascorbic acid. The antioxidant effect of iron reduction of the different extracts was significantly lower than that of ascorbic acid. However, among the extracts, the reducing power of the methanolic seed extract was better than the others. Considering that the methanolic seed extract had the most lethal effect on cancer cells, it seems that the extract that has stronger antioxidant power also has stronger anticancer properties.
کلیدواژه‌ها
Apiaceae؛ Genus Libanotis؛ MTT Assay؛ DPPH؛ FRAP
مراجع
  1. Abrahim N.N., Kanthimathi M., Abdul-Aziz A. Piper betle shows antioxidant activities, inhibits MCF-7 cell proliferation and increases activities of catalase and superoxide dismutase. BMC Complement Altern Med. 2012; 12:1-11.
  2. Cragg G.M., Newman D.J. Plants as a source of anti-cancer agents. J Ethnopharmacol. 2005; 100:72-9.
  3. Al-Mansoub M.A., Asif M., Revadigar V., Hammad M.A., Chear N.J-Y., Hamdan M.R., et al. Chemical composition, antiproliferative and antioxidant attributes of ethanolic extract of resinous sediment from Etlingera elatior (Jack.) inflorescence. Braz J Pharm Sci. 2021; 57.
  4. Bjelakovic G., Nikolova D., Simonetti R.G., Gluud C. Antioxidant supplements for prevention of gastrointestinal cancers: a systematic review and meta-analysis. Lancet. 2004; 364:1219-28.
  5. Maleki M., Ghorbanpour M., Kariman K. Physiological and antioxidative responses of medicinal plants exposed to heavy metals stress. Plant Gene. 2017; 11:247-54.
  6. Li W.Y., Chan S.W., Guo D.J., Yu PH.F. Correlation between antioxidative power and anticancer activity in herbs from traditional Chinese medicine formulae with anticancer therapeutic effect. Pharm Biol. 2007; 45:541-6.
  7. Sayed-Ahmad B., Talou T., Saad Z., Hijazi A., Merah O. The Apiaceae: Ethnomedicinal family as source for industrial uses. Ind Crops Prod. 2017; 109:661-71.
  8. Chizzola R. Essential oil composition of wild growing Apiaceae from Europe and the Mediterranean. Nat Prod Commun. 2010; 5:1934578X1000500925.
  9. Süzgeç-Selçuk S., Dikpınar T. Phytochemical evaluation of the Ferulago genus and the pharmacological activities of its coumarin constituents. J Herb Med. 2021; 25:100415.
  10. Hasheminya S.M., Dehghannya J. Chemical composition, antioxidant, antibacterial, and antifungal properties of essential oil from wild Heracleum rawianum. ISBAB. 2021; 31:101913.
  11. Zengin G., Sinan K.I., Ak G., Mahomoodally M.F., Paksoy M.Y., Picot-Allain C., et al. Chemical profile, antioxidant, antimicrobial, enzyme inhibitory, and cytotoxicity of seven Apiaceae species from Turkey: A comparative study. Ind Crops Prod. 2020; 153:112572.
  12. Amiri M.S., Joharchi M.R. Ethnobotanical knowledge of Apiaceae family in Iran: A review. AJP. 2016; 6:621.
  13. Mozaffarian V. Umbelliferae. In: Flora of Iran. Research Institute of Forests and Rangelands, Tehran. 2007:596.
  14. Önder A., Cinar A.S., Sarialtin S.Y., İzgi M.N., Çoban T. Evaluation of the antioxidant potency of Seseli L. species (Apiaceae). Turk J Pharm Sci. 2020; 17:197.
  15. Judd W.S., Campbell C.S., Kellogg E.A., PF S. Plant Systematics: A Phylogenetic Approach. Publishers Sunderland, Massachusetts, USA. 1999.
  16. Borovkov A., Petov G. Composition of the essential oils of Libanotis transcaucasica. V. Chem Nat Compd. 1967; 3:196-7.
  17. Shahabipour S., Firuzi O., Asadollahi M., Miri M., Javidnia K. Essential oil composition and cytotoxic activity of Libanotis transcaucasica schischk from Iran. Nat Prod Chem Res. 2013; 1:1-2.
  18. Rechinger K. Apiaceae. Flora Iranica Graz: Akademische Druck-u Verlagsanstalt. 1982.
  19. Prokopenko A. Libanotin: A new furocoumarin from Libanotis transcaucasica Schischk. Chem Nat Compd. 1965; 1:165-8.
  20. Haghighi S.R., Asadi M.H., Akrami H., Baghizadeh A. Anti-carcinogenic and anti-angiogenic properties of the extracts of Acorus calamus on gastric cancer cells. AJP. 2017; 7:145.
  21. Garcia E.J., Oldoni T.L.C., Alencar S.M.d., Reis A., Loguercio A.D., Grande RHM. Antioxidant activity by DPPH assay of potential solutions to be applied on bleached teeth. Braz Dent J. 2012; 23:22-7.
  22. Ferreira I.C., Baptista P., Vilas-Boas M., Barros L. Free-radical scavenging capacity and reducing power of wild edible mushrooms from northeast Portugal: Individual cap and stipe activity. Food Chem. 2007; 100:1511-6.
  23. Newman D.J., Cragg G.M. Natural products as sources of new drugs over the last 25 years. J natural products. 2007; 70:461-77.
  24. Pezzuto J.M. Plant-derived anticancer agents. Biochemical pharmacology. 1997; 53:121-33.
  25. Al-Kalaldeh J.Z., Abu-Dahab R., Afifi F.U. Volatile oil composition and antiproliferative activity of Laurus nobilis, Origanum syriacum, Origanum vulgare, and Salvia triloba against human breast adenocarcinoma cells. Nutrition Research. 2010; 30:271-8.
  26. Önder A., Cinar A., Bakar Ates F., Noguera-Artiaga L., Antonio Carbonell-Barrachina A. Chemical composition and cytotoxic potency of essential oil from Seseli petraeum M. Bieb.(Apiaceae). JResPharm. 2021; 25.
  27. Gonçalves M.J., Tavares A.C., Cavaleiro C., Cruz M.T., Lopes M.C., Canhoto J., et al. Composition, antifungal activity and cytotoxicity of the essential oils of Seseli tortuosum L. and Seseli montanum subsp. peixotoanum (Samp.) M. Laínz from Portugal. Ind Crops Prod. 2012; 39:204-9.
  28. Cinar A.S., Bakar-Ates F., Onder A. Seseli petraeum M. Bieb.(Apiaceae) Significantly inhibited cellular growth of A549 lung cancer cells through G0/G1 cell cycle arrest. Anais da Academia Brasileira de Ciencias. 2020; 92.
  29. Nordin M.L., Abdul Kadir A., Zakaria Z.A., Abdullah R., Abdullah M.N.H. In vitro investigation of cytotoxic and antioxidative activities of Ardisia crispa against breast cancer cell lines, MCF-7 and MDA-MB-231. BMC complementary and alternative medicine. 2018; 18:1-10.
  30. Baharum Z., Akim A.M., Taufiq-Yap Y.H., Hamid R.A., Kasran R. In vitro antioxidant and antiproliferative activities of methanolic plant part extracts of Theobroma cacao. Molecules. 2014; 19:18317-31.
  31. Atjanasuppat K., Wongkham W., Meepowpan P., Kittakoop P., Sobhon P., Bartlett A., et al. In vitro screening for anthelmintic and antitumour activity of ethnomedicinal plants from Thailand. J ethnopharmacology. 2009; 123:475-82.
  32. Boik J. Natural compounds in cancer therapy. Oregon Medical Press Princeton, MN, USA, 2001.
  33. Lee C., Houghton P. Cytotoxicity of plants from Malaysia and Thailand used traditionally to treat cancer. J ethnopharmacology. 2005; 100:237-43.
  34. Al-Barazanjy R.K., Dizaye K., Al-Asadye A.A. Cytotoxic and cytogenetic effects of Salvia officinalis on different tumor cell lines. Middle East J Internal Medicine. 2013; 63:1-11.
  35. Kavaz D., Faraj R.E. Investigation of composition, antioxidant, antimicrobial and cytotoxic characteristics from Juniperus sabina and Ferula communis extracts. Scientific Reports. 2023; 13:7193.
  36. Rahman M., Islam M., Biswas M., Khurshid Alam A. In vitro antioxidant and free radical scavenging activity of different parts of Tabebuia pallida growing in Bangladesh. BMC research notes. 2015; 8:1-9.
  37. Baumann J. Prostaglandin synthetase inhibiting O_2-radical scavenging properties of some flavonoids and related phenolic compounds. Naunyn-Schmiedebergs Arch Pharmacol. 1979; 308:27-32.
  38. Matejić J., Džamić A., Mihajilov-Krstev T., Ranđelović V., Krivošej Z., Marin P. Total phenolic content, flavonoid concentration, antioxidant and antimicrobial activity of methanol extracts from three Seseli L. taxa. Open Life Sci. 2012; 7:1116-22.
  39. Stankov-Jovanović V., Ilić M., Mitić V., Mihajilov-Krstev T., Simonović S., Mandić S.N., et al. Secondary metabolites of Seseli rigidum: Chemical composition plus antioxidant, antimicrobial and cholinesterase inhibition activity. J Pharm Biomed Anal. 2015; 111:78-90.
  40. Jakovljević D., Vasić S., Stanković M., Čomić L., Topuzović M. In vitro biological activity of secondary metabolites from Seseli rigidum Waldst. et Kit. (Apiaceae). Acta Biol Hung. 2015; 66:395-405.
  41. Jafri S.A.A., Khalid Z.M., Khan M.R., Ashraf S., Ahmad N., Karami A.M., et al. Evaluation of some essential traditional medicinal plants for their potential free scavenging and antioxidant properties. J King Saud University-Science. 2023:102562.
  42. Zhou X.R, Wang J.h., Jiang B., Shang J., Zhao C.Q. A study of extraction process and in vitro antioxidant activity of total phenols from Rhizoma Imperatae. Afr J Tradit Complement Altern Med. 2013; 10:175-8.
  43. Jose S.M., Anilkumar M. In vitro antioxidant activity of Litsea quinqueflora (Dennst.) Suresh. J Pharmacogn Phytochem. 2018; 7:3217-21.
  44. Mekonnen A., Atlabachew M., Kassie B. Investigation of antioxidant and antimicrobial activities of Euclea schimperi leaf extracts. Chem biol technol agric. 2018; 5:1-12.
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