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Naghashpour, M, Adelipour, M, Mobarak, S, Piri, M, Seyedtabib, M, Maghsoudi, F, Golabi, S. (1402). Evaluation of Possible Association between Serum Levels of Aldosterone and Cortisol with Clinical Symptoms Progression in COVID-19 Suspicious Outpatients Tested for SARS-CoV2 RT-PCR: An Analytical Cross-Sectional Study. سامانه مدیریت نشریات علمی, 78(3), 923-933. doi: 10.22092/ari.2021.356094.1774
M Naghashpour; M Adelipour; S Mobarak; M Piri; M Seyedtabib; F Maghsoudi; S Golabi. "Evaluation of Possible Association between Serum Levels of Aldosterone and Cortisol with Clinical Symptoms Progression in COVID-19 Suspicious Outpatients Tested for SARS-CoV2 RT-PCR: An Analytical Cross-Sectional Study". سامانه مدیریت نشریات علمی, 78, 3, 1402, 923-933. doi: 10.22092/ari.2021.356094.1774
Naghashpour, M, Adelipour, M, Mobarak, S, Piri, M, Seyedtabib, M, Maghsoudi, F, Golabi, S. (1402). 'Evaluation of Possible Association between Serum Levels of Aldosterone and Cortisol with Clinical Symptoms Progression in COVID-19 Suspicious Outpatients Tested for SARS-CoV2 RT-PCR: An Analytical Cross-Sectional Study', سامانه مدیریت نشریات علمی, 78(3), pp. 923-933. doi: 10.22092/ari.2021.356094.1774
Naghashpour, M, Adelipour, M, Mobarak, S, Piri, M, Seyedtabib, M, Maghsoudi, F, Golabi, S. Evaluation of Possible Association between Serum Levels of Aldosterone and Cortisol with Clinical Symptoms Progression in COVID-19 Suspicious Outpatients Tested for SARS-CoV2 RT-PCR: An Analytical Cross-Sectional Study. سامانه مدیریت نشریات علمی, 1402; 78(3): 923-933. doi: 10.22092/ari.2021.356094.1774

Evaluation of Possible Association between Serum Levels of Aldosterone and Cortisol with Clinical Symptoms Progression in COVID-19 Suspicious Outpatients Tested for SARS-CoV2 RT-PCR: An Analytical Cross-Sectional Study

Archives of Razi Institute
مقاله 18، دوره 78، شماره 3، مرداد و شهریور 2023، صفحه 923-933    اصل مقاله (516.59 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2021.356094.1774
نویسندگان
M Naghashpour1؛ M Adelipour2؛ S Mobarak3؛ M Piri4؛ M Seyedtabib5؛ F Maghsoudi6؛ S Golabi* 7
1Department of Nutrition, School of Medicine, Abadan University of Medical Sciences, Abadan, Iran
2Department of Biochemistry, School of Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
3Department of Infectious Diseases, School of Medicine, Abadan University of Medical Sciences, Abadan, Iran
4Vice Chancellor for Health, Abadan University of Medical Sciences, Abadan, Iran
5Department of Biostatistics and Epidemiology, School of Public Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
6Department of Public Health, School of Health, Abadan University of Medical Sciences, Abadan, Iran
7Department of Medical Physiology, School of Medicine, Abadan University of Medical Sciences, Abadan, Iran
چکیده
Aldosterone is a key component of Renin-Angiotensin-Aldosterone System (RAAS). The RAAS could play a substantial role in the pathophysiology of coronavirus disease 2019 (COVID-19). Moreover, the dynamics of the Hypothalamic-Pituitary-Adrenal (HPA) axis may have changed in COVID-19. Cortisol, as an important factor in assessing immune system activity, is an important part of this axis. The present study compared the serum levels of aldosterone and cortisol in COVID-19 outpatients with those of potentially non-infected participants. It was also aimed to assess the possible association between serum levels of aldosterone and cortisol with clinical symptoms progression in COVID-19 outpatients. Demographic characteristics (i.e., gender and age) and clinical data (i.e., oxygen saturation [SPO2], respiratory rate [RR], and heart rate) were collected. Serum cortisol and aldosterone measurements were conducted using the ELISA technique. Clinical symptoms of the positive polymerase chain reaction (PCR) group were followed up on for 28 days in weekly intervals. SPO2 was significantly lower in the positive PCR group; however, the RR was significantly higher (P=0.03 and P=0.001, respectively). Significantly higher levels of aldosterone were found in males of the negative PCR group, compared to females (P=0.05). Cortisol (OR=0.937, P=0.033) and aldosterone (OR=1.005, P=0.020) levels had a decreasing and increasing effect on the chances of respiratory symptoms occurring over time, respectively. Furthermore, over time, women were twice as likely as men to develop neurologic symptoms (OR=0.530, P=0.015). According to the findings of this study, cortisol and aldosterone are associated with the chance of respiratory symptoms occurring over time. However, the levels of these two markers do not seem to be related to the progression of clinical symptoms of lower grades of COVID-19.
کلیدواژه‌ها
Aldosterone؛ Cortisol؛ Clinical symptoms progression؛ COVID-19
عنوان مقاله [English]
ارزیابی ارتباط احتمالی بین سطوح سرمی آلدوسترون و کورتیزول با پیشرفت علائم بالینی در بیماران سرپایی مشکوک به COVID-19 آزمایش شده برای SARS-CoV2 RT-PCR: یک مطالعه مقطعی تحلیلی
چکیده [English]
آلدسترون جزء کلیدی سیستم رنین-آنژیوتانسین-آلدسترون (RAAS) است. RAAS می تواند نقش مهمی در پاتوفیزیولوژی COVID-19 ایفا کند. همچنین، دینامیک محور هیپوتالاموس-هیپوفیز-آدرنال (HPA) ممکن است در COVID-19 تغییر کرده باشد. کورتیزول، به عنوان یک عامل مهم در ارزیابی فعالیت سیستم ایمنی، جزء مهمی از این محور است. مطالعه ی حاضر، سطح سرمی آلدوسترون و کورتیزول در بیماران سرپایی COVID-19 را با شرکت کنندگان بالقوه غیر آلوده مقایسه کرد. هدف ما از این مطالعه همچنین بررسی ارتباط احتمالی بین سطوح سرمی آلدوسترون و کورتیزول با پیشرفت علائم بالینی در بیماران سرپایی COVID-19 بود. داده های جمعیت شناختی (سن، جنس) و بالینی (درصد اشباع فشار اکسیژن، سرعت تنفس و تعداد ضربان قلب) جمع آوری شد. سطوح سرمی کورتیزول و آلدوسترون با استفاده از تکنیک الایزا اندازه گیری شد. علائم بالینی گروه PCR مثبت به مدت 28 روز در فواصل هفتگی پیگیری شد. SPO2 در گروه PCR مثبت به طور قابل توجهی کمتر از گروه PCR منفی بود، اما میزان تنفس در گروه PCR مثبت به طور قابل توجهی بیشتر بود (P=0.03 and P=0.001, respectively). ما میزان قابل توجه بالاتری از آلدوسترون را در مردان گروه PCR منفی در مقایسه با زنان پیدا کردیم (0.05=P). سطح کورتیزول (OR=0.93، P=0.033) و آلدوسترون (OR=1.005، P=0.020) به ترتیب بر احتمال بروز علائم تنفسی در طول زمان تأثیر کاهشی و افزایشی داشتند. همچنین، در گذر زمان، شانس بروز علائم نورولوژیک در زنان دو برابر مردان بود (OR=0.530، P=0.015). نتیجه گیری ما از یافته های این مطالعه این است که کورتیزول و آلدوسترون با احتمال بروز علائم تنفسی در طول زمان مرتبط هستند. با این حال، به نظر نمی رسد که سطح این دو نشانگر با پیشرفت علائم بالینی در گریدهای پایین COVID-19 مرتبط باشد.
کلیدواژه‌ها [English]
کووید-19, آلدسترون, کورتیزول, پیشزفت علائم بالینی
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مراجع
  1. Hussain A, Kaler J, Tabrez E, Tabrez S, Tabrez SSM. Novel COVID-19: A Comprehensive Review of Transmission, Manifestation, and Pathogenesis. Cureus. 2020;12(5):e8184.
  2. Adams KK, Baker WL, Sobieraj DM. Myth Busters: Dietary Supplements and COVID-19. Ann Pharmacother. 2020;54(8):820-6.
  3. Justyna Miłek KB-D. Coronaviruses in avian species – review with focus on epidemiology and diagnosis in wild birds. J Vet Res. 2018;62:249-55.
  4. Nazemi K, Ghalyanchi Langeroudi A, Hashemzadeh M, Karimi V, Seger W, Ehsan MR. Molecular characterization of recent Iranian infectious bronchitis virus isolates based on S2 protein gene. Iran J Vet Med. 2016;10(4):245-51.
  5. Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020;395(10229):1054-62.
  6. Khalili H, Nourian A, Ahmadinejad Z, Emadi Kouchak H, Jafari S, Dehghan Manshadi SA, et al. Efficacy and safety of sofosbuvir/ ledipasvir in treatment of patients with COVID-19; A randomized clinical trial. Acta Biomed. 2020;91(4):e2020102.
  7. Vaduganathan M, Solomon SD. Renin-Angiotensin-Aldosterone System Inhibitors in Covid-19. Reply. N Engl J Med. 2020;382(24):e92.
  8. Burchfield JS. Renin-Angiotensin-Aldosterone System: Double-Edged Sword in COVID-19 infection. 2020.
  9. Busse LW, Chow JH, McCurdy MT, Khanna AK. COVID-19 and the RAAS-a potential role for angiotensin II? Crit Care. 2020;24(1):136.
  10. Alsufyani HA, Docherty JR. The renin angiotensin aldosterone system and COVID-19. Saudi Pharm J. 2020;28(8):977-84.
  11. Quinn KL, Fralick M, Zipursky JS, Stall NM. Renin-angiotensin-aldosterone system inhibitors and COVID-19. CMAJ. 2020;192(20):553-4.
  12. Marina Rieder LW, Luisa Pollmeier, Maren Jeserich, Isabella Goller, Niklas Baldus, Bonaventura Schmid, Hans-Joerg Busch, Maike Hofmann, Winfried Kern, Christoph Bode, Daniel Duerschmied, Achim Lother,. Serum ACE-2, angiotensin II, and aldosterone levels are unchanged in patients with COVID-19. Am J Hypertens. 2020;34(3):278-81.
  13. Fazelipour S, Kiaei M, Adhami Moghadam F, Tootian Z, Sheibani MT, Gharahjeh MR. Effects of methylphenidate on the mice adrenal glands and lymphoid organs: Results of histochemical, histometrical and histopathological investigations. Iran J Vet Med. 2017;11(4):335-44.
  14. Kotfis K, Lechowicz K, Drozdzal S, Niedzwiedzka-Rystwej P, Wojdacz TK, Grywalska E, et al. COVID-19-The Potential Beneficial Therapeutic Effects of Spironolactone during SARS-CoV-2 Infection. Pharmaceuticals (Basel). 2021;14(1).
  15. Pal R. COVID-19, hypothalamo-pituitary-adrenal axis and clinical implications. Endocrine. 2020;68(2):251-2.
  16. Lu S, Zhou Q, Huang L, Shi Q, Zhao S, Wang Z, et al. Effectiveness and safety of glucocorticoids to treat COVID-19: a rapid review and meta-analysis. Ann Transl Med. 2020;8(10):627.
  17. Yishan Zheng ZH, Guoping Yin, Xia Zhang, Wei Ye, Zhiliang Hu, Chunmei Hu,Hongxia Wei, Yi Zeng, Yun Chi, Cong Cheng, Feishen Lin, Hu Lu, Lingyan Xiao, Yan Song, Chunming Wang, Yongxiang Yi, Lei Dong. Comparative study of the lymphocyte change between COVID-19 and non-COVID-19 pneumonia cases suggesting uncontrolled inflammation might not be the main reason of tissue injury. medRxiv. 2020.
  18. Mehra P, Wolford LM. Serum nutrient deficiencies in the patient with complex temporomandibular joint problems. Proc (Bayl Univ Med Cent). 2008;21(3):243-7.
  19. Philip KEJ, Bennett B, Fuller S, Lonergan B, McFadyen C, Burns J, et al. Working accuracy of pulse oximetry in COVID-19 patients stepping down from intensive care: a clinical evaluation. BMJ Open Respir Res. 2020;7(1).
  20. Luks AM, Swenson ER. Pulse Oximetry for Monitoring Patients with COVID-19 at Home. Potential Pitfalls and Practical Guidance. Ann Am Thorac Soc. 2020;17(9):1040-6.
  21. Mansab F, Donnelly H, Kussner A, Neil J, Bhatti S, Goyal DK. Oxygen and mortality in COVID-19 pneumonia: a comparative analysis of supplemental oxygen policies and health outcomes across 26 countries. Front Public Health. 2021;13(9):580585
  22. Kaliyaperumal D, Rk K, Alagesan M, Ramalingam S. Characterization of cardiac autonomic function in COVID-19 using heart rate variability: a hospital based preliminary observational study. J Basic Clin Physiol Pharmacol. 2021.
  23. Al-Halhouli A, Al-Ghussain L, Khallouf O, Rabadi A, Alawadi J, Liu H, et al. Clinical Evaluation of Respiratory Rate Measurements on COPD (Male) Patients Using Wearable Inkjet-Printed Sensor. Sensors (Basel). 2021;21(2).
  24. Miller DJ, Capodilupo JV, Lastella M, Sargent C, Roach GD, Lee VH, et al. Analyzing changes in respiratory rate to predict the risk of COVID-19 infection. PLoS One. 2020;15(12):e0243693.
  25. Guarnotta V, Ferrigno R, Martino M, Barbot M, Isidori AM, Scaroni C, et al. Glucocorticoid excess and COVID-19 disease. Rev Endocr Metab Disord. 2020.
  26. Martine Claude Etoa Etoga AHI, Magellan Guewo-Fokeng, Mesmin Dehayem, Anne Ongmeb Boli, Jean Arnaud Ndi Manga, Charles Kouanfack, Liliane Kuate Mfeukeu, Pierre Joseph Fouda, Vicky Ama Moor, Eugène Sobngwi. Baseline Serum Total Cortisol During the Primary Corona Virus Infection in the Beginning of the Pandemic in Cameroon. 2020.
  1. Tricia Tan BK, Edouard G Mills, Maria Phylactou, Bijal Patel, Pei C Eng, Layla Thurston, Beatrice Muzi, Karim Meeran, A Toby Prevost, Alexander N Comninos, Ali Abbara, Waljit S Dhillo. Association between high serum total cortisol concentrations and mortality from COVID-19. Lancet Diabetes Endocrinol. 2020;8(8):659-60.
  2. Pasquale Campana VF, Francesco Aruta, Francesco Cacciatore, Pasquale Abete. Can aldosterone increase interleukin‐6 levels in Covid‐19 pneumonia? J Med Virol. 2021;93:622-3.
29.          Henry BM, Benoit S, Lippi G, Benoit J. Letter to the Editor - Circulating plasma levels of angiotensin II and aldosterone in patients with coronavirus disease 2019 (COVID-19): A preliminary report. Prog Cardiovasc Dis. 2020;63(5):702-3. 

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