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Safi, Ihktiyar Mohammad, Vatandoost, Jafar, Sadeghifar, Fatemeh, Hajjar, Toktam. (1401). Evaluation of Coagulation Parameters in Mice Treated with Terminalia bellirica (Gaertn.) Roxb. Extract. سامانه مدیریت نشریات علمی, 13(1), 107-112. doi: 10.22034/jmpb.2023.128871
Ihktiyar Mohammad Safi; Jafar Vatandoost; Fatemeh Sadeghifar; Toktam Hajjar. "Evaluation of Coagulation Parameters in Mice Treated with Terminalia bellirica (Gaertn.) Roxb. Extract". سامانه مدیریت نشریات علمی, 13, 1, 1401, 107-112. doi: 10.22034/jmpb.2023.128871
Safi, Ihktiyar Mohammad, Vatandoost, Jafar, Sadeghifar, Fatemeh, Hajjar, Toktam. (1401). 'Evaluation of Coagulation Parameters in Mice Treated with Terminalia bellirica (Gaertn.) Roxb. Extract', سامانه مدیریت نشریات علمی, 13(1), pp. 107-112. doi: 10.22034/jmpb.2023.128871
Safi, Ihktiyar Mohammad, Vatandoost, Jafar, Sadeghifar, Fatemeh, Hajjar, Toktam. Evaluation of Coagulation Parameters in Mice Treated with Terminalia bellirica (Gaertn.) Roxb. Extract. سامانه مدیریت نشریات علمی, 1401; 13(1): 107-112. doi: 10.22034/jmpb.2023.128871

Evaluation of Coagulation Parameters in Mice Treated with Terminalia bellirica (Gaertn.) Roxb. Extract

Journal of Medicinal plants and By-products
دوره 13، شماره 1، خرداد 2024، صفحه 107-112    اصل مقاله (646.08 K)
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22034/jmpb.2023.128871
نویسندگان
Ihktiyar Mohammad Safi1، 2؛ Jafar Vatandoost* 3؛ Fatemeh Sadeghifar* 1؛ Toktam Hajjar1
1Department of Biology, Hakim Sabzevari University, Sabzevar, Iran
2Department of Biology, Sayed Jamaluddin Afghani University, Kunar, Afghanistan
31Department of Biology, Hakim Sabzevari University, Sabzevar, Iran
چکیده
Coagulation disorders and bleeding are the main problems among people with hemophilia. Although its common treatment is replacement therapy, the effects of herbs on bleeding treatment has been proven. In this study, the coagulation effect of the Terminalia bellirica (Gaertn.) Roxb. hydro-alcoholic extract was evaluated. 32 mice were randomly divided into four groups (n = 8) and received single doses of 2000, 1500, 1000 or 500 mg/kg/day. Blood samples were taken from the animals 14-16 days after treatment, and coagulation indices were examined including PT, aPTT, BT, CT, and platelets. The hydro-alcoholic extract of T. bellirica significantly reduces bleeding time in the BT test (10-fold) and increases platelet numbers (four-fold), showing the effect of this extract on initial homeostasis. A significant reduction of coagulation time in the CT test (five-fold) also indicates the effect of this plant extract on platelet aggregation. Moreover, the results showed the effectiveness of T. bellirica hydroalcoholic extract in the extrinsic coagulation pathway because all concentrations reduced the coagulation time in the PT test. Furthermore, given the ineffectiveness of the T. bellirica extract on the aPTT test, this extract probably had no effect on intrinsic coagulation factors. Considering the results, T. bellirica extract seems to have a coagulation effect on primary homeostasis and extrinsic pathway of secondary homeostasis.
کلیدواژه‌ها
Coagulation disorders؛ Terminalia bellirica roxb؛ Homeostasis؛ Herbal medicine؛ Hydroalcoholic extraction
مراجع
  1. McPherson R., Pincus M. Clinical diagnosis and management by laboratory methods. Elsevier Health Sciences; 2021.
  2. Hoffbrand V., Steensma D.P. Hoffbrand's Essential Haematology. 2019.
  3. David G., Ludlam C. Fast facts: bleeding disorders. 2004.
  4. Fazeli-nasab B., Moshtaghi N., Forouzandeh M. Effect of solvent extraction on phenol, flavonoids and antioxidant activity of some Iranian native herbs. scientific journal of ilam university of medical sciences. 2019;27:14-26.
  5. Hazra K. Phytochemical investigation of Terminalia bellirica fruit inside. Asian Journal of Pharmaceutical and Clinical Research. 2019;12:191-4.
  6. Mazinani J. The effect of some plant extracts on the blood coagulation system: Hakim Sabzevari University; 2020.
  7. Alikhani Pour M., Sardari S., Eslamifar A., Azhar A., Rezvani M., Nazari M. Cheminformatics-based anticoagulant study of traditionally used medicinal plants. Iranian Biomedical Journal. 2017;21:400.
  8. Dejana E., Callioni A., Quintana A., de Gaetano G. Bleeding time in laboratory animals. II-A comparison of different assay conditions in rats. Thrombosis Res. 1979;15:191-7.
  9. Lee R.I., White P.D. A clinical study of the coagulation time of blood. The American Journal of the Medical Sciences. 2013;145:495.
  10. Huang L., Lin C., Li A., Wei B., Teng J., Li L. Pro-coagulant activity of phenolic acids isolated from Blumea riparia. Natural product communications. 2010;5:19-24.
  11. Brahimi M., Osmani S., Arabi A., Enta-Soltan B., Taghezout Z., Elkahili B.S., et al. The estimation of platelet count from a blood smear on the basis of the red cell: platelet ratio. Turkish J. Hematology. 2009;26.
  12. Singh M.P., Gupta A., Sisodia S.S. Wound healing activity of Terminalia bellerica Roxb. and gallic acid in experimentally induced diabetic animals. J. Complementary and Integrative Medicine. 2020;17.
  13. Fauzi A., Lamma S., Ruslin M. Total tannin levels analysis of brown algae (sargassum sp. and padina sp.) to prevent blood loss in surgery. J Dentomaxillofacial Sci. 2018;3:37-40.
  14. Huang J., Zhang J., Xu Z-w. Effect of astragalus polysaccharide on the proliferation of bone marrow mesenchymal stem cells and the expression of stem cell factor in vitro. Fudan University J. Medical Sci. 2011;38:343-8.
  15. Pignatelli P., De Biase L., Lenti L., Tocci G., Brunelli A., Cangemi R., et al. Tumor necrosis factor-α as trigger of platelet activation in patients with heart failure. Blood. 2005;106:1992-4.
  16. Doss A., Parivuguna V., Vijayasanthi M., Surendran S. Antibacterial evaluation and phytochemical analysis of Medicago sativa L. against some microbial pathogens. Indian J. Sci. Techno. 2011;4:550-2.
  17. Noha S., El-Demerdash E., Abdel-Rahman H.M., Algandaby M.M., Al-Abbasi F.A., Abdel-Naim A.B. Anti-inflammatory activity of methyl palmitate and ethyl palmitate in different experimental rat models. Toxicology and Applied Pharmacology. 2012;264:84-93.
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