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Heydari, Sonya, Hosseini, Seyed Hojjat, Kamali, Koorosh, Sardari, Saeed, Parsamanesh, Negin, Ghassemifard, Leila, Khavasi, Narjes. (1402). Capparis spinosa L. Reduces Cisplatin-induced Acute Liver Injury in Male Rats: Pretreatment and Single Dose Therapy. سامانه مدیریت نشریات علمی, 12(4), 513-524. doi: 10.22034/jmpb.2022.128219
Sonya Heydari; Seyed Hojjat Hosseini; Koorosh Kamali; Saeed Sardari; Negin Parsamanesh; Leila Ghassemifard; Narjes Khavasi. "Capparis spinosa L. Reduces Cisplatin-induced Acute Liver Injury in Male Rats: Pretreatment and Single Dose Therapy". سامانه مدیریت نشریات علمی, 12, 4, 1402, 513-524. doi: 10.22034/jmpb.2022.128219
Heydari, Sonya, Hosseini, Seyed Hojjat, Kamali, Koorosh, Sardari, Saeed, Parsamanesh, Negin, Ghassemifard, Leila, Khavasi, Narjes. (1402). 'Capparis spinosa L. Reduces Cisplatin-induced Acute Liver Injury in Male Rats: Pretreatment and Single Dose Therapy', سامانه مدیریت نشریات علمی, 12(4), pp. 513-524. doi: 10.22034/jmpb.2022.128219
Heydari, Sonya, Hosseini, Seyed Hojjat, Kamali, Koorosh, Sardari, Saeed, Parsamanesh, Negin, Ghassemifard, Leila, Khavasi, Narjes. Capparis spinosa L. Reduces Cisplatin-induced Acute Liver Injury in Male Rats: Pretreatment and Single Dose Therapy. سامانه مدیریت نشریات علمی, 1402; 12(4): 513-524. doi: 10.22034/jmpb.2022.128219

Capparis spinosa L. Reduces Cisplatin-induced Acute Liver Injury in Male Rats: Pretreatment and Single Dose Therapy

Journal of Medicinal plants and By-products
مقاله 22، دوره 12، شماره 4، اسفند 2023، صفحه 513-524    اصل مقاله (1.16 M)
نوع مقاله: Research Article
شناسه دیجیتال (DOI): 10.22034/jmpb.2022.128219
نویسندگان
Sonya Heydari1؛ Seyed Hojjat Hosseini2؛ Koorosh Kamali3؛ Saeed Sardari1؛ Negin Parsamanesh4؛ Leila Ghassemifard1؛ Narjes Khavasi* 1
1Department of Persian Medicine, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
2Department of Pharmacology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
3Department of Public Health, School of Public Health, Zanjan University of Medical Sciences, Zanjan, Iran
4Metabolic Diseases Research Center, Zanjan University of Medical Sciences, Zanjan, Iran
چکیده
Cisplatin as a chemotherapeutic agent causes liver injury by increasing inflammatory production. Capparis spinosa L. as a source of natural antioxidants can clear this production. The present study was designed to assess the effects of pretreatment as well as treatment with a single dose of hydroalcoholic extract of Capparis seed on cisplatin-induced liver damage in rats. Forty-eight male Sprague-Dawley rats were divided into six groups (control group, Cis (cisplatin) group, 200 C/S (C. spinosa), Cis + 50 C/S 1-day, Cis + 100 C/S 1-day, and 100 C/S + Cis groups). Biochemical and histopathological assessment were done. Statistical analyses were performed with Graph Pad Prism Statistics software 9.1.2. The level of significance was set at p < 0.05. Liver function tests, antioxidant and inflammatory parameters and quantitative parameters of histopathological changes were measured. Significant changes in the pathology results were obvious. The diameter of central vein, portal vein, and bile duct, the thickness of the hepatic artery wall, and hepatic sinusoids were significantly increased in the Cis and 200 C/S-fed groups, compared to the controls, and also changes in favor of improvement were evident in the treatment groups compared to the Cis and 200 C/S groups. By increasing the time interval between cisplatin injection and testing, as well as using the western blotting method to measure the level of antioxidant and inflammatory markers, we may have significant biochemical and antioxidant results. Based on pathology results, single-dose treatment with C. spinosa seed extract may be beneficial in the cisplatin-induced liver damage.
کلیدواژه‌ها
Drug-Induced Liver Injury؛ Capparis spinosa L؛ Cisplatin؛ Medicine؛ Persian
مراجع
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