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Auni Kamal, D, Fisal Shakir Agha, N, Housein, Z. (1402). Upregulation of XRCC1 DNA Repair Gene, Interleukin-8, and Bcl-2 Antiapoptotic Gene Levels in Kurdish Patients with Gastric Adenocarcinoma. سامانه مدیریت نشریات علمی, 78(3), 989-995. doi: 10.22092/ari.2022.360240.2567
D Auni Kamal; N Fisal Shakir Agha; Z Housein. "Upregulation of XRCC1 DNA Repair Gene, Interleukin-8, and Bcl-2 Antiapoptotic Gene Levels in Kurdish Patients with Gastric Adenocarcinoma". سامانه مدیریت نشریات علمی, 78, 3, 1402, 989-995. doi: 10.22092/ari.2022.360240.2567
Auni Kamal, D, Fisal Shakir Agha, N, Housein, Z. (1402). 'Upregulation of XRCC1 DNA Repair Gene, Interleukin-8, and Bcl-2 Antiapoptotic Gene Levels in Kurdish Patients with Gastric Adenocarcinoma', سامانه مدیریت نشریات علمی, 78(3), pp. 989-995. doi: 10.22092/ari.2022.360240.2567
Auni Kamal, D, Fisal Shakir Agha, N, Housein, Z. Upregulation of XRCC1 DNA Repair Gene, Interleukin-8, and Bcl-2 Antiapoptotic Gene Levels in Kurdish Patients with Gastric Adenocarcinoma. سامانه مدیریت نشریات علمی, 1402; 78(3): 989-995. doi: 10.22092/ari.2022.360240.2567

Upregulation of XRCC1 DNA Repair Gene, Interleukin-8, and Bcl-2 Antiapoptotic Gene Levels in Kurdish Patients with Gastric Adenocarcinoma

Archives of Razi Institute
مقاله 26، دوره 78، شماره 3، مرداد و شهریور 2023، صفحه 989-995    اصل مقاله (523.5 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2022.360240.2567
نویسندگان
D Auni Kamal1؛ N Fisal Shakir Agha2؛ Z Housein* 1
1Department of Medical Laboratory Technology, Erbil Health and Medical Technical College, Erbil Polytechnic University, Erbil 44001, Kurdistan Region, Iraq
2Department of Anesthesia, Erbil Medical Technical Institute, Erbil Polytechnic University, Erbil 44001, Kurdistan Region, Iraq
چکیده
Gastric cancer (GC) is one of the deadliest tumors due to its competence to invade and metastasize. The DNA repair gene (XRCC1), interleukin-8 (IL-8) gene, and B-cell lymphoma 2 (Bcl-2) gene play a crucial role in the development and progression of GC. This study aimed to evaluate the expression of these target genes in GC patients in the Kurdistan region of Iraq. Gastric cancer tissues were collected from 29 patients diagnosed with gastric adenocarcinoma that underwent gastric resection, and 21 tissue samples were obtained from healthy patients that underwent gastroscopy. The gastric tissues were collected in different hospitals in Erbil and Sulaymaniyah cities in the Kurdistan region of Iraq. Moreover, the data regarding Helicobacter pylori, age, gender, and stage of the disease were recorded and analyzed using GraphPad Prism. The gene expression levels of XRCC1, IL-8, and Bcl-2 from gastric tissue were studied by real-time quantitative polymerase chain reaction. The results showed that H. pylori infection was equally distributed among males and females in the tissues of gastric patients, while most of the H. pylori-negative patients were females. It is also found that gastric patients aged 30-60 years old are more commonly tested for the H. pylori test. Accordingly, in this study, patients diagnosed with gastric inflammation more often tested positive for H. pylori, while patients diagnosed with gastric cancer tested negative for this infection. Additionally, it was found that the target genes (XRCC1, IL-8, and Bcl-2) were significantly upregulated in GC patients, compared to the healthy group. Finally, the result revealed that XRCC1, IL-8, and Bcl-2 were upregulated in the Kurdish patients with GC, compared to the healthy control group. Targeting XRCC1, IL-8, and Bcl-2 genes can be an interesting field and promising strategy for cancer treatment.
کلیدواژه‌ها
Gastric cancer؛ XRCC1؛ IL-8؛ Bcl-2؛ Gene expression
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مراجع
  1. Rawla P, Barsouk A. Epidemiology of gastric cancer: global trends, risk factors and prevention. Prz Gastroenterol. 2019;14(1):26-38.
  2. Thrift AP, El-Serag HB. Burden of gastric cancer. Clin Gastroenterol Hepatol. 2020;18(3):534-42.
  3. Karwan M, Abdullah OS, Amin AM, Mohamed ZA, Bestoon B, Shekha M, et al. Cancer Incidence in the Kurdistan Region of Iraq: Results of a Seven-Year Cancer Registration in Erbil and Duhok Governorates. Asian Pac J Cancer Prev. 2022;23(2):601.
  4. Rawla P, Barsouk A. Epidemiology of gastric cancer: global trends, risk factors and prevention. Prz Gastroenterol. 2019;14(1):26-38.
  5. Ford AC, Yuan Y, Forman D, Hunt R, Moayyedi P. Helicobacter pylori eradication for the prevention of gastric neoplasia. Cochrane Database Syst Rev. 2020(7).
  6. Asgerov E, Şenol Ö, Güler A, Berdeli A. Distribution of nucleotide variants in the DNA sequence of ERCC1 and XRCC1 genes and the effect of phenotype in patients with gastric cancer. Turk J Gastroenterol. 2019;30(6):517.
  7. Bie Y, Ge W, Yang Z, Cheng X, Zhao Z, Li S, et al. The crucial role of CXCL8 and its receptors in colorectal liver metastasis. Dis Markers. 2019;2019.
  8. Lee KE, Khoi PN, Xia Y, Park JS, Joo YE, Kim KK, et al. Helicobacter pylori and interleukin-8 in gastric cancer. World J Gastroenterol. 2013;19(45):8192.
  9. Strasser A, Harris AW, Bath ML, Cory S. Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2. Nature. 1990;348(6299):331-3.
  10. Lee JH, Soung YH, Lee JW, Park WS, Kim SY, Cho YG, et al. Inactivating mutation of the pro‐apoptotic gene BID in gastric cancer. J Pathol. 2004;202(4):439-45.
  11. Yeni M, Korkut E, Aksungur N, Kara S, Askin S, Kartal M. Determination of Pentraxin-3, Interleukin-8 and vascular endothelial growth factor levels in patients with gastric adenocarcinoma. Asian Pac J Cancer Prev. 2021;22(5):1507.
  12. Izaldeen Sowaid Y, Ali OM, Saad Abul Hussian S. Extra-Gastroduodenal Manifestation and Helicobacter pylori Infection. Arch Razi Inst. 2022;77(3):1017-26.
  13. Yang L, Kartsonaki C, Yao P, de Martel C, Plummer M, Chapman D, et al. The relative and attributable risks of cardia and non-cardia gastric cancer associated with Helicobacter pylori infection in China: a case-cohort study. Lancet Public Health. 2021;6(12):e888-e96.
  14. Wang P, Tang JT, Peng YS, Chen XY, Zhang YJ, Fang JY. XRCC1 downregulated through promoter hypermethylation is involved in human gastric carcinogenesis. J Dig Dis. 2010;11(6):343-51.
  15. Wang W, Yang J, Yu Y, Deng J, Zhang H, Yao Q, et al. Expression of JWA and XRCC1 as prognostic markers for gastric cancer recurrence. Int J Clin Exp Pathol. 2020;13(12):3120.
  1. Li J, Xu L, Run Z-C, Feng W, Liu W, Zhang P-J, et al. Multiple cytokine profiling in serum for early detection of gastric cancer. World J Gastroenterol. 2018;24(21):2269.
  2. Campbell LM, Maxwell PJ, Waugh DJ. Rationale and means to target pro-inflammatory interleukin-8 (CXCL8) signaling in cancer. Pharmaceuticals. 2013;6(8):929-59.
  3. Shi J, Li Y-J, Yan B, Wei P-K. Interleukin-8: A potent promoter of human lymphatic endothelial cell growth in gastric cancer. Oncol Rep. 2015;33(6):2703-10.
  4. Sun X, Xiang CJ, Wu J, Dong W, Zhan Z, Wang RP, et al. Relationship between serum inflammatory cytokines and lifestyle factors in gastric cancer. Mol Clin Oncol. 2019;10(3):401-14.
  5. Xu A-G, Li S-G, Liu J-H, Gan A-H. Function of apoptosis and expression of the proteins Bcl-2, p53 and C-myc in the development of gastric cancer. World J Gastroenterol. 2001;7(3):403.
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