اخبار و اعلانات

 آمار

تعداد نشریات284
تعداد نشریات سازمان82
تعداد شماره‌ها3,044
تعداد مقالات34,046
تعداد مشاهده مقاله46,435,022
تعداد دریافت فایل اصل مقاله77,500,851
Ali Naeem, H, Nazar Ibraheim, W, Abdullah Alomar, S. A. (1402). The Impact of Human Mammary Tumor Virus (HMTV) on the Expression of Epidermal Growth Factor Receptor (EGFR) and Death–Domain Associated Protein (DAXX) in Breast Carcinoma Tissues. سامانه مدیریت نشریات علمی, 78(2), 689-699. doi: 10.22092/ari.2022.359520.2440
H Ali Naeem; W Nazar Ibraheim; S. A Abdullah Alomar. "The Impact of Human Mammary Tumor Virus (HMTV) on the Expression of Epidermal Growth Factor Receptor (EGFR) and Death–Domain Associated Protein (DAXX) in Breast Carcinoma Tissues". سامانه مدیریت نشریات علمی, 78, 2, 1402, 689-699. doi: 10.22092/ari.2022.359520.2440
Ali Naeem, H, Nazar Ibraheim, W, Abdullah Alomar, S. A. (1402). 'The Impact of Human Mammary Tumor Virus (HMTV) on the Expression of Epidermal Growth Factor Receptor (EGFR) and Death–Domain Associated Protein (DAXX) in Breast Carcinoma Tissues', سامانه مدیریت نشریات علمی, 78(2), pp. 689-699. doi: 10.22092/ari.2022.359520.2440
Ali Naeem, H, Nazar Ibraheim, W, Abdullah Alomar, S. A. The Impact of Human Mammary Tumor Virus (HMTV) on the Expression of Epidermal Growth Factor Receptor (EGFR) and Death–Domain Associated Protein (DAXX) in Breast Carcinoma Tissues. سامانه مدیریت نشریات علمی, 1402; 78(2): 689-699. doi: 10.22092/ari.2022.359520.2440

The Impact of Human Mammary Tumor Virus (HMTV) on the Expression of Epidermal Growth Factor Receptor (EGFR) and Death–Domain Associated Protein (DAXX) in Breast Carcinoma Tissues

Archives of Razi Institute
مقاله 24، دوره 78، شماره 2، خرداد و تیر 2023، صفحه 689-699    اصل مقاله (589.62 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2022.359520.2440
نویسندگان
H Ali Naeem* ؛ W Nazar Ibraheim؛ S. A Abdullah Alomar
Department of Pathology and Forensic, College of Medicine, University of Basrah, Basrah, Iraq
چکیده
The presence and characteristics of HMTV in Iraqi breast cancer women are still unknown. Furthermore, the identification of HMTV in human breast carcinoma tissue of patients differs by country, and the factors that influence it are still unknown. In many epithelial tumor types, the EGFR and its signaling pathways outcomes are necessary for the behavior of cells and regulating their proliferation, and it has been discovered that DAXX has strong carcinogenic characteristics and could be a new treatment target. This case-control retrospective study investigated the presence of HMTV in paraffin-embedded blocks (FFPT) of tumor samples from 60 Iraqi women patients diagnosed with primary breast cancer and 20 cases of benign tumors as a control group. HMTV env sequences were identified by Real-time PCR. EGFR and DAXX expression were immun0-detected by the immuno-histochemistry technique. HMTV sequences were detected in 15 (25%) samples of malignant breast tumors and 8 (40%) samples of benign breast tumors. There was no statistically significant association between the detection of env sequences of HMTV and age, grade, hormone receptors, EGFR, or DAXX expression compared to clinicopathological characteristics. However, statistically, the data showed a highly significant difference in the Expression of EGFR between study groups, age, and histological types (P=0.0001), and a significant negative association was observed between EGFR and both Her2 and TNBC. There was a statistically significant difference between DAXX (+) and DAXX (−) in study groups (P=0.002), and it was significantly associated with age and histological types of breast cancer (P=0.031 and 0.007, respectively). No significant association was found between DAXX and EGFR, grade, Her2. TNBC of breast cancer. The current study found HMTV env sequences in breast tumors of Iraqi women, suggesting that a larger sample size is needed to illustrate the potential causative role of HMTV in the development of human breast malignancy. Moreover, a negative association was found between HMTV and DAXX and EGFR Expression.
کلیدواژه‌ها
Breast cancer؛ HMTV؛ EGFR؛ DAXX
سایر فایل های مرتبط با مقاله
مراجع
  1. Parkin D. Cancer incidence in five continents: World Health Organization; 2005.
  2. O SH, L AH, N AA, Al-Hawaz MH, Al-Faddagh ZA, G NN, et al. Epidemiology of Breast Cancer among Females in Basrah. Asian Pac J Cancer Prev. 2016;17(S3):191-5.
  3. Habeeb A, Al-Attar H, Maqtoof A, Habib O. Knowledge of women from basrah about breast cancer: its risk and preventive factors. Iraqi National Journal of Medicine. 2020;2:117-23.
  4. Parkin DM. The global health burden of infection-associated cancers in the year 2002. Int J Cancer. 2006;118(12):3030-44.
  5. Bittner JJ. Some possible effects of nursing on the mammary gland tumor incidence in mice. Science. 1936;84(2172):162-.
  6. Wang F, Hou J, Shen Q, Yue Y, Xie F, Wang X, et al. Mouse mammary tumor virus-like virus infection and the risk of human breast cancer: a meta-analysis. Am J Transl Res. 2014;6(3):248.
  7. Nartey T, Mazzanti CM, Melana S, Glenn WK, Bevilacqua G, Holland JF, et al. Mouse mammary tumor-like virus (MMTV) is present in human breast tissue before development of virally associated breast cancer. Infect Agent Cancer. 2017;12:1.
  8. Masuda H, Zhang D, Bartholomeusz C, Doihara H, Hortobagyi GN, Ueno NT. Role of epidermal growth factor receptor in breast cancer. Breast Cancer Res Treat. 2012;136(2):331-45.
  9. Mendelsohn J, Baselga J. Status of epidermal growth factor receptor antagonists in the biology and treatment of cancer. J Clin Oncol. 2003;21(14):2787-99.
  10. Burness ML, Grushko TA, Olopade OI. Epidermal growth factor receptor in triple-negative and basal-like breast cancer: promising clinical target or only a marker? Cancer J. 2010;16(1):23-32.
  11. Fernandez ML. Role of DAXX as a Predictive Biomarker in Breast Cancer. 2019.
  12. Chen YC, Lee TH, Tzeng SL. Reduced DAXX Expression Is Associated with Reduced CD24 Expression in Colorectal Cancer. Cells. 2019;8(10).
  13. Cedro-Tanda A, Cordova-Solis A, Juarez-Cedillo T, Pina-Jimenez E, Hernandez-Caballero ME, Moctezuma-Meza C, et al. Prevalence of HMTV in breast carcinomas and unaffected tissue from Mexican women. BMC Cancer. 2014;14:942.
  14. Stewart TH, Sage RD, Stewart AF, Cameron DW. Breast cancer incidence highest in the range of one species of house mouse, Mus domesticus. Br J Cancer. 2000;82(2):446-51.
  15. Lawson JS, Glenn WK. Catching viral breast cancer. Infect Agent Cancer. 2021;16(1):37.
  16. Holland JF, Pogo BG. Mouse mammary tumor virus-like viral infection and human breast cancer. Clin Cancer Res. 2004;10(17):5647-9.
  17. Mant C, Gillett C, D'Arrigo C, Cason J. Human murine mammary tumour virus-like agents are genetically distinct from endogenous retroviruses and are not detectable in breast cancer cell lines or biopsies. Virology. 2004;318(1):393-404.
  18. Zangen R, Harden S, Cohen D, Parrella P, Sidransky D. Mouse mammary tumor-like env gene as a molecular marker for breast cancer? Int J Cancer. 2002;102(3):304-7.
  19. Loutfy SA, Abdallah ZF, Shaalan M, Moneer M, Karam A, Moneer MM, et al. Prevalence of MMTV-Like env Sequences and Its Association with BRCA1/2 Genes Mutations Among Egyptian Breast Cancer Patients. Cancer Manag Res. 2021;13:2835-48.
  20. Skedgel C, Rayson D, Younis T. Is adjuvant trastuzumab a cost-effective therapy for HER-2/neu-positive T1bN0 breast cancer? Ann Oncol. 2013;24(7):1834-40.
  21. Tang Y, Zhu L, Li Y, Ji J, Li J, Yuan F, et al. Overexpression of epithelial growth factor receptor (EGFR) predicts better response to neo-adjuvant chemotherapy in patients with triple-negative breast cancer. J Transl Med. 2012;10(1):4.
  22. Lee HJ, Seo AN, Kim EJ, Jang MH, Kim YJ, Kim JH, et al. Prognostic and predictive values of EGFR overexpression and EGFR copy number alteration in HER2-positive breast cancer. Br J Cancer. 2015;112(1):103-11.
  23. Nieto Y, Nawaz F, Jones RB, Shpall EJ, Nawaz S. Prognostic significance of overexpression and phosphorylation of epidermal growth factor receptor (EGFR) and the presence of truncated EGFRvIII in locoregionally advanced breast cancer. J Clin Oncol. 2007;25(28):4405-13.
  24. Lv N, Xie X, Ge Q, Lin S, Wang X, Kong Y, et al. Epidermal growth factor receptor in breast carcinoma: association between gene copy number and mutations. Diagn Pathol. 2011;6:118.
  25. Hashmi AA, Naz S, Hashmi SK, Irfan M, Hussain ZF, Khan EY, et al. Epidermal growth factor receptor (EGFR) overexpression in triple-negative breast cancer: association with clinicopathologic features and prognostic parameters. Surg Exp Pathol. 2019;2:1-7.
  26. Sadia H, Gomez MK, Rahat TB, Naushad W. 96P MMTV and breast cancer: Integration sites of MMTV in breast cancer patients and their potential role in cancer progression. Ann Oncol. 2015;26:ix16.
  27. Ko TY, Kim JI, Park ES, Mun JM, Park SD. The Clinical Implications of Death Domain-Associated Protein (DAXX) Expression. Korean J Thorac Cardiovasc Surg. 2018;51(3):187-94.
  28. Ansari MJ, Jasim SA, Taban TZ, Bokov DO, Shalaby MN, Al-Gazally ME, et al. Anticancer Drug-Loading Capacity of Green Synthesized Porous Magnetic Iron Nanocarrier and Cytotoxic Effects Against Human Cancer Cell Line. J Clust Sci. 2023;34(1):467-77.
  29. Hashim BM, Al-Naseri SK, Al Maliki A, Sa’adi Z, Malik A, Yaseen ZM. On the investigation of COVID-19 lockdown influence on air pollution concentration: regional investigation over eighteen provinces in Iraq. Environ Sci Pollut Res. 2021;28(36):50344-62.
  30. Huldani H, Abdalkareem Jasim S, Olegovich Bokov D, Abdelbasset WK, Nader Shalaby M, Thangavelu L, et al. Application of extracellular vesicles derived from mesenchymal stem cells as potential therapeutic tools in autoimmune and rheumatic diseases. Int Immunopharmacol. 2022;106:108634.
  31. Jiao Y, Shi C, Edil BH, de Wilde RF, Klimstra DS, Maitra A, et al. DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors. Science. 2011;331(6021):1199-203.
  32. Olegovich Bokov D, Jalil AT, Alsultany FH, Mahmoud MZ, Suksatan W, Chupradit S, et al. Ir-decorated gallium nitride nanotubes as a chemical sensor for recognition of mesalamine drug: a DFT study. Mol Simul. 2022;48(5):438-47.
  1. Zadeh FA, Bokov DO, Salahdin OD, Abdelbasset WK, Jawad MA, Kadhim MM, et al. Cytotoxicity evaluation of environmentally friendly synthesis Copper/Zinc bimetallic nanoparticles on MCF-7 cancer cells. Rend Lincei Sci Fis Nat. 2022;33(2):441-7.
آمار
تعداد مشاهده مقاله: 2,674
تعداد دریافت فایل اصل مقاله: 7,437


counter
سامانه مدیریت نشریات علمی. طراحی و پیاده سازی از سیناوب