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Almuttairi, R. S. (1401). The Effects of Metformin Treatment on Diabetic Albino Rats' Pancreas, Liver, and Kidney Histology. سامانه مدیریت نشریات علمی, 78(1), 459-463. doi: 10.22092/ari.2022.359289.2394
R. S Almuttairi. "The Effects of Metformin Treatment on Diabetic Albino Rats' Pancreas, Liver, and Kidney Histology". سامانه مدیریت نشریات علمی, 78, 1, 1401, 459-463. doi: 10.22092/ari.2022.359289.2394
Almuttairi, R. S. (1401). 'The Effects of Metformin Treatment on Diabetic Albino Rats' Pancreas, Liver, and Kidney Histology', سامانه مدیریت نشریات علمی, 78(1), pp. 459-463. doi: 10.22092/ari.2022.359289.2394
Almuttairi, R. S. The Effects of Metformin Treatment on Diabetic Albino Rats' Pancreas, Liver, and Kidney Histology. سامانه مدیریت نشریات علمی, 1401; 78(1): 459-463. doi: 10.22092/ari.2022.359289.2394

The Effects of Metformin Treatment on Diabetic Albino Rats' Pancreas, Liver, and Kidney Histology

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مقاله 57، دوره 78، شماره 1، فروردین و اردیبهشت 2023، صفحه 459-463    اصل مقاله (450.2 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2022.359289.2394
نویسنده
R. S Almuttairi*
Department of Clinical Laboratory Sciences, College of Pharmacy, University of Babylon, Babylon, Iraq
چکیده
Metformin, an oral hypoglycemic drug, has traditionally been considered the standard therapy for hyperglycemia. Metformin's several modes of action include inhibition of hepatic gluconeogenesis, anti-glucagon activity, and insulin-sensitizing effect. This study aims to assess the effectiveness of Metformin on the liver, pancreatic, and kidney tissues of alloxan-induced diabetic albino rats. Twenty mature albino white male rats were allocated at random into two groups. Intraperitoneal injections of alloxan monohydrate were utilised to induce diabetic Mellitus type II in the first ten rats. The second group of rats were injected intraperitoneally with normal saline. Both groups were then separated into four subgroups: Group 1 consisted of non-diabetic rats that were only administered distilled water (control), Group 2 consisted of non-diabetic rats that were administered metformin at a dose of 1000 mg/kg/day, and Group 3 consisted of diabetic control animals that were administered alloxan intravenously and distilled water orally, but were not given any medications. After seven days of DM induction, diabetic rats were administered Metformin at a dose of 1000 mg/kg/day orally. After one month of therapy, the animals were slaughtered and their organs were harvested. Compared to the control group, the histological results of pancreatic tissue were normal in the treatment groups. In contrast, liver and kidney sections from non-diabetic control, non-diabetic, and diabetic animals given 1000 mg/kg/day of Metformin had normal histology. Still, both tissues of untreated diabetic control mice exhibited lymphocyte infiltration. Metformin has been found to have significant blood glucose lowering properties and the capacity to protect several organs from the negative consequences of diabetes.
کلیدواژه‌ها
Metformin؛ Alloxan-induced؛ Albino rats؛ Pancreas؛ Liver؛ Kidney
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مراجع
  1. Bilal HM, Riaz F, Munir K, Saqib A, Sarwar MR. Histological changes in the liver of diabetic rats: A review of pathogenesis of nonalcoholic fatty liver disease in type 1 diabetes mellitus. Cogent Med. 2016;3(1):1275415.
  2. Ismail TA, Soliman MM, Nassan MA. Molecular and immunohistochemical effects of metformin in a rat model of type 2 diabetes mellitus. Exp Ther Med. 2015;9(5):1921-30.
  3. Balamash KS, Alkreathy HM, Al Gahdali EH, Khoja SO, Ahmad A. Comparative biochemical and histopathological studies on the efficacy of metformin and virgin olive oil against streptozotocin-induced diabetes in Sprague-Dawley rats. J Diabetes Res. 2018;2018.
  4. Lucchesi AN, Cassettari LL, Spadella CT. Alloxan-induced diabetes causes morphological and ultrastructural changes in rat liver that resemble the natural history of chronic fatty liver disease in humans. J Diabetes Res. 2015;2015.
  5. Sui Y, Kong X, Fan R, Ye Y, Mai H, Zhuo S, et al. Long-term treatment with metformin in the prevention of fatty liver in Zucker diabetic fatty rats. Diabetol Metab Syndr. 2019;11(1):1-9.
  6. Abd El-Hakim YM, Abdel-Rahman Mohamed A, Khater SI, Hamed Arisha A, Metwally MM, Nassan MA, et al. Chitosan-stabilized selenium nanoparticles and metformin synergistically rescue testicular oxidative damage and steroidogenesis-related genes dysregulation in high-fat diet/streptozotocin-induced diabetic rats. Antioxidants. 2020;10(1):17.
  7. Adeniji AA, Lawal SK, Osinubi AA, Kusemiju T, Uyaiabasi N-FG. The comparative effects of metformin and insulin on the kidney, lung and heart of streptozotocin-induced diabetic female Wistar rats. Nig Q J Hosp Med. 2016;26(1):353-9.
  1. Suvarna KS, Layton C, Bancroft JD. Bancroft's theory and practice of histological techniques E-Book: Elsevier health sciences; 2018.
  2. Yanardag R, Ozsoy-Sacan O, Bolkent S, Orak H, Karabulut-Bulan O. Protective effects of metformin treatment on the liver injury of streptozotocin-diabetic rats. Hum Exp Toxicol. 2005;24(3):129-35.
  3. Butler AE, Janson J, Bonner-Weir S, Ritzel R, Rizza RA, Butler PC. β-cell deficit and increased β-cell apoptosis in humans with type 2 diabetes. Diabetes. 2003;52(1):102-10.
  4. Bunnag SC, Warner NE, Bunnag S. Effect of alloxan on the mouse pancreas during and after recovery from diabetes. Diabetes. 1967;16(2):83-9.
  5. Almuttairi RS, Shwaikh AK, Alyassery AMAA. The Effect of Repaglinide on the Liver and Kidney Histology of alloxan induced diabetic albino rats. BNJHS. 2022;140(1):1459-66.
  6. Zafar M, Naeem-ul-Hassan Naqvi S, Ahmed M, Kaimkhani ZA. Altered kidney morphology and enzymes in streptozotocin induced diabetic rats. Int J Morphol. 2009;27(3):783-90.
  7. Zhang S, Xu H, Yu X, Wu Y, Sui D. Metformin ameliorates diabetic nephropathy in a rat model of low-dose streptozotocin-induced diabetes. Exp Ther Med. 2017;14(1):383-90.
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