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Ali Abd, S, Alsaffar, J. M. J, Agop, A. K, Kadhem, E. J. (1401). Comparison of Skin Bacteria between Psoriasis Patients and Healthy Control. سامانه مدیریت نشریات علمی, 77(5), 1737-1740. doi: 10.22092/ari.2022.359398.2414
S Ali Abd; J. M. J Alsaffar; A. K Agop; E. J Kadhem. "Comparison of Skin Bacteria between Psoriasis Patients and Healthy Control". سامانه مدیریت نشریات علمی, 77, 5, 1401, 1737-1740. doi: 10.22092/ari.2022.359398.2414
Ali Abd, S, Alsaffar, J. M. J, Agop, A. K, Kadhem, E. J. (1401). 'Comparison of Skin Bacteria between Psoriasis Patients and Healthy Control', سامانه مدیریت نشریات علمی, 77(5), pp. 1737-1740. doi: 10.22092/ari.2022.359398.2414
Ali Abd, S, Alsaffar, J. M. J, Agop, A. K, Kadhem, E. J. Comparison of Skin Bacteria between Psoriasis Patients and Healthy Control. سامانه مدیریت نشریات علمی, 1401; 77(5): 1737-1740. doi: 10.22092/ari.2022.359398.2414

Comparison of Skin Bacteria between Psoriasis Patients and Healthy Control

Archives of Razi Institute
مقاله 28، دوره 77، شماره 5، آذر و دی 2022، صفحه 1737-1740    اصل مقاله (373.83 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2022.359398.2414
نویسندگان
S Ali Abd* 1؛ J. M. J Alsaffar1؛ A. K Agop1؛ E. J Kadhem2
1Biotechnology Department, College of Science, University of Baghdad, Baghdad, Iraq
2Ministry of Industry, Ibn Sina Research Center, Baghdad, Iraq
چکیده
Psoriasis is an autoimmune, persistent, inflammatory skin illness that is influenced by a variety of circumstances. Psoriasis etiology is strongly linked to bacteria, particularly those in the pharynx and skin. This research intended to deepen our understanding by elucidating the connection between the skin microbiome and psoriasis to improve therapeutic balance using probiotics, antimicrobials, and even topical microbiota transplantation. In this work, the culture-dependent approach is utilized to compare the skin microbiomes of psoriatic and healthy individuals. On brane-heart infusion agar, swabs from 60 psoriasis patients in the flare-up stag and 40 healthy controls were cultured and grown for 48 hours. The resultant colonies were then subcultured and purified to produce a single pure colony. Using Macconkey agar for preliminary colony identification, Vitek then characterized the purified colonies. The results revealed substantial bacterial species and phyla variations between psoriatic patients and healthy controls. In addition, increased rates of opportunistic infections Pseudomonas stutzeri and Staphylococcus pseudintermedius were detected in psoriatic patients' normal skin and lesions.
کلیدواژه‌ها
Psoriasis؛ Skin Microbiome؛ Dysbiosis
مراجع
  1. IM. M, B. L, SM. J. Global report on psoriasis. World Health Organization; 2016.
  2. Wanke I, Steffen H, Christ C, Krismer B, Gotz F, Peschel A, et al. Skin commensals amplify the innate immune response to pathogens by activation of distinct signaling pathways. J Invest Dermatol. 2011;131(2):382-90.
  3. Alekseyenko AV, Perez-Perez GI, De Souza A, Strober B, Gao Z, Bihan M, et al. Community differentiation of the cutaneous microbiota in psoriasis. Microbiome. 2013;1(1):31.
  4. Ganju P, Nagpal S, Mohammed MH, Nishal Kumar P, Pandey R, Natarajan VT, et al. Microbial community profiling shows dysbiosis in the lesional skin of Vitiligo subjects. Sci Rep. 2016;6:18761.
  5. Assarsson M, Duvetorp A, Dienus O, Soderman J, Seifert O. Significant Changes in the Skin Microbiome in Patients with Chronic Plaque Psoriasis after Treatment with Narrowband Ultraviolet B. Acta Derm Venereol. 2018;98(4):428-36.
  6. Drago L, De Grandi R, Altomare G, Pigatto P, Rossi O, Toscano M. Skin microbiota of first cousins affected by psoriasis and atopic dermatitis. Clin Mol Allergy. 2016;14:2.
  7. Loesche MA, Farahi K, Capone K, Fakharzadeh S, Blauvelt A, Duffin KC, et al. Longitudinal Study of the Psoriasis-Associated Skin Microbiome during Therapy with Ustekinumab in a Randomized Phase 3b Clinical Trial. J Invest Dermatol. 2018;138(9):1973-81.
  1. Fahlen A, Engstrand L, Baker BS, Powles A, Fry L. Comparison of bacterial microbiota in skin biopsies from normal and psoriatic skin. Arch Dermatol Res. 2012;304(1):15-22.
  2. Gao Z, Tseng CH, Strober BE, Pei Z, Blaser MJ. Substantial alterations of the cutaneous bacterial biota in psoriatic lesions. PLoS One. 2008;3(7):2719.
  3. Sender R, Fuchs S, Milo R. Revised Estimates for the Number of Human and Bacteria Cells in the Body. PLoS Biol. 2016;14(8):1002533.
  4. Fitz-Gibbon S, Tomida S, Chiu BH, Nguyen L, Du C, Liu M, et al. Propionibacterium acnes strain populations in the human skin microbiome associated with acne. J Invest Dermatol. 2013;133(9):2152-60.
  5. Gardner SE, Hillis SL, Heilmann K, Segre JA, Grice EA. The neuropathic diabetic foot ulcer microbiome is associated with clinical factors. Diabetes. 2013;62(3):923-30.
  6. Kong HH, Oh J, Deming C, Conlan S, Grice EA, Beatson MA, et al. Temporal shifts in the skin microbiome associated with disease flares and treatment in children with atopic dermatitis. Genome Res. 2012;22(5):850-9.
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