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Ihsan Rashan, A, Mahdi Rheima, A, Ghadhanfar Alwan, M, Abed Jawad, M, Mohammed, H. T, Gaber Abdel Razzaq, M, Ahmed Al-Taweel, A, Attia Thijail, H, Ahjel, S, Jalil Obaid, A. (1401). Evaluating the Level of Serum IL-23 in Brucellosis Infection by ELISA and Investigating its Relationship in Cases with Failure to Respond to Treatment. سامانه مدیریت نشریات علمی, 77(3), 1275-1279. doi: 10.22092/ari.2022.358877.2324
A Ihsan Rashan; A Mahdi Rheima; M Ghadhanfar Alwan; M Abed Jawad; H. T Mohammed; M Gaber Abdel Razzaq; A Ahmed Al-Taweel; H Attia Thijail; S Ahjel; A Jalil Obaid. "Evaluating the Level of Serum IL-23 in Brucellosis Infection by ELISA and Investigating its Relationship in Cases with Failure to Respond to Treatment". سامانه مدیریت نشریات علمی, 77, 3, 1401, 1275-1279. doi: 10.22092/ari.2022.358877.2324
Ihsan Rashan, A, Mahdi Rheima, A, Ghadhanfar Alwan, M, Abed Jawad, M, Mohammed, H. T, Gaber Abdel Razzaq, M, Ahmed Al-Taweel, A, Attia Thijail, H, Ahjel, S, Jalil Obaid, A. (1401). 'Evaluating the Level of Serum IL-23 in Brucellosis Infection by ELISA and Investigating its Relationship in Cases with Failure to Respond to Treatment', سامانه مدیریت نشریات علمی, 77(3), pp. 1275-1279. doi: 10.22092/ari.2022.358877.2324
Ihsan Rashan, A, Mahdi Rheima, A, Ghadhanfar Alwan, M, Abed Jawad, M, Mohammed, H. T, Gaber Abdel Razzaq, M, Ahmed Al-Taweel, A, Attia Thijail, H, Ahjel, S, Jalil Obaid, A. Evaluating the Level of Serum IL-23 in Brucellosis Infection by ELISA and Investigating its Relationship in Cases with Failure to Respond to Treatment. سامانه مدیریت نشریات علمی, 1401; 77(3): 1275-1279. doi: 10.22092/ari.2022.358877.2324

Evaluating the Level of Serum IL-23 in Brucellosis Infection by ELISA and Investigating its Relationship in Cases with Failure to Respond to Treatment

Archives of Razi Institute
مقاله 46، دوره 77، شماره 3، مرداد و شهریور 2022، صفحه 1275-1279    اصل مقاله (400.72 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2022.358877.2324
نویسندگان
A Ihsan Rashan1؛ A Mahdi Rheima2، 3؛ M Ghadhanfar Alwan4؛ M Abed Jawad5؛ H. T Mohammed* 6؛ M Gaber Abdel Razzaq7؛ A Ahmed Al-Taweel8؛ H Attia Thijail9؛ S Ahjel10؛ A Jalil Obaid11
1Department of Pharmacy, Al-Hadba University College, Mosul, Iraq
2College of technical engineering, The Islamic University, Najaf, Iraq
3Department of Optics Techniques, Dijlah University College, Al-Masafi Street, Al-Dora, Baghdad 00964, Iraq
4Medical laboratory techniques Department, Medical (Technology) College, Al-Farahidi University, Baghdad, Iraq
5Al-Nisour University College, Baghdad, Iraq
6Anesthesia Techniques Department, Al-Mustaqbal University College, Babylon, Iraq
7Al-Manara College For Medical Sciences, Misan, Iraq
8Al-Esraa University College, Baghdad, Iraq
9College of Health and Medical Technology, Al-Ayen University, Thi-Qar, Iraq
10Department of Pharmacy, Al-Zahrawi University College, Karbala, Iraq
11Medical Laboratory Techniques Department, Hilla University College, Babylon, Iraq
چکیده
Brucella is belonging to the small immobile gram-negative spore-lacking cocco-bacilli bacteria family that grows in an aerobic environment, it is known as a zoonosis infection named brucellosis. This study was designed to investigate serum values of IL-23 in patient with brucellosis and investigate its relationship with cases with failure to respond to conventional medical therapy. A total of 372 individuals were divided into 2 groups (n=186) as follows: Group A comprising 186 infected participants with brucella (7-80 years-old), these people had not received antibiotics for at least 6 months ago. Group B including the healthy participants. All the participants in both groups were in the same age range. 5 ml blood samples were obtained from the participants intravenously (without anticoagulation substance). The serum level of IL-23 was investigated by ELISA diagnostic kit. The recorded data showed that the levels of IL-23 in the serum samples obtained from group A (143.64 Pg/ml) significantly (P<0.001) increased compared with this value in group B (23.14 Pg/ml). Based on the recorded data in the forms completed by all the participants at the day 0 of the experiment, 44 out of 186 individuals in group A, had experienced Brucellosis attack 2-3 times in spite of receiving medical prescriptions. A hypothesis about the possible immune system disorders in these participants lead us to did the re-sampling following drug administration. Results illustrated failure to respond to conventional medical therapy in patients with low level of serum IL-23.
کلیدواژه‌ها
IL-23؛ Serum value؛ Brucellosis؛ Medical therapy
مراجع
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