اخبار و اعلانات

 آمار

تعداد نشریات282
تعداد نشریات سازمان80
تعداد شماره‌ها3,208
تعداد مقالات35,560
تعداد مشاهده مقاله53,008,632
تعداد دریافت فایل اصل مقاله92,291,729
Farhan Bdaiwic, L, Abd ALmunim Baker, L, Zuher Jalal Aldin, S. (1401). Investigation of the Effect of Rhubarb stalks extracts on Mice Exposed to Oxidative Stress. سامانه مدیریت نشریات علمی, 77(5), 1865-1871. doi: 10.22092/ari.2022.358160.2164
L Farhan Bdaiwic; L Abd ALmunim Baker; S Zuher Jalal Aldin. "Investigation of the Effect of Rhubarb stalks extracts on Mice Exposed to Oxidative Stress". سامانه مدیریت نشریات علمی, 77, 5, 1401, 1865-1871. doi: 10.22092/ari.2022.358160.2164
Farhan Bdaiwic, L, Abd ALmunim Baker, L, Zuher Jalal Aldin, S. (1401). 'Investigation of the Effect of Rhubarb stalks extracts on Mice Exposed to Oxidative Stress', سامانه مدیریت نشریات علمی, 77(5), pp. 1865-1871. doi: 10.22092/ari.2022.358160.2164
Farhan Bdaiwic, L, Abd ALmunim Baker, L, Zuher Jalal Aldin, S. Investigation of the Effect of Rhubarb stalks extracts on Mice Exposed to Oxidative Stress. سامانه مدیریت نشریات علمی, 1401; 77(5): 1865-1871. doi: 10.22092/ari.2022.358160.2164

Investigation of the Effect of Rhubarb stalks extracts on Mice Exposed to Oxidative Stress

Archives of Razi Institute
مقاله 45، دوره 77، شماره 5، آذر و دی 2022، صفحه 1865-1871    اصل مقاله (501.84 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2022.358160.2164
نویسندگان
L Farhan Bdaiwic1؛ L Abd ALmunim Baker2؛ S Zuher Jalal Aldin2
1Department of Chemistry, College of Education for Girls, Mosul University, Mosul, Iraq
2Department of Chemistry, College of Education for Pure Science, Mosul University, Mosul, Iraq
چکیده
Normal blood lipid levels have a crucial role in lowering cardiovascular mortality. This study was designed to investigate the effect of aqueous rhubarb extract on serum glucose, cholesterol, total lipids, peroxynitrite, malondialdehyde, glutathione, and ceruloplasmin levels, as well as glutathione and malondialdehyde levels in the liver, kidney, and heart tissue in mice exposed to oxidative stress. 40 Balb/c mice were randomly allocated into 8 groups (n=5). Group 1: The control group was left eating feed and water without treatment for (15) days. Group 2: A group exposed to oxidative stress by giving hydrogen peroxide at a rate of (0.5%) with drinking water for 15 days. Group 3: A group exposed to oxidative stress induced by hydrogen peroxide at a rate of (0.5%) for 15 days with injecting on the seventh day, daily for a week, with insulin subcutaneously (15) units/kg. Group (4-8): the Groups were exposed to the oxidative stress induced by hydrogen peroxide (0.5%) for 15 days with injecting on the seventh day into the peritoneal cavity with both the cold aqueous and nonprotein extract, the extract of flavonoids at a dose of 400, 400, 0.4, 8.8, 1.96 mg/kg body weight, respectively. All animals were anesthetized on the last day of the experiment, blood samples were obtained for biochemical testing, and tissue samples from the livers were collected for research. The results revealed that the cold crude aqueous, non-proteinous extracts, flavonoids, proteinous precipitate, and proteinous compound caused a significant decrease (P<0.05) in serum glucose, cholesterol, total lipids, peroxynitrite, malondialdehyde levels in kidney, liver, and heart. The recorded data showed a significant increase (P<0.05) in serum glutathione and ceruloplasmin in serum and glutathione levels in liver, kidney, and heart tissues in male mice exposed to oxidative stress. The results showed that all Rhubarb extracts have an antioxidant effect in mice exposed to oxidative stress.
کلیدواژه‌ها
Oxidative stress؛ Antioxidant؛ Rhubarb
مراجع
  1. Berköz M, YILDIRIM M, Krośniak M, Francik R, Allahverdiyev O. Antioxidant Activity Of Different Extracts From Stalk Part Of Rhub Arb (Rheum Rhabarbarum L.). Van Sağlık Bilimleri Dergisi.11(2):11-5.
  2. Clementi EM, Misiti F. Potential health benefits of rhubarb. Bioactive foods in promoting health: Elsevier; 2010. p. 407-23.
  3. Wang J, Zhao Y, Xiao X, Li H, Zhao H, Zhang P, et al. Assessment of the renal protection and hepatotoxicity of rhubarb extract in rats. J Ethnopharmacol. 2009;124(1):18-25.
  4. Kolodziejczyk-Czepas J, Liudvytska O. Rheum rhaponticum and Rheum rhabarbarum: A review of phytochemistry, biological activities and therapeutic potential. Phytochem Rev. 2021;20(3):589-607.
  5. Kalisz S, Oszmiański J, Kolniak-Ostek J, Grobelna A, Kieliszek M, Cendrowski A. Effect of a variety of polyphenols compounds and antioxidant properties of rhubarb (Rheum rhabarbarum). Lwt. 2020;118:108775.
  6. Abed A, Saadon M. Isolation of Some Compounds from Celery (Apium graveolens) Seeds and Studying their Effects in Mice Exposed to Oxidative Stress: Ph. D. Thesis, College of Education. University, of Mosul, Mosul, Iraq; 2005.
  7. VanUFFELEN EB, Van der ZEE J, de KOSTER MB, VanSTEVENINCK J, ELFERINK GJ. Intracellular but not extracellular conversion of nitroxyl anion into nitric oxide leads to stimulation of human neutrophil migration. Biochem J. 1998;330(2):719-22.
  8. Menden EE, Boiano JM, Murthy L, Petering HG. Modification of a p-phenylenediamine oxidase method to permit non-automated ceruloplasmin determinations in batches of rat serum or plasma microsamples. Anal Lett. 1977;10(3):197-204.
  9. Sedlak J, Lindsay RH. Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent. Anal Biochem. 1968;25:192-205.
  10. Guidet B, Shah SV. Enhanced in vivo H2O2 generation by rat kidney in glycerol-induced renal failure. Am J Physiol Renal Physiol. 1989;257(3):F440-F5.
  11. Bourhia M, Laasri FE, Aghmih K, Ullah R, Alqahtani AS, Mahmood HM, et al. Phytochemical composition, antioxidant activity, antiproliferative effect and acute toxicity study of bryonia dioica roots used in north african alternative medicine. Int J Agric Biol. 2020;23:597-602.
  12. Sobenin IA, Myasoedova VA, Iltchuk MI, Zhang D-W, Orekhov AN. Therapeutic effects of garlic in cardiovascular atherosclerotic disease. Chin J Nat Med. 2019;17(10):721-8.
  13. Gholami S, Mirzaei A, Oryan S, Hossaeni SE. The Effect of Rhubarb Extracts on Lipid Profile and Oxidative Stress in Wistar Male Rats. Int Medical J. 2015;22(2).
  14. Cheng DL, Zhu N, Li CL, Lv WF, Fang WW, Liu Y, et al. Significance of malondialdehyde, superoxide dismutase and endotoxin levels in Budd‑Chiari syndrome in patients and a rat model. Exp Ther Med. 2018;16(6):5227-35.
  1. Kon R, Ikarashi N, Nagoya C, Takayama T, Kusunoki Y, Ishii M, et al. Rheinanthrone, a metabolite of sennoside A, triggers macrophage activation to decrease aquaporin-3 expression in the colon, causing the laxative effect of rhubarb extract. J Ethnopharmacol. 2014;152(1):190-200.
  2. Wang X, Wang H, Ding C, Suo Y. One‐step preparative separation of two polyhydroxystilbenes from Rheum likiangense sam. by high‐speed counter‐current chromatography. Phytochem Anal. 2012;23(6):684-8.
  3. Prabhu HR, Marakala V. Glutathione reductase, reduced glutathione and ceruloplasmin in diethyldithiocarbamate treated rats. J Evol Med Dent Sci. 2013;2(5):479-84.
آمار
تعداد مشاهده مقاله: 1,948
تعداد دریافت فایل اصل مقاله: 3,090


counter
سامانه مدیریت نشریات علمی. طراحی و پیاده سازی از سیناوب