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Al-Zuhaeri, A. A., Al-Shakour, A. A, Ali Mansour, A. (1401). Serum Level of Heat Shock Protein 70 in Patients with Type 2 Diabetes Mellitus in Basrah, Iraq. سامانه مدیریت نشریات علمی, 77(5), 1837-1844. doi: 10.22092/ari.2022.358129.2155
A. A. Al-Zuhaeri; A. A Al-Shakour; A Ali Mansour. "Serum Level of Heat Shock Protein 70 in Patients with Type 2 Diabetes Mellitus in Basrah, Iraq". سامانه مدیریت نشریات علمی, 77, 5, 1401, 1837-1844. doi: 10.22092/ari.2022.358129.2155
Al-Zuhaeri, A. A., Al-Shakour, A. A, Ali Mansour, A. (1401). 'Serum Level of Heat Shock Protein 70 in Patients with Type 2 Diabetes Mellitus in Basrah, Iraq', سامانه مدیریت نشریات علمی, 77(5), pp. 1837-1844. doi: 10.22092/ari.2022.358129.2155
Al-Zuhaeri, A. A., Al-Shakour, A. A, Ali Mansour, A. Serum Level of Heat Shock Protein 70 in Patients with Type 2 Diabetes Mellitus in Basrah, Iraq. سامانه مدیریت نشریات علمی, 1401; 77(5): 1837-1844. doi: 10.22092/ari.2022.358129.2155

Serum Level of Heat Shock Protein 70 in Patients with Type 2 Diabetes Mellitus in Basrah, Iraq

Archives of Razi Institute
مقاله 42، دوره 77، شماره 5، آذر و دی 2022، صفحه 1837-1844    اصل مقاله (566.42 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2022.358129.2155
نویسندگان
A. A. Al-Zuhaeri* 1؛ A. A Al-Shakour1؛ A Ali Mansour2
1Department of Biochemistry, Basrah Medical College, Basrah, Iraq
2Department of Medicine, Basrah Medical College, Basrah Iraq
چکیده
Diabetes mellitus is a chronic metabolic disease with an increasing prevalence, caused by a defect in insulin production, insulin action, or both, and can increase the risk for the development of microvascular as well as macrovascular complications. Heat shock protein70 is considered a family of a larger group of proteins known as heat shock proteins, which their expression is induced when the cells are subjected to environmental stress. They are believed to keep the native folding of proteins in cells under stressful conditions and their therapeutic role. Therefore, this study aimed to investigate the serum level of HSP70 in patients with type 2 diabetes mellitus (T2DM) to assess if there is an association of HSP70 with T2DM and to evaluate the effect of age and duration of disease on the serum level of HSP70. Ninety-one patients with T2DM were recruited, and 85 individuals with the same age range and sex as healthy controls. Serum HSP70, fasting blood sugar, and HbA1c were measured. The results revealed that the level of HSP70 was significantly higher in the diabetic group compared to the control group (P value<0.05). The level of HSP70 showed a significant positive correlation with age and duration of disease as well as with fasting blood sugar and HbA1c. The study suggested that HSP70 may have the potential to be used as an indicator of metabolic derangement and a prognostic biomarker in diabetes.
کلیدواژه‌ها
Type 2 diabetes mellitus؛ HSP70؛ Fasting blood sugar؛ Glycated hemoglobin؛ Duration of DM
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