اخبار و اعلانات

 آمار

تعداد نشریات284
تعداد نشریات سازمان82
تعداد شماره‌ها3,073
تعداد مقالات34,300
تعداد مشاهده مقاله47,098,731
تعداد دریافت فایل اصل مقاله78,006,422
Hashim, Z. R, Qasim, Q. A, ALabbood, M. H. (1401). The Association of Serum Calcium and Vitamin D with Insulin Resistance and Beta-Cell Dysfunction among People with Type 2 Diabetes. سامانه مدیریت نشریات علمی, 77(5), 1593-1600. doi: 10.22092/ari.2022.357641.2081
Z. R Hashim; Q. A Qasim; M. H ALabbood. "The Association of Serum Calcium and Vitamin D with Insulin Resistance and Beta-Cell Dysfunction among People with Type 2 Diabetes". سامانه مدیریت نشریات علمی, 77, 5, 1401, 1593-1600. doi: 10.22092/ari.2022.357641.2081
Hashim, Z. R, Qasim, Q. A, ALabbood, M. H. (1401). 'The Association of Serum Calcium and Vitamin D with Insulin Resistance and Beta-Cell Dysfunction among People with Type 2 Diabetes', سامانه مدیریت نشریات علمی, 77(5), pp. 1593-1600. doi: 10.22092/ari.2022.357641.2081
Hashim, Z. R, Qasim, Q. A, ALabbood, M. H. The Association of Serum Calcium and Vitamin D with Insulin Resistance and Beta-Cell Dysfunction among People with Type 2 Diabetes. سامانه مدیریت نشریات علمی, 1401; 77(5): 1593-1600. doi: 10.22092/ari.2022.357641.2081

The Association of Serum Calcium and Vitamin D with Insulin Resistance and Beta-Cell Dysfunction among People with Type 2 Diabetes

Archives of Razi Institute
مقاله 11، دوره 77، شماره 5، آذر و دی 2022، صفحه 1593-1600    اصل مقاله (524.67 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2022.357641.2081
نویسندگان
Z. R Hashim* 1؛ Q. A Qasim1، 2؛ M. H ALabbood3
1Clinical Laboratory Sciences Department, College of Pharmacy, University of Basra, Basra, Iraq
2College of Pharmacy, Al-Ayen University, Thi-Qar, Iraq
3Alzahraa College of Medicine, University of Basra, Basra, Iraq
چکیده
Cross-sectional studies have linked vitamin D deficiency and alteration of calcium levels to an increased incidence of type 2 diabetes and insulin resistance. This study investigated a possible correlation between blood vitamin D and calcium levels with insulin resistance and beta-cell dysfunction in type 2 diabetes, pre-diabetes, and healthy individuals. This cross-sectional study involved 300 participants. Participants were divided into three groups (n=100), type 2diabetic, prediabetic, and healthy. In order to measure insulin resistance and β –cell function, the HOMA IR and HOMA B were assessed, respectively. Also, the other parameters such as serum 25(OH)D, blood insulin (FPI), glucose (FBS), HbA1c, and calcium were assessed in this study. In simple regression analysis, a high vitamin D level is linked to lower levels of FBS, HbA1c, Insulin, and HOMA IR, and higher levels of HOMA B. Calcium has a positive connection with FBS and HbA1c and a negative connection with insulin level and HOMAB. Hypovitaminosis D may substantially influence diabetes patients' glycemic dysregulation. "An increased incidence of type 2 diabetes has been related to a disruption in calcium homeostasis. All in all an increament in calcium levels may have a role in developing type 2 diabetes".
کلیدواژه‌ها
Type 2M؛ 25 (OH) D؛ Calcium؛ Vitamin D deficiency؛ Insulin resistance؛ Glycemic control
مراجع
  1. Saeedi P, Petersohn I, Salpea P, Malanda B, Karuranga S, Unwin N, et al. Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas. Diabetes Res Clin Pract. 2019;157:107843.
  2. Shrivastava U, Misra A, Mohan V, Unnikrishnan R, Bachani D. Obesity, diabetes and cardiovascular diseases in India: public health challenges. Curr Diabetes Rev. 2017;13(1):65-80.
  3. Hu FB. Globalization of diabetes: the role of diet, lifestyle, and genes. Diabetes Care. 2011;34(6):1249-57.
  4. Grammatiki M, Karras S, Kotsa K. The role of vitamin D in the pathogenesis and treatment of diabetes mellitus: a narrative review. Hormones. 2019;18(1):37-48.
  5. Pittas AG, Dawson-Hughes B, Sheehan P, Ware JH, Knowler WC, Aroda VR, et al. Vitamin D supplementation and prevention of type 2 diabetes. N Engl J Med. 2019;381(6):520-30.
  6. Forouhi N, Ye Z, Rickard A, Khaw K, Luben R, Langenberg C, et al. Circulating 25-hydroxyvitamin D concentration and the risk of type 2 diabetes: results from the European Prospective Investigation into Cancer (EPIC)-Norfolk cohort and updated meta-analysis of prospective studies. Diabetologia. 2012;55(8):2173-82.
  7. Zostautiene I, Jorde R, Schirmer H, Mathiesen EB, Njølstad I, Løchen M-L, et al. Genetic variations in the Vitamin D receptor predict type 2 diabetes and myocardial infarction in a community-based population: the Tromsø study. PloS One. 2015;10(12):0145359.
  8. Mitri J, Pittas AG. Vitamin D and diabetes. Endocrinol Metab Clin. 2014;43(1):205-32.
  9. Szymczak-Pajor I, Śliwińska A. Analysis of association between vitamin D deficiency and insulin resistance. Nutrients. 2019;11(4):794.
  10. Shimodaira M, Niwa T, Nakajima K, Kobayashi M, Hanyu N, Nakayama T. The relation between CA 19-9 level and early-phase insulin secretion in normoglycemic and prediabetic subjects. Int J Biol Markers. 2015;30(2):169-73.
  11. Niroomand M, Fotouhi A, Irannejad N, Hosseinpanah F. Does high-dose vitamin D supplementation impact insulin resistance and risk of development of diabetes in patients with pre-diabetes? A double-blind randomized clinical trial. Diabetes Res Clin Pract. 2019;148:1-9.
  12. Gao Y, Zheng T, Ran X, Ren Y, Chen T, Zhong L, et al. Vitamin D and incidence of prediabetes or type 2 diabetes: a four-year follow-up community-based study. Dis Markers. 2018;2018.
  13. Branco JM, Smoraog DC, Bentes CM, Netto CC, Marinheiro LP. Association between vitamin D status and glycemic profile in postmenopausal women with type 2 diabetes. Diabetes Metab Syndr. 2019;13(3):1685-8.
  14. Alaei-Shahmiri F, Khamseh ME, Manhoei K, Yadegari H, Kazemi H, Meshkini M. The optimal vitamin D cut-off value associated with hyperglycemia in an Iranian population. J Diabetes Metab Disord. 2020;19(1):5-12.
  15. Asbaghi O, Khosroshahi MZ, Kashkooli S, Abbasnezhad A. Effect of Calcium‑Vitamin D Co‑Supplementation on Insulin, Insulin Sensitivity, and Glycemia: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. Horm Metab Res. 2019;51(05):288-95.
  16. AlHewishel MA, Bahgat M, Al Huwaiyshil A, Alsubie MA, Alhassan A. 25 (OH) D serum level in non-diabetic and type II diabetic patients: a Cross-Sectional Study. Cureus. 2020;12(6).
  17. Muñoz-Garach A, García-Fontana B, Muñoz-Torres M. Vitamin D status, calcium intake and risk of developing type 2 diabetes: an unresolved issue. Nutrients. 2019;11(3):642.
  18. Al-Shoumer KA, Al-Essa TM. Is there a relationship between vitamin D with insulin resistance and diabetes mellitus? World J Diabetes. 2015;6(8):1057.
  19. Darraj H, Badedi M, Poore KR, Hummadi A, Khawaji A, Solan Y, et al. Vitamin D deficiency and glycemic control among patients with type 2 diabetes mellitus in Jazan City, Saudi Arabia. Diabetes Metab Syndr Obes. 2019;12:853.
  20. Pannu PK, Piers LS, Soares MJ, Zhao Y, Ansari Z. Vitamin D status is inversely associated with markers of risk for type 2 diabetes: A population based study in Victoria, Australia. PloS One. 2017;12(6):0178825.
  21. Haslacher H, Nistler S, Batmyagmar D, Ponocny-Seliger E, Perkmann T, Scherzer TM, et al. Low vitamin D levels do not predict hyperglycemia in elderly endurance athletes (but in controls). PloS One. 2016;11(6):e0157695.
  22. Nigil Haroon N, Anton A, John J, Mittal M. Effect of vitamin D supplementation on glycemic control in patients with type 2 diabetes: a systematic review of interventional studies. J Diabetes Metab Disord. 2015;14(1):1-11.
  23. El Hajj C, Chardigny J-M, Boirie Y, Yammine K, Helou M, Walrand S. Effect of vitamin D treatment on glucose homeostasis and metabolism in Lebanese older adults: a randomized controlled trial. J Nutr Health Aging. 2018;22(9):1128-32.
  24. Archontogeorgis K, Papanas N, Rizos EC, Nena E, Zissimopoulos A, Tsigalou C, et al. Reduced serum Vitamin D levels are associated with insulin resistance in patients with obstructive sleep apnea syndrome. Medicina. 2019;55(5):174.
  25. Poolsup N, Suksomboon N, Plordplong N. Effect of vitamin D supplementation on insulin resistance and glycaemic control in prediabetes: a systematic review and meta‐analysis. Diabet Med. 2016;33(3):290-9.
  26. Dhas Y, Banerjee J, Damle G, Mishra N. Association of vitamin D deficiency with insulin resistance in middle-aged type 2 diabetics. Clinica Chimica Acta. 2019;492:95-101.
  27. Fondjo LA, Owiredu WK, Sakyi SA, Laing EF, Adotey-Kwofie MA, Antoh EO, et al. Vitamin D status and its association with insulin resistance among type 2 diabetics: A case-control study in Ghana. PloS One. 2017;12(4):e0175388.
  28. Tao M-f, Zhang Z, Ke Y-h, He J-w, Fu W-z, Zhang C-q, et al. Association of serum 25-hydroxyvitamin D with insulin resistance and β-cell function in a healthy Chinese female population. Acta Pharmacol Sin. 2013;34(8):1070-4.
  29. Banerjee A, Khemka VK, Roy D, Poddar J, Roy TKS, Karnam SA. Role of serum adiponectin and vitamin D in prediabetes and diabetes mellitus. Can J Diabetes. 2017;41(3):259-65.
  30. Wagner H, Alvarsson M, Mannheimer B, Degerblad M, Östenson C-G. No effect of high-dose vitamin D treatment on β-cell function, insulin sensitivity, or glucose homeostasis in subjects with abnormal glucose tolerance: a randomized clinical trial. Diabetes Care. 2016;39(3):345-52.
  1. Alloubani A, Akhu-Zaheya L, Samara R, Abdulhafiz I, Saleh A, Altowijri A. Relationship between vitamin D deficiency, diabetes, and obesity. Diabetes Metab Synd: Clin Res Rev. 2019;13(2):1457-61.
  2. Suh S, Bae JC, Jin S-M, Jee JH, Park MK, Kim DK, et al. Serum calcium changes and risk of type 2 diabetes mellitus in Asian population. Diabetes Res Clin Pract. 2017;133:109-14.
  3. Sing C-W, Cheng VK, Ho DK, Kung AW, Cheung B, Wong I, et al. Serum calcium and incident diabetes: an observational study and meta-analysis. Osteoporos Int. 2016;27(5):1747-54.
  4. Khan Z, Khan M, Bahadur S, Khan Z, Khan Y, Umair H, et al. Vitamin-D Level in Patients with Type-2 Diabetes Mellitus of different Age and Sex: its Effects on BMI, Calcium Level. J Saidu Med Col. 2020;10(1).
  5. Agrawal AA, Kolte AP, Kolte RA, Chari S, Gupta M, Pakhmode R. Evaluation and comparison of serum vitamin D and calcium levels in periodontally healthy, chronic gingivitis and chronic periodontitis in patients with and without diabetes mellitus–a cross-sectional study. Acta Odontol Scand. 2019;77(8):592-9.
  6. Kim MK, Kim G, Jang EH, Kwon HS, Baek KH, Oh KW, et al. Altered calcium homeostasis is correlated with the presence of metabolic syndrome and diabetes in middle-aged and elderly Korean subjects: the Chungju Metabolic Disease Cohort study (CMC study). Atherosclerosis. 2010;212(2):674-81.
  7. Dos Santos L, de Padua Cintra I, Fisberg M, Martini L. Calcium intake and its relationship with adiposity and insulin resistance in post‐pubertal adolescents. J Hum Nutr Diet. 2008;21(2):109-16.
  8. Nkondjock VRN, Wabo TMC, Kosgey JC, Zhang Y, Amporfro DA, Adnan H, et al. Insulin Resistance, Serum Calcium and Hypertension: A Cross-Sectional Study of a Multiracial Population, and a Similarity Assessment of Results from a Single-Race Population’s Study. Diabetes Metab Syndr Obes: Targets Ther. 2021;14:3361.
آمار
تعداد مشاهده مقاله: 1,762
تعداد دریافت فایل اصل مقاله: 2,745


counter
سامانه مدیریت نشریات علمی. طراحی و پیاده سازی از سیناوب