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Jasib Habeeb, Y, Mohammed Selman, S, Jeafer Mehrath, A. (1401). Study of the Effects of Cordia myxa Fruit Extract on Induced Animal Model of Depression in Male Rats. سامانه مدیریت نشریات علمی, 77(4), 1503-1511. doi: 10.22092/ari.2022.357642.2082
Y Jasib Habeeb; S Mohammed Selman; A Jeafer Mehrath. "Study of the Effects of Cordia myxa Fruit Extract on Induced Animal Model of Depression in Male Rats". سامانه مدیریت نشریات علمی, 77, 4, 1401, 1503-1511. doi: 10.22092/ari.2022.357642.2082
Jasib Habeeb, Y, Mohammed Selman, S, Jeafer Mehrath, A. (1401). 'Study of the Effects of Cordia myxa Fruit Extract on Induced Animal Model of Depression in Male Rats', سامانه مدیریت نشریات علمی, 77(4), pp. 1503-1511. doi: 10.22092/ari.2022.357642.2082
Jasib Habeeb, Y, Mohammed Selman, S, Jeafer Mehrath, A. Study of the Effects of Cordia myxa Fruit Extract on Induced Animal Model of Depression in Male Rats. سامانه مدیریت نشریات علمی, 1401; 77(4): 1503-1511. doi: 10.22092/ari.2022.357642.2082

Study of the Effects of Cordia myxa Fruit Extract on Induced Animal Model of Depression in Male Rats

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مقاله 26، دوره 77، شماره 4، مهر و آبان 2022، صفحه 1503-1511    اصل مقاله (436.14 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2022.357642.2082
نویسندگان
Y Jasib Habeeb* 1؛ S Mohammed Selman1؛ A Jeafer Mehrath2
1Department of Pharmacology, College of Medicine, University of Babylon, Babel, Iraq
2Department of Biochemistry, College of Medicine, University of Babylon, Babel, Iraq
چکیده
Depression is one of the most common mental illnesses. Herbal medications such as ginseng and peony have recently gained popularity in treating depression due to their safety, efficacy, and cost-effectiveness. Therefore, the present study aimed to evaluate the actions of Cordia myxa (C. myxa) fruit extract on the model of chronic unpredictable mild stress (CUMS) and antioxidant enzymes system in male rats' brains. Sixty male rats were divided into six groups (n=10). Group 1 (control) was neither exposed to CUMS nor received any treatment, while group 2 was exposed to CUMS for 24 days with normal saline treatment for 14 days, group 3 was exposed to CUMS for 24 days and received 10 mg/kg fluoxetine daily on day 10 for 14 days, and group 4, 5, and 6 were exposed to CUMS for 24 days and received C. myxa extract (125, 250, and 500 mg/kg, respectively) on day 10 for 14 days. The antidepressant effect of fluoxetine and C. myxa extract was evaluated using a forced swim test (FST). At the end of the experiments, animals were sacrificed by decapitation; and antioxidant enzyme levels, catalase (CAT), and superoxide dismutase (SOD) were determined by enzyme-linked immunosorbent assays kits (ELISA) on rats’ brain tissues. All groups subjected to CUMS showed a significant rise in duration of immobility on the tenth day compared to day zero. The CUMS showed a decrease in antioxidant enzyme levels, and groups treated with extract showed significant rise in enzyme levels (SOD and CAT) compared to group 2. According to this recent study, C. myxa may have an antidepressant-like action.
کلیدواژه‌ها
Chronic unpredictable mild stress؛ Depression؛ Cordia myxa؛ Superoxide dismutase؛ Catalase؛ Antioxidant enzyme system
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مراجع
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