اخبار و اعلانات

 آمار

تعداد نشریات285
تعداد نشریات سازمان83
تعداد شماره‌ها3,094
تعداد مقالات34,537
تعداد مشاهده مقاله49,390,664
تعداد دریافت فایل اصل مقاله79,840,172
Sabeeh, E, Thamer, N. K, Alsaady, H. A. M. (1401). Histopathological Study to Evaluate the Effect of Aqueous Extract of Portunuspelagicus and Mebendazole on Hydatid Cysts in Mice. سامانه مدیریت نشریات علمی, 78(1), 87-94. doi: 10.22092/ari.2022.358490.2231
E Sabeeh; N. K Thamer; H. A. M Alsaady. "Histopathological Study to Evaluate the Effect of Aqueous Extract of Portunuspelagicus and Mebendazole on Hydatid Cysts in Mice". سامانه مدیریت نشریات علمی, 78, 1, 1401, 87-94. doi: 10.22092/ari.2022.358490.2231
Sabeeh, E, Thamer, N. K, Alsaady, H. A. M. (1401). 'Histopathological Study to Evaluate the Effect of Aqueous Extract of Portunuspelagicus and Mebendazole on Hydatid Cysts in Mice', سامانه مدیریت نشریات علمی, 78(1), pp. 87-94. doi: 10.22092/ari.2022.358490.2231
Sabeeh, E, Thamer, N. K, Alsaady, H. A. M. Histopathological Study to Evaluate the Effect of Aqueous Extract of Portunuspelagicus and Mebendazole on Hydatid Cysts in Mice. سامانه مدیریت نشریات علمی, 1401; 78(1): 87-94. doi: 10.22092/ari.2022.358490.2231

Histopathological Study to Evaluate the Effect of Aqueous Extract of Portunuspelagicus and Mebendazole on Hydatid Cysts in Mice

Archives of Razi Institute
مقاله 13، دوره 78، شماره 1، فروردین و اردیبهشت 2023، صفحه 87-94    اصل مقاله (1.56 M)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2022.358490.2231
نویسندگان
E Sabeeh* 1، 2؛ N. K Thamer1؛ H. A. M Alsaady3، 4
1College of Veterinary Medicine, University of Basrah, Basrah, Iraq
2College of Pharmacy, University of Misan, Amarah, Iraq
3Biology Department, Science College, University of Misan, Amarah, Iraq
4College of Dentistry, University of Misan, Amarah, Iraq
چکیده
Hydatid disease is a parasitic infestation by a tapeworm of the genus Echinococcus sp., which has a global distribution. The current study was conducted to evaluate the effectiveness of the crustacean aqueous extract of Portunuspelagicus for 2 weeks of treatment compared to mebendazole on hydatid cyst in laboratory mice male Balb / C strain. Mice were infected intraperitoneally with 2000 protoscolices. After 12 weeks of infection, each mouse was treated with mebendazole (50mg/kg) and the hot aqueous extract of p. pelagicus (8, 16 g/kg). Samples of infected organs (liver, spleen, and lungs) were examined under a microscope to evaluate the morphological and histopathological changes of hydatid cysts and tissues. The study confirmed macroscopically that there were a number of hydatid cysts of different sizes in the liver, spleen, and lungs, splenomegaly, and congestion of the lungs of the positive control group. The histological changes in the organs of the group treated with the crustacean extract were represented by the vacuolation of hepatocytes in the centrilobular area of the liver. At the same time, the lungs show intensive peri-bronchiolar inflammation, pulmonary vascular congestion, and in the spleen, the deposition of amyloid-like material in the white pulp, extramedullary hematopoiesis, While the histopathological changes in the organs of mice treated with mebendazole, were represented by the presence in the mild liver vacuolation of the centrilobular area. In contrast, the lungs show mild pulmonary vascular congestion and emphysema, and the spleen shows normal white pulp, the normal red pulp of mice. The aqueous extract Portunuspelagicus and mebendazole are effective in controlling the contamination in the intermediate hosts.
کلیدواژه‌ها
hydatid cysts؛ Portunuspelagicus؛ aqueous extract mebendazole؛ Histopathology
سایر فایل های مرتبط با مقاله
مراجع
  1. Pedrosa I, Saíz A, Arrazola J, Ferreirós J, Pedrosa CS. Hydatid Disease: Radiologic and Pathologic Features and Complications 1: (CME available in print version and on RSNA Link). Radiographics. 2000;20(3):795-817.
  2. Getachew D, Almaw G, Terefe G. Occurrence and fertility rates of hydatid cysts in sheep and goats slaughtered at Modjo Luna Export Slaughter House, Ethiopia. Ethiop Vet J. 2012;16(1):83-91.
  3. Thompson R. The taxonomy, phylogeny and transmission of Echinococcus. Exp Parasitol. 2008;119(4):439-46.
  4. Torgerson P, Budke C. Echinococcosis–an international public health challenge. Res Vet Sci. 2003;74(3):191-202.
  5. Daali M, Fakir Y, Hssaida R, Hajji A, Hda A, editors. Hydatid cysts of the liver opening in the biliary tract. Report of 64 cases. Annales de chirurgie; 2001.
  6. Polat P, Kantarci M, Alper F, Suma S, Koruyucu MB, Okur A. Hydatid disease from head to toe. Radiographics. 2003;23(2):475-94.
  7. Chandrasekhar S, Parija SC. Serum antibody & Th2 cytokine profiles in patients with cystic echinococcosis. Indian J Med Res. 2009;130(6):731-6.
  8. Zhang W, Li J, McManus DP. Concepts in immunology and diagnosis of hydatid disease. Clin Microbiol Rev. 2003;16(1):18-36.
  9. Labsi M, Khelifi L, Mezioug D, Soufli I, Touil-Boukoffa C. Antihydatic and immunomodulatory effects of Punica granatum peel aqueous extract in a murine model of echinococcosis. Asian Pac J Trop Med. 2016;9(3):211-20.
  10. Shahnazi M, Azadmehr A, Latifi R, Hajiaghaee R, Saraei M, Alipour M. In vitro protoscolicidal effects of various concentrations of Ziziphora tenuior L. extract at different exposure times. Avicenna J Phytomed. 2016;6(4):376.
  1. Suvarna KS, Layton C, Bancroft JD. Bancroft's theory and practice of histological techniques E-Book: Elsevier health sciences; 2018.
  2. Mustafa JY, Azzal GY, Al-Azizz SA, Muatafa FA, Lazim AR. Comparative Molecular Study between Some Plant Extract and Tinidazole of Hydatid cysts in Basrah, Southern Iraq. Indian J Forensic Med Toxicol. 2020;14(1):1071.
  3. Mosqueda MB, Esparza RH, Padilla CR, García JPT, Reyes MM, Almaraz VB, et al. Gender as a factor of susceptibility to infection in experimental hydatidosis. Rev Latinoamr Microbiol. 2007;49:31-7.
  4. Davies DH, Halablab MA, Young TWK, Cox FEG, Clarke J. Infection and Immunity: Taylor & Francis; 2002.
  5. Prasad B, Prasad L. Note on the pathology of hydatidosis in sheep and goat. Indian Vet Med J. 1980.
  6. Al-Qaoud KM, Abdel-Hafez SK. Humoral and cytokine response during protection of mice against secondary hydatidosis caused by Echinococcus granulosus. Parasitol Res. 2005;98(1):54-60.
  7. Hamad SM, Shnawa BH, Jalil PJ, Ahmed MH. Assessment of the Therapeutic Efficacy of Silver Nanoparticles against Secondary Cystic Echinococcosis in BALB/c Mice. Surfaces. 2022;5(1):91-112.
  8. Inam Faleh LH, Murad HM. Efficacy and histopathological study of bile salts against hydatidosis comparing with antigen B in experimentally infected mice.
  9. Al-Dabagh M, Al-Moslih M, Verheyen A, Shafik M, Al-Janabi T, Al-Rawas A, et al. The effect of mebendazole on sheep hydatid cysts as demonstrated by electron microscopy. J Parasitol. 1981:709-12.
آمار
تعداد مشاهده مقاله: 2,899
تعداد دریافت فایل اصل مقاله: 6,416


counter
سامانه مدیریت نشریات علمی. طراحی و پیاده سازی از سیناوب