اخبار و اعلانات

 آمار

تعداد نشریات284
تعداد نشریات سازمان82
تعداد شماره‌ها3,036
تعداد مقالات33,971
تعداد مشاهده مقاله45,665,838
تعداد دریافت فایل اصل مقاله76,566,118
Khinteel Jabbar, N, Al-Abady, Z. N, Jasib Thaaban Almzail, A, Al-Athary, R. A. H. (1401). Relationship between Menopause and Complications of Hyperthyroidism in Female Patients in Iraq. سامانه مدیریت نشریات علمی, 77(4), 1481-1489. doi: 10.22092/ari.2022.357618.2071
N Khinteel Jabbar; Z. N Al-Abady; A Jasib Thaaban Almzail; R. A. H Al-Athary. "Relationship between Menopause and Complications of Hyperthyroidism in Female Patients in Iraq". سامانه مدیریت نشریات علمی, 77, 4, 1401, 1481-1489. doi: 10.22092/ari.2022.357618.2071
Khinteel Jabbar, N, Al-Abady, Z. N, Jasib Thaaban Almzail, A, Al-Athary, R. A. H. (1401). 'Relationship between Menopause and Complications of Hyperthyroidism in Female Patients in Iraq', سامانه مدیریت نشریات علمی, 77(4), pp. 1481-1489. doi: 10.22092/ari.2022.357618.2071
Khinteel Jabbar, N, Al-Abady, Z. N, Jasib Thaaban Almzail, A, Al-Athary, R. A. H. Relationship between Menopause and Complications of Hyperthyroidism in Female Patients in Iraq. سامانه مدیریت نشریات علمی, 1401; 77(4): 1481-1489. doi: 10.22092/ari.2022.357618.2071

Relationship between Menopause and Complications of Hyperthyroidism in Female Patients in Iraq

Archives of Razi Institute
مقاله 23، دوره 77، شماره 4، مهر و آبان 2022، صفحه 1481-1489    اصل مقاله (493.53 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2022.357618.2071
نویسندگان
N Khinteel Jabbar* 1؛ Z. N Al-Abady1؛ A Jasib Thaaban Almzail2؛ R. A. H Al-Athary3
1Department of Chemistry, College of science, University of AL-Qadisiyah, AL-Diwaniyah, Iraq
2Department of Medical Chemistry, College of Medicine, University of AL-Qadisiyah, Al-Diwaniyah, Iraq
3Department of Biology, College of Science, University of AL-Qadisiyah, AL-Diwaniyah, Iraq
چکیده
Hyperthyroidism is a health problem characterized by an overactive thyroid gland, resulting in extra triiodothyronine (T3) and thyroxine (T4) production, as well as a decrease in thyroid-stimulating hormone (TSH). The oxidative stress indicators in hyperthyroid patients and the relationship with impaired metabolism of lipid are still controversial, especially in menopausal women suffering from a lack of ovulation hormones. In this study, blood samples were withdrawn from 120 subjects, including healthy premenopausal (n=30) and postmenopausal women (n=30) as control groups (G1 and G2), as well as 30 hyperthyroid women in each group of premenopausal and postmenopausal patient groups (G3 and G4). The levels of T3, T4, and TSH, blood pressure, and lipid profiles, such as triglyceride, total cholesterol (TC), high-density lipoprotein, and low-density lipoprotein, superoxide dismutase (SOD) activity, malondialdehyde (MDA),  and advanced oxidation protein products (AOPP) in the two healthy control groups and patient groups with hyperthyroidism were measured. In addition, serum progesterone levels were measured by the Bio-Merieux kit France, according to the manufacturer’s instructions. The results revealed a significant decrease in SOD activity in the postmenopausal group, as compared to that in premenopausal women and control groups. Hyperthyroidism groups demonstrated a significant increase in MDA and AOPP levels, compared to control groups. Patient groups reported a decreased level of progesterone, in comparison with control groups. Moreover, there was a significant increase in T3 and T4 in patient groups (G3 and G4), compared to that in control groups (G1 and G2). There was a significant increase in systolic and diastolic blood pressure in menopausal hyperthyroidism (G4), compared to that in other groups. The TC decreased significantly in G3 and G4, compared to that in both control groups (P<0.05); nonetheless, there was no significant difference between patient groups (G3 and G4), as well as between control groups (G1 and G2). The study suggested that hyperthyroidism causes an increase in oxidative stress, which negatively affects the antioxidant system and drops levels of progesterone in both premenopausal and postmenopausal female patients. Therefore, low levels of progesterone are linked with hyperthyroidism, leading to aggravating symptoms of the disease.
کلیدواژه‌ها
Hyperthyroidism؛ Oxidative stress؛ Postmenopausal hyperthyroidism؛ Premenopausal hyperthyroidism؛ Progesterone
سایر فایل های مرتبط با مقاله
مراجع
  1. Farasat T, Mughal T, Liaqat A. Assessment of thyroid hormones level in premenopausal and postmenopausal females. J Appl Pharm. 2011;3:164-74.
  2. Burrow G. The thyroid gland and reproduction. In: Yen S, Jaffe R, editors. Reproductive endocrinology. Philadelphia: WB Saunders; 1986. p. 424-40.
  3. Marcocci C, Bartalena L. Role of oxidative stress and selenium in Graves' hyperthyroidism and orbitopathy. J Endocrinol Investig. 2013;36(10):15-20.
  4. Villanueva I, Alva-Sanchez C, Pacheco-Rosado J. The role of thyroid hormones as inductors of oxidative stress and neurodegeneration. Oxid Med Cell Longev. 2013;2013:218145.
  1. Potenza M, Via MA, Yanagisawa RT. Excess thyroid hormone and carbohydrate metabolism. Endocr Pract. 2009;15(3):254-62.
  2. Cutolo M, Wilder RL. Different roles for androgens and estrogens in the susceptibility to autoimmune rheumatic diseases. Rheum Dis Clin North Am. 2000;26(4):825-39.
  3. Pfeilschifter J, Koditz R, Pfohl M, Schatz H. Changes in proinflammatory cytokine activity after menopause. Endocr Rev. 2002;23(1):90-119.
  4. Straub RH. The complex role of estrogens in inflammation. Endocr Rev. 2007;28(5):521-74.
  5. Ross DS, Burch HB, Cooper DS, Greenlee MC, Laurberg P, Maia AL, et al. American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis. Thyroid. 2016;26(10):1343-421.
  6. Misra HP, Fridovich I. The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. J Biol Chem. 1972;247(10):3170-5.
  7. Guidet B, Shah SV. Enhanced in vivo H2O2 generation by rat kidney in glycerol-induced renal failure. Am J Physiol. 1989;257(3 Pt 2):440-5.
  8. Witko-Sarsat V, Friedlander M, Capeillere-Blandin C, Nguyen-Khoa T, Nguyen AT, Zingraff J, et al. Advanced oxidation protein products as a novel marker of oxidative stress in uremia. Kidney Int. 1996;49(5):1304-13.
  9. Uygur MM, Yoldemir T, Yavuz DG. Thyroid disease in the perimenopause and postmenopause period. Climacteric. 2018;21(6):542-8.
  10. Rivas AM, Pena C, Kopel J, Dennis JA, Nugent K. Hypertension and Hyperthyroidism: Association and Pathogenesis. Am J Med Sci. 2021;361(1):3-7.
  11. Prisant LM, Gujral JS, Mulloy AL. Hyperthyroidism: a secondary cause of isolated systolic hypertension. J Clin Hypertens (Greenwich). 2006;8(8):596-9.
  12. Danzi S, Klein I. Thyroid disease and the cardiovascular system. Endocrinol Metab Clin North Am. 2014;43(2):517-28.
  13. Barbagallo M, Dominguez LJ, Licata G, Shan J, Bing L, Karpinski E, et al. Vascular Effects of Progesterone: Role of Cellular Calcium Regulation. Hypertension. 2001;37(1):142-7.
  14. Stachenfeld NS, Taylor HS. Effects of estrogen and progesterone administration on extracellular fluid. J Appl Physiol (1985). 2004;96(3):1011-8.
  15. Lu Y, Li J, Li J. Estrogen and thyroid diseases: an update. Minerva medica. 2016;107(4):239-44.
  16. Duntas LH. Thyroid disease and lipids. Thyroid. 2002;12(4):287-93.
  17. Kung AW, Pang RW, Lauder I, Lam KS, Janus ED. Changes in serum lipoprotein(a) and lipids during treatment of hyperthyroidism. Clin Chem. 1995;41(2):226-31.
  18. Khan F. Lipid Profile in Thyroid Dysfunction: A Study on Patients of Bastar. J Clin Anal Med. 2014;5.
  19. Duntas LH, Brenta G. Thyroid hormones: a potential ally to LDL-cholesterol-lowering agents. Hormones (Athens). 2016;15(4):500-10.
  20. Das K, Chainy GBN. Modulation of rat liver mitochondrial antioxidant defence system by thyroid hormone. Biochimica et Biophysica Acta (BBA). Mol Basis Dis. 2001;1537(1):1-13.
  21. Bonanome A, Pagnan A, Biffanti S, Opportuno A, Sorgato F, Dorella M, et al. Effect of dietary monounsaturated and polyunsaturated fatty acids on the susceptibility of plasma low density lipoproteins to oxidative modification. Arterioscler Thromb. 1992;12(4):529-33.
  22. Bednarek-Tupikowska G, Tupikowski K, Bidzinska B, Bohdanowicz-Pawlak A, Antonowicz-Juchniewicz J, Kosowska B, et al. Serum lipid peroxides and total antioxidant status in postmenopausal women on hormone replacement therapy. Gynecol Endocrinol. 2004;19(2):57-63.
  23. Fauré M, Lissi EA, Videla LA. Evaluation of the antioxidant properties of thyroid hormones and propylthiouracil in the brain-homogenate autoxidation system and in the free radical-mediated oxidation of erythrocyte membranes. Chem Biol Interact. 1991;77(2):173-85.
  24. Assaei R, Zal F, Mostafavi-Pour Z, Dabbaghmanesh MH, Geramizadeh B, Ranjbar Omrani GH, et al. Hepatoprotective effect of satureja khuzestanica essential oil and vitamin e in experimental hyperthyroid rats: evidence for role of antioxidant effect. Iran J Med Sci. 2014;39(5):459-66.
  25. Goswami K, Nandakumar DN, Koner BC, Bobby Z, Sen SK. Oxidative changes and desialylation of serum proteins in hyperthyroidism. Clin Chim Acta. 2003;337(1-2):163-8.
  26. Dumitriu L, Bartoc R, Ursu H, Purice M, Ionescu V. Significance of high levels of serum malonyl dialdehyde (MDA) and ceruloplasmin (CP) in hyper- and hypothyroidism. Endocrinologie. 1988;26(1):35-8.
  27. Kozakiewicz M, Kornatowski M, Krzywinska O, Kedziora-Kornatowska K. Changes in the blood antioxidant defense of advanced age people. Clin Interv Aging. 2019;14:763-71.
  28. Messarah M, Boulakoud MS, Boumendjel A, Abdennour C, El Feki A. The impact of thyroid activity variations on some oxidizing-stress parameters in rats. C R Biol. 2007;330(2):107-12.
  29. Asayama K, Dobashi K, Hayashibe H, Megata Y, Kato K. Lipid peroxidation and free radical scavengers in thyroid dysfunction in the rat: a possible mechanism of injury to heart and skeletal muscle in hyperthyroidism. Endocrinology. 1987;121(6):2112-8.
  30. Bianchi G, Solaroli E, Zaccheroni V, Grossi G, Bargossi AM, Melchionda N, et al. Oxidative stress and anti-oxidant metabolites in patients with hyperthyroidism: effect of treatment. Horm Metab Res. 1999;31(11):620-4.
  31. Guerra LN, Moiguer S, Karner M, de Molina MdCR, Sreider CM, Burdman JA. Antioxidants in the treatment of Graves disease. IUBMB Life. 2001;51(2):105-9.
  32. Cetinkaya A, Kurutas EB, Buyukbese MA, Kantarceken B, Bulbuloglu E. Levels of malondialdehyde and superoxide dismutase in subclinical hyperthyroidism. Mediators Inflamm. 2005;2005(1):57-9.
  1. Krassas GE. Thyroid disease and female reproduction. Fertility and Sterility. 2000;74(6):1063-70.
  2. Rahman M. Thyroid Disorders-A common Cause of Infertility: A Review. Faridpur Med Coll J. 2021;15:95-7.
  3. Chainy GBN, Sahoo DK. Hormones and oxidative stress: an overview. Free Radic Res. 2020;54(1):1-26.
  4. Signorelli SS, Neri S, Sciacchitano S, Pino LD, Costa MP, Marchese G, et al. Behaviour of some indicators of oxidative stress in postmenopausal and fertile women. Maturitas. 2006;53(1):77-82.
  5. Unfer TC, Figueiredo CG, Zanchi MM, Maurer LH, Kemerich DM, Duarte MM, et al. Estrogen plus progestin increase superoxide dismutase and total antioxidant capacity in postmenopausal women. Climacteric. 2015;18(3):379-88.
  6. Unfer TC, Maurer LH, Kemerich DM, Figueiredo CG, Duarte MM, Gelain DP, et al. Non-genomic, direct modulatory effect of 17β-estradiol, progesterone and their synthetic derivatives on the activity of human erythrocyte CuZn superoxide dismutase. Free Radic Res. 2013;47(3):219-32.
43.          Moorthy K, Sharma D, Basir SF, Baquer NZ. Administration of estradiol and progesterone modulate the activities of antioxidant enzyme and aminotransferases in naturally menopausal rats. Exp Gerontol. 2005;40(4):295-302.

آمار
تعداد مشاهده مقاله: 1,732
تعداد دریافت فایل اصل مقاله: 2,706


counter
سامانه مدیریت نشریات علمی. طراحی و پیاده سازی از سیناوب