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Khan, S, Alam, M, Rauf, Z, Shah, K, Khan, A, Ozdemir, B, Selamoglu, Z. (1401). Comparison of Biochemical Parameters in Patients with Hepatitis B, C, and Dual Hepatitis B and C in Northwest Pakistan. سامانه مدیریت نشریات علمی, 77(2), 869-879. doi: 10.22092/ari.2022.357172.1988
S Khan; M Alam; Z Rauf; K Shah; A Khan; B Ozdemir; Z Selamoglu. "Comparison of Biochemical Parameters in Patients with Hepatitis B, C, and Dual Hepatitis B and C in Northwest Pakistan". سامانه مدیریت نشریات علمی, 77, 2, 1401, 869-879. doi: 10.22092/ari.2022.357172.1988
Khan, S, Alam, M, Rauf, Z, Shah, K, Khan, A, Ozdemir, B, Selamoglu, Z. (1401). 'Comparison of Biochemical Parameters in Patients with Hepatitis B, C, and Dual Hepatitis B and C in Northwest Pakistan', سامانه مدیریت نشریات علمی, 77(2), pp. 869-879. doi: 10.22092/ari.2022.357172.1988
Khan, S, Alam, M, Rauf, Z, Shah, K, Khan, A, Ozdemir, B, Selamoglu, Z. Comparison of Biochemical Parameters in Patients with Hepatitis B, C, and Dual Hepatitis B and C in Northwest Pakistan. سامانه مدیریت نشریات علمی, 1401; 77(2): 869-879. doi: 10.22092/ari.2022.357172.1988

Comparison of Biochemical Parameters in Patients with Hepatitis B, C, and Dual Hepatitis B and C in Northwest Pakistan

Archives of Razi Institute
مقاله 45، دوره 77، شماره 2، خرداد و تیر 2022، صفحه 869-879    اصل مقاله (427.25 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2022.357172.1988
نویسندگان
S Khan1؛ M Alam2؛ Z Rauf3؛ K Shah4؛ A Khan5؛ B Ozdemir* 6؛ Z Selamoglu7
1Institute of Molecular Biology and Biotechnology, University of Lahore, 1-KM Defense Road Lahore-54000, Pakistan
2Gomal Center of Biochemistry and Biotechnology, Gomal University, Dera Ismail Khan-29050. KPK, Pakistan
3Department of Statistics, (INS) Gomal University, Dera Ismail Khan-29050, KPK, Pakistan
4Department of Pharmaceutics, Faculty of Pharmacy, Gomal University, Dera Ismail Khan-29050, KPK, Pakistan
5Department of Sports Sciences and Physical Education, University of the Punjab, Lahore-54000, Pakistan
6Department of Cardiology Faculty of Medicine, Nigde Omer Halisdemir University, Campus, 51240, Nigde, Turkey
7Department of Medical Biology, Faculty of Medicine, Nigde Ömer Halisdemir University, Nigde, Turkey
چکیده
The leading causes of hepatitis are viral infections, Hepatitis B virus (HBV) and Hepatitis C virus (HCV). Millions of people have been infected with these deadly viral infections worldwide, and in Pakistan, every tenth person is infected with these viruses. Different populations respond with different rates to infectious diseases due to host genomic differences. To evaluate and compare the biochemical parameters in different types of hepatitis (Hepatitis B, C, and Co-infection) and different ethnic groups, a total of 200 pre-screened patients were recruited from District Headquarters Teaching Hospital Dera Ismail Khan and Tank. Blood samples (5ml) were taken from patients and were assayed for biochemical parameters, including four liver function tests (LFTs) and two renal function tests (RFTs). In 200 patients, the mean scores of Alanine transaminase (ALT) were 376±335, 315±265, and 478±519 IU/L in HBV, HCV, and co-infected patients, respectively. Moreover, the mean score of ALT was 31±7.2 IU/l in the normal control group. All other biochemical parameters demonstrated elevated levels in co-infection, HBV, and HCV, respectively, except total proteins. The RFTs showed a threshold or upper normal limit (UNL); nonetheless, when compared to normal control subjects, RFTs parameters were high in infected patients, as compared to normal control. Ethnicity wise comparison of parameters indicated that Pushtoon ethnic group indicated a high degree of severity of HBV infection and co-infection, as compared to Saraiki and Rajpoot ethnic groups, while Saraiki ethnic group showed a higher severity of HCV than both of Pushtoon and Rajpoot. Rajpoot ethnic group was least affected than both Pushtoon and Saraiki ethnic groups. Co-infected patients were more severely affected, as compared to HBV and HCV patients. The ethnicity-wise study provided evidence that different ethnic groups showed different degrees of severity. There may be some genetic background involved in hepatitis B and C viral infection due to which all three ethnic groups showed different degrees of severity. In gender-wise comparisons, male patients were more affected than female patients
کلیدواژه‌ها
Co-infected؛ HBV؛ HCV؛ LFT؛ RFT
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مراجع
  1. Bernal W, Wendon J. Acute liver failure. N Engl J Med. 2013;369(26):2525-34.
  2. Wiktor SZ, Hutin YJF. The global burden of viral hepatitis: better estimates to guide hepatitis elimination efforts. Lancet. 2016;388(10049):1030-1.
  3. Davis GL, Albright JE, Cook SF, Rosenberg DM. Projecting future complications of chronic hepatitis C in the United States. Liver Transpl. 2003;9(4):331-8.
  4. El-Serag HB, Mason AC. Rising incidence of hepatocellular carcinoma in the United States. N Engl J Med. 1999;340(10):745-50.
  5. Zarski J-P, Bohn B, Bastie A, Pawlotsky J-M, Baud M, Bost-Bezeaux F, et al. Characteristics of patients with dual infection by hepatitis B and C viruses. J Hepatol. 1998;28(1):27-33.
  6. Lavanchy D. The global burden of hepatitis C. Liver Int. 2009;29 (1):74-81.
  7. Rantala M, van de Laar MJ. Surveillance and epidemiology of hepatitis B and C in Europe - a review. Euro Surveill. 2008;13(21).
  8. Waheed Y, Tahir S, Ahmad T, Qadri I. Sequence comparison and phylogenetic analysis of core gene of hepatitis C virus from Pakistani population. Afr J Biotechnol. 2010;9(29):4561-7.
  9. Ali SA, Donahue RM, Qureshi H, Vermund SH. Hepatitis B and hepatitis C in Pakistan: prevalence and risk factors. Int J Infect Dis. 2009;13(1):9-19.
  10. Alam MM, Zaidi SZ, Malik SA, Naeem A, Shaukat S, Sharif S, et al. Serology based disease status of Pakistani population infected with hepatitis B virus. BMC Infect Dis. 2007;7:64.
  11. Hakim S, Kazmi S, Bagasra O. Seroprevalence of hepatitis B and C genotypes among young apparently healthy females of karachi-pakistan. Libyan J Med. 2008;3(2):66-70.
  12. Samina N, Shazia Tabassum H, David M, Shahana UK, Omar B. Prevalence of Hepatitis B virus genotype D in females in Karachi, Pakistan. J Infect Dev Ctries. 2008;2(5).
  13. Schumann G, Bonora R, Ceriotti F, Clerc-Renaud P, Ferrero CA, Ferard G, et al. IFCC primary reference procedures for the measurement of catalytic activity concentrations of enzymes at 37 degrees C. Part 3. Reference procedure for the measurement of catalytic concentration of lactate dehydrogenase. Clin Chem Lab Med. 2002;40(6):643-8.
  14. Koc OM, Robaeys G, Yildirim B, Posthouwer D, Hens N, Koek GH. The influence of ethnicity on disease outcome in patients with chronic hepatitis B infection. J Med Virol. 2019;91(4):623-9.
  15. Gornall AG, Bardawill CJ, David MM. Determination of serum proteins by means of the biuret reaction. J Biol Chem. 1949;177(2):751-66.
  16. Vasiliades J. Reaction of alkaline sodium picrate with creatinine: I. Kinetics and mechanism of formation of the mono-creatinine picric acid complex. Clin Chem. 1976;22(10):1664-71.
  17. Taylor AJ, Vadgama P. Analytical reviews in clinical biochemistry: the estimation of urea. Ann Clin Biochem. 1992;29 ( Pt 3):245-64.
  18. Senturk H, Tahan V, Canbakan B, Dane F, Ulger Y, Ozaras R, et al. Clinicopathologic features of dual chronic hepatitis B and C infection: A comparison with single hepatitis B, C and delta infections. Ann Hepatol. 2008;7(1):52-8.
  19. Flisiak R, Halota W, Jaroszewicz J, Juszczyk J, Malkowski P, Pawlowska M, et al. Recommendations for the treatment of hepatitis B in 2017. Clin Exp Hepatol. 2017;3(2):35-46.
  20. Papadopoulos N, Papavdi M, Pavlidou A, Konstantinou D, Kranidioti H, Kontos G, et al. Hepatitis B and C coinfection in a real-life setting: viral interactions and treatment issues. Ann Gastroenterol. 2018;31(3):365-70.
  21. Zaman M, Asad H, Roy M, Hoque N, Nasiruddin M, Choudhury M, et al., editors. Evaluation of Serum Levels of Hepatic Enzymes and Plasma Proteins between Different Types of Acute Viral Hepatitis. 2013.
  22. CDC. Surveillance for Viral Hepatitis-United States 2014. Available from: https://www.cdc.gov/hepatitis/statistics/2014surveillance/commentary.htm.
  23. Singh K, Farooq U, Singh S, Bharti AK, Kaur N, Shariq M, editors. Hepatitis B- and Hepatitis C-infected Cases and Their Correlation with Liver Function Test in Teerthanker Mahaveer Medical College & Research Centre, Moradabad, Uttar Pradesh India. 2016.
  24. Li XM, Ma L, Yang YB, Shi ZJ, Zhou SS. Clinical characteristics of fulminant hepatitis in pregnancy. World J Gastroenterol. 2005;11(29):4600-3.
  25. Chen L, Wu C, Fan X, Gao J, Yin H, Wang T, et al. Replication and infectivity of hepatitis B virus in HBV-related glomerulonephritis. Int J Infect Dis. 2009;13(3):394-8.
  26. Okuse C, Yotsuyanagi H, Yamada N, Ikeda H, Takahashi H, Suzuki M, et al. Successful treatment of hepatitis B virus-associated membranous nephropathy with lamivudine. Clin Nephrol. 2006;65(1):53-6.
  27. Takekoshi Y, Tochimaru H, Nagata Y, Itami N. Immunopathogenetic mechanisms of hepatitis B virus-related glomerulopathy. Kidney Int Suppl. 1991;35:S34-9.
  28. Adoga MP, Gyar SD, Pechulano S, Bashayi OD, Emiasegen SE, Zungwe T, et al. Hepatitis B virus infections in apparently healthy urban Nigerians: data from pre-vaccination tests. J Infect Dev Ctries. 2010;4(6):397-400.
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