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Mahdi, Harith. (1401). Evaluation of the Pharmaceutical and Microbial Safety, as well as the Reliability, of Some Natural Pharmaceutical Products Available in Iraq. سامانه مدیریت نشریات علمی, 77(4), 1465-1471. doi: 10.22092/ari.2022.357639.2079
Harith Jameel Mahdi. "Evaluation of the Pharmaceutical and Microbial Safety, as well as the Reliability, of Some Natural Pharmaceutical Products Available in Iraq". سامانه مدیریت نشریات علمی, 77, 4, 1401, 1465-1471. doi: 10.22092/ari.2022.357639.2079
Mahdi, Harith. (1401). 'Evaluation of the Pharmaceutical and Microbial Safety, as well as the Reliability, of Some Natural Pharmaceutical Products Available in Iraq', سامانه مدیریت نشریات علمی, 77(4), pp. 1465-1471. doi: 10.22092/ari.2022.357639.2079
Mahdi, Harith. Evaluation of the Pharmaceutical and Microbial Safety, as well as the Reliability, of Some Natural Pharmaceutical Products Available in Iraq. سامانه مدیریت نشریات علمی, 1401; 77(4): 1465-1471. doi: 10.22092/ari.2022.357639.2079

Evaluation of the Pharmaceutical and Microbial Safety, as well as the Reliability, of Some Natural Pharmaceutical Products Available in Iraq

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مقاله 21، دوره 77، شماره 4، مهر و آبان 2022، صفحه 1465-1471    اصل مقاله (388.23 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2022.357639.2079
نویسنده
Harith Jameel Mahdi*
Department of Biotechnology, Faculty of Applied Sciences, University of Samarra, Iraq
چکیده
The use of natural pharmaceutical products (NPPs) for the treatment or prevention of diseases is continuously increasing. The ease of obtaining them without professional observation, as well as the incorrect popular belief that natural products are completely safe, increase the possibility of harmful and toxic effects of such products. In this study, some of the widely sold NPPs in Iraqi markets were evaluated for their pharmaceutical and microbial legibility to be consumed by humans. The evaluation includes organoleptic properties, foreign matters, loss on drying, water content, total ash percentage, heavy metal tests, aflatoxins, as well as microbial limit tests. The results revealed that some of the evaluated products were contaminated with heavy metals, lead, mercury, and cadmium.  Additionally, pathogenic bacterial growth, including Salmonella species and E. coli, was detected. A high percentage of loss on drying and water content was detected in some of the tested products. All tested samples showed negative results for aflatoxins. Some of the evaluated products were pharmaceutically and/or microbiologically unacceptable and not safe to be consumed by humans. Serious and fast measures must be taken by the Drug Regulatory Authority of Iraq to issue more rigorous standards for the quality of NPPs with continuous monitoring and control of the marketed NPPs.
کلیدواژه‌ها
Herbal؛ Medicinal plant؛ Natural pharmaceutical products؛ Safety
سایر فایل های مرتبط با مقاله
مراجع
  1. Atanasov AG, Waltenberger B, Pferschy-Wenzig EM, Linder T, Wawrosch C, Uhrin P, et al. Discovery and resupply of pharmacologically active plant-derived natural products: A review. Biotechnol Adv. 2015;33(8):1582-614.
  2. Abdel-Aziz SM, Aeron A, Kahil TA. Health Benefits and Possible Risks of Herbal Medicine. In: Garg N, Abdel-Aziz SM, Aeron A, editors. Microbes in Food and Health. Cham: Springer International Publishing; 2016. p. 97-116.
  3. Monera-Penduka TG, Jani ZT, Maponga CC, Mudzengi J, Morse GD, Nhachi CF. Quality and labeling information of Moringa oleifera products marketed for HIV-infected people in Zimbabwe. J Public Health Afr. 2016;7(2):84-8.
  4. Kulhari A, Sheorayan A, Bajar S, Sarkar S, Chaudhury A, Kalia RK. Investigation of heavy metals in frequently utilized medicinal plants collected from environmentally diverse locations of north western India. Springerplus. 2013;2:676.
  5. Gaston TE, Mendrick DL, Paine MF, Roe AL, Yeung CK. "Natural" is not synonymous with "Safe": Toxicity of natural products alone and in combination with pharmaceutical agents. Regul Toxicol Pharmacol. 2020;113:104642.
  6. World Health Organization. Quality control methods for herbal materials. World Health Organization; 2011.
  7. USP -N. Articles of Botanical Origin and Loss on drying. 2020.
  8. Indrayanto G. Recent Development of Quality Control Methods for Herbal Derived Drug Preparations. Nat Prod Commun. 2018;13.
  9. Li G, Schoneker D, Ulman KL, Sturm JJ, Thackery LM, Kauffman JF. Elemental Impurities in Pharmaceutical Excipients. J Pharm Sci. 2015;104(12):4197-206.
  10. Wacoo AP, Wendiro D, Vuzi PC, Hawumba JF. Methods for Detection of Aflatoxins in Agricultural Food Crops. J Appl Chem. 2014;2014:706291.
  1. Bosiljkov T, Levaj B. The Effect of Extraction Solvents, Temperature and Time on the Composition and Mass Fraction of Polyphenols in Dalmatian Wild Sage (Salvia officinalis L.) Extracts. Food Technol Biotech. 2013;51(1):84-91.
  2. Mahdi H, Khan N, Roziahanim M, Asmawi M, Vikneswaran A. LC/MS, GC/MS screening and in vivo anti-inflammatory activity of Malaysian Moringa oleifera Lam leaf extracts and fractions against carrageenan-induced paw oedema in rats. J Innov Pharmac Biol Sci. 2017;4(3):48-54.
  1. Jan AT, Azam M, Siddiqui K, Ali A, Choi I, Haq QM. Heavy Metals and Human Health: Mechanistic Insight into Toxicity and Counter Defense System of Antioxidants. Int J Mol Sci. 2015;16(12):29592-630.
  2. Kumar P, Mahato DK, Kamle M, Mohanta TK, Kang SG. Aflatoxins: A Global Concern for Food Safety, Human Health and Their Management. Front Microbiol. 2016;7:2170.
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