اخبار و اعلانات

 آمار

تعداد نشریات285
تعداد نشریات سازمان83
تعداد شماره‌ها3,086
تعداد مقالات34,442
تعداد مشاهده مقاله48,917,043
تعداد دریافت فایل اصل مقاله79,354,736
Varadhan, S, Venkatachalam, R, Perumal, S., Ayyamkulamkara, S.. (1401). Evaluation of Oxidative Stress Parameters and Antioxidant Status in Coronary Artery Disease Patients. سامانه مدیریت نشریات علمی, 77(2), 853-859. doi: 10.22092/ari.2022.357069.1965
S Varadhan; R Venkatachalam; S. M Perumal; S. S Ayyamkulamkara. "Evaluation of Oxidative Stress Parameters and Antioxidant Status in Coronary Artery Disease Patients". سامانه مدیریت نشریات علمی, 77, 2, 1401, 853-859. doi: 10.22092/ari.2022.357069.1965
Varadhan, S, Venkatachalam, R, Perumal, S., Ayyamkulamkara, S.. (1401). 'Evaluation of Oxidative Stress Parameters and Antioxidant Status in Coronary Artery Disease Patients', سامانه مدیریت نشریات علمی, 77(2), pp. 853-859. doi: 10.22092/ari.2022.357069.1965
Varadhan, S, Venkatachalam, R, Perumal, S., Ayyamkulamkara, S.. Evaluation of Oxidative Stress Parameters and Antioxidant Status in Coronary Artery Disease Patients. سامانه مدیریت نشریات علمی, 1401; 77(2): 853-859. doi: 10.22092/ari.2022.357069.1965

Evaluation of Oxidative Stress Parameters and Antioxidant Status in Coronary Artery Disease Patients

Archives of Razi Institute
مقاله 43، دوره 77، شماره 2، خرداد و تیر 2022، صفحه 853-859    اصل مقاله (321.07 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2022.357069.1965
نویسندگان
S Varadhan1؛ R Venkatachalam* 2؛ S. M Perumal3؛ S. S Ayyamkulamkara4
1Department of Biochemistry, Bharath Institute of Higher Education and Research, Selaiyur, Chennai, Tamil Nadu, India
2Department of Biochemistry, Sreelekshmi Narayana Institute of Medical Science, Bharath Institute of Higher Education and Research, Puducherry, India
3Department of Pharmacology, Tagore Dental College and Hospital, Chennai, Tamil Nadu, India
4Department of Biochemistry, Government Medical College, Trissur, Kerala, India
چکیده
A surge in oxidative stress and weakened antioxidant defense contributes to the initiation and progression of Coronary Artery Diseases (CAD). The resultant burst in free radicals causes oxidation of lipoproteins mainly oxidized low-density lipoprotein (oxLDL). Further studies need to be conducted to find whether the management of CAD can be evaluated within the context of oxidant/antioxidant balance with the contribution of newer markers. This study was performed to evaluate, compare, and correlate oxidative stress parameters and antioxidant status in CAD patients with controls and evaluate and compare pro-oxidant, a pro-inflammatory enzyme, myeloperoxidase (MPO) and anti-oxidant, anti-inflammatory enzyme, and paraoxonase (PON) between CAD patients and controls. OxLDL, an oxidation product of low-density lipoprotein, malondialdehyde (MDA), an oxidative marker, and reduced glutathione (GSH), an anti-oxidant marker, and lipid profile were assessed and compared in CAD patients and controls. The activity of MPO was correlated with that of PON, and MDA level was correlated with GSH level. A total of 100 clinically proven CAD patients, in the age range of 35-70 years, were selected from the Out Patient Department (OPD) of our Institute. A total of 60 controls in the same age range and without CAD were selected after undergoing health checkups in the hospital. Based on the obtained results, oxLDL, MDA, and MPO were significantly increased in patients than in controls (P<0.05), and PON and GSH were significantly lowered in patients than in controls (P<0.05). Total cholesterol, triglyceride, and LDL were significantly high in CAD patients. A significant negative correlation was observed between MPO and PON levels and between MDA and GSH levels. Increased oxidative stress and decreased antioxidant status were observed in patients with CAD. Formation of oxLDL increased MPO and decreased PON are all additional risk factors for the development of CAD and can be targeted for future therapeutic purposes. Lifestyle modifications and treatment methods can reduce CAD risk through the reduction of oxidative stress and improvement of antioxidant status.
کلیدواژه‌ها
Coronary artery disease؛ Malondialdehyde؛ Myeloperoxidase؛ Oxidized low-density lipoprotein؛ Paraoxonase
سایر فایل های مرتبط با مقاله
مراجع
  1. Kotur-Stevuljevic J, Memon L, Stefanovic A, Spasic S, Spasojevic-Kalimanovska V, Bogavac-Stanojevic N, et al. Correlation of oxidative stress parameters and inflammatory markers in coronary artery disease patients. Clin Biochem. 2007;40(3-4):181-7.
  2. Peluso I, Morabito G, Urban L, Ioannone F, Serafini M. Oxidative stress in atherosclerosis development: the central role of LDL and oxidative burst. Endocr Metab Immune Disord Drug Targets. 2012;12(4):351-60.
  3. Pignatelli P, Menichelli D, Pastori D, Violi F. Oxidative stress and cardiovascular disease: new insights. Kardiol Pol. 2018;76(4):713-22.
  4. Gur M, Aslan M, Yildiz A, Demirbag R, Yilmaz R, Selek S, et al. Paraoxonase and arylesterase activities in coronary artery disease. Eur J Clin Invest. 2006;36(11):779-87.
  5. Yaghoubi A, Ghojazadeh M, Abolhasani S, Alikhah H, Khaki-Khatibi F. Correlation of Serum Levels of Vitronectin, Malondialdehyde and Hs- CRP With Disease Severity in Coronary Artery Disease. J Cardiovasc Thorac Res. 2015;7(3):113-7.
  6. Abu-Amero KK, Al-Boudari OM, Mohamed GH, Dzimiri N. T null and M null genotypes of the glutathione S-transferase gene are risk factor for CAD independent of smoking. BMC Med Genet. 2006;7:38.
  7. Huang H, Mai W, Liu D, Hao Y, Tao J, Dong Y. The oxidation ratio of LDL: a predictor for coronary artery disease. Dis Markers. 2008;24(6):341-9.
  8. Hajar R. Risk Factors for Coronary Artery Disease: Historical Perspectives. Heart Views. 2017;18(3):109-14.
  9. Kamceva G, Arsova-Sarafinovska Z, Ruskovska T, Zdravkovska M, Kamceva-Panova L, Stikova E. Cigarette Smoking and Oxidative Stress in Patients with Coronary Artery Disease. Open Access Maced J Med Sci. 2016;4(4):636-40.
  10. Chiha M, Njeim M, Chedrawy EG. Diabetes and coronary heart disease: a risk factor for the global epidemic. Int J Hypertens. 2012;2012:697240.
  11. Bacchetti T, Ferretti G, Carbone F, Ministrini S, Montecucco F, Jamialahmadi T, et al. Dysfunctional High-density Lipoprotein: The Role of Myeloperoxidase and Paraoxonase-1. Curr Med Chem. 2021;28(14):2842-50.
  1. Huang Y, Wu Z, Riwanto M, Gao S, Levison BS, Gu X, et al. Myeloperoxidase, paraoxonase-1, and HDL form a functional ternary complex. J Clin Invest. 2013;123(9):3815-28.
  2. Aggarwal G, May-Zhang LS, Yermalitsky V, Dikalov S, Voynov MA, Amarnath V, et al. Myeloperoxidase-induced modification of HDL by isolevuglandins inhibits paraoxonase-1 activity. J Biol Chem. 2021;297(3):101019.
  3. Bastani A, Rajabi S, Daliran A, Saadat H, Karimi-Busheri F. Oxidant and antioxidant status in coronary artery disease. Biomed Rep. 2018;9(4):327-32.
  4. Lixia Y, Feng Q, Ruiwei G, Xianmei W, Chuanming G. e0379 Study of correlationship between myeloperoxidase paraoxonase and coron. Clin Res Cardiol. 2010;96(3): 117-8.
  5. Haraguchi Y, Toh R, Hasokawa M, Nakajima H, Honjo T, Otsui K, et al. Serum myeloperoxidase/paraoxonase 1 ratio as potential indicator of dysfunctional high-density lipoprotein and risk stratification in coronary artery disease. Atherosclerosis. 2014;234(2):288-94.
  6. Nadro B, Szentpeteri A, Lorincz H, Juhasz L, Seres I, Pall D, et al. Changes in HDL subfraction distribution and myeloperoxidase/paraoxonase-1 ratio in untreated dyslipidemic patients. Atherosclerosis. 2018;275:e168.
  7. Yunoki K, Naruko T, Inaba M, Inoue T, Nakagawa M, Sugioka K, et al. Gender-specific correlation between plasma myeloperoxidase levels and serum high-density lipoprotein-associated paraoxonase-1 levels in patients with stable and unstable coronary artery disease. Atherosclerosis. 2013;231(2):308-14.
  8. Zsiros N, Koncsos P, Lorincz H, Seres I, Katko M, Szentpeteri A, et al. Paraoxonase-1 arylesterase activity is an independent predictor of myeloperoxidase levels in overweight patients with or without cardiovascular complications. Clin Biochem. 2016;49(12):862-7.
  9. Uppal N, Uppal V, Uppal P. Progression of Coronary Artery Disease (CAD) from Stable Angina (SA) Towards Myocardial Infarction (MI): Role of Oxidative Stress. J Clin Diagn Res. 2014;8(2):40-3.
آمار
تعداد مشاهده مقاله: 1,928
تعداد دریافت فایل اصل مقاله: 2,776


counter
سامانه مدیریت نشریات علمی. طراحی و پیاده سازی از سیناوب