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Abdul-Mohammed Al-Rawazq, Huda, Kamal Mohammed, A, Mohsen Ahmed, Z. (1400). Imipenem Resistance in Gram-Negative Bacteria in the Central Pediatric Teaching Hospital in Baghdad, Iraq. سامانه مدیریت نشریات علمی, 77(1), 123-128. doi: 10.22092/ari.2021.356678.1891
Huda Sahib Abdul-Mohammed Al-Rawazq; A Kamal Mohammed; Z Mohsen Ahmed. "Imipenem Resistance in Gram-Negative Bacteria in the Central Pediatric Teaching Hospital in Baghdad, Iraq". سامانه مدیریت نشریات علمی, 77, 1, 1400, 123-128. doi: 10.22092/ari.2021.356678.1891
Abdul-Mohammed Al-Rawazq, Huda, Kamal Mohammed, A, Mohsen Ahmed, Z. (1400). 'Imipenem Resistance in Gram-Negative Bacteria in the Central Pediatric Teaching Hospital in Baghdad, Iraq', سامانه مدیریت نشریات علمی, 77(1), pp. 123-128. doi: 10.22092/ari.2021.356678.1891
Abdul-Mohammed Al-Rawazq, Huda, Kamal Mohammed, A, Mohsen Ahmed, Z. Imipenem Resistance in Gram-Negative Bacteria in the Central Pediatric Teaching Hospital in Baghdad, Iraq. سامانه مدیریت نشریات علمی, 1400; 77(1): 123-128. doi: 10.22092/ari.2021.356678.1891

Imipenem Resistance in Gram-Negative Bacteria in the Central Pediatric Teaching Hospital in Baghdad, Iraq

Archives of Razi Institute
مقاله 18، دوره 77، شماره 1، فروردین و اردیبهشت 2022، صفحه 123-128    اصل مقاله (365.71 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2021.356678.1891
نویسندگان
Huda Sahib Abdul-Mohammed Al-Rawazq* 1؛ A Kamal Mohammed2؛ Z Mohsen Ahmed2
1Anatomy -Biology section, College of Medicine, University of Baghdad, Baghdad,Iraq
2Central Pediatric Teaching Hospital, Baghdad, Iraq
چکیده
Antimicrobial resistance (AMR) is a serious challenge for infectious disease prevention and treatment, according to the World Health Organization. It is a worldwide problem caused primarily by inappropriate and insufficient therapy, misuse of antimicrobials without physician supervision, unnecessary hospital readmissions, and other factors. AMR has several consequences, including increased medical costs and mortality. The present study aimed to evaluate imipenem resistance in gram-negative bacteria in Central Pediatric Teaching Hospital in Baghdad, Iraq, and determine this bacteria resistance in different samples. Initially, a total of 100 different samples were collected from child patients from October 1, 2020, to August 31, 2021. Each isolate was identified using VITEK 2 automated microbiology system. The recorded data showed that the isolated organisms resistant to imipenem included Klebsiella pneumonia (n=21), Pseudomonas aeruginosa (n=19), and Acinetobacter baumannii (n=16). In the current study, Klebsiella pneumonia was the most common pathogen in males (n=57) compared to female (n=43), followed by Pseudomonas aeruginosa and Acinetobacter baumannii, particularly in the age range of 1 day- 3 years. Depending on the sample type, Klebsiella pneumonia, the most imipenem-resistant bacteria, was found more in the urine of patients with urinary tract infections. Pseudomonas aeruginosa was equally found in blood, urine, wound swab, and sputum samples. In comparison to other samples, Acinetobacter baumannii was found in greater numbers in the blood and in an equal number in urine and cerebrospinal.
کلیدواژه‌ها
Children؛ Different samples؛ Gram-negative bacteria؛ Imipenem antibiotic
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مراجع
  1. Uc-Cachon AH, Gracida-Osorno C, Luna-Chi IG, Jimenez-Guillermo JG, Molina-Salinas GM. High Prevalence of Antimicrobial Resistance Among Gram-Negative Isolated Bacilli in Intensive Care Units at a Tertiary-Care Hospital in Yucatan Mexico. Medicina (Kaunas). 2019;55(9):588.
  2. Ventola CL. The antibiotic resistance crisis: part 1: causes and threats. P T. 2015;40(4):277-83.
  3. Patel TS, Nagel JL. Clinical outcomes of Enterobacteriaceae infections stratified by carbapenem MICs. J Clin Microbiol. 2015;53(1):201-5.
  4. Tam VH, Rogers CA, Chang KT, Weston JS, Caeiro JP, Garey KW. Impact of multidrug-resistant Pseudomonas aeruginosa bacteremia on patient outcomes. Antimicrob Agents Chemother. 2010;54(9):3717-22.
  5. Laxminarayan R, Duse A, Wattal C, Zaidi AKM, Wertheim HFL, Sumpradit N, et al. Antibiotic resistance;the need for global solutions. Lancet Infect Dis. 2013;13(12):1057-98.
  6. Morales E, Cots F, Sala M, Comas M, Belvis F, Riu M, et al. Hospital costs of nosocomial multi-drug resistant Pseudomonas aeruginosa acquisition. BMC Health Serv Res. 2012;12(1):122.
  7. Vasudevan A, Memon BI, Mukhopadhyay A, Li J, Tambyah PA. The costs of nosocomial resistant gram negative intensive care unit infections among patients with the systemic inflammatory response syndrome- a propensity matched case control study. Antimicrob Resist Infect Control. 2015;4(1):3.
  8. Sosa AdJ, Byarugaba DK, Amábile-Cuevas CF, Hsueh P-R, Kariuki S, Okeke IN. Antimicrobial resistance in developing countries: Springer science Business Media. 2009.
  9. Borgia S, Lastovetska O, Richardson D, Eshaghi A, Xiong J, Chung C, et al. Outbreak of carbapenem-resistant enterobacteriaceae containing blaNDM-1, Ontario, Canada. Clin Infect Dis. 2012;55(11):109-17.
  10. Walsh TR, Weeks J, Livermore DM, Toleman MA. Dissemination of NDM-1 positive bacteria in the New Delhi environment and its implications for human health: an environmental point prevalence study. Lancet Infect Dis. 2011;11(5):355-62.
  11. Helmy OM, Kashef MT. Different phenotypic and molecular mechanisms associated with multidrug resistance in Gram-negative clinical isolates from Egypt. Infect Drug Resist. 2017;10:479-98.
  12. Read AF, Woods RJ. Antibiotic resistance management. Evol Med Public Health. 2014;2014(1):147.
  13. Vasoo S, Barreto JN, Tosh PK. Emerging issues in gram-negative bacterial resistance: an update for the practicing clinician. Mayo Clin Proc. 2015;90(3):395-403.
  14. Ruppe E, Woerther PL, Barbier F. Mechanisms of antimicrobial resistance in Gram-negative bacilli. Ann Intensive Care. 2015;5(1):61.
  15. Tran GM, Ho-Le TP, Ha DT, Tran-Nguyen CH, Nguyen TSM, Pham TTN, et al. Patterns of antimicrobial resistance in intensive care unit patients: a study in Vietnam. BMC Infect Dis. 2017;17(1):429.
  16. Khorshidi A, Sharif A. Imipenem Resistance among Gram-Negative and Gram-Positive Bacteria in Hospitalized Patients. Iran J Public Health. 2010;39(2):110-3.
  17. Ameen N, Memon Z, Shaheen S, Fatima G, Ahmed F. Imipenem Resistant Pseudomonas aeruginosa: The fall of the final quarterback. Pak J Med Sci. 2015;31(3):561-5.
  18. Santajit S, Indrawattana N. Mechanisms of Antimicrobial Resistance in ESKAPE Pathogens. Biomed Res Int. 2016;2016:2475067.
  19. Radji M, Fauziah S, Aribinuko N. Antibiotic sensitivity pattern of bacterial pathogens in the intensive care unit of Fatmawati Hospital, Indonesia. Asian Pac J Trop Biomed. 2011;1(1):39-42.
  20. Parajuli NP, Acharya SP, Mishra SK, Parajuli K, Rijal BP, Pokhrel BM. High burden of antimicrobial resistance among gram negative bacteria causing healthcare associated infections in a critical care unit of Nepal. Antimicrob Resist Infect Control. 2017;6(1):67.
  21. Karlowsky JA, Lob SH, Kazmierczak KM, Hawser SP, Magnet S, Young K, et al. In vitro activity of imipenem/relebactam against Gram-negative ESKAPE pathogens isolated in 17 European countries: 2015 SMART surveillance programme. J Antimicrob Chemother. 2018;73(7):1872-9.
  22. Hancock RE. Resistance mechanisms in Pseudomonas aeruginosa and other nonfermentative gram-negative bacteria. Clin Infect Dis. 1998;27 Suppl 1:S93-9.
  23. Peleg AY, Seifert H, Paterson DL. Acinetobacter baumannii: emergence of a successful pathogen. Clin Microbiol Rev. 2008;21(3):538-82.
  24. Mohsen L, Ramy N, Saied D, Akmal D, Salama N, Abdel Haleim MM, et al. Emerging antimicrobial resistance in early and late-onset neonatal sepsis. Antimicrob Resist Infect Control. 2017;6(1):63.
  1. Boucher HW, Talbot GH, Bradley JS, Edwards JE, Gilbert D, Rice LB, et al. Bad bugs, no drugs: no ESKAPE! An update from the Infectious Diseases Society of America. Clin Infect Dis. 2009;48(1):1-12.
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