Jelokhani, M, Vazir, B, Zendehdel, M, Jahandideh, A. (1401). Interactions of Cholecystokinin and Glutamatergic Systems in Feeding Behavior of Neonatal Chickens. سامانه مدیریت نشریات علمی, 77(2), 681-688. doi: 10.22092/ari.2022.357300.2015
M Jelokhani; B Vazir; M Zendehdel; A Jahandideh. "Interactions of Cholecystokinin and Glutamatergic Systems in Feeding Behavior of Neonatal Chickens". سامانه مدیریت نشریات علمی, 77, 2, 1401, 681-688. doi: 10.22092/ari.2022.357300.2015
Jelokhani, M, Vazir, B, Zendehdel, M, Jahandideh, A. (1401). 'Interactions of Cholecystokinin and Glutamatergic Systems in Feeding Behavior of Neonatal Chickens', سامانه مدیریت نشریات علمی, 77(2), pp. 681-688. doi: 10.22092/ari.2022.357300.2015
Jelokhani, M, Vazir, B, Zendehdel, M, Jahandideh, A. Interactions of Cholecystokinin and Glutamatergic Systems in Feeding Behavior of Neonatal Chickens. سامانه مدیریت نشریات علمی, 1401; 77(2): 681-688. doi: 10.22092/ari.2022.357300.2015
Interactions of Cholecystokinin and Glutamatergic Systems in Feeding Behavior of Neonatal Chickens
1Department of Basic Sciences, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran
2Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
3Department of Clinical Sciences, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran
چکیده
This study aimed to assess the possible feeding behavior alterations by central interactions of cholecystokinin (CCK) and glutamatergic systems in neonatal chickens. In experiment 1, chickens received intracerebroventricular (ICV) administration of saline and CCK (CCK4; 0.25, 0.5, and 1 nmol). In experiment 2, birds were ICV injected with saline, CCK8s (0.25, 0.5, and 1 nmol). In experiment 3, chickens received the ICV injection of saline, CCK8s (1 nmol), MK-801 (15 nmol), and co-injection of the CCk8s+MK-801. Experiments 4-7 were performed similar to experiment 3, except for chickens that were injected with CNQX (390 nmol), AIDA (2 nmol), LY341495 (150 nmol), and UBP1112 (2 nmol) instead of MK-801. Subsequently, the total amount of the consumed food was determined. According to the results, the ICV administration of CCK4 (0.25, 0.5, and 1 nmol) could not affect the food intake in chickens (P>0.05). The ICV injection of the CCK8s (0.25, 0.5, and 1 nmol) led to a dose-dependent hypophagia (P<0.05). Moreover, hypophagia induced by CCK8s decreased by the co-injection of the CCK8s+MK-801 (P<0.05). These results showed that the hypophagic effects of the CCK on food intake can be mediated by NMDA glutamate receptors in layer-type chickens.
تداخلات سیستم های گلوتامات ارژیک و کوله سیستوکینین در رفتار تغذیه ای جوجه های نوزاد
چکیده [English]
هدف از این مطالعه ارزیابی تغییرات احتمالی رفتار تغذیه ای به وسیله تداخلات مرکزی سیستم های گلوتامات ارژیک و کوله سیستوکینین (CCK) در جوجه های نوزاد بود. در آزمایش 1، جوجه ها تزریق داخل بطنی مغزی (ICV) سالین و کوله سیستوکینین(CCK4؛ 0.25، 0.5 و 1 نانومول) دریافت کردند. در آزمایش 2، پرندگان بصورت داخل بطن مغزی با سالین، (CCK8s ؛ 0.25، 0.5 و 1 نانومول) تزریق شدند. در آزمایش 3، جوجه ها تزریق داخل بطنی مغزی سالین، CCK8s (1نانومو)، MK-801 (15نانومول) و تزریق همزمان CCk8s و MK-801 را دریافت کردند. آزمایشات 4-7 مشابه آزمایش 3 انجام شد، به جز اینکه جوجه ها CNQX (390 نانومول)، AIDA (150 نانومول)، LY341495(150 نانومول) و UBP1112 (2 نانومول) را بجای MK-801 دریافت کردند. سپس مقدار کل غذای مصرفی مشخص شد. بر اساس نتایج، تجویز CCK4( 0.25، 0.5 و 1 نانومول) نتوانست دریافت غذا را در جوجه ها تحت تأثیر قرار دهد (P>0.05). تزریق داخل بطنی مغزی CCK8s ( 0.25، 0.5 و 1 نانومول) منجر به هیپوفاژی وابسته به دوز شد (P<0.05). همچنین هیپوفاژی ناشی از CCK8s با تزریق همزمان CCK8s + MK-801 کاهش یافت (P<0.05). این نتایج نشان داد که اثرات هیپوفاژیک CCK بر مصرف غذا احتمالا می‌تواند توسط گیرنده‌های NMDA گلوتامات در جوجه‌های تخمگذار میانجی گری شود.
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