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Kazemi, M, Aliyari, H, Golabi, S, Tekieh, E, Tavakoli, H, Saberi, M, Meftahi, Gh. H, Sahraei, H. (1400). Improvement of Cognitive Indicators in Male Monkeys Exposed to Extremely Low-Frequency Electromagnetic Fields. سامانه مدیریت نشریات علمی, 77(1), 503-511. doi: 10.22092/ari.2020.352384.1560
M Kazemi; H Aliyari; S Golabi; E Tekieh; H Tavakoli; M Saberi; Gh. H Meftahi; H Sahraei. "Improvement of Cognitive Indicators in Male Monkeys Exposed to Extremely Low-Frequency Electromagnetic Fields". سامانه مدیریت نشریات علمی, 77, 1, 1400, 503-511. doi: 10.22092/ari.2020.352384.1560
Kazemi, M, Aliyari, H, Golabi, S, Tekieh, E, Tavakoli, H, Saberi, M, Meftahi, Gh. H, Sahraei, H. (1400). 'Improvement of Cognitive Indicators in Male Monkeys Exposed to Extremely Low-Frequency Electromagnetic Fields', سامانه مدیریت نشریات علمی, 77(1), pp. 503-511. doi: 10.22092/ari.2020.352384.1560
Kazemi, M, Aliyari, H, Golabi, S, Tekieh, E, Tavakoli, H, Saberi, M, Meftahi, Gh. H, Sahraei, H. Improvement of Cognitive Indicators in Male Monkeys Exposed to Extremely Low-Frequency Electromagnetic Fields. سامانه مدیریت نشریات علمی, 1400; 77(1): 503-511. doi: 10.22092/ari.2020.352384.1560

Improvement of Cognitive Indicators in Male Monkeys Exposed to Extremely Low-Frequency Electromagnetic Fields

Archives of Razi Institute
مقاله 62، دوره 77، شماره 1، فروردین و اردیبهشت 2022، صفحه 503-511    اصل مقاله (901.98 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2020.352384.1560
نویسندگان
M Kazemi1؛ H Aliyari2؛ S Golabi3؛ E Tekieh1؛ H Tavakoli1؛ M Saberi4؛ Gh. H Meftahi1؛ H Sahraei* 1
1Neuroscience Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
2Center for Human-Engaged Computing, Kochi University of Technology, Kochi, Japan
3Department of Medical Physiology, School of Medicine, Abadan University of Medical Sciences, Abadan, Iran
4Department of Pharmacology and Toxicology, Faculty of Pharmacy, Baqiyatallah University of Medical Sciences, Tehran, Iran
چکیده
Today, the production of extremely low-frequency electromagnetic fields (ELF-EMFs) has significantly increased. This study aimed to investigate the effect of the ELF-EMFs on the structure and function of the brain in male rhesus monkeys in terms of visual learning (VL), visual memory (VM), and visual working memory (VWM). To conduct the study, four monkeys were selected, of whom two monkeys were irradiated by 12-Hz ELF-EMFs with a magnitude of 0.7 microtesla, and two monkeys were tested without irradiation (control group). A blood sample was taken in three stages, namely pre- and post-irradiated and the recovery phases. Changes in the plasma levels of sodium, potassium, and adrenocorticotropic hormone (ACTH) were evaluated. Moreover, gene expression of N-methyl-D-aspartate (NMDA) receptors was assessed. The anatomical change of the brain’s prefrontal area was measured by magnetic resonance imaging and Digital Imaging and Communications in Medicine LiteBox file. The abilities of VL, VM, and VWM significantly improved after the irradiation. Furthermore, the expression of the NMDA receptors gene and the plasma levels of sodium, potassium, and ACTH significantly enhanced after the irradiation. However, the prefrontal area was not significantly affected by the irradiation. No significant differences were observed in any of the studied factors in the control group. Our findings suggested that ELF-EMFs irradiation at 12 Hz positively affected VL and VWM. Consequently, 12-Hz ELF-EMFs irradiations can be widely applied to improve cognitive abilities in monkeys.
کلیدواژه‌ها
Adrenocorticotropic hormone؛ Extremely Low-frequency electromagnetic fields؛ Rhesus monkey؛ Visual learning؛ Visual memory؛ Visual working memory
عنوان مقاله [English]
بهبود شاخص های شناختی میمون های نر که در مواجهه با میادین الکترومغناطیسی با فرکانس بسیار پایین، گزارش علمی
چکیده [English]
امروزه، تولید میدان های الکترومغناطیسی با فرکانس بسیار کم (ELF-EMF) به طور قابل توجهی افزایش یافته است. این مطالعه با هدف بررسی تأثیر ELF-EMF در ساختار و عملکرد مغز در میمون های نر رزوس از نظر یادگیری بصری (VL)، حافظه بصری (VM) و حافظه کاری بصری (VWM) انجام شد. چهار میمون انتخاب شدند که از آن ها دو میمون توسط ELF-EMF با شدت 0.7 میکروتسلا، 12 هرتز، و دو میمون بدون تابش تحت آزمایش قرار گرفتند (گروه کنترل). یک نمونه خون در سه مرحله، قبل، بعد از تابش و مراحل بهبودی گرفته شد. تغییرات سطح پلاسمایی سدیم، پتاسیم و هورمون آدرنوکورتیکوتروپیک (ACTH) بررسی شد. همچنین، بیان ژن گیرنده های N-methyl-D-aspartate (NMDA) ارزیابی شد. تغییر آناتومیکی ناحیه پیشانی مغز توسط تصویربرداری تشدید مغناطیسی (MRI) و تصویربرداری دیجیتال و ارتباطات پزشکی (DICOM) فایل LiteBox ارزیابی شد. توانایی یادگیری بصری، حافظه بصری و حافظه فعال بصری پس از تابش به طور قابل توجهی بهبود یافت. همچنین، بیان ژن گیرنده های NMDA و سطح سدیم، پتاسیم و ACTH در پلاسما پس از تابش به طور قابل توجهی افزایش یافت. با این حال، منطقه Prefrontal به طور قابل توجهی تحت تابش قرار نگرفت. تفاوت معنی داری در هیچ یک از عوامل مورد مطالعه در گروه کنترل مشاهده نشد. یافته های ما نشان می دهد که تابش ELF-EMF در 12 هرتز، یادگیری بصری و حافظه کار بصری را تحت تأثیر قرار می دهد. بنابراین ، تابش های 12 هرتز ELF-EMF می توانند به طور گسترده ای برای بهبود توانایی های شناختی در میمون ها استفاده شوند
کلیدواژه‌ها [English]
هورمون Adrenocorticotropic, میدانهای الکترومغناطیسی با فرکانس بسیار کم, میمون Rhesus, یادگیری بصری, حافظه کار بصری
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مراجع
  1. Ahlbom A, Bridges J, De Seze R, Hillert L, Juutilainen J, Mattsson M-O, et al. Possible effects of electromagnetic fields (EMF) on human health--opinion of the scientific committee on emerging and newly identified health risks (SCENIHR). Toxicology. 2008;246(2-3):248-50.
  2. Kheifets L, Repacholi M, Saunders R, Van Deventer E. The sensitivity of children to electromagnetic fields. Pediatrics. 2005;116(2):e303-e13.
  3. Kazemi M, Sahraei H, Aliyari H, Tekieh E, Saberi M, Tavacoli H, et al. Effect of Extremely Low Frequency Electromagnetic Fields (ELF/MF) on NMDA-Receptor Gene Expression and Visual Working Memory of Male Rhesus Macaques. Basic Clin Neurosci. 2017;9(3):167-176.
  4. Gao G-P, Alvira MR, Wang L, Calcedo R, Johnston J, Wilson JM. Novel adeno-associated viruses from rhesus monkeys as vectors for human gene therapy. Proc Natl Acad Sci. 2002;99(18):11854-9.
  5. Marques AC, Dupanloup I, Vinckenbosch N, Reymond A, Kaessmann H. Emergence of young human genes after a burst of retroposition in primates. PLoS Biol. 2005;3(11):e357.
  6. Fang X, Zhang Y, Zhang R, Yang L, Li M, Ye K, et al. Genome sequence and global sequence variation map with 5.5 million SNPs in Chinese rhesus macaque. Genome Biol. 2011;12(7).
  7. Adey WR. Electromagnetic field interactions in the brain. Dynamics of sensory and cognitive processing by the brain: Springer; 1988. p. 157-72.
  8. Cifra M, Fields JZ, Farhadi A. Electromagnetic cellular interactions. Prog Biophys Mol Biol. 2011;105(3):223-46.
  9. Lipton SA. The molecular basis of memantine action in Alzheimer's disease and other neurologic disorders: low-affinity, uncompetitive antagonism. Curr Alzheimer Res. 2005;2(2):155-65.
  10. Kıvrak EG, Yurt KK, Kaplan AA, Alkan I, Altun G. Effects of electromagnetic fields exposure on the antioxidant defense system. J Microsc Ultrastruct. 2017.
  11. Markesbery WR. Oxidative stress hypothesis in Alzheimer's disease. Free Radic Biol Med. 1997;23(1):134-47.
  12. Moosmang S, Haider N, Klugbauer N, Adelsberger H, Langwieser N, Müller J, et al. Role of hippocampal Cav1. 2 Ca2+ channels in NMDA receptor-independent synaptic plasticity and spatial memory. J Neurosci. 2005;25(43):9883-92.
  13. Dalmau J, Tüzün E, Wu Hy, Masjuan J, Rossi JE, Voloschin A, et al. Paraneoplastic anti–N‐methyl‐D‐aspartate receptor encephalitis associated with ovarian teratoma. Ann Neurol. 2007;61(1):25-36.
  14. Baumann N, Pham-Dinh D. Biology of oligodendrocyte and myelin in the mammalian central nervous system. Physiol Rev. 2001;81(2):871-927.
  15. Lacreuse A, Herndon JG, Moss MB. Cognitive function in aged ovariectomized female rhesus monkeys. Behav Neurosci. 2000;114(3):506.
  16. Hong ME, Yoon KH, Jung YY, Lee TJ, Park ES, Sohn UD, et al. Influence of exposure to extremely low frequency magnetic field on neuroendocrine cells and hormones in stomach of rats. Korean J Physiol Pharmacol. 2011;15(3):137-42.
  17. Rodriguez M, Petitclerc D, Burchard J, Nguyen D, Block E. Blood melatonin and prolactin concentrations in dairy cows exposed to 60 Hz electric and magnetic fields during 8 h photoperiods. Bioelectromagnetics. 2004;25(7):508-15.
  18. Haddad JB, Obolensky AG, Shinnick P. The biologic effects and the therapeutic mechanism of action of electric and electromagnetic field stimulation on bone and cartilage: new findings and a review of earlier work. J Altern Complement Med. 2007;13(5):485-90.
  19. Kwok S, Qin L, Partridge NC, Selvamurugan N. Parathyroid hormone stimulation and PKA signaling of latent transforming growth factor‐β binding protein‐1 (LTBP‐1) mRNA expression in osteoblastic cells. J Cell Biochem. 2005;95(5):1002-11.
  20. McCann J, Welsh M. Regulation of Cl− and K+ channels in airway epithelium. Annu Rev Physiol. 1990;52(1):115-35.
  21. Papadimitriou A, Priftis KN. Regulation of the hypothalamic-pituitary-adrenal axis. Neuroimmunomodulation. 2009;16(5):265-71.
  22. Smith SM, Vale WW. The role of the hypothalamic-pituitary-adrenal axis in neuroendocrine responses to stress. Dialogues Clin Neurosci. 2006;8(4):383.
  23. Duhigg C. How companies learn your secrets. The New York Times. 2012;16:2012.
  24. Roelfsema PR, van Ooyen A, Watanabe T. Perceptual learning rules based on reinforcers and attention. Trends Cogn Sci. 2010;14(2):64-71.
  25. Sotres-Bayon F, Cain CK, LeDoux JE. Brain mechanisms of fear extinction: historical perspectives on the contribution of prefrontal cortex. Biol Psychiatry. 2006;60(4):329-36.
  26. Olson CR, Colby CL. Spatial cognition. Fundamental Neuroscience (Fourth Edition): Elsevier; 2014. p. 969-88.
  1. Klimesch W. EEG alpha and theta oscillations reflect cognitive and memory performance: a review and analysis. Brain research reviews. 1999;29(2-3):169-95.
  2. Ward LM. Synchronous neural oscillations and cognitive processes. Trends Cogn Sci. 2003;7(12):553-9.
  3. Tekieh E, Riahi E, Kazemi M, Sahraei H, Tavakoli H, Aliyary H, et al. Role of basal stress hormones and amygdala dimensions in stress coping strategies of male rhesus monkeys in response to a hazard-reward conflict. Iran J Basic Med Sci. 2017;20(8):951-7.
  4. Hillmann AG, Ramdas J, Multanen K, Norman MR, Harmon JM. Glucocorticoid receptor gene mutations in leukemic cells acquired in vitro and in vivo. Cancer Res. 2000;60(7):2056-62.
  5. Hosseini HM, Soleimanirad J, Aghdam EM, Amin M, Fooladi AAI. Texosome-anchored superantigen triggers apoptosis in original ovarian cancer cells. Med Oncol. 2015;32(1):409.
  6. Xuan X, Zhu J, Church C. Particle focusing in microfluidic devices. Microfluid Nanofluidics. 2010;9(1):1-16.
  7. McAuliffe MJ, Lalonde FM, McGarry D, Gandler W, Csaky K, Trus BL, editors. Medical image processing, analysis and visualization in clinical research. Computer-Based Medical Systems, 2001 CBMS 2001 Proceedings 14th IEEE Symposium on; 2001: IEEE.
  8. El-Kafrawy P, Barsoum M. On the Visualization and Software Techniques for Medical Imaging. Science. 2012;3(1).
  9. Lyons DM, Buckmaster PS, Lee AG, Wu C, Mitra R, Duffey LM, et al. Stress coping stimulates hippocampal neurogenesis in adult monkeys. Proc Natl Acad Sci. 2010;107(33):14823-7.
  10. Darusman H, Call J, Sajuthi D, Schapiro S, Gjedde A, Kalliokoski O, et al. Delayed response task performance as a function of age in cynomolgus monkeys (Macaca fascicularis). Primates. 2014;55(2):259-67.
  11. Tsujimoto S, Postle BR. The prefrontal cortex and oculomotor delayed response: a reconsideration of the “mnemonic scotoma”. J Cogn Neurosci. 2012;24(3):627-35.
  12. Thielens A, Van den Bossche M, Brzozek C, Bhatt CR, Abramson MJ, Benke G, et al. Representativeness and repeatability of microenvironmental personal and head exposures to radio-frequency electromagnetic fields. Environ Res. 2018;162:81-96.
  1. Feychting M, Ahlbom A, Kheifets L. EMF and health. Annu Rev Public Health. 2005;26:165-89.
  2. Devesa J, Lema H, Zas E, Munín B, Taboada P, Devesa P. Learning and Memory Recoveries in a Young Girl Treated with Growth Hormone and Neurorehabilitation. J Clin Med. 2016;5(2):14.
  3. Crowder RG. Principles of learning and memory: Classic edition: Psychology Press; 2014.
  4. Consales C, Merla C, Marino C, Benassi B. Electromagnetic fields, oxidative stress, and neurodegeneration. Int J Cell Biol. 2012;2012.
  5. Grassi C, D’Ascenzo M, Torsello A, Martinotti G, Wolf F, Cittadini A, et al. Effects of 50 Hz electromagnetic fields on voltage-gated Ca2+ channels and their role in modulation of neuroendocrine cell proliferation and death. Cell Calcium. 2004;35(4):307-15.
  6. Trillo MÁ, Martínez MA, Cid MA, Úbeda A. Retinoic acid inhibits the cytoproliferative response to weak 50‑Hz magnetic fields in neuroblastoma cells. Oncol Rep. 2013;29(3):885-94.
  7. Varró P, Szemerszky R, Bárdos G, Világi I. Changes in synaptic efficacy and seizure susceptibility in rat brain slices following extremely low‐frequency electromagnetic field exposure. Bioelectromagnetics. 2009;30(8):631-40.
  8. Komaki A, Khalili A, Salehi I, Shahidi S, Sarihi A. Effects of exposure to an extremely low frequency electromagnetic field on hippocampal long-term potentiation in rat. Brain Res. 2014;1564:1-8.
  9. Başar E. A review of alpha activity in integrative brain function: fundamental physiology, sensory coding, cognition and pathology. Int J Psychophysiol. 2012;86(1):1-24.
  10. Klimesch W. Alpha-band oscillations, attention, and controlled access to stored information. Trends Cogn Sci. 2012;16(12):606-17.
  11. Harach T, Marungruang N, Dutilleul N, Cheatham V, Mc Coy K, Neher J, et al. Reduction of Alzheimer's disease beta-amyloid pathology in the absence of gut microbiota. Sci Rep. 2017;7(1):41802.
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